Clinical Trials

The Department of Radiation Oncology enrolls as many as 80 new patients each year in clinical trials. Faculty members hold leadership positions in the Radiation Therapy Oncology Group (RTOG), which develops and oversees all national radiation oncology trials funded by the National Cancer Institute.

See current clinical trial information below or contact the Clinical Research office at 214-645-7322.

Breast

Therapeutic

STU 042018-083: GammaPod 5 fxn - Phase II Multi-Center Trial Evaluating 5 Fraction S-PBI (Stereotactic Partial Breast Irradiation) for Early Stage Breast Cancer Using the GammaPod. Learn about the GammaPod.

STU 052018-052: GammaPod Boost - Tumor Bed Boost Using a Breast-Specific Radiosurgery Device, the GammaPod: Registry Study and Evaluation of Quality of Life with Development of Sizing Nomogram. Learn about the GammaPod.

STU 2018-0236: Tailor RT - A Randomized Trial of Regional Radiotherapy in Biomarker Low-Risk Node-Positive Breast Cancer.

STU 2019-1099 28231 - Single Institution Pilot Study to Detect Radiation-Induced Cardiotoxicity in Left-Sided Breast Cancer Patients Using Hyperpolarized Carbon 13-Based Magnetic Resonance Spectroscopic Imaging. 

STU 2019-1183 - A Phase I Dose-Escalation Study of Single Fraction Pre-Operative Partial Breast (S-PBI) for Early Stage Breast Cancer.

Central Nervous System

Therapeutic

STU 122016-064: Neurocog. Decline - Phase I/II Trial to Determine the Neurocognitive Decline in Patients with Multiple (>6) Brain Metastases Treated with Distributed Stereotactic Radiosurgery.

STU 022015-106: SRS-Dose Escalation - A Phase I Dose-Escalation Study of Stereotactic Radiosurgery for Brain Metastasis without Whole Brain Radiation.

STU 2020-0176: Alliance A071801 Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared with Fractionated SRS (FSRS) for Resected Metastatic Brain Disease.

Non-Therapeutic

STU 042018-100: AVM - Validation Study of Treating Arteriovenous Malformation with Stereotactic Radiosurgery Using CT Angiography for Treatment Planning.

Gastrointestinal

Therapeutic

STU 102014-018: Liver Mets Brachy - A Phase I Therapeutic Dose-Escalation Study Using Percutaneous Image-Guided Navigation for High-Dose Rate Brachyablation of Primary Liver Lesions.

STU 2019-1492: INNATE - Immunotherapy During Neoadjuvant Therapy for Rectal Cancer, a Phase II Randomized Multicenter Trial with and without APX005M, an Anti-CD40 Agonist.

STU 2020-0166: EA2182 - A Randomized Phase II Study of Deintensified Chemoradiation for Early Stage Anal Squamous Cell Carcinoma.

STU 2020-1216: GRECO-2 - A Randomized, Phase 2 Study of Stereotactic Body Radiation Therapy (SBRT) in Combination with GC4711 in the Treatment of Locally Advanced or Borderline Resectable, Non-Metastatic Pancreatic Cancer.

STU 2020-1394: Phase I Trial of Ultra-Fractionated Adaptive Radiotherapy, Chemotherapy and Selective Omission of Surgery for Locally Advanced Rectal Cancer.

Genitourinary

Therapeutic

STU 022017-032: NRG-GU002 - Phase II-III Trial of Adjuvant Radiotherapy and Androgen Deprivation Following Radical Prostatectomy with or without Adjuvant Docetaxel.

STU 122016-067: Salvenza - Phase II Randomized Placebo-Controlled Double-Blinded Study of Salvage Radiation Therapy (SRT) Plus Placebo Versus SRT Plus Enzalutamide in Men with High-Risk PSA-Recurrent Prostate Cancer after Radical Prostatectomy (SALV-ENZA).

STU 022015-058: IVC Thrombus - Safety Lead-In Phase II Trial of Neo-Adjuvant SABR for IVC Tumor Thrombus in Newly Diagnosed RCC.

STU 092017-018: POTEN-C - Prostate Oncologic Therapy While Ensuring Neurovascular Conservation (POTEN-C): A Phase II Randomized Controlled Trial of Stereotactic Ablative Body Radiotherapy (SAbR) with or without Neurovascular Sparing for Erectile Function Preservation in Localized Prostate Cancer. Learn more about the POTEN-C trial.

STU 2019-1065: STEEL - A Randomized Phase II Trial of Salvage Radiotherapy with Standard vs Enhanced Androgen Deprivation Therapy (with Enzalutamide) in Patients with Post-Prostatectomy PSA Recurrences with Aggressive Disease Features.

STU 2019-1596: F-SHARP - A Phase I/II Trial of Focal Salvage High-Dose-Rate Brachytherapy for Locally Recurrent Prostate Cancer in Patients Treated with Prior Radiotherapy.

