Awards for August 2015

Federal Awards

Abrams, John (Fellow P. Kurtz), NIH, Non-Canonical Gene Regulation Through a Drosophila p53 Enhancer, $30,485; Beutler, Bruce, NIH, Mutagenic Analysis of LPS Response, $813,237; Brown, Sherwood, NIH, Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders, $700,994; Brown, Sherwood, Fast-Track Drugs & Biologics/NIH, Trial of Horizant for Treatment of Alcohol Use Disorder, $546,570; Burstein, Ezra (Fellow A. Singla), NIH, Altered Endosomal Protein Sorting in the Pathogenesis of Hepatocellular Carcinoma, $125,540; Cheng, Edaire, NIH, Role of Periostin and Th2 Cytokines in Eosinophilic Esophagitis Fibrogenesis, $148,711; Cobb, Melanie, NIH, Fundamentals of Professional Communication & Project Management, $79,206; Cobb, Melanie (Fellow C. Thorne), NIH, The Role of Kinase Signaling in Intestinal Epithelial Homeostasis, $87,237;

Danuser, Gaudenz (Fellow M. Driscoll), NIH, Bleb Functions in 3D Morphogenesis, $56,894; Deberardinis, Ralph (Fellow R. Egnatchik), NIH, Targeting the Control of Calcium Signaling by the Warburg Effect, $52,406; D'Orso, Ivan, NIH, Novel Small Molecules to Reactivate Latent HIV and Sensitize to Anti-Viral Therapies, $218,625; Eisch, Amelia, NIH, Molecular and Chemogenetic Control of Dentate Gyrus Inputs: a Novel Approach, $240,744; Fontoura, Beatriz, NIH, Crosstalk Between Human mRNA Nuclear Export and Polyadenylation Machineries, $403,750; Gattineni, Jyothsna, NIH, GAT FGF23 and Vascular Calcification, $80,750; Hobbs, Helen (Fellow M. Mitsche), NIH, Determining Function of PNPLA3 Utilizing Metabolomics and Stable Isotope Labeling, $103,204; Holland, William, NIH, Adiponectin Receptors and S1P Signaling in Beta Cell Survival and Proliferation, $244,203; Holland, William (Fellow J. Johnson), NIH, Sphingolipid-Mediated Dysregulation of Glucose and Energy Homeostasis by POMC, $30,992;

Huang, Chou-Long, NIH, Klotho and Chronic Kidney Disease, $238,500; Johnson, Jane (Fellow T. Vue), NIH, Underlying Molecular Mechanisms of Gliogenesis and Gliomagenesis in the Central Nervous System, $82,184; Kim, Taekyung, NIH, Epigenetic Mechanism of Enhancer RNA in Behavioral Plasticity, $347,813; Kittler, Ralf, UT Med Branch/NASA, Molecular Characterization of Transmissible Chromosome Aberrations, $21,099; Knudsen, Erik, NIH, Pathway Heterogeneity: Etiology and Treatment of TNBC, $329,925; Konopka, Genevieve, NIH, The Role of Foxp1-Regulated Signaling Pathways in Brain Development and Behavior, $403,750; Kramer, Helmut, NIH, AMPylation, Novel Mechanism Regulating Visual Neurotransmission, $311,640; Lee, William, NIH, Hepatitis B Research Network Clinical Centers, $388,133; Lega, Bradley, Univ of Pennsylvania/DARPA, Brain Recording and Stimulation for Memory, $79,642;

Lenkinski, Robert, QT Ultrasound/NIH, Multimode Quantitative Ultrasound Prototype Breast Scan, $355,276; Levine, Benjamin, NIH, Aging, Fitness & Failure: Mechanisms of Diastolic Dysfunction, $534,379; Liu, Yi, NIH, Molecular Mechanism of the Neurospora Circadian Clock, $361,356; MacMillan, John, NIH, Center for High-Throughput Functional Annotation of Natural Products, $993,265; McFadden, David, NIH, Comparative Gene Resequencing in Mouse Cancer Models, $180,360; McKnight, Steven, NIH, Reversible Polymerization of Low Complexity Polypeptide Sequences, $490,933; Mendell, Joshua, NIH, The Intersection of RNA Biology and Tumor Biology, $521,828; Mineo, Chieko, NIH, Endothelial SR-BI and Metabolic Health, $403,750;

