Awards for June 2015

Federal Awards

Abrams, John, NIH, A High Throughput Discovery Platform Captures Mosquito-Specific Toxins, $242,250; Alto, Neal (Fellow A. Jimenez), Natl Science Fdn, Graduate Research Fellowship Program, $44,000; Amatruda, James, NIH, A Novel Functional Genomic Pipeline for Target Identification in Sarcoma, $165,530; Amatruda, James, Children’s Hosp of Phila/NIH, COG SMITSCS (U10CA180884), $13,308; Beutler, Bruce, NIH, Genetic Analysis of Resistance to Viral Infection, $2,627,681; Bibb, James, NIH, Role of Cdk5 in Stroke, $347,813; Bowen, Michael, NIH, Predicting Diabetes Risk Using Glucose Data in the Electronic Medical Record, $171,910;

Brown, Sherwood, Fast-Track Drugs & Biologics/NIH, Trial of Horizant for Treatment of Alcohol Use Disorder, $160,885; Burgess, Shawn, Duke Univ/NIH, Development of Novel Therapies for NIDDM: Pj 3, $349,800; Carroll, Thomas, NIH, UTSW Summer Undergraduate Research Institute for the Study of Kidney Diseases, $100,764; Casey, Brian, George Washington Univ/NIH, MEFU NICHD Network, $74,857; Chen, Chuo, NIH, Identifying Molecular Targets and Biological Signatures of CAM Natural Products, $431,985; Chiang, Cheng-Ming, Univ of Iowa/NIH, Factors Involved in Transcription by RNA Polymerase II, $14,542; Chuang, David, NIH, Structure and Function of Mitochondrial Protein Kinases, $474,345; Diamond, Marc, Washington Univ St. Louis/NIH, Effect of APOE on CNS Neurons: Role of LRP, $16,635;

Eisch, Amelia, NIH, Basic Science Training Program in Drug Abuse, $448,783; Fontoura, Beatriz, Mount Sinai School of Med/NIH, Chemical Intervention of Influenza Virus RNA Nuclear Export, $226,436; Frohman, Elliot, New York Univ/Natl Multiple Sclerosis Soc, Mechanisms of Retinal Neurodegeneration and Visual Pathway Axonal Loss in MS, $48,038; Gao, Jinming, NIH, Nanoprobe-Enabled Delineation of Tumor Margins for Improved Surgical Therapy, $369,431; Garcia, Christine, NIH, Pulmonary Fibrosis and Telomerase Dysfunction, $437,735; Ghose, Subroto, NIH, Synaptic Plasticity in Adolescent Cannabis Users: Relevance to Schizophrenia, $388,327; Goldberg, Mark, NIH, Network of Excellence in Neuroscience Clinical Trials (NEXT) (MPI), $318,000;

Goldstein, Joseph, NIH, Molecular Basis of Cholesterol Metabolism, $4,218,700; Green, Carla, NIH, Circadian Regulation of Mitochondrial RNA Polyadenylation, $306,075; Hendrixson, David, NIH, Campylobacter Jejuni Flagellar Regulation and Synthesis, $397,500; Hendrixson, David, NIH, Signal Transduction Pathways for Flagellar Gene Expression in Polar Flagellates, $242,250; Henkemeyer, Mark, NIH, Bidirectional Tyrosine Kinase Signaling, $523,695; Hsiang, Michelle, NIH, Evaluating Re-active Surveillance Strategies for Malaria Elimination, $131,490; Hsieh, Jenny, NIH, Novel Mechanisms of Adult Neurogenesis in Physiological and Pathological Contexts, $129,168; Hsieh, Jenny, Children’s Hosp of Phila/NIH, Neuronal Circuit Mechanisms of Epileptogenesis, $32,691;

