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Cancer Biology Faculty

Program Chair

Rolf Brekken, Ph.D.
Rolf A. Brekken, Ph.D.

Professor

Research Interests: Tumor-host interactions in pancreatic cancer

Faculty

John M. Abrams, Ph.D.

Professor

Research Interests: Molecular genetics of cell death in cancer

John Abrams, Ph.D.
Michalis Agathocleous, Ph.D.

Assistant Professor

Research Interests: Hematopoietic stem cell and leukemia metabolism; metabolites and the stem cell genome

Michalis Agathocleous, Ph.D.
Todd Aguilera, M.D., Ph.D.

Assistant Professor

Research Interests: Tumor microenvironment, immunotherapy, radiotherapy, tumor immunology

Todd Aguilera, M.D., Ph.D.
Esra Akbay, Ph.D.

Assistant Professor

Research Interests: Lung cancer microenvironment, immunotherapy

Asaithamby Aroumougame
Asaithamby Aroumougame, Ph.D.

Assistant Professor

Research Interests: Cellular and molecular understanding of Werner Syndrome, Fanconi anemia, and space radiation induced carcinogenesi

Asaithamby Aroumougame, Ph.D.
James Brugarolas, M.D., Ph.D.

Professor

Research Interests: Molecular mechanisms of cell growth and proliferation control

James Brugarolas, M.D., Ph.D.
Diego Castrillon, M.D., Ph.D.

Professor

Research Interests: PI3K/PTEN/AKT/FoxO pathways in cancer biology

Diego Castrillon, M.D., Ph.D.
Benjamin Chen, Ph.D.

Associate Professor

Research Interests: Radiation biology; DNA damage response in somatic stem cells to tissue homeostasis and cancer initiation

Benjamin Chen, Ph.D.
Kenneth Chen, M.D.

Assistant Professor

Research Interests: Childhood cancer, microRNA, and the kidney.

Kenneth Chen, M.D.
Cheng-Ming Chiang, Ph.D.

Professor

Research Interests: Oncogenes and tumor suppressor function, transcription mechanisms and epigenetic control of gene programming, BRD4 in gene regulation and cancer therapy, human papillomavirus-associated cancers, post-translational modification of protein function and diversity, DNA damage response and repair pathways, molecular virology

Cheng-Ming Chiang, Ph.D.
Melanie H. Cobb, Ph.D.

Professor

Research Interests: Function and regulation of protein kinases in signal transduction pathways in breast cancer

Melanie Cobb, Ph.D.
Ian Corbin, Ph.D.

Associate Professor

Research Interests: Utilizing molecular imaging and nanomedicine techniques to better characterize, detect, and treat hepatocellular carcinoma

Ian Corbin, Ph.D.
Lindsay Cowell, Ph.D.

Associate Professor

Research Interests: Cancers with viral etiology, adaptive immune responses to pre-neoplastic lesions, immunotherapy

Lindsay Cowell, Ph.D.
Gaudenz Danuser, Ph.D.

Professor

Research Interests: Regulation of cell morphogenesis during metastasis; roles of mechanics in cell survival and drug resistance

Gaudenz Danuser, Ph.D.
Anthony Davis, Ph.D.

Assistant Professor

Research Interests: Cellular response to DNA double strand breaks, the role of aberrant DNA repair and signaling in cancer etiology, basic radiation biology, and intrinsic and tumor/cancer radioresponses

Anthony Davis, Ph.D.
Ralph DeBerardinis, M.D., Ph.D.

Professor

Research Interests: Metabolic pathways that support tumor cell growth and exploiting tumor metabolism to improve imaging and therapy in cancer

Ralph DeBerardinis, M.D., Ph.D.
Beatriz Fontoura, Ph.D.

Professor

Research Interests: Nuclear transport pathways as regulators of cell cycle, cancer, and antiviral response

Beatriz Fontoura, Ph.D.
Rene Galindo, M.D., Ph.D.

Associate Professor

Research Interests: Molecular mechanisms of pediatric sarcoma tumorigenesis and developmental skeletal muscle patterning

Rene Galindo, M.D., Ph.D
Jinming Gao, Ph.D.

Professor

Research Interests: Nanoparticles for cancer therapeutic drug delivery

Jinming Gao, Ph.D.
Amyn Habib, M.D.

Associate Professor

Research Interests: Interactions between inflammatory and oncogenic signaling pathways with a focus on glioblastoma (GBM) as our cancer model

Amyn Habib, Ph.D.
Yujin Hoshida, M.D., Ph.D.

Associate Professor

Research Interests: Translational research in liver cancer; prognostic liver signature, hepatocellular carcinoma molecular subtypes, hepatocellular carcinoma chemoprevention discovery

Yujin Hoshida, Ph.D
Lily Huang, Ph.D.

Associate Professor

Research Interests: Cytokine receptor; signal transduction; hematopoiesis; structure-function analysis of protein; cancer

Jun-Shen 'Lily' Huang, Ph.D.
Jenna Jewell, Ph.D.

