Biomedical Engineering Faculty

Program Director

Research Interests: Cell motility and mechanics, corneal repair and regeneration, in vivo confocal imaging

Associate Director of BME Joint Programs

Research Interests: Development of noninvasive molecular imaging tools to elucidate in vivo metabolism

Faculty

Research Interests: Molecular Imaging; optical imaging; instrument development; image-guided surgery; cancer treatment, molecular probes; spectroscopy, multimodal nuclear and magnetic imaging; stimulated thermal imaging, nanomedicine

Research Interests: Drug resistance mechanism, drug delivery systems, nanoparticles, immunotherapy, tissue engineering

Research Interests: Development of hybrid positron emission tomography (PET) (e.g. PET-CT and PET-MR) tools to enable precision imaging for the care and study of oncology, neurology, and cardiology patients.

Research Interests: Developing non- and minimally invasive optical tools to monitor deep tissues in health and disease, as well as throughout therapy

Research Interests: Cancer, cell polarity, developmental biology, morphogenesis, stem/progenitor cells, tissue engineering and regeneration

Research Interests:Biomechanical Modeling of Cardiovascular System; Computational Physiology; Cardiovascular MRI; Heart Failure; Congenital Heart Disease

Research Interests: Genomic, genetic, and molecular approaches to autism spectrum disorders

Research Interests: Metastasis, Breast Cancer, Tumor Immunology, Immunotherapy

Research Interests: MR spectroscopy, MR spectroscopic imaging, MRI, Brain, GABA, glutamate, glutatamate, Glioma, Major depressive disorder, Bipolar disorder, epilepsy, MEGA-PRESS, metabolite mapping, AI, neural networks

Research Interests: Nerve regeneration; long nerve gap repair; nerve-machine interface

Research Interests: Computational protein science, evolutionary genomics, machine learning, structural biology

Research Interests: Nanomedicine and image-guided drug delivery for novel diagnostic and therapeutic applications in oncology

Research Interests: Somatic diversification of antigen receptor genes; repertoire characteristics as biomarkers of immune status and disease; host-pathogen interactions

Research Interests: Cognitive neuroscience; language; cognition; social communication; fMRI; neuroimaging; autism spectrum disorders; development; cerebellum

Research Interests: Regulation of cell morphogenesis during metastasis; roles of mechanics in cell survival and drug resistance

Research Interests: Sub concussive head impact exposure in contact sports, traumatic brain injury, magnetoencephalography

Research Interests: Metastatic colonization, autonomous light-sheet microscopy, optical probes, computer vision

Research Interests: Ultrasound contrast agent, perfluorocarbon emulsions, development of new ultrasound-based strategies for early detection and treatment of diseases

Research Interests: MR medical physics, adaptive radiotherapy, imaging, deep learning, MRI, radiology, NMR, pattern recognition, neuroradiology, AI, artificial intelligence, oncology

Research Interests: Understand the basic biomechanical and neurophysiological properties of the lower limb after neurological lesions. Explore the neuro-mechanical underpinnings of lower limb impairments after stroke, with the goal of informing future clinical interventions

Research Interests: The long-term goal of our lab’s research is to develop and implement imaging technologies that provide unprecedented insight into cancer biology.

Research Interests: Activatable optical/MRI imaging probes to study tumor metabolism and theranostic nanomedicine for cancer-targeted drug therapy

Research Interests: Molecular imaging, Synthetic chemistry, Spin physics, Metabolism

Research Interests: Evaluate the use of newly designed biodegradable stints to treat pulmonary artery stenosis

Research Interests: Computational biology; analysis of protein sequences and structures

Research Interests: Statistical methods, clinical trials, epidemiology, health economics

Research Interests: Resonance Imaging; Magnetic Resonance Spectroscopy; ultra-high field MRI; hardware; RF coils; B0 shimming; sequence development; data analysis

Research Interests: Single-cell regulatory genomics, cell fate engineering, function of non-coding elements and genetic variants.

Research Interests: Heart-lung interaction; lung morphometry; structure-function correlation of lung growth

Research Interests: Colorectal cancer, tumor microenvironment, regeneration, cancer stem cells

Research Interests: Assessment of ventriculographie-arterial coupling in congenital and acquired heart disease. Cardiac MRI for improved vascular imaging

Tarique Hussain-M.D., Ph.D.-Faculty Photo

Research Interests:Large language models, AI, spatial biology, image analysis, machine learning

Research Interests: Quantitative single-molecule imaging of receptor organization and signaling; linking molecular and cellular behavior across multiple scales; computational image analysis and data multiplexing

Research Interests: Artificial intelligence in medical imaging, radiotherapy treatment planning, and adaptive radiotherapy, etc.

