Kraus Lab

Kraus Lab 25 years Est. 1999

Happy anniversary, Kraus Lab!

The Kraus Lab is celebrating its 25th anniversary in 2024. From its beginning in 1999 at Cornell University through the move to UT Southwestern in 2010, the Kraus Lab has hosted and trained 140+ students, postdocs, clinical fellows, visiting scientists, and research staff and published over 150 papers. We will celebrate that legacy with a lab reunion event in May!

The Kraus Lab is making strides in understanding fundamental questions related to important areas of human health and disease

The Kraus Lab is interested in the basic mechanisms of nuclear signaling and gene regulation by small molecules and how these signaling pathways relate to human physiology and disease states. Our interdisciplinary approach has led to new information about the connections among metabolism, hormone-regulated gene expression, and the gene-regulating effects of chromatin. We have made major contributions in the broad areas of nuclear receptors, poly(ADP-ribose) polymerases (PARPs) and ADP-ribosylation, chromatin structure and function, and gene regulation. We have focused on key aspects of (1) steroid hormone signaling (e.g., nuclear receptor function, gene regulation, genomics) and (2) nuclear NAD+ signaling (e.g., nuclear NAD+ synthesis, PARP-1 enzymology, ADP-ribosylation, the ADP-ribosylated proteome), as they relate to reproduction, cancer, adipogenesis, inflammation, and the maintenance of pluripotency in embryonic stem cells.

Meet the Principal Investigator

W. Lee Kraus, Ph.D.

W. Lee Kraus, Ph.D.

Endowed Title: Cecil H. and Ida Green Distinguished Chair in Reproductive Biology Sciences

Department: Green Center for Reproductive Biology Sciences | Obstetrics and Gynecology | Pharmacology

Graduate Program: Genetics, Development, and Disease

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Kraus Lab Team

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Chemical structures of estradiol, NAD+, and other molecules