Publications"/> Publications">

Publications

2018

Cai, L., Lin, S., Girard, L., Zhou, Y., Yang, L., Ci, B., Zhou, Q., Luo, D., Yao, B., Tang, H., Allen, J., Huffman, K., Gazdar, A., Heymach, J., Wistuba, I., Xiao, G., Minna, J., Xie, Y., LCE: an open web portal to explore gene expression and clinical associations in lung cancer. Oncogene, 2018

Zhang, Q.J., Tran, T.A.T., Wang, M., Ranek, M.J., Kokkonen-Simon, K.M., Gao, J., Luo, X., Tan, W., Kyrychenko, V., Liao, L., Xu, J., Hill, J.A., Olson, E.N., Kass, D.A., Martinez, E.D., Liu, Z.P., Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis. Nat Commun, 9: 5230, 2018

Updegraff, B.L., Zhou, X., Guo, Y., Padanad, M.S., Chen, P.H., Yang, C., Sudderth, J., Rodriguez-Tirado, C., Girard, L., Minna, J.D., Mishra, P., DeBerardinis, R.J., O'Donnell, K.A., Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism. Cell Rep, 25: 2223-2233 e6, 2018

Du, W., Huang, H., Sorrelle, N., Brekken, R.A., Sitravatinib potentiates immune checkpoint blockade in refractory cancer models. JCI Insight, 3, 2018

Bayo, J., Tran, T.A., Wang, L., Pena-Llopis, S., Das, A.K., Martinez, E.D., Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks. Cell Rep, 25: 1040-1050 e5, 2018

Ruder, D., Papadimitrakopoulou, V., Shien, K., Behrens, C., Kalhor, N., Chen, H., Shen, L., Lee, J.J., Hong, W.K., Tang, X., Girard, L., Minna, J.D., Diao, L., Wang, J., Mino, B., Villalobos, P., Rodriguez-Canales, J., Hanson, N.E., Sun, J., Miller, V., Greenbowe, J., Frampton, G., Herbst, R.S., Baladandayuthapani, V., Wistuba, II, Izzo, J.G., Concomitant targeting of the mTOR/MAPK pathways: novel therapeutic strategy in subsets of RICTOR/KRAS-altered non-small cell lung cancer. Oncotarget, 9: 33995-34008, 2018

Pozo, K., Kelenis, D.P., Minna, J.D., Johnson, J.E., Different Originating Cells Underlie Intertumoral Heterogeneity in Lung Neuroendocrine Tumors. Cancer Discov, 8: 1216-1218, 2018

Du, W., Brekken, R.A., Does Axl have potential as a therapeutic target in pancreatic cancer? Expert Opin Ther Targets, 22: 955-966, 2018

Akbay, E.A., Kim, J., Autochthonous murine models for the study of smoker and never-smoker associated lung cancers. Transl Lung Cancer Res, 7: 464-486, 2018

Song, K., Bi, J.H., Qiu, Z.W., Felizardo, R., Girard, L., Minna, J.D., Gazdar, A.F., A quantitative method for assessing smoke associated molecular damage in lung cancers. Transl Lung Cancer Res, 7: 439-449, 2018

Gazdar, A.F., Preface: lung cancer in never smokers. Transl Lung Cancer Res, 7: 437-438, 2018

Hiramitsu, S., Ishikawa, T., Lee, W.R., Khan, T., Crumbley, C., Khwaja, N., Zamanian, F., Asghari, A., Sen, M., Zhang, Y., Hawse, J.R., Minna, J.D., Umetani, M., Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol. Front Endocrinol (Lausanne), 9: 470, 2018

Nichols, B.A., Oswald, N.W., McMillan, E.A., McGlynn, K., Yan, J., Kim, M.S., Saha, J., Mallipeddi, P.L., LaDuke, S.A., Villalobos, P.A., Rodriguez-Canales, J., Wistuba, II, Posner, B.A., Davis, A.J., Minna, J.D., MacMillan, J.B., Whitehurst, A.W., HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress. Cancer Res, 78: 6196-6208, 2018

Pozo, K., Minna, J.D., Johnson, J.E., Corrigendum: Identifying a missing lineage driver in a subset of lung neuroendocrine tumors. Genes Dev, 32: 1266, 2018

Jia, D., Augert, A., Kim, D.W., Eastwood, E., Wu, N., Ibrahim, A.H., Kim, K.B., Dunn, C.T., Pillai, S.P.S., Gazdar, A.F., Bolouri, H., Park, K.S., MacPherson, D., Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition. Cancer Discov, 8: 1422-1437, 2018

Motea, E.A., Fattah, F.J., Xiao, L., Girard, L., Rommel, A., Morales, J.C., Patidar, P., Zhou, Y., Porter, A., Xie, Y., Minna, J.D., Boothman, D.A., Kub5-Hera (RPRD1B) Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers. Clin Cancer Res, 24: 6459-6470, 2018

Wang, Z., Zhang, Y., Pinkas, D.M., Fox, A.E., Luo, J., Huang, H., Cui, S., Xiang, Q., Xu, T., Xun, Q., Zhu, D., Tu, Z., Ren, X., Brekken, R.A., Bullock, A.N., Liang, G., Ding, K., Lu, X., Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2. J Med Chem, 61: 7977-7990, 2018

Huang, F., Ni, M., Chalishazar, M.D., Huffman, K.E., Kim, J., Cai, L., Shi, X., Cai, F., Zacharias, L.G., Ireland, A.S., Li, K., Gu, W., Kaushik, A.K., Liu, X., Gazdar, A.F., Oliver, T.G., Minna, J.D., Hu, Z., DeBerardinis, R.J., Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers. Cell Metab, 28: 369-382 e5, 2018

Du, L., Zhao, Z., Suraokar, M., Shelton, S.S., Ma, X., Hsiao, T.H., Minna, J.D., Wistuba, I., Pertsemlidis, A., LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer. Oncotarget, 9: 29601-29618, 2018

Mender, I., LaRanger, R., Luitel, K., Peyton, M., Girard, L., Lai, T.P., Batten, K., Cornelius, C., Dalvi, M.P., Ramirez, M., Du, W., Wu, L.F., Altschuler, S.J., Brekken, R., Martinez, E.D., Minna, J.D., Wright, W.E., Shay, J.W., Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance. Neoplasia, 20: 826-837, 2018

Sathyanarayana, U.G., Moore, A.Y., Li, L., Padar, A., Majmudar, K., Stastny, V., Makarla, P., Suzuki, M., Minna, J.D., Feng, Z., Gazdar, A.F., Retraction notice to "Sun exposure related methylation in malignant and non-malignant skin lesions" [Cancer Letters 245/1-2 (2007) 112-120]. Cancer Lett, 432: 272, 2018

Wang, S., Chen, A., Yang, L., Cai, L., Xie, Y., Fujimoto, J., Gazdar, A., Xiao, G., Comprehensive analysis of lung cancer pathology images to discover tumor shape and boundary features that predict survival outcome. Sci Rep, 8: 10393, 2018

Pozo, K., Minna, J.D., Johnson, J.E., Identifying a missing lineage driver in a subset of lung neuroendocrine tumors. Genes Dev, 32: 865-867, 2018

Cruz, V.H., Arner, E.N., Wynne, K.W., Scherer, P.E., Brekken, R.A., Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction. Mol Metab, 16: 139-149, 2018

Jin, H., Ham, I.H., Oh, H.J., Bae, C.A., Lee, D., Kim, Y.B., Son, S.Y., Chwae, Y.J., Han, S.U., Brekken, R.A., Hur, H., Inhibition of Discoidin Domain Receptor 1 Prevents Stroma-Induced Peritoneal Metastasis in Gastric Carcinoma. Mol Cancer Res, 16: 1590-1600, 2018

Rashdan, S., Minna, J.D., Gerber, D.E., Diagnosis and management of pulmonary toxicity associated with cancer immunotherapy. Lancet Respir Med, 6: 472-478, 2018

Dellinger, M.T., Witte, M.H., Lymphangiogenesis, lymphatic systemomics, and cancer: context, advances and unanswered questions. Clin Exp Metastasis, 35: 419-424, 2018

Li, Q., Wang, X., Liang, F., Yi, F., Xie, Y., Gazdar, A., Xiao, G., A Bayesian hidden Potts mixture model for analyzing lung cancer pathology images. Biostatistics, 2018

Wang, C., Niederstrasser, H., Douglas, P.M., Lin, R., Jaramillo, J., Li, Y., Oswald, N.W., Zhou, A., McMillan, E.A., Mendiratta, S., Wang, Z., Zhao, T., Lin, Z., Luo, M., Huang, G., Brekken, R.A., Posner, B.A., MacMillan, J.B., Gao, J., White, M.A., Author Correction: Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nat Commun, 9: 2050, 2018

Yang, L., Wang, S., Gerber, D.E., Zhou, Y., Xu, F., Liu, J., Liang, H., Xiao, G., Zhou, Q., Gazdar, A., Xie, Y., Main bronchus location is a predictor for metastasis and prognosis in lung adenocarcinoma: A large cohort analysis. Lung Cancer, 120: 22-26, 2018

McMillan, E.A., Ryu, M.J., Diep, C.H., Mendiratta, S., Clemenceau, J.R., Vaden, R.M., Kim, J.H., Motoyaji, T., Covington, K.R., Peyton, M., Huffman, K., Wu, X., Girard, L., Sung, Y., Chen, P.H., Mallipeddi, P.L., Lee, J.Y., Hanson, J., Voruganti, S., Yu, Y., Park, S., Sudderth, J., DeSevo, C., Muzny, D.M., Doddapaneni, H., Gazdar, A., Gibbs, R.A., Hwang, T.H., Heymach, J.V., Wistuba, I., Coombes, K.R., Williams, N.S., Wheeler, D.A., MacMillan, J.B., Deberardinis, R.J., Roth, M.G., Posner, B.A., Minna, J.D., Kim, H.S., White, M.A., Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell, 173: 864-878 e29, 2018

Fu, G., Sanjay, S.T., Zhou, W., Brekken, R.A., Kirken, R.A., Li, X., Exploration of Nanoparticle-Mediated Photothermal Effect of TMB-H2O2 Colorimetric System and Its Application in a Visual Quantitative Photothermal Immunoassay. Anal Chem, 90: 5930-5937, 2018

Kim, J., Minna, J.D., Evaluating tumor-suppressor gene combinations. Nat Genet, 50: 480-482, 2018

