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Publications

2020

von Itzstein, M.S., Gonugunta, A.S., Mayo, H.G., Minna, J.D., Gerber, D.E., Immunotherapy Use in Patients With Lung Cancer and Comorbidities. Cancer J, 26: 525-536, 2020

Kim, J., Lee, H.M., Cai, F., Ko, B., Yang, C., Lieu, E.L., Muhammad, N., Rhyne, S., Li, K., Haloul, M., Gu, W., Faubert, B., Kaushik, A.K., Cai, L., Kasiri, S., Marriam, U., Nham, K., Girard, L., Wang, H., Sun, X., Kim, J., Minna, J.D., Unsal-Kacmaz, K., DeBerardinis, R.J., The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer. Nat Metab, 2: 1401-1412, 2020

Layeghi-Ghalehsoukhteh, S., Pal Choudhuri, S., Ocal, O., Zolghadri, Y., Pashkov, V., Niederstrasser, H., Posner, B.A., Kantheti, H.S., Azevedo-Pouly, A.C., Huang, H., Girard, L., MacDonald, R.J., Brekken, R.A., Wilkie, T.M., Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics. Sci Rep, 10: 20662, 2020

Morla, S., Deguchi, H., Fernandez, J.A., Ruf, W., Brekken, R.A., Griffin, J.H., Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids. Blood, 2020

Zhang, W., Pham, T.H., Wang, D.H., A "Clue" to Improving Liquid Biopsies for Cancer: Microfluidic Multiparametric Exosome Analysis. Clin Chem, 2020

Engelsen, A.S.T., Wnuk-Lipinska, K., Bougnaud, S., Pelissier Vatter, F.A., Tiron, C., Villadsen, R., Miyano, M., Lotsberg, M.L., Madeleine, N., Panahandeh, P., Dhakal, S., Tan, T.Z., Peters, S.D., Grondal, S., Aziz, S.M., Nord, S., Herfindal, L., Stampfer, M.R., Sorlie, T., Brekken, R.A., Straume, O., Halberg, N., Gausdal, G., Thiery, J.P., Akslen, L.A., Petersen, O.W., LaBarge, M.A., Lorens, J.B., AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer. iScience, 23: 101649, 2020

Osborne, J.K., Minna, J.D., Defining the First Part of the Oncogenic KRAS Journey. Cell Stem Cell, 27: 499-500, 2020

von Itzstein, M.S., Burke, M.C., Brekken, R.A., Aguilera, T.A., Zeh, H.J., Beg, M.S., Targeting TAM to Tame Pancreatic Cancer. Target Oncol, 15: 579-588, 2020

von Itzstein, M.S., Gerber, D.E., Minna, J.D., Do mRNA profiles of lung adenocarcinomas provide information that will help individual patients? EBioMedicine, 60: 103006, 2020

Ganguly, D., Chandra, R., Karalis, J., Teke, M., Aguilera, T., Maddipati, R., Wachsmann, M.B., Ghersi, D., Siravegna, G., Zeh, H.J., 3rd, Brekken, R., Ting, D.T., Ligorio, M., Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment. Cancers (Basel), 12, 2020

Dellinger, M.T., McCormack, F.X., The emergence of targetable MEKanisms in sporadic lymphatic disorders. EMBO Mol Med, 12: e12822, 2020

Wang, Y., Ma, J., Martinez, E.D., Liang, D., Xie, H., A UHPLC-MS/MS method for the quantification of JIB-04 in rat plasma: Development, validation and application to pharmacokinetics study. J Pharm Biomed Anal, 191: 113587, 2020

Gerber, D.E., Putnam, W.C., Fattah, F.J., Kernstine, K.H., Brekken, R.A., Pedrosa, I., Skelton, R., Saltarski, J.M., Lenkinski, R.E., Leff, R.D., Ahn, C., Padmanabhan, C., Chembukar, V., Kasiri, S., Kallem, R.R., Subramaniyan, I., Yuan, Q., Do, Q.N., Xi, Y., Reznik, S.I., Pelosof, L., Faubert, B., DeBerardinis, R.J., Kim, J., Concentration-dependent Early Antivascular and Antitumor Effects of Itraconazole in Non-Small Cell Lung Cancer. Clin Cancer Res, 26: 6017-6027, 2020

Chung, A.S., Mettlen, M., Ganguly, D., Lu, T., Wang, T., Brekken, R.A., Hsiehchen, D., Zhu, H., Immune Checkpoint Inhibition is Safe and Effective for Liver Cancer Prevention in a Mouse Model of Hepatocellular Carcinoma. Cancer Prev Res (Phila), 13: 911-922, 2020

Scarpignato, C., Sloan, J.A., Wang, D.H., Hunt, R.H., Gastrointestinal pharmacology: practical tips for the esophagologist. Ann N Y Acad Sci, 1481: 90-107, 2020

Drapkin, B.J., Minna, J.D., Studying Lineage Plasticity One Cell at a Time. Cancer Cell, 38: 150-152, 2020

Badgery, H., Chong, L., Iich, E., Huang, Q., Georgy, S.R., Wang, D.H., Read, M., Recent insights into the biology of Barrett's esophagus. Ann N Y Acad Sci, 1481: 198-209, 2020

Westcott, J.M., Camacho, S., Nasir, A., Huysman, M.E., Rahhal, R., Dang, T.T., Riegel, A.T., Brekken, R.A., Pearson, G.W., DeltaNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader-Follower Relationship That Drives Collective Invasion. Cancer Res, 80: 3933-3944, 2020

Sato, M., Shay, J.W., Minna, J.D., Immortalized normal human lung epithelial cell models for studying lung cancer biology. Respir Investig, 58: 344-354, 2020
Drapkin, B.J., Rudin, C.M., Advances in Small-Cell Lung Cancer (SCLC) Translational Research. Cold Spring Harb Perspect Med, 2020

Hight, S.K., Mootz, A., Kollipara, R.K., McMillan, E., Yenerall, P., Otaki, Y., Li, L.S., Avila, K., Peyton, M., Rodriguez-Canales, J., Mino, B., Villalobos, P., Girard, L., Dospoy, P., Larsen, J., White, M.A., Heymach, J.V., Wistuba, II, Kittler, R., Minna, J.D., An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis. Neoplasia, 22: 294-310, 2020

Huang, H., Brekken, R.A., Beyond Stiffness: Collagen Signaling in Pancreatic Cancer and Pancreas Regeneration. Am J Pathol, 190: 1622-1624, 2020
Shukla, A., Ramirez, N.P., D'Orso, I., HIV-1 Proviral Transcription and Latency in the New Era. Viruses, 12, 2020

Huang, H., Brekken, R.A., Recent advances in understanding cancer-associated fibroblasts in pancreatic cancer. Am J Physiol Cell Physiol, 319: C233-C243, 2020

Hosein, A.N., Brekken, R.A., Maitra, A., Pancreatic cancer stroma: an update on therapeutic targeting strategies. Nat Rev Gastroenterol Hepatol, 17: 487-505, 2020

Brekken, R.A., Loss of BAP1 Leads to More YAPing in Pancreatic Cancer. Cancer Res, 80: 1624-1625, 2020

Matthews, K.A., Senagbe, K.M., Notzel, C., Gonzales, C.A., Tong, X., Rijo-Ferreira, F., Bhanu, N.V., Miguel-Blanco, C., Lafuente-Monasterio, M.J., Garcia, B.A., Kafsack, B.F.C., Martinez, E.D., Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases. ACS Infect Dis, 6: 1058-1075, 2020

Bae, C.A., Ham, I.H., Oh, H.J., Lee, D., Woo, J., Son, S.Y., Yoon, J.H., Lorens, J.B., Brekken, R.A., Kim, T.M., Han, S.U., Park, W.S., Hur, H., Inhibiting the GAS6/AXL axis suppresses tumor progression by blocking the interaction between cancer-associated fibroblasts and cancer cells in gastric carcinoma. Gastric Cancer, 23: 824-836, 2020

Monroy, M., McCarter, A.L., Hominick, D., Cassidy, N., Dellinger, M.T., Lymphatics in bone arise from pre-existing lymphatics. Development, 147, 2020

Kasiri, S., Chen, B., Wilson, A.N., Reczek, A., Mazambani, S., Gadhvi, J., Noel, E., Marriam, U., Mino, B., Lu, W., Girard, L., Solis, L.M., Luby-Phelps, K., Bishop, J., Kim, J.W., Kim, J., Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species. Oncogene, 39: 3258-3275, 2020

Dayoub, A.S., Brekken, R.A., TIMs, TAMs, and PS- antibody targeting: implications for cancer immunotherapy. Cell Commun Signal, 18: 29, 2020

