Biological Chemistry Faculty

Research Interests: Lipidomics; ocular (bio)chemistry; molecular enzymology; lipoxygenases, lipid peroxidation, and arachidonic acid cascade

Research Interests: Natural product synthesis, synthetic methodology development, small molecule library synthesis and chemical biology

Research Interests: Structure and function of macromolecular machines; mechanism of chaperone-mediated protein folding

Research Interests: Gene expression and RNA biogenesis in Kaposi's sarcoma-associated herpes virus

Research Interests: Engineering proteins and nucleic acids for novel function

Research Interests: Regulation of HMG-CoA reductase and sterol metabolism

Research Interests: Transcription control by RNA Polymerase II; assembly and regulation of viral and human transcription complexes; mechanisms of transcription activation in HIV

Research Interests: Biochemical mechanisms and regulation of intracellular protein degradation; structure and function of intracellular proteases

Research Interests: Protein misfolding diseases, stress-responsive signaling, chemical biology, high-throughput screening, drug discovery, age-related macular degeneration, retinal dystrophies

Research Interests: Understanding and exploiting the molecular foundations of glycoconjugate biosynthesis

Research Interests: Informational carbohydrates in the endoplasmic reticulum: roles in protein folding, stress responses, and human disease

Research Interests: Transcription regulation and epigenetics; enome integrity; cancer biology; chemical biology and protein semi-synthesis; protein post-translational modifications

Research Interests: The role of hypoxia inducible factors in tumor growth and metastasis

Research Interests: Genetically engineered mouse models of cancer, chemical and genetic screens for new vulnerabilities in small cell lung cancer and Ewing sarcoma

Research Interests: Molecular genetics and biochemical studies of mammalian gene regulation

Research Interests: Biochemical and structural study of receptor-mediated endocytosis and the membrane skeleton of the plasma membrane

Research Interests: Mechanisms of RNA-mediated gene regulation; Structural and biochemical studies of RNA function

Research Interests: Using chemistry to identify new cancer drug targets

Research Interests: Signal transduction in the microbial pathogen Yersinia pestis

Research Interests: Polyamine and pyrimidine metabolism in trypanosomes and in malaria parasites

Research Interests: Protein-lipid interactions at membrane interfaces

Research Interests: Bioactive natural product synthesis; asymmetric catalysis; cancer biology

Research Interests: Quorum sensing in enteropathogenic Escherichia coli

Research Interests: Synthesis of complex biologically active natural products; development of new tandem methodologies

Research Interests: Membrane protein trafficking and function; autophagy and its developmental roles; organelle biogenesis and communication

Research Interests: Cancer biology and development of new therapeutic drugs

Research Interests: Geranylgeranylation and HCV replication; regulation of geranylgeranyl lipid homeostasis; regulated intramembrane proteolysis

Research Interests: We are interested in developing novel mass spectrometry-based proteomic technologies (including sample preparation, instrumentation, and computation methods) and applying them to study biologically relevant questions. Our current research in focused on using these techniques to characterize various protein posttranslational modifications, in particular, phosphorylation, ubiquitination, and ADP-ribosylation.

Research Interests: The role of mitochondrial signaling in sepsis-induced cardiac dysfunction

Research Interests: Mechanisms of O2, CO, and NO sensing and in novel signal-transduction heme proteins

Research Interests: Intercellular communications through gap junctions; molecular engineering of fluorescent sensors for cellular imaging; wide field, confocal, and multiphoton fluorescence microscopy; mechanisms and functions of cellular calcium signaling<

Research Interests: Evolution of biosynthetic diversity; role of polyamines in cellular processes

Research Interests: Structural characterization of signal-transduction protein complexes, proteins involved in reproductive biology, and novel proteins from pathogenic bacteria; improved methods of crystallographic data collection, processing, and phasing; automated crystallization techniques

Research Interests: Development of novel chemical leads from high throughput screens, new natural products, or rational target-based chemical design as viable therapeutics for preclinical models; areas explored include pharmacokinetics, formulation, metabolism, toxicology, and efficacy for a variety of disease models, including cancer, bacterial infections, and neurological disorders