Molecular Genetic Pathology Fellowship

Overview

The Molecular Genetic Pathology Fellowship is a one year ACGME-accredited program sponsored by the Department of Pathology. Fellows rotate through the Molecular Diagnostics labs at UT Southwestern’s BioCenter and Children’s Healthâ„  Children’s Medical Center. The fellowship also incorporates clinical rotations in Clinical Genetics at Children’s and Parkland Hospital, and Cancer Genetics at Harold C. Simmons Comprehensive Cancer Center. The Fellowship qualifies the trainee to sit for the ABP-ABMG Molecular Genetic Pathology certification examination.

Program Description

The laboratory rotations train fellows in molecular assay development, validation, troubleshooting, interpretation, and independent sign-out along with lab management and clinician consultation. Experience in real-time PCR, Sanger sequencing, Illumina and Ion Torrent next generation sequencing, bioinformatics, fragment analysis, Sequenom mass spec, Invader, liquid handlers, and nucleic acid extraction are provided. We run clinical assays for single cancer gene mutation analysis, NGS cancer panels, NGS epilepsy panel, pediatric developmental delay assays, infectious agents (CMV, EBV, VZV, HHV6, BK, HPV, HCV, CT, NG), IgH/TCR clonality, coagulopathies, bone marrow engraftment, and 1p19q LOH.

A series of formal lectures in cancer biology, molecular microbiology, and medical genetics are given throughout the year. Fellows will participate in journal clubs, molecular and clinical conferences, and can attend UT Southwestern basic science and clinical conferences to fit their interests. Involvement in a translational or clinical research project is expected. Elective rotations in cytogenetics, FISH, DNA arrays, and HLA are available. Fellows share office space with hematopathology and cytogenetics fellows, along with pathology residents and other visitors.

Research

The Molecular Diagnostics Lab research includes development of new research and clinical assays and their applications to oncology and infectious disease.

Requirements

Candidates should be board-eligible or certified in AP, CP, or Medical Genetics. At this time we do not accept H1b visas.

Benefits

  • Financial support to attend conferences
  • Educational funds
  • Laptop
  • Additional benefits dependent upon program

Fellowship Faculty

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