The cellular response to DSBs is extensive and includes recognition of the DNA lesion, signal transduction responses including modulation of the cell cycle, and, finally, repair of the DSB.
There is a delicate and synchronized balance that allows a cell to select the appropriate DNA repair pathway for each DNA lesion that it encounters.
A main component of the cellular response to DNA damage is a signaling cascade that is driven primarily by phosphorylation events on serine/threonine residues.
The goal of the Davis lab is to uncover the mechanisms that modulate the cellular response to DSBs.
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