Lotsberg, M.L., Wnuk-Lipinska, K., Terry, S., Tan, T.Z., Lu, N., Trachsel-Moncho, L., Rosland, G.V., Siraji, M.I., Hellesoy, M., Rayford, A., Jacobsen, K., Ditzel, H.J., Vintermyr, O.K., Bivona, T.G., Minna, J., Brekken, R.A., Baguley, B., Micklem, D., Akslen, L.A., Gausdal, G., Simonsen, A., Thiery, J.P., Chouaib, S., Lorens, J.B., Engelsen, A.S.T., AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells. J Thorac Oncol, 15: 973-999, 2020

Yenerall, P., Das, A.K., Wang, S., Kollipara, R.K., Li, L.S., Villalobos, P., Flaming, J., Lin, Y.F., Huffman, K., Timmons, B.C., Gilbreath, C., Sonavane, R., Kinch, L.N., Rodriguez-Canales, J., Moran, C., Behrens, C., Hirasawa, M., Takata, T., Murakami, R., Iwanaga, K., Chen, B.P.C., Grishin, N.V., Raj, G.V., Wistuba, II, Minna, J.D., Kittler, R., RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer. Cell Chem Biol, 27: 105-121.e14, 2020

Zhang, W., Williams, T.A., Bhagwath, A.S., Hiermann, J.S., Peacock, C.D., Watkins, D.N., Ding, P., Park, J.Y., Montgomery, E.A., Forastiere, A.A., Jie, C., Cantarel, B.L., Pham, T.H., Wang, D.H., GEAMP, a novel gastroesophageal junction carcinoma cell line derived from a malignant pleural effusion. Lab Invest, 100: 16-26, 2020

Yanev, P., Poinsatte, K., Hominick, D., Khurana, N., Zuurbier, K.R., Berndt, M., Plautz, E.J., Dellinger, M.T., Stowe, A.M., Impaired meningeal lymphatic vessel development worsens stroke outcome. J Cereb Blood Flow Metab, 40: 263-275, 2020

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2019

Mulshine, J.L., Ujhazy, P., Antman, M., Burgess, C.M., Kuzmin, I., Bunn, P.A., Jr., Johnson, B.E., Roth, J.A., Pass, H.I., Ross, S.M., Aldige, C.R., Wistuba, II, Minna, J.D., From clinical specimens to human cancer preclinical models-a journey the NCI-cell line database-25 years later. J Cell Biochem, 121: 3986-99, 2019

Cuevas, I.C., Sahoo, S.S., Kumar, A., Zhang, H., Westcott, J., Aguilar, M., Cortez, J.D., Sullivan, S.A., Xing, C., Hayes, D.N., Brekken, R.A., Bae-Jump, V.L., Castrillon, D.H., Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition. Proc Natl Acad Sci U S A, 116: 25880-25890, 2019

Wang, W., Wang, H., Zhou, X., Li, X., Sun, W., Dellinger, M., Boyce, B.F., Xing, L., Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice. J Bone Miner Res, 34: 2162, 2019

Arner, E.N., Du, W., Brekken, R.A., Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers. Front Oncol, 9: 1049, 2019

Huang, H., Zhang, Y., Gallegos, V., Sorrelle, N., Zaid, M.M., Toombs, J., Du, W., Wright, S., Hagopian, M., Wang, Z., Hosein, A.N., Sathe, A.A., Xing, C., Koay, E.J., Driscoll, K.E., Brekken, R.A., Targeting TGFbetaR2-mutant tumors exposes vulnerabilities to stromal TGFbeta blockade in pancreatic cancer. EMBO Mol Med, 11: e10515, 2019

Liang, Y., Besch-Williford, C., Cook, M.T., Belenchia, A., Brekken, R.A., Hyder, S.M., APR-246 alone and in combination with a phosphatidylserine-targeting antibody inhibits lung metastasis of human triple-negative breast cancer cells in nude mice. Breast Cancer (Dove Med Press), 11: 249-259, 2019

Zoeller, E.L., Pedro, B., Konen, J., Dwivedi, B., Rupji, M., Sundararaman, N., Wang, L., Horton, J.R., Zhong, C., Barwick, B.G., Cheng, X., Martinez, E.D., Torres, M.P., Kowalski, J., Marcus, A.I., Vertino, P.M., Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes. J Cell Sci, 132, 2019

Tuladhar, R., Yeu, Y., Tyler Piazza, J., Tan, Z., Rene Clemenceau, J., Wu, X., Barrett, Q., Herbert, J., Mathews, D.H., Kim, J., Hyun Hwang, T., Lum, L., CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation. Nat Commun, 10: 4056, 2019

Hsieh, M.H., Choe, J.H., Gadhvi, J., Kim, Y.J., Arguez, M.A., Palmer, M., Gerold, H., Nowak, C., Do, H., Mazambani, S., Knighton, J.K., Cha, M., Goodwin, J., Kang, M.K., Jeong, J.Y., Lee, S.Y., Faubert, B., Xuan, Z., Abel, E.D., Scafoglio, C., Shackelford, D.B., Minna, J.D., Singh, P.K., Shulaev, V., Bleris, L., Hoyt, K., Kim, J., Inoue, M., DeBerardinis, R.J., Kim, T.H., Kim, J.W., p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Cell Rep, 28: 1860-1878.e9, 2019

Hosein, A.N., Huang, H., Wang, Z., Parmar, K., Du, W., Huang, J., Maitra, A., Olson, E., Verma, U., Brekken, R.A., Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution. JCI Insight, 5, 2019

Zhu, D., Huang, H., Pinkas, D.M., Luo, J., Ganguly, D., Fox, A.E., Arner, E., Xiang, Q., Tu, Z.C., Bullock, A.N., Brekken, R.A., Ding, K., Lu, X., 2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy. J Med Chem, 62: 7431-7444, 2019

Faubert, B., DeBerardinis, R.J., Minna, J.D., AIF: an acquired metabolic liability in lung cancer. Cell Res, 29: 607-608, 2019

Stefanius, K., Servage, K., de Souza Santos, M., Gray, H.F., Toombs, J.E., Chimalapati, S., Kim, M.S., Malladi, V.S., Brekken, R., Orth, K., Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation. Elife, 8, 2019

Huang, H., Wright, S., Zhang, J., Brekken, R.A., Getting a grip on adhesion: Cadherin switching and collagen signaling. Biochim Biophys Acta Mol Cell Res, 1866: 118472, 2019

Cruz, V.H., Arner, E.N., Du, W., Bremauntz, A.E., Brekken, R.A., Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer. JCI Insight, 5, 2019

Ham, I.H., Oh, H.J., Jin, H., Bae, C.A., Jeon, S.M., Choi, K.S., Son, S.Y., Han, S.U., Brekken, R.A., Lee, D., Hur, H., Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer. Mol Cancer, 18: 68, 2019

Rudin, C.M., Poirier, J.T., Byers, L.A., Dive, C., Dowlati, A., George, J., Heymach, J.V., Johnson, J.E., Lehman, J.M., MacPherson, D., Massion, P.P., Minna, J.D., Oliver, T.G., Quaranta, V., Sage, J., Thomas, R.K., Vakoc, C.R., Gazdar, A.F., Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nat Rev Cancer, 19: 289-297, 2019

Haave, T.R., Manstad-Hulaas, F., Brekken, R., Treatment of restenosis in radiocephalic arteriovenous hemodialysis fistulas: percutaneous transluminal angioplasty or drug-coated balloon. Acta Radiol, 60: 1584-1589, 2019

Bayo, J., Fiore, E.J., Dominguez, L.M., Real, A., Malvicini, M., Rizzo, M., Atorrasagasti, C., Garcia, M.G., Argemi, J., Martinez, E.D., Mazzolini, G.D., A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets. J Hepatol, 71: 78-90, 2019

Gazdar, A.F., Minna, J.D., Small cell lung cancers made from scratch. J Exp Med, 216: 476-478, 2019

Tuladhar, R., Yarravarapu, N., Ma, Y., Zhang, C., Herbert, J., Kim, J., Chen, C., Lum, L., Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN). J Biol Chem, 294: 6273-6282, 2019

Zhou, H., Belzile, O., Zhang, Z., Wagner, J., Ahn, C., Richardson, J.A., Saha, D., Brekken, R.A., Mason, R.P., The effect of flow on blood oxygen level dependent (R(*) 2 ) MRI of orthotopic lung tumors. Magn Reson Med, 81: 3787-3797, 2019

