Our lab investigates the dysregulation of dynamin in neuromyopathies, and the role of phosphoinositides in endocytic trafficking.
We study how the chemical properties of synthetic nucleic acids affect recognition of RNA and DNA, investigating allele-selective recognition of disease genes that contain expanded repeat regions, and developing RNAi proteins to control splicing or transcription.
Dr. Lehrman serves as Assistant Dean for Academic Facilities and Resource Planning. His scientific expertise is synthesis and recognition of glycoconjugates—polysaccharides coupled to proteins and lipids—with focus on the stress-signaling pathways of the endoplasmic reticulum.
The Mango/Kliewer Lab studies the physiology of nuclear hormone receptors and fibroblast growth factors. We hope to exploit their signaling networks to create therapies for diseases such as atherosclerosis, cholestasis, obesity, cancer, and nematode parasitism.
Our research focuses on elucidation of pathways and mechanisms by which cell surface receptors regulate intracellular function. Current studies, which center on G protein pathways, combine biochemical, structural, fluorescent, and cell-based techniques to gain better understanding of both molecular mechanisms and physiological impact of these pathways.
We investigate genetic and molecular basis of phenotypic diversity using whole genome sequencing, transcriptome analysis, fluidics, fluorescence, long-term evolution experiments, large-scale combinatorial mutagenesis, computational methods, and other tools.
The Whitehurst Lab uses RNAi-based functional genomics to identify gene products that support viability and/or modulate chemotherapeutic sensitivity in tumor cells. Using this strategy, we discovered that tumor cells can depend on aberrantly activated gametogenic genes for survival.