Assistant Professor

Research Interests: Cancer biology, CRISPR genome editing, mechanistic target of rapamycin (mTOR), nutrient sensing, signal transduction

Jenna Jewell, Ph.D.
Jin Jiang, Ph.D.

Professor

Research Interests: Signal-transduction pathways in development and human disease; genetic control of organ growth and patterning; tumor suppressor genes<

Jin Jiang, Ph.D.
Daehwan Kim, Ph.D.

Assistant Professor

Research Interests: Computational biology, DNA and RNA sequence alignment, graph alignment to population of genomes, genotyping, personalized medicine

Daehwan Kim, Ph.D.
James Kim, M.D., Ph.D.

Assistant Professor

Research Interests: Cancer biology, lung cancer, developmental pathways, hedgehog signaling pathway, Wnt signaling pathway, tumor-stromal interactions, tumor microenvironment

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Ralf Kittler, Ph.D.

Associate Professor

Research Interests: Functions of cancer-relevant transcription factors and to translate this knowledge into new approaches for the detection and treatment of cancer

Ralf Kittler, Ph.D.
Lu Q. Le, M.D., Ph.D.

Professor

Research Interests: Tumor cell of origin; roles of tumor microenvironment in cancer development; cellular and molecular mechanisms of neurofibromatosis; stem cell and cancer biology

Lu Le, M.D., Ph.D.
Bo Li, Ph.D.

Assistant Professor

Research Interests: Cancer immunology; cancer genomics; computational biology

Bo Li, Ph.D.
Guo-Min Li, Ph.D.

Professor

Research Interests: DNA mismatch repair

Guo-Min Li, Ph.D.
Weibo Luo, Ph.D.

Assistant Professor

Research Interests: The role of hypoxia inducible factors in tumor growth and metastasis

Weibo Luo, Ph.D.
Peter Ly, Ph.D.

Assistant Professor

Research Interests: Mechanisms of genomic instability and chromosomal alterations in cancer

Peter Ly, Ph.D.
Ravikanth Maddipati, M.D.

Assistant Professor

Research Interests: Tumor metastasis, tumor heterogeneity, therapy resistance, circulation tumor cells, and cellular plasticity

Ravikanth Maddipati, M.D.
Srinivas Malladi, Ph.D.

Assistant Professor

Research Interests: Cancer metastasis; metastatic stem cells; tumor biology and microenvironment

Srinivas Malladi, Ph.D.
Ram Mani, Ph.D.

Assistant Professor

Research Interests: Epigenetic mechanisms underlying cancer progression; ETS gene fusions in prostate cancer; genomic rearrangements in cancer; transcriptional regulation in prostate cancer

Ram Mani, Ph.D.
Elisabeth Martinez, Ph.D.

Associate Professor

Research Interests: Discovery and characterization of novel chemical epigenetic modulators of gene expression with specific anti-cancer activity

Elisabeth Martinez, Ph.D.
Ralph Mason, Ph.D.

Professor

Research Interests: Animal imaging in cancer

Ralph Mason, Ph.D.
Samuel McBrayer, Ph.D.

Assistant Professor

Research Interests: Nitrogen metabolism, crosstalk between the metabolome and epigenome, metabolic mechanisms of tumor initiation, synthetic lethality, glioma biology, CRISPR/Cas9-based mouse models of cancer

Samuel McBrayer, Ph.D.
Joshua Mendell, M.D., Ph.D.

Professor

Research Interests: Regulation and function of microRNAs and other noncoding RNAs in normal physiology and cancer

Joshua Mendell, M.D., Ph.D.
John Minna, M.D.

Professor

Research Interests: Molecular pathogenesis of human cancer; signal transduction in human tumors; cancer stem cells; targeted cancer therapy

John Minna, M.D.
Sean Morrison, Ph.D.

Professor

Research Interests: Normal and cancerous stem cells

Sean Morrison, Ph.D.
Ping Mu, Ph.D.

Assistant Professor

Research Interests: Antiandrogen resistance, novel biomarkers, prostate cancer

Ping Mu, Ph.D.
Saikat Mukhopadhyay, M.D., Ph.D.

Assistant Professor

Research Interests: Role of primary cilia in normal development and cancer, functional proteomics in ciliary diseases, ciliary signaling pathways

Saikat Mukhopadhyay, M.D., Ph.D.
Kathryn A. O’Donnell, Ph.D.

Associate Professor

Research Interests: Mechanisms of tumorigenesis; Regulation and function of cell surface receptors in lung cancer pathogenesis

Kathryn O'Donnell, Ph.D.
Ganesh Raj, M.D., Ph.D.

Professor

Research Interests: Hormone dependent malignancies (prostate and breast); steroid receptor crosstalk; therapeutic drug development; ex vivo model development

Satwik Rajaram, Ph.D.
Satwik Rajaram, Ph.D.

Assistant Professor

Research Interests: Digital pathology, intra-tumor heterogeneity, tumor microenvironment, machine learning

Satwik Rajaram, Ph.D.
Joachim Seemann, Ph.D.

