Neuronal dysfunction precedes neuronal loss and represents an outstanding target for therapy. We examine the basis for alterations in cerebellar Purkinje neuron firing in degenerative cerebellar ataxia.
Mechanisms of brainstem dysfunction, the cause of death in human disease is poorly understood.
Use novel high-throughput screen followed by validation of target engagement in genetically precise disease models.
Participation in human studies to understand disease course, and clinical trials to test novel therapies.
Meet the entire Shakkottai Lab team.
Learn more about our research.
We are always looking for creative people who would like to work in an exciting, highly collaborative research environment. We'd love to hear from you.