STU 2020-0329: RAVENS - A Phase II Randomized Trial of RAdium-223 and SABR Versus SABR for oligomEtastatic prostate caNcerS (RAVENS).

STU 022011-213: ASCLEPIuS - A Multi-Center Study of Androgen Suppression with Abiraterone aCetate, LEuprolide, PARP Inhibition and Stereotactic Body Radiotherapy (ASCLEPIuS). A phase 1/2 trial in high-risk or node-positive prostate cancer.

Head and Neck

Therapeutic

STU 072014-041: NRG-HN001 - Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA).

STU 2019-0748: IPET - Pilot Study of Interim PET/CT in Patients Treated with Definitive Chemoradiotherapy for Head and Neck Cancer.

STU 2019-1316: KEYSTROKE - A Randomized Phase II Study of Pembrolizumab (KEYTRUDA) Plus Stereotactic Re-Irradiation versus SBRT Alone for Locoregionally Recurrent or Second Primary Head and Neck Carcinoma.

STU 2020-0522: HYPORT-HN - A Randomized Non-Inferiority Phase II Study of Hypofractionated Post-Operative Radiation Therapy for Head and Neck Squamous Cell Carcinoma.

STU 2020-1079: HYHOPE - Phase I Study of De-Intensified Hypofractionated Radiation Therapy for Human Papilloma Virus-Associated Oropharynx Cancer.

STU 2020-1000: EA3161 - A Phase II/III Randomized Study of Maintenance Nivolumab versus Observation in Patients with Locally Advanced, Intermediate Risk HPV-Positive OPCA.

STU 022013-055: RTOG 1216 - Randomized Phase II/III Trial of Surgery and Postoperative Radiation Delivered with Concurrent Cisplatin versus Docetaxel versus Docetaxel and Cetuximab for High-Risk Squamous Cell Cancer of the Head and Neck.

Non-Therapeutic

STU 2021-0529: Registry Study to Evaluate the Clinical and Dosimetric Outcomes of Cancer Patients Adaptive Radiation Therapy (ART).

Lung

Therapeutic

STU 042017-024: NRG-LU002 - Maintenance Systemic Therapy Versus Consolidative Stereotactic Body Radiation Therapy (SBRT) plus Maintenance Systemic Therapy for Limited Metastatic Non-Small Cell Cancer (NSCLC): A Randomized Phase II/III Trial. Learn more about the NRG trial.

STU 022015-069: JoLT-Ca/STABLEMATES - A Randomized Phase III Study of Sublobar Resection (SR) versus Stereotactic Ablative Radiotherapy (SAbR) in High-Risk Patients with Stage I Non-Small Cell Lung Cancer (NSCLC), the STABLEMATES Trial. Learn more about the JoLT-CA/STABLEMATES trial.

STU 2018-0261: ADRIATIC - A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multi-Center, International Study of Durvalumab or Durvalumab and Tremelimumab as Consolidation Treatment for Patients with Limited Stage Small-Cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy (ADRIATIC).

STU 2019-0858: PACIFIC 4/RTOG-3515 - A Phase III, Randomized, Placebo-Controlled, Double-Blind, Multi-Center, International Study of Durvalumab Following Stereotactic Body Radiation Therapy (SBRT) for the Treatment of Patients with Stage I/II Non-Small Cell Lung Cancer (PACIFIC-4/RTOG-3515).

STU 2019-1082 - A Phase II Concurrent Durvalumab (MEDI4736) and Radiotherapy Followed by Consolidative Durvalumab (MEDI4736) for Stage III Non-Small Cell Lung Cancer (NSCLC).

STU 2019-1764 - Phase I/II Study of Stereotactic Body Radiation Therapy (SBRT) with or without GC4711 for Early Stage, Centrally Located or Large Non-Small Cell Lung Cancer (NSCLC).

Non-Therapeutic

STU 062016-073: Lung SAbR - Investigating Radiation-Induced Injury to Airways and Pulmonary Vasculature in Lung Stereotactic Ablative Body Radiotherapy (SAbR).

STU 2019-1390: Tissue Procurement and Outcome Collection for Cancer Patients With and Without Cachexia.

Lymphoma

Therapeutic

STU 2020-1106: A Phase I/II Trial of ‘Re-Priming’ Stereotactic Ablative Radiotherapy (SAbR) for Relapsed/Refractory Non-Hodgkin Lymphoma Patients in Incomplete Response after Chimeric Antigen Receptor T-cell (CAR-T) Salvage Therapy.

Pediatrics

Non-Therapeutic

STU 2019-1142: Video-Based Motion Detection and Prediction for Pediatric Radiotherapy.

Other

Non-Therapeutic

STU 072010-098: Tissue Procurement - Tissue Procurement and Outcome Collection for Radiotherapy-Treated Patients.

STU 2021-0206: Volunteer Scanning for Testing, Evaluating, and Enhancing 1.5T MRI Systems Dedicated to Radiation Treatment Planning and MRI-Guided Radiation Therapy.