Huber, Kimberly, NIH, Role of MEF2 and Neural Activity in Cortical Synaptic Weakening and Elimination, $388,354; Ivleva, Elena, NIH, Neural Network Biomarkers for Relational Memory and Psychosis in Schizophrenia, $169,668; Jia, Xun, NIH, A Progressive Cone-beam CT Dose Control Scheme for Image-Guided Radiation Therapy, $207,495; Jin, Eunsook, NIH, 13C Asymmetry in Blood Glucose as a Marker for Oxidative Stress in Liver, $276,660; Johnson, Jane, NIH, Regulation and Function of Asc11 in Neural Development, $347,813; Johnson, Mark, Massachusetts Genl Hosp/NIH, NN104 RHAPSODY, $30,527; Khera, Amit, Yale Univ/NIH, Young Women with Acute Myocardial Infarction (VIRGO), $825;

Kohler, Jennifer, NIH, Study of Sialoside Function Using Photocrosslinking Sialic Acid - Equipment Supplement, $100,000; Kramer, Helmut (Fellow L. Tyra), Natl Science Fdn, Graduate Research Fellowship Program - Tyra, $44,000; Le, Lu, Dept of Defense, Malignant Peripheral Nerve Sheath Tumors: Models, Biology and Translation, $278,250; Lin, Rueyling, NIH, Reprogramming by mRNA Clearance: The Maternal-to-Zygotic Transition, $407,018; Lingvay, Ildiko, Joslin Diabetes Center/NIH, PERL Study: Preventing Early Renal Function Loss in Diabetes, $124,912;

Malloy, Craig, NIH, Clinical Polarizer for Carbon-13 (SpinLab), $1,000,000; McFadden, David, NIH, Comparative Gene Resequencing in Mouse Cancer Models, $143,248; Mendelson, Carole, NIH, Mechanisms in the Regulation of SP-A Gene Expression, $454,710; Moe, Orson, NIH, UT Southwestern O'Brien Kidney Research Core Center, $1,165,505; Okada, Pamela, Univ of Virginia/NIH, Established Status Epilepticus Treatment Trial (ESETT), $49,977; Olson, Eric (Fellow A. Bookout), NIH, Regulation of Systemic Energy Metabolism by Myokines, $54,194; Olson, Eric (Fellow J. Papizan), NIH, The Role of DNA Methylation in Cardiac Regeneration, $54,194;

Pascual, Juan, NIH, Modulation of Neural Function in Energy Failure, $347,813; Pfeiffer, Julie, NIH, Enteric Virus-Microbiota Interactions, $420,757; Phelan, Herbert, Univ of Pittsburgh/Dept of Defense, Prehospital Air Medical Plasma (PAMPer) Trial, $120,000; Raskin, Philip, Tufts Univ/NIH, Vitamin D and Type 2 Diabetes (D2d Study), $47,612; Rice, Luke, NIH, Conformation and Recognition in Microtubule Dynamics, $302,100; Rogers, Zora, Cincinnati Children’s Hosp/NIH, TDC With Transfusions Changing to Hydroxyurea (TWiTCH) - Closeout, $2,810; Rothenfluh, Adrian, NIH, Role of Histone Demethylases in Experience Dependent Alcohol Behavior (MPI), $221,705; Schaffer, Joseph, RTI Intl/NIH, NICHD Pelvic Floor Disorders Network - Capitation Funding, $56,308;

Scherer, Philipp, NIH, Novel Mechanism Regulating the Adipocyte-Brain-Hepatocyte Axis, $1,938,000; Schoggins, John, NIH, Interactions between Type 1 and III Interferon During Resolution of HCV Infection, $102,087; Shaul, Philip, NIH, Fc Gramma RIIB and Inflammation-Related Vascular Disease, $352,383; Shay, Jerry, Georgetown Univ/NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation - Project 2, $152,992; Shay, Jerry, Georgetown Univ/NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation - Project 3, $50,997; Shay, Jerry, Georgetown Univ/NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation - Project 1, $37,582; Shay, Jerry, Georgetown Univ/NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation - Core D, $12,107; Shay, Jerry, Georgetown Univ/NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation - Core B, $11,218; Shay, Jerry, Georgetown Univ/NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation - Core A, $5,137;

