Faculty and Research

Xiaochen Bai, Ph.D. • Xiaochen.Bai@UTSouthwestern.edu

Xiaochen Bai, Ph.D.

Xiaochen’s lab uses electron cryo-microscopy to study the structure of membrane protein complex in signaling transduction pathway, especially receptor tyrosine kinases which are important drug targets for cancer therapy.

Bai research image

Chad Brautigam, Ph.D. • Lab Website • chad.brautigam@utsouthwestern.edu

Chad Brautigam, Ph.D.

Chad’s lab uses biophysical methods to study protein-protein and protein-ligand interactions. He is also working to improve the presentation and analysis of biophysical data.

Brautigam Lab image

Jan Erzberger, Ph.D. • Lab Website • jan.erzberger@utsouthwestern.edu

Jan Erzberger

Jan’s lab is interested in understanding the dynamics of protein-RNA complexes during ribosome biogenesis. We are particularly focused on the roles of ATPases in coordinating ribosomal RNA processing and remodeling events, and in signaling between the ribosome biogenesis pathway and the cell cycle machinery.


Kendra Frederick, Ph.D. • Lab Website  • kendra.frederick@utsouthwestern.edu

Kendra Frederick

Kendra's lab uses NMR spectroscopy, protein chemistry and yeast genetics to determine the structures, dynamics and energetics of protein folding in complex physiological environments such as those involved in the initiation and progression of human disease.


Elizabeth Goldsmith, Ph.D. • Lab Website • elizabeth.goldsmith@utsouthwestern.edu

Elizabeth Goldsmith, Ph.D.

Betsy's lab studies how proteins are regulated by conformational changes, focusing on protein kinases and using crystallography, NMR, mass spectrometry, and biochemistry.

Goldsmith Lab image

Nick Grishin, Ph.D. • Lab Website • nick.grishin@utsouthwestern.edu

Nick Grishin, Ph.D.

We work at the interface of biology, computer science, mathematics, and physics. Our group specializes in computational biology of proteins and combines sequence and structure analysis with evolutionary considerations to facilitate discoveries of biological significance.

Khuloud Jaqaman, Ph.D. •  Lab Website • khuloud.jaqaman@utsouthwestern.edu

Khuloud Jaqaman, Ph.D.

Khuloud's lab develops integrative approaches combining single-molecule and super-resolution imaging, computational image analysis, and mathematical modeling to investigate the contribution of cell-surface receptor organization and interactions to cell signaling.

Khuloud Jaqaman Science

Zbyszek Otwinowski, Ph.D. •  Lab Website  • zbyszek.otwinowski@utsouthwestern.edu

Zbyszek Otwinowski, Ph.D.

The main research focus of the Otwinowski Lab is on developing computational and statistical methods and protocols for macromolecular structure determination using X-ray crystallography.

Otwinowski Lab image

Matthew Parker, Ph.D. •  matthew.parker@utsouthwestern.edu

Matthew Parker, Ph.D.

Matthew’s lab utilizes a multidisciplinary approach to study the mechanisms underlying DNA replication initiation in metazoans. Insights gleaned from cellular studies guide in vitro reconstitution experiments to illuminate the molecular basis of this fundamental process

Parker Lab image

Luke Rice, Ph.D. •  Lab Website • luke.rice@utsouthwestern.edu

Luke Rice, Ph.D.

Luke’s lab studies microtubule dynamics, seeking to discover how complex behavior emerges from the biochemical properties of molecular components.

Rice Lab image

Jose Rizo-Rey, Ph.D. • Lab Website • jose@arnie.swmed.edu

Jose Rizo-Rey, Ph.D.

Jose’s lab studies the molecular mechanisms of intracellular membrane fusion, with particular focus on neurotransmitter release and its regulation during presynaptic plasticity.

Rizo-Rey Lab image

Michael Rosen, Ph.D., Chair • Lab Website • michael.rosen@utsouthwestern.edu

Michael Rosen, Ph.D.

The Rosen Lab studies the physical mechanisms of actin regulation. We seek to understand both the structure and dynamics of individual pathway components and also how and why those components are organized into micron-scale cellular assemblies.

Rosen Lab image

Dan Rosenbaum, Ph.D. • Lab Website • dan.rosenbaum@utsouthwestern.edu

Dan Rosenbaum, Ph.D.

Dan's lab studies the structure and function of eukaryotic integral membrane proteins. The goal of his research is to understand how ligands and the membrane environment influence the conformational landscape of key membrane proteins involved in cellular signaling.

Diana Tomchick, Ph.D. •  Lab Website • diana.tomchick@utsouthwestern.edu

Diana Tomchick, Ph.D.

Diana's lab is focused on the relationship of protein structure to biological function, primarily characterized via the technique of protein crystallography. She is also interested in improving protein crystallization techniques, crystallographic data acquisition, and experimental methods of phasing.

Tomchick Lab image

Weiwei Wang, Ph.D. •  Lab Website  weiwei.wang@utsouthwestern.edu

Weiwei Wang, Ph.D.

Weiwei’s lab focuses on how ion channels associate with scaffolding proteins to form large signaling assemblies using electrophysiology, single molecule fluorescence microscopy and cyro-electron microscopy methods.

Wang Lab image