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Induced Pluripotent Stem Cell Model

Our recently published model, taking ulcerative colitis fibroblast and turning them into induced pluripotent stem cells (iPSCS) and after differentation deriving induce human UC-derived organic model.

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Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

Our latest nature paper, discussing our newest model to study ulcerative colitis pathogenesis.

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Metastatic Colorectal Cancer Model

Research is currently ongoing to develop a technically feasible model for human metastasis.

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Cytokine Expression in Cancer and Colitic-associated Fibroblasts 

To better understand the microenvironment of colitis and cancer-associated fibroblasts we are investigating how the modulation of CXCL8 affects the pathogenesis of Colitis-associated cancer.

Research

Currently, there are no curative, CAC-preventing, or CAC-reversing options for UC patients, as the pathogenesis remains unclear. Due to this , our long-term goal is to understand the pathogenesis of UC and CAC.

Post-Doc Opportunity Available

Position to study and assess the microenvironment, associated with colorectal cancer development and metastasis. 

Individuals should send a CV, statement of interests, & 3 references to Dr. Huang.

 

Dr. Emina Huang

Executive Vice Chair of Research

Professor, Colon & Rectal Surgery

Contact: Emina.Huang@UTsouthwestern.edu

Location

Simmons Biomedical Research Building

NB5.226, UT Southwestern Medical Center

5323 Harry Hines Blvd.

Dallas, TX 75390-9169