Tanaka, I., Sato, M., Kato, T., Goto, D., Kakumu, T., Miyazawa, A., Yogo, N., Hase, T., Morise, M., Sekido, Y., Girard, L., Minna, J.D., Byers, L.A., Heymach, J.V., Coombes, K.R., Kondo, M., Hasegawa, Y., eIF2beta, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer. Cancer Sci, 109: 1843-1852, 2018

Hominick, D., Silva, A., Khurana, N., Liu, Y., Dechow, P.C., Feng, J.Q., Pytowski, B., Rutkowski, J.M., Alitalo, K., Dellinger, M.T., VEGF-C promotes the development of lymphatics in bone and bone loss. Elife, 7, 2018

Gong, K., Guo, G., Gerber, D.E., Gao, B., Peyton, M., Huang, C., Minna, J.D., Hatanpaa, K.J., Kernstine, K., Cai, L., Xie, Y., Zhu, H., Fattah, F.J., Zhang, S., Takahashi, M., Mukherjee, B., Burma, S., Dowell, J., Dao, K., Papadimitrakopoulou, V.A., Olivas, V., Bivona, T.G., Zhao, D., Habib, A.A., TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer. J Clin Invest, 128: 2500-2518, 2018

Manders, D.B., Kishore, H.A., Gazdar, A.F., Keller, P.W., Tsunezumi, J., Yanagisawa, H., Lea, J., Word, R.A., Dysregulation of fibulin-5 and matrix metalloproteases in epithelial ovarian cancer. Oncotarget, 9: 14251-14267, 2018

Kontarakis, Z., Rossi, A., Ramas, S., Dellinger, M.T., Stainier, D.Y.R., Mir-126 is a conserved modulator of lymphatic development. Dev Biol, 437: 120-130, 2018

Zhang, W., Girard, L., Zhang, Y.A., Haruki, T., Papari-Zareei, M., Stastny, V., Ghayee, H.K., Pacak, K., Oliver, T.G., Minna, J.D., Gazdar, A.F., Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes. Transl Lung Cancer Res, 7: 32-49, 2018

Yingling, J.M., McMillen, W.T., Yan, L., Huang, H., Sawyer, J.S., Graff, J., Clawson, D.K., Britt, K.S., Anderson, B.D., Beight, D.W., Desaiah, D., Lahn, M.M., Benhadji, K.A., Lallena, M.J., Holmgaard, R.B., Xu, X., Zhang, F., Manro, J.R., Iversen, P.W., Iyer, C.V., Brekken, R.A., Kalos, M.D., Driscoll, K.E., Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-beta receptor type I inhibitor. Oncotarget, 9: 6659-6677, 2018

Walser, T.C., Jing, Z., Tran, L.M., Lin, Y.Q., Yakobian, N., Wang, G., Krysan, K., Zhu, L.X., Sharma, S., Lee, M.H., Belperio, J.A., Ooi, A.T., Gomperts, B.N., Shay, J.W., Larsen, J.E., Minna, J.D., Hong, L.S., Fishbein, M.C., Dubinett, S.M., Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells. Cancer Res, 78: 1986-1999, 2018

Gazdar, A.F., Morphologic and Other Forms of Heterogeneity in Small Cell Lung Cancer: What Can We Learn from Them? J Thorac Oncol, 13: 148-150, 2018

Belzile, O., Huang, X., Gong, J., Carlson, J., Schroit, A.J., Brekken, R.A., Freimark, B.D., Antibody targeting of phosphatidylserine for the detection and immunotherapy of cancer. Immunotargets Ther, 7: 1-14, 2018

He, M., Liu, S., Gallolu Kankanamalage, S., Borromeo, M.D., Girard, L., Gazdar, A.F., Minna, J.D., Johnson, J.E., Cobb, M.H., The Epithelial Sodium Channel (alphaENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors. Transl Oncol, 11: 292-299, 2018

Fan, C.W., Yarravarapu, N., Shi, H., Kulak, O., Kim, J., Chen, C., Lum, L., A synthetic combinatorial approach to disabling deviant Hedgehog signaling. Sci Rep, 8: 1133, 2018

Cruz, V.H., Brekken, R.A., Assessment of TANK-binding kinase 1 as a therapeutic target in cancer. J Cell Commun Signal, 12: 83-90, 2018

Aisner, D.L., Sholl, L.M., Berry, L.D., Rossi, M.R., Chen, H., Fujimoto, J., Moreira, A.L., Ramalingam, S.S., Villaruz, L.C., Otterson, G.A., Haura, E., Politi, K., Glisson, B., Cetnar, J., Garon, E.B., Schiller, J., Waqar, S.N., Sequist, L.V., Brahmer, J., Shyr, Y., Kugler, K., Wistuba, II, Johnson, B.E., Minna, J.D., Kris, M.G., Bunn, P.A., Kwiatkowski, D.J., The Impact of Smoking and TP53 Mutations in Lung Adenocarcinoma Patients with Targetable Mutations-The Lung Cancer Mutation Consortium (LCMC2). Clin Cancer Res, 24: 1038-1047, 2018

Ludwig, K.F., Du, W., Sorrelle, N.B., Wnuk-Lipinska, K., Topalovski, M., Toombs, J.E., Cruz, V.H., Yabuuchi, S., Rajeshkumar, N.V., Maitra, A., Lorens, J.B., Brekken, R.A., Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer. Cancer Res, 78: 246-255, 2018

Lu, W., Wang, X., Zhan, X., Gazdar, A., Meta-analysis approaches to combine multiple gene set enrichment studies. Stat Med, 37: 659-672, 2018

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2017

Shimada, Y., Minna, J.D., Exosome mediated phenotypic changes in lung cancer pathophysiology. Transl Cancer Res, 6: S1040-S1042, 2017

Wang, C., Niederstrasser, H., Douglas, P.M., Lin, R., Jaramillo, J., Li, Y., Oswald, N.W., Zhou, A., McMillan, E.A., Mendiratta, S., Wang, Z., Zhao, T., Lin, Z., Luo, M., Huang, G., Brekken, R.A., Posner, B.A., MacMillan, J.B., Gao, J., White, M.A., Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nat Commun, 8: 2270, 2017

Gazdar, A.F., Bunn, P.A., Minna, J.D., Small-cell lung cancer: what we know, what we need to know and the path forward. Nat Rev Cancer, 17: 725-737, 2017

Dalvi, M.P., Martinez, E.D., JumonjiC demethylase inhibitors show potential for targeting chemotherapy-resistant lung cancers. Mol Cell Oncol, 4: e1345352, 2017

Yang, L., Wang, S., Zhou, Y., Lai, S., Xiao, G., Gazdar, A., Xie, Y., Evaluation of the 7(th) and 8(th) editions of the AJCC/UICC TNM staging systems for lung cancer in a large North American cohort. Oncotarget, 8: 66784-66795, 2017

Thu, K.L., Papari-Zareei, M., Stastny, V., Song, K., Peyton, M., Martinez, V.D., Zhang, Y.A., Castro, I.B., Varella-Garcia, M., Liang, H., Xing, C., Kittler, R., Milchgrub, S., Castrillon, D.H., Davidson, H.L., Reynolds, C.P., Lam, W.L., Lea, J., Gazdar, A.F., A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas. Oncotarget, 8: 50489-50499, 2017

Aguilera, K.Y., Huang, H., Du, W., Hagopian, M.M., Wang, Z., Hinz, S., Hwang, T.H., Wang, H., Fleming, J.B., Castrillon, D.H., Ren, X., Ding, K., Brekken, R.A., Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther, 16: 2473-2485, 2017

Huang, H., Du, W., Brekken, R.A., Extracellular Matrix Induction of Intracellular Reactive Oxygen Species. Antioxid Redox Signal, 27: 774-784, 2017

Pagano, P.C., Tran, L.M., Bendris, N., O'Byrne, S., Tse, H.T., Sharma, S., Hoech, J.W., Park, S.J., Liclican, E.L., Jing, Z., Li, R., Krysan, K., Paul, M.K., Fontebasso, Y., Larsen, J.E., Hakimi, S., Seki, A., Fishbein, M.C., Gimzewski, J.K., Carlo, D.D., Minna, J.D., Walser, T.C., Dubinett, S.M., Identification of a Human Airway Epithelial Cell Subpopulation with Altered Biophysical, Molecular, and Metastatic Properties. Cancer Prev Res (Phila), 10: 514-524, 2017

Zhao, X., Huffman, K.E., Fujimoto, J., Canales, J.R., Girard, L., Nie, G., Heymach, J.V., Wistuba, II, Minna, J.D., Yu, Y., Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer. J Am Soc Mass Spectrom, 28: 2078-2089, 2017

Shien, K., Papadimitrakopoulou, V.A., Ruder, D., Behrens, C., Shen, L., Kalhor, N., Song, J., Lee, J.J., Wang, J., Tang, X., Herbst, R.S., Toyooka, S., Girard, L., Minna, J.D., Kurie, J.M., Wistuba, II, Izzo, J.G., JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer. Mol Cancer Ther, 16: 2234-2245, 2017

Kasiri, S., Shao, C., Chen, B., Wilson, A.N., Yenerall, P., Timmons, B.C., Girard, L., Tian, H., Behrens, C., Wistuba, II, Gazdar, A.F., Kim, J., GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma. Cancer Res, 77: 4448-4459, 2017

Sharma, R., Huang, X., Brekken, R.A., Schroit, A.J., Detection of phosphatidylserine-positive exosomes for the diagnosis of early-stage malignancies. Br J Cancer, 117: 545-552, 2017

Li, L., Wang, X., Xiao, G., Gazdar, A., Integrative gene set enrichment analysis utilizing isoform-specific expression. Genet Epidemiol, 41: 498-510, 2017

Goodwin, J., Neugent, M.L., Lee, S.Y., Choe, J.H., Choi, H., Jenkins, D.M.R., Ruthenborg, R.J., Robinson, M.W., Jeong, J.Y., Wake, M., Abe, H., Takeda, N., Endo, H., Inoue, M., Xuan, Z., Yoo, H., Chen, M., Ahn, J.M., Minna, J.D., Helke, K.L., Singh, P.K., Shackelford, D.B., Kim, J.W., The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition. Nat Commun, 8: 15503, 2017

