2025 Article Archive
Artificial intelligence predicts kidney cancer therapy response
An artificial intelligence (AI)-based model developed by UT Southwestern Medical Center researchers can accurately predict which kidney cancer patients will benefit from anti-angiogenic therapy, a class of treatments that’s only effective in some cases.
Lifelong physical activity may slow cognitive decline
High levels of physical activity may mitigate brain loss in adults and help maintain long-term cognitive health, researchers at UT Southwestern Medical Center report in a study published in the Journal of Applied Physiology.
Immune protein STING key for repairing, generating lysosomes
– The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a quality control sensor for organelles that serve as cellular waste disposal systems, UT Southwestern Medical Center researchers found. Their study, published in Molecular Cell, helps explain critical features of diseases called lysosomal storage disorders and could eventually lead to new treatments for these and other neurodegenerative diseases.
Researchers create ‘wiring diagram’ for key songbird brain region
Much like human beings, songbirds learn how to vocalize from their parents. Males imitate songs from their fathers and then sing to attract mates. Although the circuits that generate human speech are more complicated to decipher, the brains of songbirds offer a viable model for better understanding how humans learn to speak and what goes wrong in communication disorders such as autism.
New method identifies protein that may govern cancer cell movement and metastasis
Using a novel method that gives a readout of which proteins are in specific locations within cells, UT Southwestern Medical Center researchers have identified a protein that plays a key role in cell adhesion and movement.
Neonatal diabetes model provides insights on how condition develops
A preclinical model developed at UT Southwestern Medical Center that recapitulates a rare infant-onset form of diabetes suggests the condition stems from gradual damage to the pancreas through misregulation of a molecular pathway called the unfolded protein response (UPR).
Grant worth up to $5 million aids research for cerebellar disorders
A multidisciplinary team of UT Southwestern Medical Center specialists, led by Nader Pouratian, M.D., Ph.D., and Peter Tsai, M.D., Ph.D., has received a grant worth up to $5 million from the Raynor Cerebellum Project to develop neuromodulation therapies for patients with cerebellar disorders of the brain.
UTSW Research: Mosquito saliva and malaria, brain tumors, and more
Malaria, responsible for hundreds of thousands of deaths each year worldwide, is caused by a parasite transmitted through the salivary glands of female Anopheles mosquitoes. Understanding the biology of these tissues is critical to developing new treatments for the disease, found mostly in tropical countries.
UT Southwestern Q&A: What you need to know about the measles
The outbreak of measles that started in West Texas in January and spread to other regions and states has focused renewed attention on a childhood disease that had been eliminated in the United States in recent decades.
Social media may heighten depression severity in youth
An emotional overattachment to social media may be associated with increased severity of mental health symptoms among young people being treated for depression, anxiety, and suicidal thoughts, according to researchers at UT Southwestern Medical Center.