Ye, R., Onodera, T., Blanchard, P.G., Kusminski, C.M., Esser, V., Brekken, R.A., Scherer, P.E., beta1 Syntrophin Supports Autophagy Initiation and Protects against Cerulein-Induced Acute Pancreatitis. Am J Pathol, 189: 813-825, 2019

Huang, H., Brekken, R.A., The Next Wave of Stroma-Targeting Therapy in Pancreatic Cancer. Cancer Res, 79: 328-330, 2019

Zhang, L.S., Kang, X., Lu, J., Zhang, Y., Wu, X., Wu, G., Zheng, J., Tuladhar, R., Shi, H., Wang, Q., Morlock, L., Yao, H., Huang, L.J., Maire, P., Kim, J., Williams, N., Xu, J., Chen, C., Zhang, C.C., Lum, L., Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9. EBioMedicine, 39: 145-158, 2019

Sorrelle, N., Ganguly, D., Dominguez, A.T.A., Zhang, Y., Huang, H., Dahal, L.N., Burton, N., Ziemys, A., Brekken, R.A., Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues. J Immunol, 202: 292-299, 2019

Huang, H., Salavaggione, O., Rivera, L., Mukherjee, S., Brekken, R., Tennant, B., Iyer, R., Adjei, A., Woodchuck VEGF (wVEGF) characteristics: Model for angiogenesis and human hepatocellular carcinoma directed therapies. Arch Biochem Biophys, 661: 97-106, 2019

Zhang, Y., Kirane, A., Huang, H., Sorrelle, N.B., Burrows, F.J., Dellinger, M.T., Brekken, R.A., Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer. Mol Cancer Res, 17: 348-355, 2019

Li, X., Lee, Y., Kang, Y., Dai, B., Perez, M.R., Pratt, M., Koay, E.J., Kim, M., Brekken, R.A., Fleming, J.B., Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma. Cell Death Differ, 26: 382-393, 2019

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2018

Cai, L., Lin, S., Girard, L., Zhou, Y., Yang, L., Ci, B., Zhou, Q., Luo, D., Yao, B., Tang, H., Allen, J., Huffman, K., Gazdar, A., Heymach, J., Wistuba, I., Xiao, G., Minna, J., Xie, Y., LCE: an open web portal to explore gene expression and clinical associations in lung cancer. Oncogene, 2018

Zhang, Q.J., Tran, T.A.T., Wang, M., Ranek, M.J., Kokkonen-Simon, K.M., Gao, J., Luo, X., Tan, W., Kyrychenko, V., Liao, L., Xu, J., Hill, J.A., Olson, E.N., Kass, D.A., Martinez, E.D., Liu, Z.P., Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis. Nat Commun, 9: 5230, 2018

Updegraff, B.L., Zhou, X., Guo, Y., Padanad, M.S., Chen, P.H., Yang, C., Sudderth, J., Rodriguez-Tirado, C., Girard, L., Minna, J.D., Mishra, P., DeBerardinis, R.J., O'Donnell, K.A., Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism. Cell Rep, 25: 2223-2233 e6, 2018

Du, W., Huang, H., Sorrelle, N., Brekken, R.A., Sitravatinib potentiates immune checkpoint blockade in refractory cancer models. JCI Insight, 3, 2018

Bayo, J., Tran, T.A., Wang, L., Pena-Llopis, S., Das, A.K., Martinez, E.D., Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks. Cell Rep, 25: 1040-1050 e5, 2018

Ruder, D., Papadimitrakopoulou, V., Shien, K., Behrens, C., Kalhor, N., Chen, H., Shen, L., Lee, J.J., Hong, W.K., Tang, X., Girard, L., Minna, J.D., Diao, L., Wang, J., Mino, B., Villalobos, P., Rodriguez-Canales, J., Hanson, N.E., Sun, J., Miller, V., Greenbowe, J., Frampton, G., Herbst, R.S., Baladandayuthapani, V., Wistuba, II, Izzo, J.G., Concomitant targeting of the mTOR/MAPK pathways: novel therapeutic strategy in subsets of RICTOR/KRAS-altered non-small cell lung cancer. Oncotarget, 9: 33995-34008, 2018

Pozo, K., Kelenis, D.P., Minna, J.D., Johnson, J.E., Different Originating Cells Underlie Intertumoral Heterogeneity in Lung Neuroendocrine Tumors. Cancer Discov, 8: 1216-1218, 2018

Du, W., Brekken, R.A., Does Axl have potential as a therapeutic target in pancreatic cancer? Expert Opin Ther Targets, 22: 955-966, 2018

Akbay, E.A., Kim, J., Autochthonous murine models for the study of smoker and never-smoker associated lung cancers. Transl Lung Cancer Res, 7: 464-486, 2018

Song, K., Bi, J.H., Qiu, Z.W., Felizardo, R., Girard, L., Minna, J.D., Gazdar, A.F., A quantitative method for assessing smoke associated molecular damage in lung cancers. Transl Lung Cancer Res, 7: 439-449, 2018

Gazdar, A.F., Preface: lung cancer in never smokers. Transl Lung Cancer Res, 7: 437-438, 2018

Hiramitsu, S., Ishikawa, T., Lee, W.R., Khan, T., Crumbley, C., Khwaja, N., Zamanian, F., Asghari, A., Sen, M., Zhang, Y., Hawse, J.R., Minna, J.D., Umetani, M., Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol. Front Endocrinol (Lausanne), 9: 470, 2018

Nichols, B.A., Oswald, N.W., McMillan, E.A., McGlynn, K., Yan, J., Kim, M.S., Saha, J., Mallipeddi, P.L., LaDuke, S.A., Villalobos, P.A., Rodriguez-Canales, J., Wistuba, II, Posner, B.A., Davis, A.J., Minna, J.D., MacMillan, J.B., Whitehurst, A.W., HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress. Cancer Res, 78: 6196-6208, 2018

Pozo, K., Minna, J.D., Johnson, J.E., Corrigendum: Identifying a missing lineage driver in a subset of lung neuroendocrine tumors. Genes Dev, 32: 1266, 2018

Jia, D., Augert, A., Kim, D.W., Eastwood, E., Wu, N., Ibrahim, A.H., Kim, K.B., Dunn, C.T., Pillai, S.P.S., Gazdar, A.F., Bolouri, H., Park, K.S., MacPherson, D., Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition. Cancer Discov, 8: 1422-1437, 2018

Motea, E.A., Fattah, F.J., Xiao, L., Girard, L., Rommel, A., Morales, J.C., Patidar, P., Zhou, Y., Porter, A., Xie, Y., Minna, J.D., Boothman, D.A., Kub5-Hera (RPRD1B) Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers. Clin Cancer Res, 24: 6459-6470, 2018

Wang, Z., Zhang, Y., Pinkas, D.M., Fox, A.E., Luo, J., Huang, H., Cui, S., Xiang, Q., Xu, T., Xun, Q., Zhu, D., Tu, Z., Ren, X., Brekken, R.A., Bullock, A.N., Liang, G., Ding, K., Lu, X., Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2. J Med Chem, 61: 7977-7990, 2018

Huang, F., Ni, M., Chalishazar, M.D., Huffman, K.E., Kim, J., Cai, L., Shi, X., Cai, F., Zacharias, L.G., Ireland, A.S., Li, K., Gu, W., Kaushik, A.K., Liu, X., Gazdar, A.F., Oliver, T.G., Minna, J.D., Hu, Z., DeBerardinis, R.J., Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers. Cell Metab, 28: 369-382 e5, 2018

Du, L., Zhao, Z., Suraokar, M., Shelton, S.S., Ma, X., Hsiao, T.H., Minna, J.D., Wistuba, I., Pertsemlidis, A., LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer. Oncotarget, 9: 29601-29618, 2018

Mender, I., LaRanger, R., Luitel, K., Peyton, M., Girard, L., Lai, T.P., Batten, K., Cornelius, C., Dalvi, M.P., Ramirez, M., Du, W., Wu, L.F., Altschuler, S.J., Brekken, R., Martinez, E.D., Minna, J.D., Wright, W.E., Shay, J.W., Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance. Neoplasia, 20: 826-837, 2018

Sathyanarayana, U.G., Moore, A.Y., Li, L., Padar, A., Majmudar, K., Stastny, V., Makarla, P., Suzuki, M., Minna, J.D., Feng, Z., Gazdar, A.F., Retraction notice to "Sun exposure related methylation in malignant and non-malignant skin lesions" [Cancer Letters 245/1-2 (2007) 112-120]. Cancer Lett, 432: 272, 2018

Wang, S., Chen, A., Yang, L., Cai, L., Xie, Y., Fujimoto, J., Gazdar, A., Xiao, G., Comprehensive analysis of lung cancer pathology images to discover tumor shape and boundary features that predict survival outcome. Sci Rep, 8: 10393, 2018