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y.F., Ni, M., Huffman, K.E., Girard, L., Byers, L.A., Unsal-Kacmaz, K., Pena, C.G., Heymach, J.V., Wauters, E., Vansteenkiste, J., Castrillon, D.H., Chen, B.P.C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J.D., DeBerardinis, R.J., CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature, 546: 168-172, 2017

Dalvi, M.P., Wang, L., Zhong, R., Kollipara, R.K., Park, H., Bayo, J., Yenerall, P., Zhou, Y., Timmons, B.C., Rodriguez-Canales, J., Behrens, C., Mino, B., Villalobos, P., Parra, E.R., Suraokar, M., Pataer, A., Swisher, S.G., Kalhor, N., Bhanu, N.V., Garcia, B.A., Heymach, J.V., Coombes, K., Xie, Y., Girard, L., Gazdar, A.F., Kittler, R., Wistuba, II, Minna, J.D., Martinez, E.D., Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors. Cell Rep, 19: 1669-1684, 2017

Sen, T., Tong, P., Stewart, C.A., Cristea, S., Valliani, A., Shames, D.S., Redwood, A.B., Fan, Y.H., Li, L., Glisson, B.S., Minna, J.D., Sage, J., Gibbons, D.L., Piwnica-Worms, H., Heymach, J.V., Wang, J., Byers, L.A., CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib. Cancer Res, 77: 3870-3884, 2017

Xiang, Z., Zhou, Z.J., Xia, G.K., Zhang, X.H., Wei, Z.W., Zhu, J.T., Yu, J., Chen, W., He, Y., Schwarz, R.E., Brekken, R.A., Awasthi, N., Zhang, C.H., A positive crosstalk between CXCR4 and CXCR2 promotes gastric cancer metastasis. Oncogene, 36: 5122-5133, 2017

Zhang, Y., Zhang, L., Li, R., Chang, D.W., Ye, Y., Minna, J.D., Roth, J.A., Han, B., Wu, X., Genetic variations in cancer-related significantly mutated genes and lung cancer susceptibility. Ann Oncol, 28: 1625-1630, 2017

Qiu, Z.W., Bi, J.H., Gazdar, A.F., Song, K., Genome-wide copy number variation pattern analysis and a classification signature for non-small cell lung cancer. Genes Chromosomes Cancer, 56: 559-569, 2017

Deb, D., Rajaram, S., Larsen, J.E., Dospoy, P.D., Marullo, R., Li, L.S., Avila, K., Xue, F., Cerchietti, L., Minna, J.D., Altschuler, S.J., Wu, L.F., Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers. Cancer Res, 77: 3070-3081, 2017

Windhorst, S., Song, K., Gazdar, A.F., Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types. Biochem Pharmacol, 137: 1-9, 2017

Celiktas, M., Tanaka, I., Tripathi, S.C., Fahrmann, J.F., Aguilar-Bonavides, C., Villalobos, P., Delgado, O., Dhillon, D., Dennison, J.B., Ostrin, E.J., Wang, H., Behrens, C., Do, K.A., Gazdar, A.F., Hanash, S.M., Taguchi, A., Role of CPS1 in Cell Growth, Metabolism and Prognosis in LKB1-Inactivated Lung Adenocarcinoma. J Natl Cancer Inst, 109: 1-9, 2017

Sorrelle, N., Dominguez, A.T.A., Brekken, R.A., From top to bottom: midkine and pleiotrophin as emerging players in immune regulation. J Leukoc Biol, 102: 277-286, 2017

Mulcrone, P.L., Campbell, J.P., Clement-Demange, L., Anbinder, A.L., Merkel, A.R., Brekken, R.A., Sterling, J.A., Elefteriou, F., Skeletal Colonization by Breast Cancer Cells Is Stimulated by an Osteoblast and beta2AR-Dependent Neo-Angiogenic Switch. J Bone Miner Res, 32: 1442-1454, 2017

Hatch, S.B., Yapp, C., Montenegro, R.C., Savitsky, P., Gamble, V., Tumber, A., Ruda, G.F., Bavetsias, V., Fedorov, O., Atrash, B., Raynaud, F., Lanigan, R., Carmichael, L., Tomlin, K., Burke, R., Westaway, S.M., Brown, J.A., Prinjha, R.K., Martinez, E.D., Oppermann, U., Schofield, C.J., Bountra, C., Kawamura, A., Blagg, J., Brennan, P.E., Rossanese, O., Muller, S., Assessing histone demethylase inhibitors in cells: lessons learned. Epigenetics Chromatin, 10: 9, 2017

Tang, H., Wang, S., Xiao, G., Schiller, J., Papadimitrakopoulou, V., Minna, J., Wistuba, II, Xie, Y., Comprehensive evaluation of published gene expression prognostic signatures for biomarker-based lung cancer clinical studies. Ann Oncol, 28: 733-740, 2017

Li, J., Zhao, W., Akbani, R., Liu, W., Ju, Z., Ling, S., Vellano, C.P., Roebuck, P., Yu, Q., Eterovic, A.K., Byers, L.A., Davies, M.A., Deng, W., Gopal, Y.N., Chen, G., von Euw, E.M., Slamon, D., Conklin, D., Heymach, J.V., Gazdar, A.F., Minna, J.D., Myers, J.N., Lu, Y., Mills, G.B., Liang, H., Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays. Cancer Cell, 31: 225-239, 2017

Kakumu, T., Sato, M., Goto, D., Kato, T., Yogo, N., Hase, T., Morise, M., Fukui, T., Yokoi, K., Sekido, Y., Girard, L., Minna, J.D., Byers, L.A., Heymach, J.V., Coombes, K.R., Kondo, M., Hasegawa, Y., Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer. Cancer Sci, 108: 732-743, 2017

Hur, H., Ham, I.H., Lee, D., Jin, H., Aguilera, K.Y., Oh, H.J., Han, S.U., Kwon, J.E., Kim, Y.B., Ding, K., Brekken, R.A., Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma. BMC Cancer, 17: 87, 2017

Dai, B., Roife, D., Kang, Y., Gumin, J., Rios Perez, M.V., Li, X., Pratt, M., Brekken, R.A., Fueyo-Margareto, J., Lang, F.F., Fleming, J.B., Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-targeting Antibody in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther, 2017

Pelosof, L., Ahn, C., Gao, A., Horn, L., Madrigales, A., Cox, J., McGavic, D., Minna, J.D., Gazdar, A.F., Schiller, J., Proportion of Never-Smoker Non-Small Cell Lung Cancer Patients at Three Diverse Institutions. J Natl Cancer Inst, 109, 2017

Tagal, V., Wei, S., Zhang, W., Brekken, R.A., Posner, B.A., Peyton, M., Girard, L., Hwang, T., Wheeler, D.A., Minna, J.D., White, M.A., Gazdar, A.F., Roth, M.G., SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers. Nat Commun, 8: 14098, 2017

Mollaoglu, G., Guthrie, M.R., Bohm, S., Bragelmann, J., Can, I., Ballieu, P.M., Marx, A., George, J., Heinen, C., Chalishazar, M.D., Cheng, H., Ireland, A.S., Denning, K.E., Mukhopadhyay, A., Vahrenkamp, J.M., Berrett, K.C., Mosbruger, T.L., Wang, J., Kohan, J.L., Salama, M.E., Witt, B.L., Peifer, M., Thomas, R.K., Gertz, J., Johnson, J.E., Gazdar, A.F., Wechsler-Reya, R.J., Sos, M.L., Oliver, T.G., MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition. Cancer Cell, 31: 270-285, 2017

Wang, W., Wang, H., Zhou, X., Li, X., Sun, W., Dellinger, M., Boyce, B.F., Xing, L., Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice. J Bone Miner Res, 32: 939-950, 2017

Gao, B., Huang, C., Kernstine, K., Pelekanou, V., Kluger, Y., Jiang, T., Peters-Hall, J.R., Coquelin, M., Girard, L., Zhang, W., Huffman, K., Oliver, D., Kinose, F., Haura, E., Teer, J.K., Rix, U., Le, A.T., Aisner, D.L., Varella-Garcia, M., Doebele, R.C., Covington, K.R., Hampton, O.A., Doddapaneni, H.V., Jayaseelan, J.C., Hu, J., Wheeler, D.A., Shay, J.W., Rimm, D.L., Gazdar, A., Minna, J.D., Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions. Oncotarget, 8: 11114-11126, 2017

Luo, X., Zang, X., Yang, L., Huang, J., Liang, F., Rodriguez-Canales, J., Wistuba, II, Gazdar, A., Xie, Y., Xiao, G., Comprehensive Computational Pathological Image Analysis Predicts Lung Cancer Prognosis. J Thorac Oncol, 12: 501-509, 2017

Zhou, X., Updegraff, B.L., Guo, Y., Peyton, M., Girard, L., Larsen, J.E., Xie, X.J., Zhou, Y., Hwang, T.H., Xie, Y., Rodriguez-Canales, J., Villalobos, P., Behrens, C., Wistuba, II, Minna, J.D., O'Donnell, K.A., PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK Signaling by EGFR and KRAS during Lung Tumorigenesis. Cancer Res, 77: 187-197, 2017

Fu, R., Wang, P., Ma, W., Taguchi, A., Wong, C.H., Zhang, Q., Gazdar, A., Hanash, S.M., Zhou, Q., Zhong, H., Feng, Z., A statistical method for detecting differentially expressed SNVs based on next-generation RNA-seq data. Biometrics, 73: 42-51, 2017

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2016

Ludwig, K.F., Slone, T., Cederberg, K.B., Silva, A.T., Dellinger, M., A New Case and Review of Chylothorax in Generalized Lymphatic Anomaly and Gorham-Stout Disease. Lymphology, 49: 73-84, 2016

Zhao, T., Huang, G., Li, Y., Yang, S., Ramezani, S., Lin, Z., Wang, Y., Ma, X., Zeng, Z., Luo, M., de Boer, E., Xie, X.J., Thibodeaux, J., Brekken, R.A., Sun, X., Sumer, B.D., Gao, J., A Transistor-like pH Nanoprobe for Tumour Detection and Image-guided Surgery. Nat Biomed Eng, 1, 2016

Gao, B., Huang, C., Kernstine, K., Pelekanou, V., Kluger, Y., Jiang, T., Peters-Hall, J.R., Coquelin, M., Girard, L., Zhang, W., Huffman, K., Oliver, D., Kinose, F., Haura, E., Teer, J.K., Rix, U., Le, A.T., Aisner, D.L., Varella-Garcia, M., Doebele, R.C., Covington, K.R., Hampton, O.A., Doddapaneni, H.V., Jayaseelan, J.C., Hu, J., Wheeler, D.A., Shay, J.W., Rimm, D.L., Gazdar, A., Minna, J.D., Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions. Oncotarget, 2016

