Skin cancers are the most common group of malignancies in humans. Our research focuses on how the conserved signaling pathways that underlie normal skin development are altered during the development of non-melanoma skin cancers. We study these questions in cell culture, mouse models, and patient samples. Specific areas of interest include:
- The regulation of glucose transport and metabolism in normal skin development and how they are altered in hyperproliferative skin diseases.
- The contribution of human papillomaviruses (HPVs) and polyomaviruses (MCPyV, HPyV6, and HPyV7) to infectious and neoplastic skin diseases.
- The role of autophagy, a conserved cellular catabolic pathway, in skin biology and the pathogenesis of squamous cell carcinoma.