Research Interests: Molecular recognition in protein folding, chaperone structural biology,and neurodegeneration

Research Interests: Comparative genomics, epigenetics, and alternative splicing analyses relevant to brain evolution and cognitive disorders

Research Interests: Generation and application of hyperpolarized¹³C-labeled compounds and⁸⁹Y-complexes for MRI/Radiopharmaceutical applications

Research Interests: Computational genomics. Using molecular, genetic, genomic, and computational approaches to understanding signal-regulated gene expression. Integrating data from different genomic platforms using computational approaches

Research Interests: Development of novel computational algorithms/models/pipelines for big, heterogeneous biological and medical data

Research Interests: Cell fate, wound healing, muscle fibrosis, heterotopic ossification, injury response

Research Interests: Neuroimaging, MRI, Dynamic Brain Connectivity, Dopamine, Astrocytes, Reward and Learning

Research Interests: Probe engineering and targeted drug delivery to islet cells for treating diabetes; Islet biology with an emphasis on functional analysis on zinc signaling and zinc transporters in islet endocrine cells.

Research Interests: Structural and biochemical characterization of membrane proteins in cholesterol biosynthesis, metabolism and signaling

Research Interests: Theoretical and computational approaches to predict protein folding and aggregation; evolutionary dynamics

Research Interests:Fast and motion-robust MRI acquisition and reconstruction, High-resolution MRI for in vivo imaging intracortical structure and deep nuclei, Novel MRI contrast and quantification of tissue properties

Research Interests: Molecular Imaging, lung cancer, kidney cancer, tumor microenvironment

Research Interests: Mechanisms of protein folding, misfolding, and aggregation; Studying amyloid assembly and their heterotypic interactions with other cellular components, with a particular focus on neurodegenerative diseases, such as Alzheimer's and Parkinson's disease; Development of anti-amyloid inhibitors as novel therapeutics; Functional amyloids in organisms

Research Interests: Adaptive radiation therapy; treatment-plan optimization; radiation-dose calculations

Research Interests: Ultrasound-guided drug and gene delivery, Targeted drug delivery system, Materials Science, Immunotherapy, Image-guided therapy, Nanomedicine

Research Interests: Parturition (the process of labor); cervical ripening; male and female reproductive biology

Research Interests: Deep Learning applications in neuroimaging including brain tumor molecular marker prediction, Traumatic Brain Injury, MEG, MRI, fMRI

Research Interests: Tumor pathophysiology and MR assessment of prognostic biomarkers/hypoxia and pH

Research Interests: Developing state-of-the-art machine-learning approaches to extract radiological imaging and imaging-genomic biomarkers for individualized prognostics in neuroscience and oncological applications

Research Interests: Radiation therapy treatment planning, optimization techniques and algorithms, artificial intelligence technology development and applications

Research Interests: Statistical causal inference, Computational analysis of live-cell imaging, Computational modeling of sub-cellular protein-protein interactions from live-cell video data Image-based modeling of information flow within biological neural networks/p>

Research Interests: Methods development for cryo-electron microscopy, X-ray crystallography, and next-generation sequencing; Structural studies of macromolecules with X-ray crystallography and cryo-EM single particle reconstruction; Higher-order structure of eukaryotic chromatin.

Research Interests: Application of structural (X-ray, CT, and MR) and functional (SPECT and PET) imaging methods to quantify changes in bone mass and metabolism induced by metabolic bone diseases; in vivo assessment of beta-cell mass and function by novel probes; novel PET and SPECT probe development for bone cells

Research Interests: Development of noninvasive molecular imaging tools to elucidate in vivo metabolism

Research Interests: Development of novel MRI techniques for improved diagnosis of abdominal/pelvic diseases and noninvasive in vivo assessment of physiology and response to therapy in tumors

Research Interests: Heart, lung, and perfusion preservation, magnetic resonance spectroscopy

Research Interests: Translational biophotonics, optical spectroscopy & imaging, instrumentation

Research Interests: Spatial organization of tumors by combining machine identified phenotypes and existing pathology scoring within the framework established by cancer biology

Research Interests: Nanomedicine, immunotherapy, ultrasound and radiation guided chemo-immunonotherapy

Research Interests: Molecular evolution, using protein sequence analysis to predict mutational effects on function, engineering protein regulation, mapping and modeling the relationship between enzyme activity and cellular growth rate, co-evolution in metabolic pathways.