Huang, X., Motea, E.A., Moore, Z.R., Yao, J., Dong, Y., Chakrabarti, G., Kilgore, J.A., Silvers, M.A., Patidar, P.L., Cholka, A., Fattah, F., Cha, Y., Anderson, G.G., Kusko, R., Peyton, M., Yan, J., Xie, X.J., Sarode, V., Williams, N.S., Minna, J.D., Beg, M., Gerber, D.E., Bey, E.A., Boothman, D.A., Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors. Cancer Cell, 30: 940-952, 2016

Pena-Llopis, S., Wan, Y., Martinez, E.D., Unique epigenetic gene profiles define human breast cancers with poor prognosis. Oncotarget, 7: 85819-85831, 2016

Wieczorek, M., Tcherkezian, J., Bernier, C., Prota, A.E., Chaaban, S., Rolland, Y., Godbout, C., Hancock, M.A., Arezzo, J.C., Ocal, O., Rocha, C., Olieric, N., Hall, A., Ding, H., Bramoulle, A., Annis, M.G., Zogopoulos, G., Harran, P.G., Wilkie, T.M., Brekken, R.A., Siegel, P.M., Steinmetz, M.O., Shore, G.C., Brouhard, G.J., Roulston, A., The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity. Sci Transl Med, 8: 365ra159, 2016

Posner, B.A., Peyton, M., Girard, L., Hwang, T., Wheeler, D.A., Minna, J.D., White, M.A., Gazdar, A.F., Roth, M.G., Zhang, Y.A., Zhou, Y., Luo, X., Song, K., Ma, X., Sathe, A., Girard, L., Xiao, G., Gazdar, A.F., SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II-III Diffuse Gliomas. Nat Commun, 13: 80-89, 2016

Zhang, Y.A., Zhou, Y., Luo, X., Song, K., Ma, X., Sathe, A., Girard, L., Xiao, G., Gazdar, A.F., SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II-III Diffuse Gliomas. EBioMedicine, 13: 80-89, 2016

Kim, J., McMillan, E., Kim, H.S., Venkateswaran, N., Makkar, G., Rodriguez-Canales, J., Villalobos, P., Neggers, J.E., Mendiratta, S., Wei, S., Landesman, Y., Senapedis, W., Baloglu, E., Chow, C.B., Frink, R.E., Gao, B., Roth, M., Minna, J.D., Daelemans, D., Wistuba, II, Posner, B.A., Scaglioni, P.P., White, M.A., XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer. Nature, 538: 114-117, 2016

Wojtukiewicz, M.Z., Sierko, E., Skalij, P., Kaminska, M., Zimnoch, L., Brekken, R.A., Thorpe, P.E., Granulocyte-Colony Stimulating Factor Receptor, Tissue Factor, and VEGF-R Bound VEGF in Human Breast Cancer In Loco. Adv Clin Exp Med, 25: 505-11, 2016

Yan, Y., Liu, L., Xiong, H., Miller, J.B., Zhou, K., Kos, P., Huffman, K.E., Elkassih, S., Norman, J.W., Carstens, R., Kim, J., Minna, J.D., Siegwart, D.J., Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells. Proc Natl Acad Sci U S A, 113: E5702-10, 2016

Frankel, A.E., Liu, X., Minna, J.D., Developing EZH2-Targeted Therapy for Lung Cancer. Cancer Discov, 6: 949-52, 2016

Topalovski, M., Hagopian, M., Wang, M., Brekken, R.A., Hypoxia and Transforming Growth Factor beta Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer. J Biol Chem, 291: 22244-22252, 2016

Larsen, J.E., Nathan, V., Osborne, J.K., Farrow, R.K., Deb, D., Sullivan, J.P., Dospoy, P.D., Augustyn, A., Hight, S.K., Sato, M., Girard, L., Behrens, C., Wistuba, II, Gazdar, A.F., Hayward, N.K., Minna, J.D., ZEB1 drives epithelial-to-mesenchymal transition in lung cancer. J Clin Invest, 126: 3219-35, 2016

Padanad, M.S., Konstantinidou, G., Venkateswaran, N., Melegari, M., Rindhe, S., Mitsche, M., Yang, C., Batten, K., Huffman, K.E., Liu, J., Tang, X., Rodriguez-Canales, J., Kalhor, N., Shay, J.W., Minna, J.D., McDonald, J., Wistuba, II, DeBerardinis, R.J., Scaglioni, P.P., Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis. Cell Rep, 16: 1614-1628, 2016

Mineo, C., Lanier, L., Jung, E., Sengupta, S., Ulrich, V., Sacharidou, A., Tarango, C., Osunbunmi, O., Shen, Y.M., Salmon, J.E., Brekken, R.A., Huang, X., Thorpe, P.E., Shaul, P.W., Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis. PLoS One, 11: e0158757, 2016

Borromeo, M.D., Savage, T.K., Kollipara, R.K., He, M., Augustyn, A., Osborne, J.K., Girard, L., Minna, J.D., Gazdar, A.F., Cobb, M.H., Johnson, J.E., ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs. Cell Rep, 16: 1259-72, 2016

Diaz, B., Ostapoff, K.T., Toombs, J.E., Lo, J., Bonner, M.Y., Curatolo, A., Adsay, V., Brekken, R.A., Arbiser, J.L., Tris DBA palladium is highly effective against growth and metastasis of pancreatic cancer in an orthotopic model. Oncotarget, 7: 51569-51580, 2016

Minna, J.D., Johnson, J.E., Opening a Chromatin Gate to Metastasis. Cell, 166: 275-6, 2016

Girard, L., Rodriguez-Canales, J., Behrens, C., Thompson, D.M., Botros, I.W., Tang, H., Xie, Y., Rekhtman, N., Travis, W.D., Wistuba, II, Minna, J.D., Gazdar, A.F., An Expression Signature as an Aid to the Histologic Classification of Non-Small Cell Lung Cancer. Clin Cancer Res, 22: 4880-4889, 2016

Lammoglia, G.M., Van Zandt, C.E., Galvan, D.X., Orozco, J.L., Dellinger, M.T., Rutkowski, J.M., Hyperplasia, de novo lymphangiogenesis, and lymphatic regression in mice with tissue-specific, inducible overexpression of murine VEGF-D. Am J Physiol Heart Circ Physiol, 311: H384-94, 2016

Gazdar, A.F., Hirsch, F.R., Minna, J.D., Correction: "From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers". J Thorac Oncol, 11: e88-9, 2016

Thu, K.L., Papari-Zareei, M., Stastny, V., Song, K., Peyton, M., Martinez, V.D., Zhang, Y.A., Castro, I.B., Varella-Garcia, M., Liang, H., Xing, C., Kittler, R., Milchgrub, S., Castrillon, D.H., Davidson, H.L., Reynolds, C.P., Lam, W.L., Lea, J., Gazdar, A.F., A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas. Oncotarget, 2016

Kim, D.W., Wu, N., Kim, Y.C., Cheng, P.F., Basom, R., Kim, D., Dunn, C.T., Lee, A.Y., Kim, K., Lee, C.S., Singh, A., Gazdar, A.F., Harris, C.R., Eisenman, R.N., Park, K.S., MacPherson, D., Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer. Genes Dev, 30: 1289-99, 2016

Taruvai Kalyana Kumar, R., Liu, S., Minna, J.D., Prasad, S., Monitoring drug induced apoptosis and treatment sensitivity in non-small cell lung carcinoma using dielectrophoresis. Biochim Biophys Acta, 1860: 1877-83, 2016

Gazdar, A.F., Minna, J.D., Developing New, Rational Therapies for Recalcitrant Small Cell Lung Cancer. J Natl Cancer Inst, 108, 2016

Wang, Y.W., Ma, X., Zhang, Y.A., Wang, M.J., Yatabe, Y., Lam, S., Girard, L., Chen, J.Y., Gazdar, A.F., ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers. J Thorac Oncol, 11: 1469-81, 2016

Zhang, Z., Wodzak, M., Belzile, O., Zhou, H., Sishc, B., Yan, H., Stojadinovic, S., Mason, R.P., Brekken, R.A., Chopra, R., Story, M.D., Timmerman, R., Saha, D., Effective Rat Lung Tumor Model for Stereotactic Body Radiation Therapy. Radiat Res, 185: 616-22, 2016

Wang, Z., Bian, H., Bartual, S.G., Du, W., Luo, J., Zhao, H., Zhang, S., Mo, C., Zhou, Y., Xu, Y., Tu, Z., Ren, X., Lu, X., Brekken, R.A., Yao, L., Bullock, A.N., Su, J., Ding, K., Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. J Med Chem, 59: 5911-6, 2016

Tong, P., Diao, L., Shen, L., Li, L., Heymach, J.V., Girard, L., Minna, J.D., Coombes, K.R., Byers, L.A., Wang, J., Selecting Reliable mRNA Expression Measurements Across Platforms Improves Downstream Analysis. Cancer Inform, 15: 81-9, 2016

Frink, R.E., Peyton, M., Schiller, J.H., Gazdar, A.F., Shay, J.W., Minna, J.D., Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner. Oncotarget, 7: 31639-51, 2016

Udayakumar, D., Pandita, R.K., Horikoshi, N., Liu, Y., Liu, Q., Wong, K.K., Hunt, C.R., Gray, N.S., Minna, J.D., Pandita, T.K., Westover, K.D., Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair. Radiat Res, 185: 527-38, 2016

Levin, P.A., Brekken, R.A., Byers, L.A., Heymach, J.V., Gerber, D.E., Axl Receptor Axis: A New Therapeutic Target in Lung Cancer. J Thorac Oncol, 11: 1357-62, 2016

Desai, T.J., Toombs, J.E., Minna, J.D., Brekken, R.A., Udugamasooriya, D.G., Identification of lipid-phosphatidylserine (PS) as the target of unbiasedly selected cancer specific peptide-peptoid hybrid PPS1. Oncotarget, 7: 30678-90, 2016

Freimark, B.D., Gong, J., Ye, D., Gray, M.J., Nguyen, V., Yin, S., Hatch, M.M., Hughes, C.C., Schroit, A.J., Hutchins, J.T., Brekken, R.A., Huang, X., Antibody-Mediated Phosphatidylserine Blockade Enhances the Antitumor Responses to CTLA-4 and PD-1 Antibodies in Melanoma. Cancer Immunol Res, 4: 531-40, 2016