Pozo, K., Minna, J.D., Johnson, J.E., Identifying a missing lineage driver in a subset of lung neuroendocrine tumors. Genes Dev, 32: 865-867, 2018

Cruz, V.H., Arner, E.N., Wynne, K.W., Scherer, P.E., Brekken, R.A., Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction. Mol Metab, 16: 139-149, 2018

Jin, H., Ham, I.H., Oh, H.J., Bae, C.A., Lee, D., Kim, Y.B., Son, S.Y., Chwae, Y.J., Han, S.U., Brekken, R.A., Hur, H., Inhibition of Discoidin Domain Receptor 1 Prevents Stroma-Induced Peritoneal Metastasis in Gastric Carcinoma. Mol Cancer Res, 16: 1590-1600, 2018

Rashdan, S., Minna, J.D., Gerber, D.E., Diagnosis and management of pulmonary toxicity associated with cancer immunotherapy. Lancet Respir Med, 6: 472-478, 2018

Dellinger, M.T., Witte, M.H., Lymphangiogenesis, lymphatic systemomics, and cancer: context, advances and unanswered questions. Clin Exp Metastasis, 35: 419-424, 2018

Li, Q., Wang, X., Liang, F., Yi, F., Xie, Y., Gazdar, A., Xiao, G., A Bayesian hidden Potts mixture model for analyzing lung cancer pathology images. Biostatistics, 2018

Wang, C., Niederstrasser, H., Douglas, P.M., Lin, R., Jaramillo, J., Li, Y., Oswald, N.W., Zhou, A., McMillan, E.A., Mendiratta, S., Wang, Z., Zhao, T., Lin, Z., Luo, M., Huang, G., Brekken, R.A., Posner, B.A., MacMillan, J.B., Gao, J., White, M.A., Author Correction: Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nat Commun, 9: 2050, 2018

Yang, L., Wang, S., Gerber, D.E., Zhou, Y., Xu, F., Liu, J., Liang, H., Xiao, G., Zhou, Q., Gazdar, A., Xie, Y., Main bronchus location is a predictor for metastasis and prognosis in lung adenocarcinoma: A large cohort analysis. Lung Cancer, 120: 22-26, 2018

McMillan, E.A., Ryu, M.J., Diep, C.H., Mendiratta, S., Clemenceau, J.R., Vaden, R.M., Kim, J.H., Motoyaji, T., Covington, K.R., Peyton, M., Huffman, K., Wu, X., Girard, L., Sung, Y., Chen, P.H., Mallipeddi, P.L., Lee, J.Y., Hanson, J., Voruganti, S., Yu, Y., Park, S., Sudderth, J., DeSevo, C., Muzny, D.M., Doddapaneni, H., Gazdar, A., Gibbs, R.A., Hwang, T.H., Heymach, J.V., Wistuba, I., Coombes, K.R., Williams, N.S., Wheeler, D.A., MacMillan, J.B., Deberardinis, R.J., Roth, M.G., Posner, B.A., Minna, J.D., Kim, H.S., White, M.A., Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell, 173: 864-878 e29, 2018

Fu, G., Sanjay, S.T., Zhou, W., Brekken, R.A., Kirken, R.A., Li, X., Exploration of Nanoparticle-Mediated Photothermal Effect of TMB-H2O2 Colorimetric System and Its Application in a Visual Quantitative Photothermal Immunoassay. Anal Chem, 90: 5930-5937, 2018

Kim, J., Minna, J.D., Evaluating tumor-suppressor gene combinations. Nat Genet, 50: 480-482, 2018

Tanaka, I., Sato, M., Kato, T., Goto, D., Kakumu, T., Miyazawa, A., Yogo, N., Hase, T., Morise, M., Sekido, Y., Girard, L., Minna, J.D., Byers, L.A., Heymach, J.V., Coombes, K.R., Kondo, M., Hasegawa, Y., eIF2beta, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer. Cancer Sci, 109: 1843-1852, 2018

Hominick, D., Silva, A., Khurana, N., Liu, Y., Dechow, P.C., Feng, J.Q., Pytowski, B., Rutkowski, J.M., Alitalo, K., Dellinger, M.T., VEGF-C promotes the development of lymphatics in bone and bone loss. Elife, 7, 2018

Gong, K., Guo, G., Gerber, D.E., Gao, B., Peyton, M., Huang, C., Minna, J.D., Hatanpaa, K.J., Kernstine, K., Cai, L., Xie, Y., Zhu, H., Fattah, F.J., Zhang, S., Takahashi, M., Mukherjee, B., Burma, S., Dowell, J., Dao, K., Papadimitrakopoulou, V.A., Olivas, V., Bivona, T.G., Zhao, D., Habib, A.A., TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer. J Clin Invest, 128: 2500-2518, 2018

Manders, D.B., Kishore, H.A., Gazdar, A.F., Keller, P.W., Tsunezumi, J., Yanagisawa, H., Lea, J., Word, R.A., Dysregulation of fibulin-5 and matrix metalloproteases in epithelial ovarian cancer. Oncotarget, 9: 14251-14267, 2018

Kontarakis, Z., Rossi, A., Ramas, S., Dellinger, M.T., Stainier, D.Y.R., Mir-126 is a conserved modulator of lymphatic development. Dev Biol, 437: 120-130, 2018

Zhang, W., Girard, L., Zhang, Y.A., Haruki, T., Papari-Zareei, M., Stastny, V., Ghayee, H.K., Pacak, K., Oliver, T.G., Minna, J.D., Gazdar, A.F., Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes. Transl Lung Cancer Res, 7: 32-49, 2018

Yingling, J.M., McMillen, W.T., Yan, L., Huang, H., Sawyer, J.S., Graff, J., Clawson, D.K., Britt, K.S., Anderson, B.D., Beight, D.W., Desaiah, D., Lahn, M.M., Benhadji, K.A., Lallena, M.J., Holmgaard, R.B., Xu, X., Zhang, F., Manro, J.R., Iversen, P.W., Iyer, C.V., Brekken, R.A., Kalos, M.D., Driscoll, K.E., Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-beta receptor type I inhibitor. Oncotarget, 9: 6659-6677, 2018

Walser, T.C., Jing, Z., Tran, L.M., Lin, Y.Q., Yakobian, N., Wang, G., Krysan, K., Zhu, L.X., Sharma, S., Lee, M.H., Belperio, J.A., Ooi, A.T., Gomperts, B.N., Shay, J.W., Larsen, J.E., Minna, J.D., Hong, L.S., Fishbein, M.C., Dubinett, S.M., Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells. Cancer Res, 78: 1986-1999, 2018

Gazdar, A.F., Morphologic and Other Forms of Heterogeneity in Small Cell Lung Cancer: What Can We Learn from Them? J Thorac Oncol, 13: 148-150, 2018

Belzile, O., Huang, X., Gong, J., Carlson, J., Schroit, A.J., Brekken, R.A., Freimark, B.D., Antibody targeting of phosphatidylserine for the detection and immunotherapy of cancer. Immunotargets Ther, 7: 1-14, 2018

He, M., Liu, S., Gallolu Kankanamalage, S., Borromeo, M.D., Girard, L., Gazdar, A.F., Minna, J.D., Johnson, J.E., Cobb, M.H., The Epithelial Sodium Channel (alphaENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors. Transl Oncol, 11: 292-299, 2018

Fan, C.W., Yarravarapu, N., Shi, H., Kulak, O., Kim, J., Chen, C., Lum, L., A synthetic combinatorial approach to disabling deviant Hedgehog signaling. Sci Rep, 8: 1133, 2018

Cruz, V.H., Brekken, R.A., Assessment of TANK-binding kinase 1 as a therapeutic target in cancer. J Cell Commun Signal, 12: 83-90, 2018

Aisner, D.L., Sholl, L.M., Berry, L.D., Rossi, M.R., Chen, H., Fujimoto, J., Moreira, A.L., Ramalingam, S.S., Villaruz, L.C., Otterson, G.A., Haura, E., Politi, K., Glisson, B., Cetnar, J., Garon, E.B., Schiller, J., Waqar, S.N., Sequist, L.V., Brahmer, J., Shyr, Y., Kugler, K., Wistuba, II, Johnson, B.E., Minna, J.D., Kris, M.G., Bunn, P.A., Kwiatkowski, D.J., The Impact of Smoking and TP53 Mutations in Lung Adenocarcinoma Patients with Targetable Mutations-The Lung Cancer Mutation Consortium (LCMC2). Clin Cancer Res, 24: 1038-1047, 2018