Research Interests: Integrating structure, kinetics, and computation to understand the molecular determinants and regulatory mechanisms of microtubule dynamics

Research Interests: Biomaterials, hydrogels, tissue engineering, stem cells, regenerative medicine, drug delivery

Research Interests: Cellular information processing; molecular mechanisms of G protein-mediated signaling: amplification, selectivity, response kinetics and signal integration

Research Interests: Biostatistics, statistical genomics, multi-omics

Research Interests: Role of cycloxygenase-2 in radiation and chemo-resistance, role of small molecule inhibitors as radio-sensitizers

Research Interests: Intermediary Metabolism in Cardiovascular & Metabolic Diseases, Hyperpolarized Carbon-13 Metabolic Imaging, Metabolomics in the Heart, Lung, and Perfusion Preservation, Nuclear Magnetic Resonance (NMR) based Metabolomics

Research Interests: Innovate, develop, and apply artificial intelligence and other advance computational technologies to empower clinicians to improve cancer care

Research Interests: Polymer and materials chemistry, drug and gene delivery, RNAi, biomedical imaging, detection and treatment of cancer

Research Interests: Clinical application of nanoprobes with unique nanoscale behavior

Research Interests: Development of PET, SPECT, and MRI imaging probes to assess biological abnormalities and evaluation of disease treatment

Research Interests: Biomaterials, immunoengineering, infection tissue engineering

Research Interests:Aging, Cerebral blood flow, Cerebral metabolic rate of oxygen consumption, Cerebrovascular physiology, Mild cognitive impairment and Alzheimer's disease

Research Interests: Antibiotic resistance and sensitivity; single molecule biophysics; synthetic biology

Research Interests: Endogenous and exogenous MRI contrast agents and mechanisms in vivo, CEST and PARACEST imaging, hyperpolarization

Research Interests: Immunogenomics, Tumor genomics, Bioinformatics, Biostatistics, and Machine learning

Research Interests: Biomedical optics, In Vivo cell tracking, Optical tomography-guided radiation therapy and Ultra-high dose rate irradiation

Research Interests: Diffusion MRI; QSM; Neuroimaging; ML/AI; Alzheimer's Disease; Osteoarthritis

Research Interests: My methodology research is focused on model development for high-dimensional data such as gene expression, epigenomics, copy number variation, proteomics, genome-wide RNAi functional screening data and brain image data.

Research Interests: Biostatistics, bioinformatics, statistical genomics, clinical trial design, and biomarker studies

Research Interests: Statistical genetics, genetic epidemiology, bioinformatics, gene mapping for complex traits

Research Interests: Epigenomics, single-cell data analysis, machine learning and deep learning algorithm development

Research Interests: Artificial intelligence, clinical informatics, AI applications for prostate radiotherapy, genitourinary oncology

Research Interests: PET, SPECT, Deep Learning

Research Interests: Detect early changes in the mitochondrial metabolism, in situ, as a marker for asymptomatic, subclinical, doxorubicin induced cardiotoxicity

Research Interests: Instrumentation, imaging

Research Interests: Radiation therapy treatment planning, optimization techniques and algorithms, artificial intelligence technology development and applications

Research Interests: Computational Neuroscience

Research Interests: Artificial intelligence; MRI-guided adaptive radiotherapy (MRgART); Large Language Model (LLM) based Al agent

Research Interests: 3D/4D CT/CBCT reconstruction and analysis, 4D MRI reconstruction, artificial intelligence and automation in radiation therapy, biomechanical modeling and finite element analysis, deformable registration and its application in image-guided radiation therapy, radiotherapy dose calculation and plan optimization

Research Interests: Computational Biology; Systems biology and functional Genomics; Machine learning and statistics for biomedical science; Genomic sequence-based regulation

Research Interests: Cardiac MRI, Deep Learning, MR Sequence Development

Associate Faculty

These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program activities.

Research Interests: Biomedical imaging, molecular imaging, optical device design, nanomaterials, cancer biology and treatment

Research Interests: Applying new technologies to improve clinical operations, and working in partnership with physicians to develop novel techniques.