DeNicola, G.M., Chen, P.H., Mullarky, E., Sudderth, J.A., Hu, Z., Wu, D., Tang, H., Xie, Y., Asara, J.M., Huffman, K.E., Wistuba, II, Minna, J.D., DeBerardinis, R.J., Cantley, L.C., Erratum: NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat Genet, 48: 473, 2016

Li, R., Pu, X., Chang, J.Y., Ye, Y., Komaki, R., Minna, J.D., Roth, J.A., Han, B., Wu, X., MiRNA-Related Genetic Variations Associated with Radiotherapy-Induced Toxicities in Patients with Locally Advanced Non-Small Cell Lung Cancer. PLoS One, 11: e0150467, 2016

Regan, E., Sibley, R.C., Cenik, B.K., Silva, A., Girard, L., Minna, J.D., Dellinger, M.T., Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines. PLoS One, 11: e0150963, 2016

Goel, H.L., Pursell, B., Shultz, L.D., Greiner, D.L., Brekken, R.A., Vander Kooi, C.W., Mercurio, A.M., P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer. Cell Rep, 14: 2193-208, 2016

Martinez, E.D., Gazdar, A.F., Inhibiting the Jumonji family: a potential new clinical approach to targeting aberrant epigenetic mechanisms. Epigenomics, 8: 313-6, 2016

Birge, R.B., Boeltz, S., Kumar, S., Carlson, J., Wanderley, J., Calianese, D., Barcinski, M., Brekken, R.A., Huang, X., Hutchins, J.T., Freimark, B., Empig, C., Mercer, J., Schroit, A.J., Schett, G., Herrmann, M., Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer. Cell Death Differ, 23: 962-78, 2016

Cheng, X., Li, L., Thorpe, P.E., Yopp, A.C., Brekken, R.A., Huang, X., Antibody-Mediated Blockade of Phosphatidylserine Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinomas Xenografts. Ann Surg Oncol, 23: 583-591, 2016

Bunn, P.A., Jr., Minna, J.D., Augustyn, A., Gazdar, A.F., Ouadah, Y., Krasnow, M.A., Berns, A., Brambilla, E., Rekhtman, N., Massion, P.P., Niederst, M., Peifer, M., Yokota, J., Govindan, R., Poirier, J.T., Byers, L.A., Wynes, M.W., McFadden, D.G., MacPherson, D., Hann, C.L., Farago, A.F., Dive, C., Teicher, B.A., Peacock, C.D., Johnson, J.E., Cobb, M.H., Wendel, H.G., Spigel, D., Sage, J., Yang, P., Pietanza, M.C., Krug, L.M., Heymach, J., Ujhazy, P., Zhou, C., Goto, K., Dowlati, A., Christensen, C.L., Park, K., Einhorn, L.H., Edelman, M.J., Giaccone, G., Gerber, D.E., Salgia, R., Owonikoko, T., Malik, S., Karachaliou, N., Gandara, D.R., Slotman, B.J., Blackhall, F., Goss, G., Thomas, R., Rudin, C.M., Hirsch, F.R., Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes? J Thorac Oncol, 11: 453-74, 2016

Chen, B., Trang, V., Lee, A., Williams, N.S., Wilson, A.N., Epstein, E.H., Jr., Tang, J.Y., Kim, J., Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma. Mol Cancer Ther, 15: 866-76, 2016

Young, J.H., Peyton, M., Kim, H.S., McMillan, E., Minna, J.D., White, M.A., Marcotte, E.M., Computational Discovery of Pathway-Level Genetic Vulnerabilities in Non-Small-Cell Lung Cancer. Bioinformatics, 2016

Young, J.H., Peyton, M., Seok Kim, H., McMillan, E., Minna, J.D., White, M.A., Marcotte, E.M., Computational discovery of pathway-level genetic vulnerabilities in non-small-cell lung cancer. Bioinformatics, 32: 1373-9, 2016

Topalovski, M., Brekken, R.A., Matrix control of pancreatic cancer: New insights into fibronectin signaling. Cancer Lett, 381: 252-8, 2016

Hu, R., Huffman, K.E., Chu, M., Zhang, Y., Minna, J.D., Yu, Y., Quantitative Secretomic Analysis Identifies Extracellular Protein Factors that Modulate the Metastatic Phenotype of Non-Small Cell Lung Cancer. J Proteome Res, 2016

Zhang, Y.A., Ma, X., Sathe, A., Fujimoto, J., Wistuba, II, Lam, S., Yatabe, Y., Wang, Y.W., Stastny, V., Gao, B., Larsen, J.E., Girard, L., Liu, X., Song, K., Behrens, C., Kalhor, N., Xie, Y., Zhang, M.Q., Minna, J.D., Gazdar, A.F., Validation of SCT Methylation as a Hallmark Biomarker for Lung Cancers. J Thorac Oncol, 11: 346-60, 2016

Zhang, Y.A., Ma, X., Sathe, A., Fujimoto, J., Wistuba, I., Lam, S., Yatabe, Y., Wang, Y.W., Stastny, V., Gao, B., Larsen, J.E., Girard, L., Liu, X., Song, K., Behrens, C., Kalhor, N., Xie, Y., Zhang, M.Q., Minna, J.D., Gazdar, A.F., Validation of SCT Methylation as a Hallmark Biomarker for Lung Cancers. J Thorac Oncol, 11: 346-360, 2016

Gazdar, A.F., Hirsch, F.R., Minna, J.D., From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers. J Thorac Oncol, 11: 287-99, 2016

Riquelme, E., Behrens, C., Lin, H.Y., Simon, G., Papadimitrakopoulou, V., Izzo, J., Moran, C., Kalhor, N., Lee, J.J., Minna, J.D., Wistuba, II, Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations. Cancer Res, 76: 675-85, 2016

Li, H., Hu, J., Wu, S., Wang, L., Cao, X., Zhang, X., Dai, B., Cao, M., Shao, R., Zhang, R., Majidi, M., Ji, L., Heymach, J.V., Wang, M., Pan, S., Minna, J., Mehran, R.J., Swisher, S.G., Roth, J.A., Fang, B., Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells. Oncotarget, 7: 3548-58, 2016

Mastri, M., Rosario, S., Tracz, A., Frink, R.E., Brekken, R.A., Ebos, J.M., The Challenges of Modeling Drug Resistance to Antiangiogenic Therapy. Curr Drug Targets, 17: 1747-1754, 2016

Lam, D.C., Luo, S.Y., Fu, K.H., Lui, M.M., Chan, K.H., Wistuba, II, Gao, B., Tsao, S.W., Ip, M.S., Minna, J.D., Nicotinic acetylcholine receptor expression in human airway correlates with lung function. Am J Physiol Lung Cell Mol Physiol, 310: L232-9, 2016

Ferrarotto, R., Goonatilake, R., Yoo, S.Y., Tong, P., Giri, U., Peng, S., Minna, J., Girard, L., Wang, Y., Wang, L., Li, L., Diao, L., Peng, D.H., Gibbons, D.L., Glisson, B.S., Heymach, J.V., Wang, J., Byers, L.A., Johnson, F.M., Epithelial-Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor-Mediated Apoptosis in Non-Small Cell Lung Cancer. Clin Cancer Res, 22: 1674-1686, 2016

Trost, N., Pena-Llopis, S., Koirala, S., Stojan, J., Potts, P.R., Fon Tacer, K., Martinez, E.D., gammaKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers. Oncotarget, 7: 2611-28, 2016

Lou, T.F., Sethuraman, D., Dospoy, P., Srivastva, P., Kim, H.S., Kim, J., Ma, X., Chen, P.H., Huffman, K.E., Frink, R.E., Larsen, J.E., Lewis, C., Um, S.W., Kim, D.H., Ahn, J.M., DeBerardinis, R.J., White, M.A., Minna, J.D., Yoo, H., Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker. Cancer Prev Res (Phila), 9: 43-52, 2016

Iacobas, I., Klepper, L., Kelly, J., Ferry, T., Dellinger, M.T., Meeting Report for the 2016 Conference on GLA and Gorham-Stout disease. BoneKEy, 13, 2016

Ludwig, K.F., Slone, T., Cederberg, K.B., Silva, A.T., Dellinger, M.T., A new case and review of chylothorax in generalized lymphatic anomaly and Gorham-Stout disease. Lymphology, 49: 73-84, 2016

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2015

Hagopian, M.M., Brekken, R.A., Stromal TGFbetaR2 signaling: a gateway to progression for pancreatic cancer. Mol Cell Oncol, 2: e975606, 2015

Topalovski, M., Brekken, R.A., Matrix control of pancreatic cancer: New insights into fibronectin signaling. Cancer Lett, 2015

Zhang, Y.A., Ma, X., Sathe, A., Fujimoto, J., Wistuba, II, Lam, S., Yatabe, Y., Wang, Y.W., Stastny, V., Gao, B., Larsen, J.E., Girard, L., Liu, X., Song, K., Behrens, C., Kalhor, N., Xie, Y., Zhang, M.Q., Minna, J.D., Gazdar, A.F., Validation of SCT Methylation As a Hallmark Biomarker for Lung Cancers. J Thorac Oncol, 2015

Gazdar, A.F., Hirsch, F.R., Minna, J.D., From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers. J Thorac Oncol, 2015

Wang, L., Kofler, M., Brosch, G., Melesina, J., Sippl, W., Martinez, E.D., Easmon, J., 2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity. PLoS One, 10: e0134556, 2015

Riquelme, E., Behrens, C., Lin, H.Y., Simon, G., Papadimitrakopoulou, V., Izzo, J., Moran, C., Kalhor, N., Lee, J.J., Minna, J.D., Wistuba, II, Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations. Cancer Res, 2015

Li, H., Hu, J., Wu, S., Wang, L., Cao, X., Zhang, X., Dai, B., Cao, M., Shao, R., Zhang, R., Majidi, M., Ji, L., Heymach, J.V., Wang, M., Pan, S., Minna, J., Mehran, R.J., Swisher, S.G., Roth, J.A., Fang, B., Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells. Oncotarget, 2015

