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Small Angle X-ray Scattering (SAXS)

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Single Particle Cryo-Electron Microscopy

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Micro-crystal Electron Diffraction (MicroED)

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Macromolecular X-ray Crystallography

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High Resolution Imaging of
Cryo-EM Samples

The Structural Biology Lab (SBL) provides access and assistance with the techniques of X-ray crystallography, small angle X-ray scattering and high-resolution imaging as well as single particle reconstruction in cryo-electron microscopy.

Getting Started

  1. Review our fees and rates.

  2. Study our resources.

  3. Create an iLab account to schedule equipment.



For X-ray, SBL offers assistance with crystal screening and optimization, in-house X-ray diffraction screening and data collection, synchrotron data collection at the Advanced Photon Source (APS) and other synchrotron sources for single crystals and small angle X-ray scattering (SAXS) measurements.

Single Particle Cryo-EM

For single particle cryo-EM, SBL offers assistance with protein sample preparation, grid preparation for negative staining and cryo-EM, grid optimization, collection, processing, and analysis of data from in-house or remote microscopes, structure determination and validation.


SBL is on-track to offer micro-crystal electron diffraction (MicroED) services for small molecule crystal screening and structure determination by the end of 2022.

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About Our Funding

SBL is an Institutionally Supported Core and is supported through a combination of:

  • institutional funds
  • user fees
  • federal and state grants, including one from the Cancer Prevention & Research Institute of Texas (RP170644).


North Campus Building ND

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  • Office Suite: ND10.214 and NB8.608
  • X-ray Diffraction Facility: ND10.223
  • Cryo-EM Sample Preparation Facility: ND8.226

Mailing Address

Structural Biology Lab (SBL)
Department of Biophysics
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8816

FedEx Address

Structural Biology Lab (SBL)
Department of Biophysics
UT Southwestern Medical Center
Room ND10.214
6001 Forest Park Rd.
Dallas, TX 75390

Core Directors

Cryo-EM or SAXS

Zhe (James) Chen, Ph.D.

Zhe (James) Chen, Ph.D.
Co-Director, Associate Professor

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