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Understanding Cerebellar Dysfunction and Degeneration in Ataxia

Neuronal dysfunction precedes neuronal loss and represents an outstanding target for therapy. We examine the basis for alterations in cerebellar Purkinje neuron firing in degenerative cerebellar ataxia.

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Brainstem dysfunction in Spinocerebellar Ataxia

Mechanisms of brainstem dysfunction, the cause of death in human disease is poorly understood.

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Discovery of Novel Ion Channel Modulators

Use novel high-throughput screen followed by validation of target engagement in genetically precise disease models.

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Understanding human disease

Participation in human studies to understand disease course, and clinical trials to test novel therapies.

Meet the Team

Meet the entire Shakkottai Lab team.

Our Research

Learn more about our research.

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We are always looking for creative people who would like to work in an exciting, highly collaborative research environment. We'd love to hear from you.

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