Shields, B.B., Pecot, C.V., Gao, H., McMillan, E., Potts, M., Nagel, C., Purinton, S., Wang, Y., Ivan, C., Kim, H.S., Borkowski, R.J., Khan, S., Rodriguez-Aguayo, C., Lopez-Berestein, G., Lea, J., Gazdar, A., Baggerly, K.A., Sood, A.K., White, M.A., A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Mol Syst Biol, 11: 842, 2015

Mastri, M., Rosario, S., Tracz, A., Frink, R.E., Brekken, R.A., Ebos, J.M., The challenges of modeling drug resistance to antiangiogenic therapy. Curr Drug Targets, 2015

Soh, J., Toyooka, S., Matsuo, K., Yamamoto, H., Wistuba, II, Lam, S., Fong, K.M., Gazdar, A.F., Miyoshi, S., Ethnicity affects and gene alterations of lung adenocarcinoma. Oncol Lett, 10: 1775-1782, 2015

Lam, D.C., Luo, S.Y., Fu, K.H., Lui, M.M., Chan, K.H., Wistuba, II, Gao, B., Tsao, S.W., Ip, M.S., Minna, J.D., Nicotinic acetylcholine receptor expression in human airway correlates with lung function. Am J Physiol Lung Cell Mol Physiol: ajplung 00101 2015, 2015

Dearborn, J.T., Ramachandran, S., Shyng, C., Lu, J.Y., Thornton, J., Hofmann, S.L., Sands, M.S., Histochemical localization of palmitoyl protein thioesterase-1 activity. Mol Genet Metab, 2015

Ferrarotto, R., Goonatilake, R., Yoo, S.Y., Tong, P., Giri, U., Peng, S., Minna, J.D., Girard, L., Wang, Y., Wang, L., Li, L., Diao, L., Peng, D.H., Gibbons, D.L., Glisson, B.S., Heymach, J.V., Wang, J., Byers, L.A., Johnson, F.M., Epithelial-Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor-Mediated Apoptosis in Non-Small Cell Lung Cancer. Clin Cancer Res, 2015

Wang, M., Topalovski, M., Toombs, J.E., Wright, C.M., Moore, Z.R., Boothman, D.A., Yanagisawa, H., Wang, H., Witkiewicz, A., Castrillon, D.H., Brekken, R.A., Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer. Cancer Res, 75: 5058-69, 2015

Trost, N., Pena-Llopis, S., Koirala, S., Stojan, J., Potts, P.R., Tacer, K.F., Martinez, E.D., gammaKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers. Oncotarget, 2015

Gerber, D.E., Hao, G., Watkins, L., Stafford, J.H., Anderson, J., Holbein, B., Oz, O.K., Mathews, D., Thorpe, P.E., Hassan, G., Kumar, A., Brekken, R.A., Sun, X., Tumor-specific targeting by Bavituximab, a phosphatidylserine-targeting monoclonal antibody with vascular targeting and immune modulating properties, in lung cancer xenografts. Am J Nucl Med Mol Imaging, 5: 493-503, 2015

Li, T., Aredo, B., Zhang, K., Zhong, X., Pulido, J.S., Wang, S., He, Y.G., Huang, X., Brekken, R.A., Ufret-Vincenty, R.L., Phosphatidylserine (PS) Is Exposed in Choroidal Neovascular Endothelium: PS-Targeting Antibodies Inhibit Choroidal Angiogenesis In Vivo and Ex Vivo. Invest Ophthalmol Vis Sci, 56: 7137-45, 2015

Bayo, J., Dalvi, M.P., Martinez, E.D., Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential. Future Med Chem, 7: 2243-61, 2015

Matharage, J.M., Minna, J.D., Brekken, R.A., Udugamasooriya, D.G., Unbiased Selection of Peptide-Peptoid Hybrids Specific for Lung Cancer Compared to Normal Lung Epithelial Cells. ACS Chem Biol, 10: 2891-9, 2015

Schneider, P., Bayo-Fina, J.M., Singh, R., Dhanyamraju, P.K., Holz, P., Baier, A., Fendrich, V., Ramaswamy, A., Baumeister, S., Martinez, E.D., Lauth, M., Corrigendum: Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1. Nat Commun, 6: 8741, 2015

DeNicola, G.M., Chen, P.H., Mullarky, E., Sudderth, J.A., Hu, Z., Wu, D., Tang, H., Xie, Y., Asara, J.M., Huffman, K.E., Wistuba, II, Minna, J.D., DeBerardinis, R.J., Cantley, L.C., NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat Genet, 47: 1475-81, 2015

Ocal, O., Pashkov, V., Kollipara, R.K., Zolghadri, Y., Cruz, V.H., Hale, M.A., Heath, B.R., Artyukhin, A.B., Christie, A.L., Tsoulfas, P., Lorens, J.B., Swift, G.H., Brekken, R.A., Wilkie, T.M., A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics. Dis Model Mech, 8: 1201-11, 2015

Pena, C.G., Nakada, Y., Saatcioglu, H.D., Aloisio, G.M., Cuevas, I., Zhang, S., Miller, D.S., Lea, J.S., Wong, K.K., DeBerardinis, R.J., Amelio, A.L., Brekken, R.A., Castrillon, D.H., LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment. J Clin Invest, 125: 4063-76, 2015

Duan, L., Rai, G., Roggero, C., Zhang, Q.J., Wei, Q., Ma, S.H., Zhou, Y., Santoyo, J., Martinez, E.D., Xiao, G., Raj, G.V., Jadhav, A., Simeonov, A., Maloney, D.J., Rizo, J., Hsieh, J.T., Liu, Z.P., KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes. Chem Biol, 22: 1185-96, 2015

Wei, Q., Chen, Z.H., Wang, L., Zhang, T., Duan, L., Behrens, C., Wistuba, II, Minna, J.D., Gao, B., Luo, J.H., Liu, Z.P., LZTFL1 suppresses lung tumorigenesis by maintaining differentiation of lung epithelial cells. Oncogene, 2015

Elkin, S.R., Bendris, N., Reis, C.R., Zhou, Y., Xie, Y., Huffman, K.E., Minna, J.D., Schmid, S.L., A Systematic Analysis Reveals Heterogeneous Changes in the Endocytic Activities of Cancer Cells. Cancer Res, 75: 4640-50, 2015

Thinnes, C.C., Tumber, A., Yapp, C., Scozzafava, G., Yeh, T., Chan, M.C., Tran, T.A., Hsu, K., Tarhonskaya, H., Walport, L.J., Wilkins, S.E., Martinez, E.D., Muller, S., Pugh, C.W., Ratcliffe, P.J., Brennan, P.E., Kawamura, A., Schofield, C.J., Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases. Chem Commun (Camb), 51: 15458-61, 2015

Schneider, P., Bayo-Fina, J.M., Singh, R., Kumar Dhanyamraju, P., Holz, P., Baier, A., Fendrich, V., Ramaswamy, A., Baumeister, S., Martinez, E.D., Lauth, M., Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1. Nat Commun, 6: 8023, 2015

Kim, J., Sato, M., Choi, J.W., Kim, H.W., Yeh, B.I., Larsen, J.E., Minna, J.D., Cha, J.H., Jeong, Y., Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis. PLoS One, 10: e0134842, 2015

Huffman, K.E., Carstens, R., Martinez, E.D., A Subset of Nuclear Receptors are Uniquely Expressed in Uveal Melanoma Cells. Front Endocrinol (Lausanne), 6: 93, 2015

Kirane, A., Ludwig, K.F., Sorrelle, N., Haaland, G., Sandal, T., Ranaweera, R., Toombs, J.E., Wang, M., Dineen, S.P., Micklem, D., Dellinger, M.T., Lorens, J.B., Brekken, R.A., Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis. Cancer Res, 75: 3699-705, 2015

Skoulidis, F., Byers, L.A., Diao, L., Papadimitrakopoulou, V.A., Tong, P., Izzo, J., Behrens, C., Kadara, H., Parra, E.R., Canales, J.R., Zhang, J., Giri, U., Gudikote, J., Cortez, M.A., Yang, C., Fan, Y., Peyton, M., Girard, L., Coombes, K.R., Toniatti, C., Heffernan, T.P., Choi, M., Frampton, G.M., Miller, V., Weinstein, J.N., Herbst, R.S., Wong, K.K., Zhang, J., Sharma, P., Mills, G.B., Hong, W.K., Minna, J.D., Allison, J.P., Futreal, A., Wang, J., Wistuba, II, Heymach, J.V., Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities. Cancer Discov, 5: 860-77, 2015

Ding, L.H., Park, S., Xie, Y., Girard, L., Minna, J.D., Story, M.D., Elucidation of changes in molecular signalling leading to increased cellular transformation in oncogenically progressed human bronchial epithelial cells exposed to radiations of increasing LET. Mutagenesis, 30: 685-94, 2015

Lu, J.Y., Nelvagal, H.R., Wang, L., Birnbaum, S.G., Cooper, J.D., Hofmann, S.L., Intrathecal enzyme replacement therapy improves motor function and survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis. Mol Genet Metab, 116: 98-105, 2015

Pietanza, M.C., Byers, L.A., Minna, J.D., Rudin, C.M., Small cell lung cancer: will recent progress lead to improved outcomes? Clin Cancer Res, 21: 2244-55, 2015

Neverman, N.J., Best, H.L., Hofmann, S.L., Hughes, S.M., Experimental therapies in the neuronal ceroid lipofuscinoses. Biochim Biophys Acta, 1852: 2292-300, 2015

Hubaux, R., Thu, K.L., Vucic, E.A., Pikor, L.A., Kung, S.H., Martinez, V.D., Mosslemi, M., Becker-Santos, D.D., Gazdar, A.F., Lam, S., Lam, W.L., Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer. Int J Cancer, 137: 2072-82, 2015

Pozo, K., Hillmann, A., Augustyn, A., Plattner, F., Hai, T., Singh, T., Ramezani, S., Sun, X., Pfragner, R., Minna, J.D., Cote, G.J., Chen, H., Bibb, J.A., Nwariaku, F.E., Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis. Oncotarget, 6: 12080-93, 2015

Potts, M.B., McMillan, E.A., Rosales, T.I., Kim, H.S., Ou, Y.H., Toombs, J.E., Brekken, R.A., Minden, M.D., MacMillan, J.B., White, M.A., Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B. Nat Chem Biol, 11: 401-8, 2015