Skapek, Stephen, Children’s Hosp of Phila/NIH, Skapek - COG SMITSCS (U10CA180884), $34,105; Skinner, Celette, NIH, Parkland-UT Southwestern PROSPR Center: Colon Cancer Screening in Safety Net (MPI), $1,207,118; Skinner, Celette, NIH, Parkland-UT Southwestern PROSPR Center: Colon Cancer Screening in Safety Net (MPI) - Supplement, $649,133; Sperandio, Vanessa, NIH, Sugar Regulation of EHEC Virulence, $397,500; Tambar, Uttam, NIH, Stereoselective Rearrangements for Synthesis of Bioactive Small Molecules - Equipment Supplement, $150,000; Tamminga, Carol, NIH, Bipolar-Schizophrenia Network for Intermediate Phenotypes 2 (B-SNIP 2), $802,307; Torrealba, Jose, Univ of Wisconsin/NIH, The Role of Complement Inhibition in Expanded Criteria Kidney Transplantation, $10,420;

Trivedi, Madhukar, NIH, Translational Research Activities in Neuropsychiatry (TRAIN), $199,843; Tu, Benjamin, NIH, Metabolic Signals Driving Cell Growth and Proliferation - Interim Funding Supplement, $106,590; van Oers, Nicolai, NIH, Long Noncoding RNAs and their Contribution to 22q11 Deletion Syndrome, $223,040; Wang, Junmei, Univ of Calif Davis/NIH, AMBER Force Field Consortium: a Coherent Biomolecular Simulation Platform, $103,970; White, Michael, NIH, Components of RAS Mediated Growth Control, $324,730; Willson, James, NIH, Cancer Center Support Grant, $1,615,000;

Word, Ruth, NIH, Mechanisms of Prostaglandin-induced Cervical Ripening in Humans, $335,113; Word, Ruth, NIH, Elastic Fiber Homeostasis in the Vaginal Wall (MPI), $313,785; Yan, Nan (Fellow C. Fermaintt), Natl Science Fdn, Graduate Research Fellowship Program - Fermaintt, $44,000; Yu, Gang, St. Jude Children’s/NIH, RNA Splicing Dysfunction in Alzheimer's disease, $99,323; Zhang, Chun-Li, NIH, Transcriptional Control of Adult Neural Stem Cells, $347,813; Zinn, Andrew, NIH, Medical Scientist Training Program at UT Southwestern, $947,984; Zinn, Andrew (Fellow E. Aguilera), Natl Science Fdn, Graduate Research Fellowship Program - Aguilera, $44,000.

Nonfederal Awards

Amatruda, James (Fellow G. Kendall), Alex’s Lemonade Stand, Zebrafish Modeling of PAX3-FOXO1 Driven Rhabdomyosarcoma, $50,000; Bird, John, Food Allergy Res & Educ, FARE Clinical Network, $131,999; Bird, John, Amer Coll of Allergy Asthma & Imm, Sublingual Immunotherapy (SLIT) as an Early Interventional Treatment for Peanut Allergy, $50,000; Blount, Paul, CPRIT, Imaging Cancerous Tissues with Liposomal MRI Contrast Agents that Utilize Bioengineered Nanovalves, $436,257; Brugarolas, James, CPRIT, Evaluation of the Role of the BAP1 Tumor Suppressor Gene in Renal Cancer, $401,817; Bruick, Richard, CPRIT, Discovery and Optimization of Natural and Artificial Ligands Regulating Hypoxia Inducible Factor, $486,842; Burstein, Ezra, CPRIT, COMMD1 and the Control of Tumor Invasion, $271,552;

