Neuroscience Program Faculty

Research Interests:Epigenetics, neurological disorders, genome engineering, single-cell genomics

Research Interests: Engineering adeno-associated viral (AAV) vectors; Developing viral-mediated gene therapies for pediatric neurological disorders; developing gene therapies for Alzheimer’s and neurogenerative diseases; selective targeting of AAV vectors to the central and peripheral nervous systems; facilitating the translation of gene therapies to use in clinical trials

Research Interests: Calcium channels and calcium signaling in the nervous system; deranged calcium signaling and neurodegeneration in Huntington’s and Alzheimer’s disease

Research Interests: Autism spectrum disorders, genetics of neurodevelopmental disorders, ubiquitin proteasome pathway

Research Interests: Motor function, dystonia, Parkinson’s disease, neural circuits, neurodegeneration

Research Interests: Mechanisms of amyloid propagation in neurodegenerative diseases, especially tauopathies (e.g. Alzheimer’s disease), synucleinopathies (e.g. Parkinson’s disease), and polyglutamine diseases (e.g. Huntington’s disease); linkage between amyloid structure and biological impact

Research Interests: Aging and stress response signaling in traumatic brain injury and neurodegeneration

Research Interests: Functional neuroanatomy of the mammalian hypothalamus

Research Interests: Prevention and early detection of neurological injury associated with surgery

Research Interests: Alzheimer’s disease, Parkinson’s disease, autism

Research Interests: Molecular mechanisms of circadian rhythms and how they control metabolism

Research Interests: Circuit dysfunction in psychiatric disorders; role of adenosine in function of sleep

Research Interests: Dissection of neural mechanisms that support integration of sensory information, memory, and internal state to guide behavior using a multidisciplinary approach that encompasses molecular genetics, neural recording, optogenetics, behavioral experiments, and computational modeling.

Research Interests: Molecular biology of axon guidance

Research Interests: Cell migration, survival, stress response, cancer

Research Interests: Ion channel structure and function; membrane protein structural biology; electrophysiology

Research Interests: Function and regulation of membrane transporters; electrophysiology; biophysics of ion pumps and channels

Research Interests: Mechanisms of synapse development, plasticity and circuit function, and alterations of these processes in mouse models of mental retardation and autism

Research Interests: Molecular control of neuronal diversity and balancing progenitor cell maintenance with neuronal differentiation in the vertebrate central nervous system implications for tumor progression in neural and neuroendocrine cancers

Research Interests: Neural circuit genetics, neural representation and memory engrams for learning and memory in entorhinal-hippocampal circuits of rodent brain under normal and psychotic conditions by applying in vivo calcium imaging, in vivo electrophysiology, viral-tracing and circuit manipulation

Research Interests: Genetic dissection of endocytic trafficking in Drosophila

Research Interests: Connectivity and development of neuronal circuits generating somatosensation; molecular and functional diversity of spinal cord interneurons

Research Interests: Memory encoding and retrieval; Restoring memory function after brain injury

Research Interests: Developmental neurobiology

Research Interests: Cellular and functional diversity in the hypothalamus; 5-HT circuits underlying energy and glucose homeostasis; Fetal programming of obesity and diabetes

Research Interests: Chromatin dynamics and epigenetic regulation of activity-dependent gene expression; the role of genomic instability in neurological disorders and cancer

Research Interests: Understanding the molecular basis of glycogen malformation in the fatal Lafora epilepsy and devising gene and small-molecule based therapies for this and other childhood neurogenetic disorders

Research Interests: Regulatory mechanisms impacting structure, function and location of glycogen; Molecular consequences of glycogen storage diseases; Development of treatment strategies on molecular basis of the disease pathogenesis; Engineering proteins for improved Gene Therapy

Research Interests: Animal and cellular models of neurogenetic disorders; synaptic transmission in experimental epilepsies; disorders of brain energy metabolism; developmental neurobiology; genotype:phenotype correlations in novel childhood encephalopathies; clinical pediatric neurology

Research Interests: Consolidation and recall of memory via large-scale, high-density in vivo recordings of neural activity during free behavior in rodents, focusing on spatial navigation as a specific example of more general memory formation and use

Research Interests: Biophysical studies of the mechanisms of neurotransmitter release and intracellular membrane fusion

Research Interests: Cellular and circuit mechanisms for vocal imitation, learning from vocal models, and using auditory feedback to learn from vocal practice

Research Interests: Alzheimer’s disease and genetic neurological disease

Research Interests: Amyloid deposition, cardiac amyloidosis, cryo-electron microscopy, crystallography

Research Interests: Neurobiology of motivational systems and drug addiction

Research Interests: Reward circuit function in animal models of depression and addiction

Research Interests: Cerebellar ataxia, SCA, ion channels, neurodegeneration, selective neuronal vulnerability, potassium channels, Purkinje neurons

Research Interests: Molecular biology of sensory transduction in Drosophila

Research Interests: Neuron-glia interaction, oligodendrocyte, myelination, neurological disorders

Research Interests: Mechanistic studies of volume sensors and mechanosensors, ion channel structure-function and related channelopathies

Research Interests: Molecular and genetic analysis of the mammalian circadian clock system

Research Interests: Schizophrenia; postmortem brain; human brain imaging; human translational neuroscience

Research Interests: Axon growth and guidance; neuronal connectivity; axon regeneration; actin cytoskeleton; spinal cord injury and degeneration

Research Interests: Molecular and cellular mechanisms underlying the formation of neuronal circuits responsible for cognition and behavior

Research Interests: Elucidating the molecular, synaptic, and circuit mechanisms underlying memory persistence

Research Interests: Mitochondrial dysfunction, neurodegeneration and PARP-1-dependent cell death (PARthanatos) in ischemic and traumatic brain injury

Research Interests: Movement Disorders, Dystonia, Motor control, Dopamine, Striatum, Human development, MRI, Diffusion imaging, Deep brain stimulation