Minna, John, NIH, Developing New Rationale, Personalized Medicine for Lung Cancer (SPORE), $2,041,142; Moe, Orson, NIH, UT Southwestern O'Brien Kidney Research Core Center – Summer Supplement, $47,628; Monteggia, Lisa, NIH, MeCP2 Dependent Transcriptional Repression & Neurotransmission, $397,500; Niederkorn, Jerry, NIH, Core Grant for Vision Research, $610,481; Olson, Eric (Fellow C. Makarewich), NIH, Elucidation of the Role of a Novel Cardiac Micropeptide in the Control of Heart, $52,406; Olson, Eric (Fellow S. DeLeon), NIH, Regulation of Striated Muscle Development and Function by MED12, $30,812; Pedrosa, Ivan, NIH, Non-Invasive Physiologic Predictors of Aggressiveness in Renal Cell Carcinoma, $293,871; Powell, Craig, NIH, Novel Genetic Models of Autism, $329,427;

Rahn, David, NIH, Investigation to Minimize Prolapse Recurrence Of the Vagina Using Estrogen (IMPROVE), $569,601; Raskin, Philip, Benaroya Res Inst at Virginia Mason/NIH, EXTEND - Preserving Beta-Cell Function with Tocilizumab in New Onset Type 1 Diabetes, $40,418; Repa, Joyce, Baylor Col of Med/NIH, Defining Lipidomic Signatures of Nuclear Hormone Receptor Activity Using MS/MSALL, $150,000; Roberts, Todd, Natl Science Fdn, The Neuronal Basis of Tutor Song Memory, $252,713; Rodan, Aylin, NIH, Probing Intracellular Cl- in a WNK Signaling-Dependent Transporting Epithelium, $80,750; Rosen, Michael (Fellow J. Ditlev), NIH, Stability and Dynamics of Nephrin/Nck/N-WASp Clusters on Membranes, $54,194; Rypma, Bart, NIH, BOLD and Its Discontents: Age-Differences in the Neurophysiology of fMRI Signal (MPI), $340,198;

Scaglioni, Pier (Fellow J. Constanzo), NIH, SUMO Ligase PIAS1: An Unexpected Role In Mouse Embryogenesis and Cancer Survival, $30,632; Schaffer, Joseph, RTI Intl/NIH, NICHD Pelvic Floor Disorders Network, $1,464; Scherer, Philipp (Fellow J. Xia), NIH, Intracrine Metabolic Effects of Adiponectin Mutants, $30,600; Schiller, Joan, NIH, Physician Scientist Oncology Training Prgm, $228,698; Shay, Jerry, NIH, Cancer Biology Training Grant, $371,713; Shay, Jerry, Georgetown Univ/NASA, GU/NASA Project 3, $121,492; Shay, Jerry, Georgetown Univ/NASA, GU/NASA Project 1, $109,929; Shay, Jerry, Georgetown Univ/NASA, GU/NASA Core C, $25,356; Skapek, Stephen, Children’s Hosp of Phila/NIH, Skapek – COG STS Biology Vice Chair, $14,187; Skapek, Stephen, Children’s Hosp of Phila/NIH, NIH National Clinical Trials Network (NCTN) Scientific Leadership, $14,048;

Sperandio, Vanessa, NIH, SdiA Regulation of EHEC Virulence, $373,650; Terada, Lance, NIH, Training PRGM in Lung Biology and Disease, $445,258; Ufret-Vincenty, Rafael, NIH, Role of Complement Factor H and Immunity in AMD: Novel Transgenic Model, $389,550; Vazquez, Miguel, NIH, Improving Chronic Disease Management with Pieces (ICD-Pieces), $1,374,845; White, Michael, NIH, Targeting Mechanistic Subtypes of Neoplastic Disease, $725,453; Williams, Kevin, NIH, Central Mechanisms Regulating Acute Leptin and Insulin Signaling, $357,750; Williamson, Jon, Dallas Fdn/DHHS, Teen Pregnancy Prevention NTARuPT, $171,070; Womack, Kyle, Univ of Southern Calif/NIH, ADC-046-INI, $238,460; Wyckoff, Myra, RTI Intl/NIH, NICHD Neonatal Research Network, $58,717; Yan, Nan, NIH, DNase-Independent Function of TREX1/DNase III in Systemic Lupus Erythematosus, $349,800; Zang, Qun, NIH, Pathological Responses to Mitochondrial ROS in Sepsis-Induced Cardiac Dysfunction, $290,700; Zhang, Xuewu, NIH, Signaling and Regulation Mechanisms of Plexin, $321,215.

