Our diverse faculty members share a common goal of probing fundamental mechanisms of disease through basic, translational, and clinical research. Our ultimate aim is to enhance patient care through the continual refinement of diagnostic and treatment methods.
The Department of Pathology is home to a well-resourced basic and translational science research center that houses 15 principal investigators occupying two floors of research space in the Simmons (NB) and Pickens (ND) Biomedical Research Buildings. Our research interests are diverse and include cancer biology, immunology and therapeutics, and neurodegenerative disorders. Our investigators are active in the Cancer Biology, Cell & Molecular Biology, Genetics Development & Disease, Immunology, and Integrative Biology Graduate Programs as well as the Medical Scientist and Physician Scientist Training Programs at UT Southwestern.
The laboratories are supported through multiple grants from the National Institutes of Health, the Department of Defense, the Cancer Prevention Research Institute of Texas, and numerous private foundations. The Department sponsors a combined clinical and basic research seminar series and two University Lectures per year.
- Akbay Lab: Molecular drivers of tumor immune escape, particularly activation of the PD-1/PD-L1 pathway.
- Castrillon Lab: Molecular basis of women’s cancers, especially endometrial (uterine) cancer.
- Evers Lab: Morphologic and histologic assessment of murine transgenic and knockout phenotypes.
- Fu Lab: Cancer immunology, with a particular focus on immunotherapeutics.
- Galindo Lab: Genetic and molecular underpinnings of childhood cancer.
- Luo Lab: Oxygen homeostasis in human cancers with a focus on hypoxia-inducible factors.
- Ly Lab: Mechanisms of genomic instability and chromosomal alterations in cancer
- Malladi Lab: Dissemination and survival of cancer cells for insights into metastasis.
- Malter Lab: Characterization of intracellular signaling pathways in the immune and nervous systems
- Mani Lab: Molecular genetic and epigenetic events associated with cancer development.
- Southern Lab: Prevalence of infection due to Trypanosoma cruzi (Chagas Disease) in the human population.
- Wang Lab: Molecular and cellular mechanisms of PARP-1-dependent DNA damage and cell death.
- Zaki Lab: Gastrointestinal inflammation and cancer.
- Zheng Lab: Oncologic and hormone related pathology in gynecologic tumors.