Schliekelman, M.J., Taguchi, A., Zhu, J., Dai, X., Rodriguez, J., Celiktas, M., Zhang, Q., Chin, A., Wong, C.H., Wang, H., McFerrin, L., Selamat, S.A., Yang, C., Kroh, E.M., Garg, K.S., Behrens, C., Gazdar, A.F., Laird-Offringa, I.A., Tewari, M., Wistuba, II, Thiery, J.P., Hanash, S.M., Molecular portraits of epithelial, mesenchymal, and hybrid States in lung adenocarcinoma and their relevance to survival. Cancer Res, 75: 1789-800, 2015

Sholl, L.M., Aisner, D.L., Varella-Garcia, M., Berry, L.D., Dias-Santagata, D., Wistuba, II, Chen, H., Fujimoto, J., Kugler, K., Franklin, W.A., Iafrate, A.J., Ladanyi, M., Kris, M.G., Johnson, B.E., Bunn, P.A., Minna, J.D., Kwiatkowski, D.J., Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience. J Thorac Oncol, 10: 768-77, 2015

Gazdar, A.F., Savage, T.K., Johnson, J.E., Berns, A., Sage, J., Linnoila, R.I., MacPherson, D., McFadden, D.G., Farago, A., Jacks, T., Travis, W.D., Brambilla, E., The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. J Thorac Oncol, 10: 553-64, 2015

Chen, Y., Terajima, M., Yang, Y., Sun, L., Ahn, Y.H., Pankova, D., Puperi, D.S., Watanabe, T., Kim, M.P., Blackmon, S.H., Rodriguez, J., Liu, H., Behrens, C., Wistuba, II, Minelli, R., Scott, K.L., Sanchez-Adams, J., Guilak, F., Pati, D., Thilaganathan, N., Burns, A.R., Creighton, C.J., Martinez, E.D., Zal, T., Grande-Allen, K.J., Yamauchi, M., Kurie, J.M., Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest, 125: 1147-62, 2015

Nasu, M., Emi, M., Pastorino, S., Tanji, M., Powers, A., Luk, H., Baumann, F., Zhang, Y.A., Gazdar, A., Kanodia, S., Tiirikainen, M., Flores, E., Gaudino, G., Becich, M.J., Pass, H.I., Yang, H., Carbone, M., High Incidence of Somatic BAP1 alterations in sporadic malignant mesothelioma. J Thorac Oncol, 10: 565-76, 2015

Wei, Z.W., Xia, G.K., Wu, Y., Chen, W., Xiang, Z., Schwarz, R.E., Brekken, R.A., Awasthi, N., He, Y.L., Zhang, C.H., CXCL1 promotes tumor growth through VEGF pathway activation and is associated with inferior survival in gastric cancer. Cancer Lett, 359: 335-43, 2015

Akbani, R., Ng, P.K., Werner, H.M., Shahmoradgoli, M., Zhang, F., Ju, Z., Liu, W., Yang, J.Y., Yoshihara, K., Li, J., Ling, S., Seviour, E.G., Ram, P.T., Minna, J.D., Diao, L., Tong, P., Heymach, J.V., Hill, S.M., Dondelinger, F., Stadler, N., Byers, L.A., Meric-Bernstam, F., Weinstein, J.N., Broom, B.M., Verhaak, R.G., Liang, H., Mukherjee, S., Lu, Y., Mills, G.B., Corrigendum: A pan-cancer proteomic perspective on The Cancer Genome Atlas. Nat Commun, 6: 4852, 2015

Moore, Z., Chakrabarti, G., Luo, X., Ali, A., Hu, Z., Fattah, F.J., Vemireddy, R., DeBerardinis, R.J., Brekken, R.A., Boothman, D.A., NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by beta-lapachone. Cell Death Dis, 6: e1599, 2015

Tian, H., Lu, J.Y., Shao, C., Huffman, K.E., Carstens, R.M., Larsen, J.E., Girard, L., Liu, H., Rodriguez-Canales, J., Frenkel, E.P., Wistuba, II, Minna, J.D., Hofmann, S.L., Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5. Mol Cancer Res, 13: 784-94, 2015

Awasthi, N., Hinz, S., Brekken, R.A., Schwarz, M.A., Schwarz, R.E., Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer. Cancer Lett, 358: 59-66, 2015

Borkowski, R., Du, L., Zhao, Z., McMillan, E., Kosti, A., Yang, C.R., Suraokar, M., Wistuba, II, Gazdar, A.F., Minna, J.D., White, M.A., Pertsemlidis, A., Genetic mutation of p53 and suppression of the miR-17 approximately 92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D Signaling. Cancer Res, 75: 666-75, 2015

Steininger, R.J., 3rd, Rajaram, S., Girard, L., Minna, J.D., Wu, L.F., Altschuler, S.J., On comparing heterogeneity across biomarkers. Cytometry A, 87: 558-67, 2015

Villaruz, L.C., Socinski, M.A., Abberbock, S., Berry, L.D., Johnson, B.E., Kwiatkowski, D.J., Iafrate, A.J., Varella-Garcia, M., Franklin, W.A., Camidge, D.R., Sequist, L.V., Haura, E.B., Ladanyi, M., Kurland, B.F., Kugler, K., Minna, J.D., Bunn, P.A., Kris, M.G., Clinicopathologic features and outcomes of patients with lung adenocarcinomas harboring BRAF mutations in the Lung Cancer Mutation Consortium. Cancer, 121: 448-56, 2015

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2014

Lin, S.H., Wang, J., Saintigny, P., Wu, C.C., Giri, U., Zhang, J., Menju, T., Diao, L., Byers, L., Weinstein, J.N., Coombes, K.R., Girard, L., Komaki, R., Wistuba, II, Date, H., Minna, J.D., Heymach, J.V., Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition. BMC Genomics, 15: 1079, 2014

Dbouk, H.A., Weil, L.M., Perera, G.K., Dellinger, M.T., Pearson, G., Brekken, R.A., Cobb, M.H., Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK. Proc Natl Acad Sci U S A, 111: 15999-6004, 2014

Dunleavey, J.M., Xiao, L., Thompson, J., Kim, M.M., Shields, J.M., Shelton, S.E., Irvin, D.M., Brings, V.E., Ollila, D.W., Brekken, R.A., Dayton, P.A., Melero-Martin, J.M., Dudley, A.C., Vascular channels formed by subpopulations of PECAM1+ melanoma cells. Nat Commun, 5: 5200, 2014

Mateo, F., Meca-Cortes, O., Celia-Terrassa, T., Fernandez, Y., Abasolo, I., Sanchez-Cid, L., Bermudo, R., Sagasta, A., Rodriguez-Carunchio, L., Pons, M., Canovas, V., Marin-Aguilera, M., Mengual, L., Alcaraz, A., Schwartz, S., Jr., Mellado, B., Aguilera, K.Y., Brekken, R., Fernandez, P.L., Paciucci, R., Thomson, T.M., SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations. Mol Cancer, 13: 237, 2014

Taguchi, A., Delgado, O., Celiktas, M., Katayama, H., Wang, H., Gazdar, A.F., Hanash, S.M., Proteomic signatures associated with p53 mutational status in lung adenocarcinoma. Proteomics, 14: 2750-9, 2014

Augustyn, A., Borromeo, M., Wang, T., Fujimoto, J., Shao, C., Dospoy, P.D., Lee, V., Tan, C., Sullivan, J.P., Larsen, J.E., Girard, L., Behrens, C., Wistuba, II, Xie, Y., Cobb, M.H., Gazdar, A.F., Johnson, J.E., Minna, J.D., ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers. Proc Natl Acad Sci U S A, 111: 14788-93, 2014

Barone, A., Sengupta, R., Warrington, N.M., Smith, E., Wen, P.Y., Brekken, R.A., Romagnoli, B., Douglas, G., Chevalier, E., Bauer, M.P., Dembowsky, K., Piwnica-Worms, D., Rubin, J.B., Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma. Oncotarget, 5: 9811-22, 2014

Gao, W., Wang, M., Wang, L., Lu, H., Wu, S., Dai, B., Ou, Z., Zhang, L., Heymach, J.V., Gold, K.A., Minna, J., Roth, J.A., Hofstetter, W.L., Swisher, S.G., Fang, B., Selective antitumor activity of ibrutinib in EGFR-mutant non-small cell lung cancer cells. J Natl Cancer Inst, 106, 2014

Tran, T.A., Wichterman-Kouznetsova, J., Varghese, D., Huang, R., Huang, W., Becker, M., Austin, C.P., Inglese, J., Johnson, R.L., Martinez, E.D., Identification of small molecule modulators of gene transcription with anticancer activity. ACS Chem Biol, 9: 2603-11, 2014

Kim, J., Hsia, E.Y., Kim, J., Sever, N., Beachy, P.A., Zheng, X., Simultaneous measurement of smoothened entry into and exit from the primary cilium. PLoS One, 9: e104070, 2014

Ostapoff, K.T., Cenik, B.K., Wang, M., Ye, R., Xu, X., Nugent, D., Hagopian, M.M., Topalovski, M., Rivera, L.B., Carroll, K.D., Brekken, R.A., Neutralizing murine TGFbetaR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis. Cancer Res, 74: 4996-5007, 2014

Pu, X., Wang, L., Chang, J.Y., Hildebrandt, M.A., Ye, Y., Lu, C., Skinner, H.D., Niu, N., Jenkins, G.D., Komaki, R., Minna, J.D., Roth, J.A., Weinshilboum, R.M., Wu, X., Inflammation-related genetic variants predict toxicity following definitive radiotherapy for lung cancer. Clin Pharmacol Ther, 96: 609-15, 2014

Zaganjor, E., Weil, L.M., Gonzales, J.X., Minna, J.D., Cobb, M.H., Ras transformation uncouples the kinesin-coordinated cellular nutrient response. Proc Natl Acad Sci U S A, 111: 10568-73, 2014

Luo, S.Y., Sit, K.Y., Sihoe, A.D., Suen, W.S., Au, W.K., Tang, X., Ma, E.S., Chan, W.K., Wistuba, II, Minna, J.D., Tsao, G.S., Lam, D.C., Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas. Lung Cancer, 85: 282-92, 2014

Taguchi, A., Taylor, A.D., Rodriguez, J., Celiktas, M., Liu, H., Ma, X., Zhang, Q., Wong, C.H., Chin, A., Girard, L., Behrens, C., Lam, W.L., Lam, S., Minna, J.D., Wistuba, II, Gazdar, A.F., Hanash, S.M., A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets. Cancer Res, 74: 4694-705, 2014