Ludwig, K.F., Du, W., Sorrelle, N.B., Wnuk-Lipinska, K., Topalovski, M., Toombs, J.E., Cruz, V.H., Yabuuchi, S., Rajeshkumar, N.V., Maitra, A., Lorens, J.B., Brekken, R.A., Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer. Cancer Res, 78: 246-255, 2018

Lu, W., Wang, X., Zhan, X., Gazdar, A., Meta-analysis approaches to combine multiple gene set enrichment studies. Stat Med, 37: 659-672, 2018

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2017

Shimada, Y., Minna, J.D., Exosome mediated phenotypic changes in lung cancer pathophysiology. Transl Cancer Res, 6: S1040-S1042, 2017

Wang, C., Niederstrasser, H., Douglas, P.M., Lin, R., Jaramillo, J., Li, Y., Oswald, N.W., Zhou, A., McMillan, E.A., Mendiratta, S., Wang, Z., Zhao, T., Lin, Z., Luo, M., Huang, G., Brekken, R.A., Posner, B.A., MacMillan, J.B., Gao, J., White, M.A., Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nat Commun, 8: 2270, 2017

Gazdar, A.F., Bunn, P.A., Minna, J.D., Small-cell lung cancer: what we know, what we need to know and the path forward. Nat Rev Cancer, 17: 725-737, 2017

Dalvi, M.P., Martinez, E.D., JumonjiC demethylase inhibitors show potential for targeting chemotherapy-resistant lung cancers. Mol Cell Oncol, 4: e1345352, 2017

Yang, L., Wang, S., Zhou, Y., Lai, S., Xiao, G., Gazdar, A., Xie, Y., Evaluation of the 7(th) and 8(th) editions of the AJCC/UICC TNM staging systems for lung cancer in a large North American cohort. Oncotarget, 8: 66784-66795, 2017

Thu, K.L., Papari-Zareei, M., Stastny, V., Song, K., Peyton, M., Martinez, V.D., Zhang, Y.A., Castro, I.B., Varella-Garcia, M., Liang, H., Xing, C., Kittler, R., Milchgrub, S., Castrillon, D.H., Davidson, H.L., Reynolds, C.P., Lam, W.L., Lea, J., Gazdar, A.F., A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas. Oncotarget, 8: 50489-50499, 2017

Aguilera, K.Y., Huang, H., Du, W., Hagopian, M.M., Wang, Z., Hinz, S., Hwang, T.H., Wang, H., Fleming, J.B., Castrillon, D.H., Ren, X., Ding, K., Brekken, R.A., Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther, 16: 2473-2485, 2017

Huang, H., Du, W., Brekken, R.A., Extracellular Matrix Induction of Intracellular Reactive Oxygen Species. Antioxid Redox Signal, 27: 774-784, 2017

Pagano, P.C., Tran, L.M., Bendris, N., O'Byrne, S., Tse, H.T., Sharma, S., Hoech, J.W., Park, S.J., Liclican, E.L., Jing, Z., Li, R., Krysan, K., Paul, M.K., Fontebasso, Y., Larsen, J.E., Hakimi, S., Seki, A., Fishbein, M.C., Gimzewski, J.K., Carlo, D.D., Minna, J.D., Walser, T.C., Dubinett, S.M., Identification of a Human Airway Epithelial Cell Subpopulation with Altered Biophysical, Molecular, and Metastatic Properties. Cancer Prev Res (Phila), 10: 514-524, 2017

Zhao, X., Huffman, K.E., Fujimoto, J., Canales, J.R., Girard, L., Nie, G., Heymach, J.V., Wistuba, II, Minna, J.D., Yu, Y., Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer. J Am Soc Mass Spectrom, 28: 2078-2089, 2017

Shien, K., Papadimitrakopoulou, V.A., Ruder, D., Behrens, C., Shen, L., Kalhor, N., Song, J., Lee, J.J., Wang, J., Tang, X., Herbst, R.S., Toyooka, S., Girard, L., Minna, J.D., Kurie, J.M., Wistuba, II, Izzo, J.G., JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer. Mol Cancer Ther, 16: 2234-2245, 2017

Kasiri, S., Shao, C., Chen, B., Wilson, A.N., Yenerall, P., Timmons, B.C., Girard, L., Tian, H., Behrens, C., Wistuba, II, Gazdar, A.F., Kim, J., GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma. Cancer Res, 77: 4448-4459, 2017

Sharma, R., Huang, X., Brekken, R.A., Schroit, A.J., Detection of phosphatidylserine-positive exosomes for the diagnosis of early-stage malignancies. Br J Cancer, 117: 545-552, 2017

Li, L., Wang, X., Xiao, G., Gazdar, A., Integrative gene set enrichment analysis utilizing isoform-specific expression. Genet Epidemiol, 41: 498-510, 2017

Goodwin, J., Neugent, M.L., Lee, S.Y., Choe, J.H., Choi, H., Jenkins, D.M.R., Ruthenborg, R.J., Robinson, M.W., Jeong, J.Y., Wake, M., Abe, H., Takeda, N., Endo, H., Inoue, M., Xuan, Z., Yoo, H., Chen, M., Ahn, J.M., Minna, J.D., Helke, K.L., Singh, P.K., Shackelford, D.B., Kim, J.W., The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition. Nat Commun, 8: 15503, 2017

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y.F., Ni, M., Huffman, K.E., Girard, L., Byers, L.A., Unsal-Kacmaz, K., Pena, C.G., Heymach, J.V., Wauters, E., Vansteenkiste, J., Castrillon, D.H., Chen, B.P.C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J.D., DeBerardinis, R.J., CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature, 546: 168-172, 2017

Dalvi, M.P., Wang, L., Zhong, R., Kollipara, R.K., Park, H., Bayo, J., Yenerall, P., Zhou, Y., Timmons, B.C., Rodriguez-Canales, J., Behrens, C., Mino, B., Villalobos, P., Parra, E.R., Suraokar, M., Pataer, A., Swisher, S.G., Kalhor, N., Bhanu, N.V., Garcia, B.A., Heymach, J.V., Coombes, K., Xie, Y., Girard, L., Gazdar, A.F., Kittler, R., Wistuba, II, Minna, J.D., Martinez, E.D., Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors. Cell Rep, 19: 1669-1684, 2017

Sen, T., Tong, P., Stewart, C.A., Cristea, S., Valliani, A., Shames, D.S., Redwood, A.B., Fan, Y.H., Li, L., Glisson, B.S., Minna, J.D., Sage, J., Gibbons, D.L., Piwnica-Worms, H., Heymach, J.V., Wang, J., Byers, L.A., CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib. Cancer Res, 77: 3870-3884, 2017

Xiang, Z., Zhou, Z.J., Xia, G.K., Zhang, X.H., Wei, Z.W., Zhu, J.T., Yu, J., Chen, W., He, Y., Schwarz, R.E., Brekken, R.A., Awasthi, N., Zhang, C.H., A positive crosstalk between CXCR4 and CXCR2 promotes gastric cancer metastasis. Oncogene, 36: 5122-5133, 2017

Zhang, Y., Zhang, L., Li, R., Chang, D.W., Ye, Y., Minna, J.D., Roth, J.A., Han, B., Wu, X., Genetic variations in cancer-related significantly mutated genes and lung cancer susceptibility. Ann Oncol, 28: 1625-1630, 2017

Qiu, Z.W., Bi, J.H., Gazdar, A.F., Song, K., Genome-wide copy number variation pattern analysis and a classification signature for non-small cell lung cancer. Genes Chromosomes Cancer, 56: 559-569, 2017

Deb, D., Rajaram, S., Larsen, J.E., Dospoy, P.D., Marullo, R., Li, L.S., Avila, K., Xue, F., Cerchietti, L., Minna, J.D., Altschuler, S.J., Wu, L.F., Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers. Cancer Res, 77: 3070-3081, 2017

Windhorst, S., Song, K., Gazdar, A.F., Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types. Biochem Pharmacol, 137: 1-9, 2017

Celiktas, M., Tanaka, I., Tripathi, S.C., Fahrmann, J.F., Aguilar-Bonavides, C., Villalobos, P., Delgado, O., Dhillon, D., Dennison, J.B., Ostrin, E.J., Wang, H., Behrens, C., Do, K.A., Gazdar, A.F., Hanash, S.M., Taguchi, A., Role of CPS1 in Cell Growth, Metabolism and Prognosis in LKB1-Inactivated Lung Adenocarcinoma. J Natl Cancer Inst, 109: 1-9, 2017

Sorrelle, N., Dominguez, A.T.A., Brekken, R.A., From top to bottom: midkine and pleiotrophin as emerging players in immune regulation. J Leukoc Biol, 102: 277-286, 2017

