Genetics, Development and Disease Faculty

Research Interests: Molecular genetics of cell death; genomic “dark matter”; p53 tumor suppressor function; 3D genome organization

Research Interests: Hematopoietic stem cell and leukemia metabolism; metabolites and the stem cell genome

Research Interests: Molecular mechanisms of normal genitourinary development and congenital birth defects

Research Interests: Chromatin biology, developmental gene regulation, histone variants, stem cells

Research Interests: Molecular mechanisms of cell growth proliferation control

Research Interests: Molecular control of inflammatory responses in the intestine, inflammation and cancer progression, regulation of NF-kB activity, COMM.D. proteins

Research Interests: Stem cell biology; niche signaling; chromatin; translational repression

Research Interests: Molecular mechanisms regulating kidney tubule formation and maintenance

Research Interests: Genetics of autism spectrum disorder (ASD); molecular mechanisms underlying ASD; the ubiquitin proteasome pathway in neurodevelopmental disorders

Research Interests: Cell-cell fusion, actin cytosleletal dynamics, mechanobiology, muscle development and regeneration

Research Interests: NF-B signaling and the ubiquitin-proteasome pathway

Research Interests: Genetics of quantitative traits; genetic determinants of plasma lipoprotein levels

Research Interests: Schistosomes are parasitic flatworms that cause significant disease and disability in more than 200 million of the world’s poorest people. Using a variety of functional genomic approaches, we seek to understand fundamental aspects of schistosome biology, including the biology of somatic and reproductive stem cells.

Research Interests: Regulation of metabolism during cell growth and tumorigenesis; integrating signal transduction with metabolic flux; understanding pediatric metabolic diseases

Research Interests: Calcium channels and calcium signalling in the nervous system;he development of the lymphatic vasculature and human diseases caused by errors in the development of the lymphatic vasculature

Research Interests: Molecular genetics of aging and stress response in blunt trauma, degenerative disease and cancer

Research Interests: Molecular mechanisms of pediatric sarcoma tumorigenesis and developmental skeletal muscle patterning

Research Interests: Transcriptional control of fat cell development and adipose tissue expansion in obesity; manipulating the adipose lineage as a therapeutic treatment for metabolic disease

Research Interests: Host-pathogen interactions, genetic conflicts, positive selection​, genome evolution, innate immunity, evolutionary immunology, horizontal gene transfer, poxviruses, mutation, genetic disease, genomics

Research Interests: Molecular genetics of axon guidance and brain development; bidirectional tyrosine kinase signaling

Research Interests: Identification of genetic factors contributing to inter-individual differences in the concentration of lipoproteins in the blood

Research Interests: Developing (epi)genomic/bioinformatic tools to assess and predict the functions of regulatory elements, epigenetic biomarkers of disease state, epigenetics in development and disease, global regulation of mammalian gene expression, non-coding genome function

Research Interests: Cancer biology, CRISPR genome editing, mechanistic target of rapamycin (mTOR), nutrient sensing, signal transduction

Research Interests: Signal-transduction pathways in development and human disease; genetic control of organ growth and patterning; tumor suppressor genes

Research Interests: Development of the mammalian nervous system; transcriptional regulation of neural cell-type specification

Research Interests: Genetic and epigenetic programs underlying brain development and function

Research Interests: Molecular genetics endosomal trafficking in Drosophila

Research Interests: Cellular signaling, gene regulation, and epigenetic control in the chromatin environment of the nucleus; biological systems include: reproduction, cancer, inflammation, adipogenesis, stem cells, differentiation

Research Interests: Tumor cell of origin; roles of tumor microenvironment in cancer development; cellular and molecular mechanisms of neurofibromatosis; stem cell and cancer biology

Research Interests: Synonymous codons as new genetic codes to regulate protein structure and gene expression, mechanism of circadian clocks, small and long coding RNAs

Research Interests: Elucidate transcriptional regulatory mechanisms of genes involved in cardiovascular diseases and characterize the signaling pathways coupling these transcriptional programs to extracellular signals that trigger this disease