Mathur, A., Ware, C., Davis, L., Gazdar, A., Pan, B.S., Lutterbach, B., FGFR2 is amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival. PLoS One, 9: e98515, 2014

Liclican, E.L., Walser, T.C., Hazra, S., Krysan, K., Park, S.J., Pagano, P.C., Gardner, B.K., Larsen, J.E., Minna, J.D., Dubinett, S.M., Loss of miR125a expression in a model of K-ras-dependent pulmonary premalignancy. Cancer Prev Res (Phila), 7: 845-55, 2014

Shao, C., Sullivan, J.P., Girard, L., Augustyn, A., Yenerall, P., Rodriguez-Canales, J., Liu, H., Behrens, C., Shay, J.W., Wistuba, II, Minna, J.D., Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway. Clin Cancer Res, 20: 4154-66, 2014

Akbani, R., Ng, P.K., Werner, H.M., Shahmoradgoli, M., Zhang, F., Ju, Z., Liu, W., Yang, J.Y., Yoshihara, K., Li, J., Ling, S., Seviour, E.G., Ram, P.T., Minna, J.D., Diao, L., Tong, P., Heymach, J.V., Hill, S.M., Dondelinger, F., Stadler, N., Byers, L.A., Meric-Bernstam, F., Weinstein, J.N., Broom, B.M., Verhaak, R.G., Liang, H., Mukherjee, S., Lu, Y., Mills, G.B., A pan-cancer proteomic perspective on The Cancer Genome Atlas. Nat Commun, 5: 3887, 2014

Riquelme, E., Suraokar, M., Behrens, C., Lin, H.Y., Girard, L., Nilsson, M.B., Simon, G., Wang, J., Coombes, K.R., Lee, J.J., Hong, W.K., Heymach, J., Minna, J.D., Wistuba, II, VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy. Clin Cancer Res, 20: 3849-61, 2014

Kris, M.G., Johnson, B.E., Berry, L.D., Kwiatkowski, D.J., Iafrate, A.J., Wistuba, II, Varella-Garcia, M., Franklin, W.A., Aronson, S.L., Su, P.F., Shyr, Y., Camidge, D.R., Sequist, L.V., Glisson, B.S., Khuri, F.R., Garon, E.B., Pao, W., Rudin, C., Schiller, J., Haura, E.B., Socinski, M., Shirai, K., Chen, H., Giaccone, G., Ladanyi, M., Kugler, K., Minna, J.D., Bunn, P.A., Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA, 311: 1998-2006, 2014

Kaisani, A., Delgado, O., Fasciani, G., Kim, S.B., Wright, W.E., Minna, J.D., Shay, J.W., Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture. Differentiation, 87: 119-26, 2014

Li, X., Xu, Z., Du, W., Zhang, Z., Wei, Y., Wang, H., Zhu, Z., Qin, L., Wang, L., Niu, Q., Zhao, X., Girard, L., Gong, Y., Ma, Z., Sun, B., Yao, Z., Minna, J.D., Terada, L.S., Liu, Z., Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells. Cancer Cell, 25: 575-89, 2014

Pu, X., Hildebrandt, M.A., Lu, C., Roth, J.A., Stewart, D.J., Zhao, Y., Heist, R.S., Ye, Y., Chang, D.W., Su, L., Minna, J.D., Lippman, S.M., Spitz, M.R., Christiani, D.C., Wu, X., Inflammation-related genetic variations and survival in patients with advanced non-small cell lung cancer receiving first-line chemotherapy. Clin Pharmacol Ther, 96: 360-9, 2014

Gazdar, A., Robinson, L., Oliver, D., Xing, C., Travis, W.D., Soh, J., Toyooka, S., Watumull, L., Xie, Y., Kernstine, K., Schiller, J.H., Hereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutations. J Thorac Oncol, 9: 456-63, 2014

Osborne, J.K., Guerra, M.L., Gonzales, J.X., McMillan, E.A., Minna, J.D., Cobb, M.H., NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas. Mol Biol Cell, 25: 1782-92, 2014

Leroy, B., Girard, L., Hollestelle, A., Minna, J.D., Gazdar, A.F., Soussi, T., Analysis of TP53 mutation status in human cancer cell lines: a reassessment. Hum Mutat, 35: 756-65, 2014

McGuire, M.J., Gray, B.P., Li, S., Cupka, D., Byers, L.A., Wu, L., Rezaie, S., Liu, Y.H., Pattisapu, N., Issac, J., Oyama, T., Diao, L., Heymach, J.V., Xie, X.J., Minna, J.D., Brown, K.C., Identification and characterization of a suite of tumor targeting peptides for non-small cell lung cancer. Sci Rep, 4: 4480, 2014

Hubers, A.J., van der Drift, M.A., Prinsen, C.F., Witte, B.I., Wang, Y., Shivapurkar, N., Stastny, V., Bolijn, A.S., Hol, B.E., Feng, Z., Dekhuijzen, P.N., Gazdar, A.F., Thunnissen, E., Methylation analysis in spontaneous sputum for lung cancer diagnosis. Lung Cancer, 84: 127-33, 2014

Dellinger, M.T., Garg, N., Olsen, B.R., Viewpoints on vessels and vanishing bones in Gorham-Stout disease. Bone, 63: 47-52, 2014

Yang, L., Kwon, J., Popov, Y., Gajdos, G.B., Ordog, T., Brekken, R.A., Mukhopadhyay, D., Schuppan, D., Bi, Y., Simonetto, D., Shah, V.H., Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology, 146: 1339-50 e1, 2014

Kim, D.J., Kim, J., Spaunhurst, K., Montoya, J., Khodosh, R., Chandra, K., Fu, T., Gilliam, A., Molgo, M., Beachy, P.A., Tang, J.Y., Open-Label, Exploratory Phase II Trial of Oral Itraconazole for the Treatment of Basal Cell Carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014

Delgado, O., Batten, K.G., Richardson, J.A., Xie, X.J., Gazdar, A.F., Kaisani, A.A., Girard, L., Behrens, C., Suraokar, M., Fasciani, G., Wright, W.E., Story, M.D., Wistuba, II, Minna, J.D., Shay, J.W., Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer. Clin Cancer Res, 20: 1610-22, 2014

D'Amico, G., Korhonen, E.A., Anisimov, A., Zarkada, G., Holopainen, T., Hagerling, R., Kiefer, F., Eklund, L., Sormunen, R., Elamaa, H., Brekken, R.A., Adams, R.H., Koh, G.Y., Saharinen, P., Alitalo, K., Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest, 124: 824-34, 2014

Gazdar, A.F., EGFR mutations in lung cancer: different frequencies for different folks. J Thorac Oncol, 9: 139-40, 2014

Brekken, R.A., Faulty ECM signaling facilitates autoimmune lymphomagenesis. Cancer Discov, 4: 25-6, 2014

Song, S.Y., Das, A.K., Minna, J.D., Comparison between concurrent and sequential chemoradiation for non-small cell lung cancer. Oncol Lett, 7: 307-310, 2014

Pop, L.M., Barman, S., Shao, C., Poe, J.C., Venturi, G.M., Shelton, J.M., Pop, I.V., Gerber, D.E., Girard, L., Liu, X.Y., Behrens, C., Rodriguez-Canales, J., Liu, H., Wistuba, II, Richardson, J.A., Minna, J.D., Tedder, T.F., Vitetta, E.S., A reevaluation of CD22 expression in human lung cancer. Cancer Res, 74: 263-71, 2014

Aguilera, K.Y., Rivera, L.B., Hur, H., Carbon, J.G., Toombs, J.E., Goldstein, C.D., Dellinger, M.T., Castrillon, D.H., Brekken, R.A., Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma. Cancer Res, 74: 1032-44, 2014

Xiao, G., Ma, S., Minna, J., Xie, Y., Adaptive prediction model in prospective molecular signature-based clinical studies. Clin Cancer Res, 20: 531-9, 2014

Mayba, O., Gnad, F., Peyton, M., Zhang, F., Walter, K., Du, P., Huntley, M.A., Jiang, Z., Liu, J., Haverty, P.M., Gentleman, R.C., Li, R., Minna, J.D., Li, Y., Shames, D.S., Zhang, Z., Integrative analysis of two cell lines derived from a non-small-lung cancer patient--a panomics approach. Pac Symp Biocomput: 75-86, 2014

Grant, J.L., Fishbein, M.C., Hong, L.S., Krysan, K., Minna, J.D., Shay, J.W., Walser, T.C., Dubinett, S.M., A novel molecular pathway for Snail-dependent, SPARC-mediated invasion in non-small cell lung cancer pathogenesis. Cancer Prev Res (Phila), 7: 150-60, 2014

Zaganjor, E., Osborne, J.K., Weil, L.M., Diaz-Martinez, L.A., Gonzales, J.X., Singel, S.M., Larsen, J.E., Girard, L., Minna, J.D., Cobb, M.H., Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene, 33: 5457-66, 2014

Wilson, I.M., Vucic, E.A., Enfield, K.S., Thu, K.L., Zhang, Y.A., Chari, R., Lockwood, W.W., Radulovich, N., Starczynowski, D.T., Banath, J.P., Zhang, M., Pusic, A., Fuller, M., Lonergan, K.M., Rowbotham, D., Yee, J., English, J.C., Buys, T.P., Selamat, S.A., Laird-Offringa, I.A., Liu, P., Anderson, M., You, M., Tsao, M.S., Brown, C.J., Bennewith, K.L., MacAulay, C.E., Karsan, A., Gazdar, A.F., Lam, S., Lam, W.L., EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene, 33: 4464-73, 2014

Ribeiro, N., Sousa, S.R., Brekken, R.A., Monteiro, F.J., Role of SPARC in bone remodeling and cancer-related bone metastasis. J Cell Biochem, 115: 17-26, 2014

Du, L., Zhao, Z., Ma, X., Hsiao, T.H., Chen, Y., Young, E., Suraokar, M., Wistuba, I., Minna, J.D., Pertsemlidis, A., miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer. Oncogene, 33: 4307-15, 2014

Aguilera, K.Y., Brekken, R.A., Recruitment and retention: factors that affect pericyte migration. Cell Mol Life Sci, 71: 299-309, 2014

Gazdar, A., Zhou, C., Lung cancer in never smokers: A different disease, in The IASLC multidisciplinary approach to thoracic oncology, H. Pass, D. Ball, and G. Scagliotti, Editors. 2014, IASLC Press: Aurora, CO. p. 35-44.

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