Mulcrone, P.L., Campbell, J.P., Clement-Demange, L., Anbinder, A.L., Merkel, A.R., Brekken, R.A., Sterling, J.A., Elefteriou, F., Skeletal Colonization by Breast Cancer Cells Is Stimulated by an Osteoblast and beta2AR-Dependent Neo-Angiogenic Switch. J Bone Miner Res, 32: 1442-1454, 2017

Hatch, S.B., Yapp, C., Montenegro, R.C., Savitsky, P., Gamble, V., Tumber, A., Ruda, G.F., Bavetsias, V., Fedorov, O., Atrash, B., Raynaud, F., Lanigan, R., Carmichael, L., Tomlin, K., Burke, R., Westaway, S.M., Brown, J.A., Prinjha, R.K., Martinez, E.D., Oppermann, U., Schofield, C.J., Bountra, C., Kawamura, A., Blagg, J., Brennan, P.E., Rossanese, O., Muller, S., Assessing histone demethylase inhibitors in cells: lessons learned. Epigenetics Chromatin, 10: 9, 2017

Tang, H., Wang, S., Xiao, G., Schiller, J., Papadimitrakopoulou, V., Minna, J., Wistuba, II, Xie, Y., Comprehensive evaluation of published gene expression prognostic signatures for biomarker-based lung cancer clinical studies. Ann Oncol, 28: 733-740, 2017

Li, J., Zhao, W., Akbani, R., Liu, W., Ju, Z., Ling, S., Vellano, C.P., Roebuck, P., Yu, Q., Eterovic, A.K., Byers, L.A., Davies, M.A., Deng, W., Gopal, Y.N., Chen, G., von Euw, E.M., Slamon, D., Conklin, D., Heymach, J.V., Gazdar, A.F., Minna, J.D., Myers, J.N., Lu, Y., Mills, G.B., Liang, H., Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays. Cancer Cell, 31: 225-239, 2017

Kakumu, T., Sato, M., Goto, D., Kato, T., Yogo, N., Hase, T., Morise, M., Fukui, T., Yokoi, K., Sekido, Y., Girard, L., Minna, J.D., Byers, L.A., Heymach, J.V., Coombes, K.R., Kondo, M., Hasegawa, Y., Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer. Cancer Sci, 108: 732-743, 2017

Hur, H., Ham, I.H., Lee, D., Jin, H., Aguilera, K.Y., Oh, H.J., Han, S.U., Kwon, J.E., Kim, Y.B., Ding, K., Brekken, R.A., Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma. BMC Cancer, 17: 87, 2017

Dai, B., Roife, D., Kang, Y., Gumin, J., Rios Perez, M.V., Li, X., Pratt, M., Brekken, R.A., Fueyo-Margareto, J., Lang, F.F., Fleming, J.B., Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-targeting Antibody in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther, 2017

Pelosof, L., Ahn, C., Gao, A., Horn, L., Madrigales, A., Cox, J., McGavic, D., Minna, J.D., Gazdar, A.F., Schiller, J., Proportion of Never-Smoker Non-Small Cell Lung Cancer Patients at Three Diverse Institutions. J Natl Cancer Inst, 109, 2017

Tagal, V., Wei, S., Zhang, W., Brekken, R.A., Posner, B.A., Peyton, M., Girard, L., Hwang, T., Wheeler, D.A., Minna, J.D., White, M.A., Gazdar, A.F., Roth, M.G., SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers. Nat Commun, 8: 14098, 2017

Mollaoglu, G., Guthrie, M.R., Bohm, S., Bragelmann, J., Can, I., Ballieu, P.M., Marx, A., George, J., Heinen, C., Chalishazar, M.D., Cheng, H., Ireland, A.S., Denning, K.E., Mukhopadhyay, A., Vahrenkamp, J.M., Berrett, K.C., Mosbruger, T.L., Wang, J., Kohan, J.L., Salama, M.E., Witt, B.L., Peifer, M., Thomas, R.K., Gertz, J., Johnson, J.E., Gazdar, A.F., Wechsler-Reya, R.J., Sos, M.L., Oliver, T.G., MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition. Cancer Cell, 31: 270-285, 2017

Wang, W., Wang, H., Zhou, X., Li, X., Sun, W., Dellinger, M., Boyce, B.F., Xing, L., Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice. J Bone Miner Res, 32: 939-950, 2017

Gao, B., Huang, C., Kernstine, K., Pelekanou, V., Kluger, Y., Jiang, T., Peters-Hall, J.R., Coquelin, M., Girard, L., Zhang, W., Huffman, K., Oliver, D., Kinose, F., Haura, E., Teer, J.K., Rix, U., Le, A.T., Aisner, D.L., Varella-Garcia, M., Doebele, R.C., Covington, K.R., Hampton, O.A., Doddapaneni, H.V., Jayaseelan, J.C., Hu, J., Wheeler, D.A., Shay, J.W., Rimm, D.L., Gazdar, A., Minna, J.D., Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions. Oncotarget, 8: 11114-11126, 2017

Luo, X., Zang, X., Yang, L., Huang, J., Liang, F., Rodriguez-Canales, J., Wistuba, II, Gazdar, A., Xie, Y., Xiao, G., Comprehensive Computational Pathological Image Analysis Predicts Lung Cancer Prognosis. J Thorac Oncol, 12: 501-509, 2017

Zhou, X., Updegraff, B.L., Guo, Y., Peyton, M., Girard, L., Larsen, J.E., Xie, X.J., Zhou, Y., Hwang, T.H., Xie, Y., Rodriguez-Canales, J., Villalobos, P., Behrens, C., Wistuba, II, Minna, J.D., O'Donnell, K.A., PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK Signaling by EGFR and KRAS during Lung Tumorigenesis. Cancer Res, 77: 187-197, 2017

Fu, R., Wang, P., Ma, W., Taguchi, A., Wong, C.H., Zhang, Q., Gazdar, A., Hanash, S.M., Zhou, Q., Zhong, H., Feng, Z., A statistical method for detecting differentially expressed SNVs based on next-generation RNA-seq data. Biometrics, 73: 42-51, 2017

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2016

Ludwig, K.F., Slone, T., Cederberg, K.B., Silva, A.T., Dellinger, M., A New Case and Review of Chylothorax in Generalized Lymphatic Anomaly and Gorham-Stout Disease. Lymphology, 49: 73-84, 2016

Zhao, T., Huang, G., Li, Y., Yang, S., Ramezani, S., Lin, Z., Wang, Y., Ma, X., Zeng, Z., Luo, M., de Boer, E., Xie, X.J., Thibodeaux, J., Brekken, R.A., Sun, X., Sumer, B.D., Gao, J., A Transistor-like pH Nanoprobe for Tumour Detection and Image-guided Surgery. Nat Biomed Eng, 1, 2016

Gao, B., Huang, C., Kernstine, K., Pelekanou, V., Kluger, Y., Jiang, T., Peters-Hall, J.R., Coquelin, M., Girard, L., Zhang, W., Huffman, K., Oliver, D., Kinose, F., Haura, E., Teer, J.K., Rix, U., Le, A.T., Aisner, D.L., Varella-Garcia, M., Doebele, R.C., Covington, K.R., Hampton, O.A., Doddapaneni, H.V., Jayaseelan, J.C., Hu, J., Wheeler, D.A., Shay, J.W., Rimm, D.L., Gazdar, A., Minna, J.D., Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions. Oncotarget, 2016

Huang, X., Motea, E.A., Moore, Z.R., Yao, J., Dong, Y., Chakrabarti, G., Kilgore, J.A., Silvers, M.A., Patidar, P.L., Cholka, A., Fattah, F., Cha, Y., Anderson, G.G., Kusko, R., Peyton, M., Yan, J., Xie, X.J., Sarode, V., Williams, N.S., Minna, J.D., Beg, M., Gerber, D.E., Bey, E.A., Boothman, D.A., Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors. Cancer Cell, 30: 940-952, 2016

Pena-Llopis, S., Wan, Y., Martinez, E.D., Unique epigenetic gene profiles define human breast cancers with poor prognosis. Oncotarget, 7: 85819-85831, 2016

Wieczorek, M., Tcherkezian, J., Bernier, C., Prota, A.E., Chaaban, S., Rolland, Y., Godbout, C., Hancock, M.A., Arezzo, J.C., Ocal, O., Rocha, C., Olieric, N., Hall, A., Ding, H., Bramoulle, A., Annis, M.G., Zogopoulos, G., Harran, P.G., Wilkie, T.M., Brekken, R.A., Siegel, P.M., Steinmetz, M.O., Shore, G.C., Brouhard, G.J., Roulston, A., The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity. Sci Transl Med, 8: 365ra159, 2016