Nonfederal Awards

Bassel-Duby, Rhonda (Fellow K. Anderson), Amer Heart Assoc SW, Hand2-Associated Long Non-Coding RNA is Required for Normal Development, $25,000; Bibb, James, Amer Cancer Soc, Development of New Treatment Strategies for MEN2 Cancer, $240,000; Dewey, Richard, UT System, Big Data Analysis of Gait in Parkinson Disease, $100,000; Galindo, Rene, Amer Cancer Soc, New Pathways Underlying Rhabdomyosarcoma Pathogenesis, $240,000; Gardner, Lisa (Fellow C. Morales-Perez), Howard Hughes Med Inst, HHMI Fellowship – Morales-Perez, C., $43,000; Gardner, Lisa (Fellow L. Qi), Howard Hughes Med Inst, HHMI Fellowship – Qi, L., $43,000; Greenberg, Benjamin, Guthy-Jackson Fdn, NMO Repository Traveling Nurse, $119,900; Henkemeyer, Mark, UT System, Peptoid Ligands that Target the Pro-Synaptic EphB2 Receptor, $100,000; Hibbs, Ryan, McKnight Endowment Fund, Structure and Mechanism of Neuronal Acetylcholine Receptors, $75,000;

Hibbs, Ryan, Klingenstein Third Generation Fdn, Structure and Mechanism of Neuronal Nicotinic Acetylcholine Receptors, $75,000; Hill, Joseph, Amer Heart Assoc Natl Ctr, UT Southwestern Medical Center Strategically Focused Prevention Research Center, $954,800; Holland, William, UT System, Mapping the Mouse Brain Lipidome in Metabolic Disease, $100,000; Hon, Gary, CPRIT, Recruitment of First-Time, Tenure-Track Faculty Members, $514,449; Hsieh, Jenny, Amer Heart Assoc SW, Deciphering the Role of Aberrant new Neurons in Post-Stroke Epilepsy, $70,000; Hulleman, John, Research to Prevent Blindness, RPB 2015 Career Development Award, $75,000; Lega, Bradley, UT System, Functional Correspondence Between Neuronal Activity and Gene Expression, $100,000; Mammen, Pradeep (Fellow D. Stoller), Heart Failure Soc of America, Discovery of Unique MicroRNA Signatures in Muscular Dystrophy Patients, $10,000;

McKnight, Steven (Fellow T. Han), Life Sciences Res Fdn, Structural and Functional Analyses of Fibers Formed from Low Complexity Sequences, $60,000; Meeks, Julian, UT System, Improved Light Sheet Microscopy for Rapid Multicolor 3D Imaging in vivo, $100,000; Moe, Orson (Fellow J. Neyra Lozano), Amer Soc of Nephrology, Klotho and Acute Kidney Injury: A Case-Control Study in Humans, $50,000; Moe, Orson (Fellow S. Ferre), Amer Soc of Nephrology, Understanding the Regulation of HNF-1beta Expression by ER Stress Effectors, $50,000; Nam, Yunsun, Pew Scholars Prgm, Mechanism and Regulation of MicroRNA Processing by Microprocessor, $60,000; Olson, Daiwai, Rehabilitation Nursing Fdn, Is the CABIC Clean Intermittent Catheterization Patient Education Effective (ICPEE)?, $4,482; Olson, Daiwai, Agnes Marshall Walker Fdn, When is an ICP Transducer Providing a Value Reflecting True ICP?, $3,551; Olson, Eric (Fellow H. Zhou), Amer Heart Assoc SW, Enhancement of Cardiac RePRGMming Using Cardiogenic Molecules, $25,000;

