D'Orso Lab

Defining the underlying molecular mechanisms of cell signaling and transcriptional regulation in human health and disease

D'orso Lab logo with diagrams of Virology, Cell Biology, Genetics and genomics, Systems, Biochemistry, and Structural Biology


Our research program aims to elucidate the basic principles of gene regulatory programs in human health and disease. Specifically, we are exploring new mechanisms of cell signaling and transcriptional control, factor-chromatin interactions, viral latency and cancer drivers, and discovering targets that can be chemically manipulated.