Choi, Changho, CPRIT, Clinical MR Spectroscopy Development of 2-Hydroxyglutarate as a Specific Biomarker for Malignant Gliomas, $330,921; Choti, Michael (Fellow S. Ganji), Venturewell, Pneumom: Mitigating Impacted Fetal Head - Stage 1, $5,000; Cleaver, Ondine (Fellow C. Braitsch), Juvenile Diabetes Res Fdn, YAP/TAZ in Pancreas Epithelial Stratification and Progenitor Cell Fate, $50,932; Deberardinis, Ralph, CPRIT, The Metabolic Phenome of Human Lung Cancer, $226,092; Evans, Walter, Susan G. Komen for the Cure, Mobile Mammography Outreach Project, $103,388; Finklea, James, Cystic Fibrosis Fdn, Program for Adult Care Excellence (PACE), $27,000; Galindo, Rene (Fellow S. Ingram), Howard Hughes Med Inst, HHMI Fellowship for Sally Igham, $41,000;

Garrard, William, Welch Fdn, Formaldehyde Cross-Linking for Discovery of Novel Regulatory Elements Exhibiting, $60,000; Hobbs, Helen (Fellow S. Basuray), Amer Liver Fdn, Role of PNPLA3 in Fatty Liver Disease, $12,500; Holland, William (Fellow A. Sharma), Amer Heart Assoc SW, Adiponectin Signaling and Cardiac Lipotoxicity, $4,000; Iyengar, Puneeth, Amer Cancer Society, Unchecked Adipocyte Lipolysis and Tumor Progression in Cachexia, $198,000; Jiang, Jin, Welch Fdn, Study of Cell Signaling at the Primary Cilium, $100,000; Johnson, Jane, CPRIT, Requirement for Ascl1 in Gliomagenesis, $279,927; Kirkwood, Melissa, Society for Vascular Surgery, SVS Women’s Leadership Training Grant, $5,000; Kohler, Jennifer, Welch Fdn, Discovering Toxin Receptors with Photocrosslinking Sugars, $100,000;

Kraus, William, CPRIT, Role of Long Non-Coding RNAs in Breast Cancers: Identification, Characterization, and Determination of Molecular Functions, $278,293; Liu, Qinghua, Welch Fdn, Mechanistic Studies of the Drosophila RNA Interference Pathway, $60,000; Lum, Lawrence, CPRIT, Molecularly Targeted Anticancer Therapeutic Strategy Premised upon Attack of Aberrant Wnt Pathway Responses, $463,208; MacMillan, John, Welch Fdn, Role of Non-enzymatic Transformations in Natural Product Biosynthesis, $75,000; Maher, Elizabeth, CPRIT, Genotype and Metabolic Phenotype in Pediatric Brain Cancer, $350,000; Michael, Anthony, Burroughs Wellcome Fund, Integrating Chemistry with Biochemistry and Molecular Biology to Engineer, $5,250; Mirzaei, Hamid, Welch Fdn, Development of a Fully Automated 3D Separation Platform, $60,000; Nam, Yunsun, Welch Fdn, Structure and Function Relationship of MicroRNA Precursors, $60,000;

Pillai, Anil, Society of Interventional Radiology Fdn, Clinical and Financial Impact of Long-Term Nephrostomy Tube, $30,000; Ready, Joseph, Welch Fdn, Catalytic Synthesis and Application of Substituted Ynol Ethers, $75,000; Siegwart, Daniel, Welch Fdn, Smart, Linear-Dendritic Block Copolymers to Increase siRNA Release in Response, $60,000; Wan, Yihong, CPRIT, Osteoclast Regulation of Bone Metastasis of Cancer, $361,206; Wan, Yihong, March of Dimes Fdn, Maternal VLDLR Regulation of Milk PAFAH and Neonatal Inflammation, $130,967; Wang, Jing, CPRIT, Quantitative Cone-Beam CT for Adaptive Radiation Therapy, $219,999;