Posner, B.A., Peyton, M., Girard, L., Hwang, T., Wheeler, D.A., Minna, J.D., White, M.A., Gazdar, A.F., Roth, M.G., Zhang, Y.A., Zhou, Y., Luo, X., Song, K., Ma, X., Sathe, A., Girard, L., Xiao, G., Gazdar, A.F., SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II-III Diffuse Gliomas. Nat Commun, 13: 80-89, 2016

Zhang, Y.A., Zhou, Y., Luo, X., Song, K., Ma, X., Sathe, A., Girard, L., Xiao, G., Gazdar, A.F., SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II-III Diffuse Gliomas. EBioMedicine, 13: 80-89, 2016

Kim, J., McMillan, E., Kim, H.S., Venkateswaran, N., Makkar, G., Rodriguez-Canales, J., Villalobos, P., Neggers, J.E., Mendiratta, S., Wei, S., Landesman, Y., Senapedis, W., Baloglu, E., Chow, C.B., Frink, R.E., Gao, B., Roth, M., Minna, J.D., Daelemans, D., Wistuba, II, Posner, B.A., Scaglioni, P.P., White, M.A., XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer. Nature, 538: 114-117, 2016

Wojtukiewicz, M.Z., Sierko, E., Skalij, P., Kaminska, M., Zimnoch, L., Brekken, R.A., Thorpe, P.E., Granulocyte-Colony Stimulating Factor Receptor, Tissue Factor, and VEGF-R Bound VEGF in Human Breast Cancer In Loco. Adv Clin Exp Med, 25: 505-11, 2016

Yan, Y., Liu, L., Xiong, H., Miller, J.B., Zhou, K., Kos, P., Huffman, K.E., Elkassih, S., Norman, J.W., Carstens, R., Kim, J., Minna, J.D., Siegwart, D.J., Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells. Proc Natl Acad Sci U S A, 113: E5702-10, 2016

Frankel, A.E., Liu, X., Minna, J.D., Developing EZH2-Targeted Therapy for Lung Cancer. Cancer Discov, 6: 949-52, 2016

Topalovski, M., Hagopian, M., Wang, M., Brekken, R.A., Hypoxia and Transforming Growth Factor beta Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer. J Biol Chem, 291: 22244-22252, 2016

Larsen, J.E., Nathan, V., Osborne, J.K., Farrow, R.K., Deb, D., Sullivan, J.P., Dospoy, P.D., Augustyn, A., Hight, S.K., Sato, M., Girard, L., Behrens, C., Wistuba, II, Gazdar, A.F., Hayward, N.K., Minna, J.D., ZEB1 drives epithelial-to-mesenchymal transition in lung cancer. J Clin Invest, 126: 3219-35, 2016

Padanad, M.S., Konstantinidou, G., Venkateswaran, N., Melegari, M., Rindhe, S., Mitsche, M., Yang, C., Batten, K., Huffman, K.E., Liu, J., Tang, X., Rodriguez-Canales, J., Kalhor, N., Shay, J.W., Minna, J.D., McDonald, J., Wistuba, II, DeBerardinis, R.J., Scaglioni, P.P., Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis. Cell Rep, 16: 1614-1628, 2016

Mineo, C., Lanier, L., Jung, E., Sengupta, S., Ulrich, V., Sacharidou, A., Tarango, C., Osunbunmi, O., Shen, Y.M., Salmon, J.E., Brekken, R.A., Huang, X., Thorpe, P.E., Shaul, P.W., Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis. PLoS One, 11: e0158757, 2016

Borromeo, M.D., Savage, T.K., Kollipara, R.K., He, M., Augustyn, A., Osborne, J.K., Girard, L., Minna, J.D., Gazdar, A.F., Cobb, M.H., Johnson, J.E., ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs. Cell Rep, 16: 1259-72, 2016

Diaz, B., Ostapoff, K.T., Toombs, J.E., Lo, J., Bonner, M.Y., Curatolo, A., Adsay, V., Brekken, R.A., Arbiser, J.L., Tris DBA palladium is highly effective against growth and metastasis of pancreatic cancer in an orthotopic model. Oncotarget, 7: 51569-51580, 2016

Minna, J.D., Johnson, J.E., Opening a Chromatin Gate to Metastasis. Cell, 166: 275-6, 2016

Girard, L., Rodriguez-Canales, J., Behrens, C., Thompson, D.M., Botros, I.W., Tang, H., Xie, Y., Rekhtman, N., Travis, W.D., Wistuba, II, Minna, J.D., Gazdar, A.F., An Expression Signature as an Aid to the Histologic Classification of Non-Small Cell Lung Cancer. Clin Cancer Res, 22: 4880-4889, 2016

Lammoglia, G.M., Van Zandt, C.E., Galvan, D.X., Orozco, J.L., Dellinger, M.T., Rutkowski, J.M., Hyperplasia, de novo lymphangiogenesis, and lymphatic regression in mice with tissue-specific, inducible overexpression of murine VEGF-D. Am J Physiol Heart Circ Physiol, 311: H384-94, 2016

Gazdar, A.F., Hirsch, F.R., Minna, J.D., Correction: "From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers". J Thorac Oncol, 11: e88-9, 2016

Thu, K.L., Papari-Zareei, M., Stastny, V., Song, K., Peyton, M., Martinez, V.D., Zhang, Y.A., Castro, I.B., Varella-Garcia, M., Liang, H., Xing, C., Kittler, R., Milchgrub, S., Castrillon, D.H., Davidson, H.L., Reynolds, C.P., Lam, W.L., Lea, J., Gazdar, A.F., A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas. Oncotarget, 2016

Kim, D.W., Wu, N., Kim, Y.C., Cheng, P.F., Basom, R., Kim, D., Dunn, C.T., Lee, A.Y., Kim, K., Lee, C.S., Singh, A., Gazdar, A.F., Harris, C.R., Eisenman, R.N., Park, K.S., MacPherson, D., Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer. Genes Dev, 30: 1289-99, 2016

Taruvai Kalyana Kumar, R., Liu, S., Minna, J.D., Prasad, S., Monitoring drug induced apoptosis and treatment sensitivity in non-small cell lung carcinoma using dielectrophoresis. Biochim Biophys Acta, 1860: 1877-83, 2016

Gazdar, A.F., Minna, J.D., Developing New, Rational Therapies for Recalcitrant Small Cell Lung Cancer. J Natl Cancer Inst, 108, 2016

Wang, Y.W., Ma, X., Zhang, Y.A., Wang, M.J., Yatabe, Y., Lam, S., Girard, L., Chen, J.Y., Gazdar, A.F., ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers. J Thorac Oncol, 11: 1469-81, 2016

Zhang, Z., Wodzak, M., Belzile, O., Zhou, H., Sishc, B., Yan, H., Stojadinovic, S., Mason, R.P., Brekken, R.A., Chopra, R., Story, M.D., Timmerman, R., Saha, D., Effective Rat Lung Tumor Model for Stereotactic Body Radiation Therapy. Radiat Res, 185: 616-22, 2016

Wang, Z., Bian, H., Bartual, S.G., Du, W., Luo, J., Zhao, H., Zhang, S., Mo, C., Zhou, Y., Xu, Y., Tu, Z., Ren, X., Lu, X., Brekken, R.A., Yao, L., Bullock, A.N., Su, J., Ding, K., Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. J Med Chem, 59: 5911-6, 2016

Tong, P., Diao, L., Shen, L., Li, L., Heymach, J.V., Girard, L., Minna, J.D., Coombes, K.R., Byers, L.A., Wang, J., Selecting Reliable mRNA Expression Measurements Across Platforms Improves Downstream Analysis. Cancer Inform, 15: 81-9, 2016

Frink, R.E., Peyton, M., Schiller, J.H., Gazdar, A.F., Shay, J.W., Minna, J.D., Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner. Oncotarget, 7: 31639-51, 2016

Udayakumar, D., Pandita, R.K., Horikoshi, N., Liu, Y., Liu, Q., Wong, K.K., Hunt, C.R., Gray, N.S., Minna, J.D., Pandita, T.K., Westover, K.D., Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair. Radiat Res, 185: 527-38, 2016

Levin, P.A., Brekken, R.A., Byers, L.A., Heymach, J.V., Gerber, D.E., Axl Receptor Axis: A New Therapeutic Target in Lung Cancer. J Thorac Oncol, 11: 1357-62, 2016