Patrie, Steven, UT System, Proteoform Network Analysis and Whole Animal Biomarker Discovery, $100,000; Roberts, Todd, UT System, Identifying Novel Viral Vectors for Neuroscience Research, $100,000; Roberts, Todd, Klingenstein Fund, Dissecting the Cellular Representation of the Template used for Vocal Learning, $75,000; Sadeghi, Navid, V Fdn for Cancer Res, Breast Cancer Clinical Research Navigator, $65,000; Volk, Lenora, UT System, Synaptic and Circuit Mechanisms of Memory Consolidation During Sleep, $100,000; Xu, Wei, UT System, Visualizing Brain Rewiring by Engineering A-B Toxins, $100,000.

Industry-Sponsored Awards

(Dollar amounts not available)

Arriaga, Yull, Phase 2 Study of B-701 in Trtmt of Urothelial Cell Carcinoma in Sbjs Relapsed After or Refractory to Standard Therapy, BioClin Therapeutics Inc; Battaile, John, Phase 2 Study of Pazopanib Dosing on Bleeding in Sbjs with Hereditary Haemorrhagic Telangiectasia, GlaxoSmithKline; Chin, Kelly, U.S. CTEPH Registry, Univ of Calif, San Diego/Bayer; De Lemos, James, Create multivariable predictive models for heart failure development, Roche Diagnostics Corp; Desai, Dev, Phase 2 Study of Topical Fibrocaps in Intraoperative Surgical Hemostasis in Pediatric Population, PPD Inc/Medicines Co; Glazer, Craig, Study of SAR156597 for Idiopathic Pulmonary Fibrosis (IPF), Sanofi US Services Inc; Greenberg, Benjamin, Ascending Dose IV Infusion Study of rHIgM22 in Sbjs with Multiple Sclerosis Immediately Following a Relapse, PRA Health Sci/Acorda Therap; Haley, Barbara, Phase 1b/2 Study of MLN0128 with Exemestane or Fulvestrant in Postmenopausal Women with ER+/HER2- Advanced or Metastatic Breast Cancer, Quintiles/Millennium Pharm;

Haley, Barbara, Phase 3 Study of Olaparib Monotherapy vs. Chemotherapy for Metastatic Breast Cancer Pts with germline BRCA1/2 Mutations, Astrazeneca Pharma; Haley, Barbara, Phase 3 Trial of Carboplatin and Paclitaxel in HER2-Negative Metastatic or Locally Advanced Unresectable BRCA-Associated Breast Cancer, Abbvie Inc; Khera, Amit, Long-Term Study of Statin Residual Risk reduction with EpaNova in High Cardiovascular Risk Patients with Hypertriglyceridemia (STRENGTH), Quintiles/Astrazeneca; Lotan, Yair, Validation BCA in a Clinical Utility Study-USA, Laboratory Corp of America; Miller, David, Phase 2 Study of Niraparib in Women with Advanced, Relapsed, Hugh-Grade Serous Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer, DrugDev/Tesaro; Pan, Edward, ABT-414 Alone or ABT-414 Plus Temozolomide Versus Lomust, Abbvie Inc; Patel, Vishal, Exploratory Studies in Autosomal Dominant Polycystic Kidney Disease (ADPKD), Regulus Therapeutics;

Schaffer, Joseph, Phase 4 Study of Mirabegron in Older Adult Sbjs with Overactive Bladder, Icon Clinical Res/Astellas Pharma; Szmuk, Peter, Evaluation of SEDLine EEG Monitoring in Pediatric Patients Undergoing General Anesthesia or Sedation, Masimo Corp; Torres, Fernando, Phase 2 Dose-Ranging Study of GS-4997 in Sbjs with Pulmonary Arterial Hypertension, Gilead Sciences Inc; Vusirikala, Madhuri, Phase 1 Study of Recombinant L-Asparaginase Encapsulated in Erythrocytes (ERY-ASP/GRASPA), Erytech Pharma.