Wolf, Matthias, Amer Society of Nephrology, The role of Mucin 1 in Protection Against Nephrolithiasis by Regulation of the Renal Calcium Channel TRPV5, $100,000; Word, Ruth (Fellow K. Chin), PFD Res Fdn, Therapeutic Potential of Protease Inhibitors in the Vaginal Wall, $12,500; Xu, Jian, CPRIT, Recruitment of First-Time, Tenure-Track Faculty Members, $398,902; Xu, Jian, Amer Society of Hematology, Molecular Analysis of BCL11A Structure-Function, $50,000; Yan, Nan, Burroughs Wellcome Fund, STING Activation at the Nexus of Microbial Infection and Host Innate Immunity, $100,000; Yan, Nan, Welch Fdn, Tail-Anchor of a Critical Innate Immunity Regulator TREX1 on the ER, $60,000; Zhang, Chengcheng, March of Dimes Fdn, Angptl Receptor Supported Expansion of Cord Blood Stem Cells, $107,224.

Industry Sponsored Awards, dollar amounts not available

Bartolome, Sonja, Study of Oral Sildenafil on Mortality in Adults with Pulmonary Arterial Hypertension (PAH); Beutler, Bruce, Genetic Studies of IBD and Autoimmunity; Cohen, Jonathan, Sponsored Research Agreement OTD Contract #106761; Greenberg, Benjamin, Phase 3 Study of SA237 as Monotherapy for Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD); Greenberg, Benjamin, Study of MEDI-551 in Adults with Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders; Jain, Raksha, Study of P-1037 Solution for Inhalation in Pts with Cystic Fibrosis (CLEAN-CF); Jessen, Michael, Study of PerClot Polysaccharide Hemostatic System; Khan, Saad, LDK378 in Anaplastic Thyroid Cancer with ALK Gene Mutations; Laetsch, Theodore, Long Term Follow-Up of Pts Exposed to Lentiviral-Based CD19 Directed CART Cell Therapy; Laetsch, Theodore, Phase 2 Study of CTL019 in Ped Pts with Relapsed and Refractory B-Cell Acute Lymphoblastic Leukemia; Laetsch, Theodore, Study of Apheresis Collection of Peripheral Blood Mononuclear Cells (PBMC) in Pts with CD19 Expressing Malignancies who could be Eligible for a CTL019 clinical Research Trial;

Liang, Guosheng, Sponsored Research Agreement OTD Contract # 107869; Liu, Qinghua, Molecular Circuit of Sleep Regulation; Lotan, Yair, Evaluation of Xpert Bladder Assay for Detection of Bladder Cancer in Symptomatic Pts; Lotan, Yair, Evaluation of Xpert Bladder Assay for Monitoring the Recurrence of Bladder Cancer; Mammen, Pradeep, Outcomes AlloMap Registry (OAR) Study; Sub-Study (D-OAR); Miller, David, Phase 2 Study of AZD1775 plus Chemo vs. Chemo Alone for Platinum-Resistant TP53-Mutated Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer; Minei, Joseph, Phase 4 Study of IrriSept System vs Standard of Care (SoC) on Prevalence of Surgical Site Infection in Pts with Abdominal Trauma or Acute Surgical Abdomen; Monson, Nancy, Sponsored Research Agreement OTD Contract #107436; Naina, Harris, Phase 2 Study of PNT2258 in Pts with Relapsed or Refractory Diffuse Large B-Cell Lymphoma; Pelosof, Lorraine, Phase 1 First-In-Human Study of Oral TVB-2640 in Pts with Solid Tumors;

Slone, Tamra, Phase 3 Testing of Blinatumomab in First Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL); Stegner, Martha, Study of Romisplostim in Thrombocytopenic Pediatric Sbjs with Immune Thrombocytopenia (ITP); Verma, Udit, Phase 3 Study of Capecitabine and Cisplatin with or without Ramucirumad for Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma (RAINFALL); Verma, Udit, Ruxolitinib or Placebo with Regorafenib in Sbjs with Relapsed or Refractory Metastatic Colorectal Cancer; White, Jonathan, Study of Reverse Medical Barrel Vascular Reconstruction Device (VRD).