Associate Professor

Research Interests: To understand the mechanisms that regulate the mitotic division of the Golgi in mammalian cells as it relates to cancer

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Jerry Shay, Ph.D.

Professor

Research Interests: Molecular mechanisms of human cellular aging and immortalization; the role of telomeres and telomerase in cancer/p>

Jerry Shay, Ph.D.
Daniel Siegwart, Ph.D.

Associate Professor

Research Interests: Polymer and materials chemistry, drug and gene delivery, RNAi, biomedical imaging, detection and treatment of cancer

Daniel Siegwart, Ph.D.
Stephen Skapek, M.D.

Professor

Research Interests: Tumor suppressor gene function; angiogenesis; skeletal muscle differentiation; oncogene-induced senescence

Stephen Skapek, M.D.
Maralice Conacci-Sorrell, Ph.D.

Assistant Professor

Research Interests: Cell migration, survival, stress responses, cancer

Maralice Conacci-Sorrell, Ph.D.
Michael Story, Ph.D.

Professor

Research Interests: Radiation biology/oncology; cancer genomics; intrinsic radiosensitivity

Michael Story, Ph.D.
Yihong Wan, Ph.D.

Associate Professor

Research Interests: Regulation of the initiation, progression, and bone metastasis of breast cancer by the microenvironment

Yihong Wan, Ph.D.
Richard Wang, M.D., Ph.D.

Associate Professor

Research Interests: Regulation of glucose uptake; autophagy and skin cancer

Richard Wang, M.D., Ph.D.
Zhigao Wang, Ph.D.

Assistant Professor

Research Interests: Molecular mechanisms of necrotic cell death; development of chemical inhibitors and activators of necrotic cell death

Zhigao Wang, Ph.D.
Kenneth Westover, M.D., Ph.D.

Associate Professor

Research Interests: The Westover Lab works at the intersections of biochemistry, structural biology, chemical biology, and chemistry as part of a collaborative team to understand and manipulate the molecular basis of cancer

Kenneth Westover, M.D., Ph.D.
Angelique Whitehurst, Ph.D.

Associate Professor

Research Interests: The role of ectopically activated gametogenic programs in supporting tumor cell proliferation and survival

Angelique Whitehurst, Ph.D.
Thomas Wilkie, Ph.D.

Associate Professor

Research Interests: CG-protein signaling during mouse development, energy homeostasis, and feeding behavior

Thomas Wilkie, Ph.D.
Yang Xie, Ph.D.

Professor

Research Interests: Processing and analysis of high throughput data; false discovery rate estimation; integrated analysis methodology; Bayesian analysis methodology; design and analysis of clinical trials

Yang Xie, Ph.D.
Jian Xu, Ph.D.

Assistant Professor

Research Interests: We are investigating the epigenetic and genetic basis of disease-associated genes and gene networks in blood stem cell development and disorders, focusing on both single gene and genomic levels.

Jian Xu, Ph.D.
Hasan Zaki, Ph.D.

Assistant Professor

Research Interests: How intestinal microbiota and pathogen recognition receptors regulate gastrointestinal cancer

Hasan Zaki, Ph.D.
Qing Zhang, Ph.D.

Associate Professor

Research Interests: Oxygen sensing signaling in breast cancer and kidney cancer

Qing Zhang, Ph.D.
Jian Zhou, Ph.D.

Assistant Professor

Research Interests: Machine Learning and Statistical Methods for Genomics, Sequence Basis of Genome Regulation, Statistical Methods for Single-cell Data Analysis, The Evolution of Noncoding Genome.

Jian Zhou, Ph.D.
Hao Zhu, Ph.D.

Associate Professor

Research Interests: Genetic and cellular mechanisms of organ regeneration and dysregulation of these mechanisms in liver cancer

Hao Zhu, Ph.D.

Associate Members

These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.

Carlos Arteaga, M.D.

Professor and Director

Research Interests: Breast cancer; oncogenes; drug resistance; targeted therapies; molecules of interest: ERα, ERBB2 (HER2), CDK4/6, PI3K, FGFR

Carlos Arteaga M.D.
Robert Bachoo, M.D., Ph.D.

Associate Professor

Research Interests: Molecular mechanisms underlying brain tumors

Robert Bachoo, M.D., Ph.D.
Robert E. Hammer, Ph.D.

Professor

Research Interests: Transforming growth factor beta signaling

Jer-Tsong Hsieh, Ph.D.
Jer-Tsong (J.T.) Hsieh, Ph.D.

Professor

Research Interests: Human cancer gene therapy; signaling defects in urogenital cancers

Jer-Tsong (J.T.) Hsieh, Ph.D.
Puneeth Iyengar, M.D., Ph.D.

Assistant Professor

Research Interests: Metabolic dysregulation and lung cancer

Puneeth Iyengar, M.D., Ph.D.
Michael Roth, Ph.D.

Professor

Research Interests: High throughput screening for novel cancer therapeutics; recognition and sorting of cell-surface glycoproteins

Michael Roth, Ph.D.