Research Interests: Mechanisms of genomic instability and chromosomal alterations in cancer

Research Interests: Tumor metastasis, tumor heterogeneity, therapy resistance, circulation tumor cells, and cellular plasticity

Research Interests: Epigenetic mechanisms underlying cancer progression; ETS gene fusions in prostate cancer; genomic rearrangements in cancer; transcriptional regulation in prostate cancer

Research Interests: Transcriptional control of cell differentiation; muscle development

Research Interests: Size-control mechanisms in development, regeneration, and cancer

Research Interests: Gene regulation, nuclear organization by biomolecular condensates, phase separation, gene activation in development and cancer

Research Interests: Metabolic profiling of stem cells

Research Interests: Endothelial cell biology, vascular development and disease; signaling molecules in endothelial cell caveolae/lipid rafts

Research Interests: Cellular metabolism, mitochondria, reproduction, cellular quiescence

Research Interests: Benign and malignant urologic diseases, computational and translational biology, cellular anatomy, single cell technology

Research Interests: Tumor suppressor gene function; angiogenesis; skeletal muscle differentiation; oncogene-induced senescence

Research Interests: Neuron-glia interaction, oligodendrocyte, myelination, neurological disorders

Research Interests: Kinases in the secretory pathway and the extracellular space; secreted protein and peptide hormone phosphorylation; CRISPR/Cas9 genome editing

Research Interests: PARP-1 signaling, DNA damage, and cell death in neurologic diseases and human cancer

Research Interests: Molecular mechanisms of necrotic cell death; development of chemical inhibitors and activators of necrotic cell death

Research Interests: Inherited retinal degenerations, stem cell biology, gene editing, gene therapy, mouse models of ocular disease, metabolism and metabolic reprogramming, photoreceptor cells, genetic mechanisms of disease

Research Interests: G-protein signaling during mouse development, energy homeostasis, and feeding behavior

Research Interests: Genetics of pediatric musculoskeletal and autoinflammatory diseases

Research Interests: Chromatin regulation of neural development; neural stem cell differentiation; activity dependent gene expression

Research Interests: Stem cells and pluripotency, genome and epigenome editing, interspecies chimera and organogenesis, species preservation

Research Interests: Processing and analysis of high throughput data; false discovery rate estimation; integrated analysis methodology; Bayesian analysis methodology; design and analysis of clinical trials

Research Interests: Statistical genetics, genetic epidemiology, bioinformatics, gene mapping for complex traits

Research Interests: Epigenetic and genetic basis of disease-associated genes and gene networks in blood stem cell development and disorders, focusing on both single gene and genomic levels

Research Interests: Nuclear receptor signaling and adult neural stem cells

Research Interests: Regulation and function of oxygen sensing pathway in diseases including cancer; post-translational modifications of proteins; tumor suppressor signaling and synthetic lethality

Research Interests: Computational Biology; Systems biology and functional Genomics; Machine learning and statistics for biomedical science; Genomic sequence-based regulation

Research Interests: Genetic and cellular mechanisms of organ regeneration and dysregulation of these mechanisms in liver cancer

Research Interests: Genetic mechanisms of muscle development, growth, disease, and regeneration

Research Interests: Pathology; comparative histopathology; neuropathology; developmental biology; ophthalmic pathology

Research Interests: Transforming growth factor beta signaling

Research Interests: Role of progenitor cells in skeletal muscle function during homeostasis and aging

Research Interests: Transcriptional control of organogenesis

Research Interests: Molecular control of germ-cell development and meiosis

Research Interests: Wnt signaling; cardiovascular calcification; transgenic preclinical disease models; protein arginine methylation; transcriptional regulation; fibrosis; vascular smooth muscle phenotypic modulation; osteogenic differentiation.

Research Interests: Molecular mechanisms of major metabolic diseases including obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD)

Research Interests: Genetic disorders of human growth and reproduction; Turner syndrome; infertility; obesity