Reto Fiolka is an Assistant Professor at UT Southwestern in the Department of Cell Biology. He oversees the development of advanced light microscopes with a focus on 3D live cell imaging in physiologically relevant microenvironments. This has led to the creation of novel light-sheet technologies that enable isotropic spatial resolution over large volumes and rapid image acquisition. Further research competence and interest include adaptive optics for high-resolution imaging in complex samples and super-resolution microscopy.
Dr. Fiolka received a master's degree in mechanical engineering at ETH Zurich in 2006. He did his Ph.D. thesis at the institute of Nanotechnology at ETH Zurich in optical microscopy. From 2009 – 2013, he conducted postdoctoral research at the Howard Hughes Medical Institute's Janelia Farm Research Campus under the late Dr. Mats Gustafsson, working on 3D structured illumination microscopy; he later worked under Dr. Meng Cui on adaptive optics. Reto Fiolka joined the Department of Cell Biology at UT Southwestern in 2013 as an instructor and worked on high-resolution light sheet microscope technologies. In 2016, after receiving a CPRIT recruitment award, he became an assistant professor.
Bo-Jui Chang is an Assistant Instructor in Department of Cell Biology at UT Southwestern. He is very interested in Bio-imaging and he particularly specializes in light sheet microscopy (LSM) and super-resolution structured illumination microscopy (SIM). Currently, he focuses on (1) collaborating with biologists to study behaviors of cells, tissues, embryos, .etc in physiologically relevant environments, and (2) developing advanced light sheet microscopes and structured illumination microscopes.
Bo-Jui was born and raised in Taiwan. He received his Ph.D. degree in Electro-Optical Engineering from National Chiao Tung University in Taiwan in 2006. He focused on the development and application of optical tweezers during his Ph.D. From 2007 – 2011 he worked on SIM in Dr. Su-Yu Chiang’s group at National Synchrotron Radiation Research Center, Hsinchu, Taiwan. From 2011 – 2016 he worked on LSM and implemented SIM in LSM in Dr. Ernst H.K. Stelzer’s group in Frankfurt, Germany. He was also an Adjunct Investigator from 2013- 2015 in the Cluster of excellent Frankfurt Macromolecular Complexes. From 2016 – 2017 he worked on lattice light sheet microscope in Dr. Bi-Chang Chen’s group in Taipei, Taiwan. He joined Dr. Reto Fiolka’s group since Sep. 2017. Outside the lab, Bo-Jui likes almost all kinds of sports, especially baseball/softball. He is also a big fan of Star Trek.
Stephan Daetwyler is a postdoctoral researcher at UT Southwestern in the Department of Cell Biology. He is particularly interested in understanding dynamic processes in development and disease such as cancer. The Fiolka lab and UT Southwestern provide the ideal environment to study such processes by applying and developing state-of-the art microscopy, custom data processing and analysis.
Stephan was born and raised in Switzerland where he received his B.Sc. and M.Sc. in Interdisciplinary Sciences at ETH Zurich with a major in Biology and Physics. In 2013, he joined the lab of Dr. Jan Huisken at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany, for his Ph.D. thesis. There, he studied the formation of the vasculature on a whole embryo level in zebrafish. For this, he implemented a dedicated multi-sample light-sheet imaging, processing and analysis workflow. During his Ph.D. wrap up time, Stephan was also supported by Dr. Alf Honigmann and Dr. Carl Modes. In collaborations, he contributed amongst others to our understanding of cancer cell dissemination, initiation of metastasis, and formation of organoids. From 2007-2017, Stephan was supported by the Swiss Study Foundation.
Meghan Driscoll was born and raised in Seattle, WA. She received a B.S. in Physics from Harvey Mudd College in 2006 and a Ph.D. in Physics from the University of Maryland in 2013. In graduate school, she researched the shape and actin dynamics of cells in suspension and cells migrating on gratings and ratcheted surfaces. Currently, Meghan holds a joint appointment with the Danuser and Fiolka labs. In the Danuser lab she studies cell migration within three-dimensional matrices by developing image analysis techniques for high-resolution light-sheet microscopy. She is supported by a K99 Pathway to Independence Award (NIGMS) from the National Institutes of Health and was previously supported by an F32 Ruth L. Kirschstein National Research Service Award (NIGMS). In her free time, she enjoys eating chocolate.
Etai Sapoznik is a postdoctoral researcher in the Cell Biology department. He received his B.S. in Biomedical Engineering from the Technion in Israel in 2009, and his PhD from the Virginia Tech-Wake Forest school of Biomedical Engineering in 2017. Etai is interested in developing new imaging tools and bridging the gap between biologists and physicists.
Bingying Chen is a postdoctoral researcher at UT Southwestern in the Department of Cell Biology. She is interested in developing novel optical imaging technologies and applying them to biomedical applications.
Bingying received a B.S. in Optoelectronic Engineering from Beihang University in 2014 and a Ph.D. from Peking University in 2019, Beijing. She has 3 years’ research experience in developing femtosecond fiber lasers, which could serve as the light source of two-photon microscopy. During her Ph.D., She focused on three-photon fluorescence microscopic imaging and its application.
Conor is a Research Associate in the Department of Cell Biology at UTSW. He received his B.Sc. in Applied Physics from Carleton University in Ottawa, Canada in 2011, and later received his M.Sc. in Medical Physics in 2013, where he developed a laser scanning fluorescence confocal microscope to image charged particle tracks in fluorescent nuclear track detectors. From 2013-2020 he worked as a Research Engineer at UT MD Anderson Cancer Center in Houston, TX in the Department of Radiation Physics building portable confocal microscopes for live-cell imaging to study DNA damage response of cancer cells in particle therapy beams.
Conor joined Dr. Fiolka's and Dr. Kevin Dean's lab in 2020 under a joint appointment and aims to apply his engineering skills to further development of light sheet and multiphoton microscopy. In his free time, you may catch him playing guitar or working on his golf game.
Shilpita Mitra-Behura is a research intern at UT Southwestern working in the Fiolka lab for the year. She is an undergraduate at Columbia University majoring in Applied Math and completing the pre-med track, though she is currently taking a gap year due to the pandemic. She's excited to work with the Fiolka lab to understand how to use up and coming technology to develop faster and more accurate microscopes.
Olwyn Doyle is a research intern working in the Fiolka lab. Born and raised in Colorado, she received her B.A. in Computer Science and Political Science from the University of Colorado Boulder in 2020. Olwyn is passionate about the ways in which computer science interacts with other fields of study, and is thrilled to be able to develop her skills further through work in the lab. In her free time, Olwyn enjoys hiking and playing the bass.
Ezi Kalunta-Crumpton is a research intern in the Fiolka Lab at UT Southwestern. She is currently studying Neuroscience at UT Dallas and will complete her B.S. by 2021. During her time in the lab, Ezi will be working on imaging excitatory and inhibitory chemical synapses within mice brains. She is excited to study the ways in which advances in various 3D microscopic imaging technologies can be used to increase our understanding of biological processes within living cells. She is hoping that her time in the lab will prepare her for a career in both clinical medicine and research by providing her with insight into the roles that cellular pathways play in human biology and disease.