Research Interests: Eukaryotic chromatin organization, mutational rates and spectra, biological signals and noise

Research Interests: NMR spectroscopy and mass spectroscopy in conjunction with the application of stable isotope tracers to study metabolic function

Research Interests: Evolution of molecular components of the nervous system, gene therapy for genetic disorders, how pain alters cognitive function and leads to co-morbid addiction, how pain is altered by cognitive state

Research Interests: Urology; laparoscopy, telesurgical mentoring

Research Interests: Light-sheet fluorescencemicroscopy (LSFM), oblique plane microscope (OPM), structured illumination microscopy (SIM), super-resolution, DNA-PAINT, live-imaging, zebrafish, spheroid, organoid

Research Interests: Computational neuroimaging of neurodegenerative diseases including multiple sclerosis, functional network modeling using resting-state functional MRI, imaging biomarker development and validation, microstructural imaging using high-gradient diffusion MRI

Research Interests: Biomaterials; circulatory assist devices

Research Interests: Nanomedicine, lipid nanoparticles, mRNA, siRNA, CRISPR/Cas, base editing, genetic medicines, gene editing

Research Interests: Nanomaterials, cancer research, axon regeneration

Research Interests:

Research Interests: Deep learning application in magnetic resonance imaging, dynamic contrast-enhanced magnetic resonance imaging (DCE- MRI)

Research Interests: PET, SPECT, and optical imaging probes to assess biological abnormalities and evaluate disease treatment; radiotheranostics for cancer treatment

Research Interests: Tissue-Response modeling in radiation therapy

Research Interests: General psychiatry, aging and geriatric issues, new applications of lead placement in ECT and novel treatments of major depressive disorder including magnetic seizure therapy, transcranial magnetic stimulation, deep brain stimulation, and vagus nerve stimulation

Research Interests: Circulatory assist devices, cardiac metabolism

Research Interests: Developing advanced signal processing and AI-driven tools to enhance the diagnosis and treatment of brain injuries in newborns

Research Interests: Statistics, statistical genetics, genetic epidemiology, genome-wide association studies

Research Interests: Cervical cancer, developmental therapeutics, ovarian cancer, early detection of ovarian cancer

Research Interests: Molecular-imaging instrumentation, linear and nonlinear diffraction tomography, tensor tomography, applied inverse problems

Research Interests: fMRI; DICOMs

Research Interests: Tissue-response modeling in radiation therapy; stereotactic radiation therapy

Research Interests: Surgery, vascular surgery, medical devices, diagnostics

Research Interests: In vivo MRS for studies of energy and phospholipids metabolism in brain and skeletal muscle

Research Interests: Stable isotope tracers for imaging metabolism in vivo, responsive MR imaging agents for detecting changes in biology or physiology in vivo, hyperpolarized 13C metabolite probes for imaging metabolism in vivo

Research Interests: Neural cardiovascular control during exercise; reflex dysfunction in heart failure; reflex dysfunction in hypertension

Research Interests: Pathogen inactivation, cancer prevention, aging research

Research Interests: Application of biomedical engineering to cancer research, developing novel cancer diagnostics and therapeutics to improve cancer treatment, genitourinary cancer, gastrointestinal cancers, biomedical engineering, nanotechnology, radiation oncology, translational research, cancer immunotherapy, cancer nanotherapeutics, cancer biomarkers, radioisotopes, nanoparticles, prostate cancer, chemoradiotherapy

Research Interests: Machine learning in ophthalmology, ophthalmic image processing and visualization, ocular disease early detection and progression monitoring, optical coherence tomography, retinal layer segmentation

Research Interests: Application of Advanced Neuroimaging Techniques (fMRI, DTI, MRS, etc). Correction of magnetic susceptibility artifacts on brain MRI caused by orthodontic appliances. MR Quality Assurance and Safety. MRI Assessment of Body Iron. Application of AI in medical imaging

Research Interests: MRI Physics, Radiomics, Synthetic MRI, Cardiac MRI

Research Interests: Biomaterial grafts, coatings and scaffolds; finite element analysis; polymer synthesis; bioresorbable polymer characterization

Research Interests: High-performance computing; infrastructure for radiation therapy; radiobiological effects

Research Interests: Applied mathematics and MRI methods for translational research in liver imaging with special focus on evaluation of nonalcoholic fatty liver disease (NAFLD)

Research Interests: Magnetic resonance imaging, in vivo histology using non-invasive imaging, Alzheimer's Disease, Multiple sclerosis, dementia