Desai, T.J., Toombs, J.E., Minna, J.D., Brekken, R.A., Udugamasooriya, D.G., Identification of lipid-phosphatidylserine (PS) as the target of unbiasedly selected cancer specific peptide-peptoid hybrid PPS1. Oncotarget, 7: 30678-90, 2016

Freimark, B.D., Gong, J., Ye, D., Gray, M.J., Nguyen, V., Yin, S., Hatch, M.M., Hughes, C.C., Schroit, A.J., Hutchins, J.T., Brekken, R.A., Huang, X., Antibody-Mediated Phosphatidylserine Blockade Enhances the Antitumor Responses to CTLA-4 and PD-1 Antibodies in Melanoma. Cancer Immunol Res, 4: 531-40, 2016

DeNicola, G.M., Chen, P.H., Mullarky, E., Sudderth, J.A., Hu, Z., Wu, D., Tang, H., Xie, Y., Asara, J.M., Huffman, K.E., Wistuba, II, Minna, J.D., DeBerardinis, R.J., Cantley, L.C., Erratum: NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat Genet, 48: 473, 2016

Li, R., Pu, X., Chang, J.Y., Ye, Y., Komaki, R., Minna, J.D., Roth, J.A., Han, B., Wu, X., MiRNA-Related Genetic Variations Associated with Radiotherapy-Induced Toxicities in Patients with Locally Advanced Non-Small Cell Lung Cancer. PLoS One, 11: e0150467, 2016

Regan, E., Sibley, R.C., Cenik, B.K., Silva, A., Girard, L., Minna, J.D., Dellinger, M.T., Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines. PLoS One, 11: e0150963, 2016

Goel, H.L., Pursell, B., Shultz, L.D., Greiner, D.L., Brekken, R.A., Vander Kooi, C.W., Mercurio, A.M., P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer. Cell Rep, 14: 2193-208, 2016

Martinez, E.D., Gazdar, A.F., Inhibiting the Jumonji family: a potential new clinical approach to targeting aberrant epigenetic mechanisms. Epigenomics, 8: 313-6, 2016

Birge, R.B., Boeltz, S., Kumar, S., Carlson, J., Wanderley, J., Calianese, D., Barcinski, M., Brekken, R.A., Huang, X., Hutchins, J.T., Freimark, B., Empig, C., Mercer, J., Schroit, A.J., Schett, G., Herrmann, M., Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer. Cell Death Differ, 23: 962-78, 2016

Cheng, X., Li, L., Thorpe, P.E., Yopp, A.C., Brekken, R.A., Huang, X., Antibody-Mediated Blockade of Phosphatidylserine Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinomas Xenografts. Ann Surg Oncol, 23: 583-591, 2016

Bunn, P.A., Jr., Minna, J.D., Augustyn, A., Gazdar, A.F., Ouadah, Y., Krasnow, M.A., Berns, A., Brambilla, E., Rekhtman, N., Massion, P.P., Niederst, M., Peifer, M., Yokota, J., Govindan, R., Poirier, J.T., Byers, L.A., Wynes, M.W., McFadden, D.G., MacPherson, D., Hann, C.L., Farago, A.F., Dive, C., Teicher, B.A., Peacock, C.D., Johnson, J.E., Cobb, M.H., Wendel, H.G., Spigel, D., Sage, J., Yang, P., Pietanza, M.C., Krug, L.M., Heymach, J., Ujhazy, P., Zhou, C., Goto, K., Dowlati, A., Christensen, C.L., Park, K., Einhorn, L.H., Edelman, M.J., Giaccone, G., Gerber, D.E., Salgia, R., Owonikoko, T., Malik, S., Karachaliou, N., Gandara, D.R., Slotman, B.J., Blackhall, F., Goss, G., Thomas, R., Rudin, C.M., Hirsch, F.R., Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes? J Thorac Oncol, 11: 453-74, 2016

Chen, B., Trang, V., Lee, A., Williams, N.S., Wilson, A.N., Epstein, E.H., Jr., Tang, J.Y., Kim, J., Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma. Mol Cancer Ther, 15: 866-76, 2016

Young, J.H., Peyton, M., Kim, H.S., McMillan, E., Minna, J.D., White, M.A., Marcotte, E.M., Computational Discovery of Pathway-Level Genetic Vulnerabilities in Non-Small-Cell Lung Cancer. Bioinformatics, 2016

Young, J.H., Peyton, M., Seok Kim, H., McMillan, E., Minna, J.D., White, M.A., Marcotte, E.M., Computational discovery of pathway-level genetic vulnerabilities in non-small-cell lung cancer. Bioinformatics, 32: 1373-9, 2016

Topalovski, M., Brekken, R.A., Matrix control of pancreatic cancer: New insights into fibronectin signaling. Cancer Lett, 381: 252-8, 2016

Hu, R., Huffman, K.E., Chu, M., Zhang, Y., Minna, J.D., Yu, Y., Quantitative Secretomic Analysis Identifies Extracellular Protein Factors that Modulate the Metastatic Phenotype of Non-Small Cell Lung Cancer. J Proteome Res, 2016

Zhang, Y.A., Ma, X., Sathe, A., Fujimoto, J., Wistuba, II, Lam, S., Yatabe, Y., Wang, Y.W., Stastny, V., Gao, B., Larsen, J.E., Girard, L., Liu, X., Song, K., Behrens, C., Kalhor, N., Xie, Y., Zhang, M.Q., Minna, J.D., Gazdar, A.F., Validation of SCT Methylation as a Hallmark Biomarker for Lung Cancers. J Thorac Oncol, 11: 346-60, 2016

Zhang, Y.A., Ma, X., Sathe, A., Fujimoto, J., Wistuba, I., Lam, S., Yatabe, Y., Wang, Y.W., Stastny, V., Gao, B., Larsen, J.E., Girard, L., Liu, X., Song, K., Behrens, C., Kalhor, N., Xie, Y., Zhang, M.Q., Minna, J.D., Gazdar, A.F., Validation of SCT Methylation as a Hallmark Biomarker for Lung Cancers. J Thorac Oncol, 11: 346-360, 2016

Gazdar, A.F., Hirsch, F.R., Minna, J.D., From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers. J Thorac Oncol, 11: 287-99, 2016

Riquelme, E., Behrens, C., Lin, H.Y., Simon, G., Papadimitrakopoulou, V., Izzo, J., Moran, C., Kalhor, N., Lee, J.J., Minna, J.D., Wistuba, II, Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations. Cancer Res, 76: 675-85, 2016

Li, H., Hu, J., Wu, S., Wang, L., Cao, X., Zhang, X., Dai, B., Cao, M., Shao, R., Zhang, R., Majidi, M., Ji, L., Heymach, J.V., Wang, M., Pan, S., Minna, J., Mehran, R.J., Swisher, S.G., Roth, J.A., Fang, B., Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells. Oncotarget, 7: 3548-58, 2016

Mastri, M., Rosario, S., Tracz, A., Frink, R.E., Brekken, R.A., Ebos, J.M., The Challenges of Modeling Drug Resistance to Antiangiogenic Therapy. Curr Drug Targets, 17: 1747-1754, 2016

Lam, D.C., Luo, S.Y., Fu, K.H., Lui, M.M., Chan, K.H., Wistuba, II, Gao, B., Tsao, S.W., Ip, M.S., Minna, J.D., Nicotinic acetylcholine receptor expression in human airway correlates with lung function. Am J Physiol Lung Cell Mol Physiol, 310: L232-9, 2016

Ferrarotto, R., Goonatilake, R., Yoo, S.Y., Tong, P., Giri, U., Peng, S., Minna, J., Girard, L., Wang, Y., Wang, L., Li, L., Diao, L., Peng, D.H., Gibbons, D.L., Glisson, B.S., Heymach, J.V., Wang, J., Byers, L.A., Johnson, F.M., Epithelial-Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor-Mediated Apoptosis in Non-Small Cell Lung Cancer. Clin Cancer Res, 22: 1674-1686, 2016

Trost, N., Pena-Llopis, S., Koirala, S., Stojan, J., Potts, P.R., Fon Tacer, K., Martinez, E.D., gammaKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers. Oncotarget, 7: 2611-28, 2016

Lou, T.F., Sethuraman, D., Dospoy, P., Srivastva, P., Kim, H.S., Kim, J., Ma, X., Chen, P.H., Huffman, K.E., Frink, R.E., Larsen, J.E., Lewis, C., Um, S.W., Kim, D.H., Ahn, J.M., DeBerardinis, R.J., White, M.A., Minna, J.D., Yoo, H., Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker. Cancer Prev Res (Phila), 9: 43-52, 2016

Iacobas, I., Klepper, L., Kelly, J., Ferry, T., Dellinger, M.T., Meeting Report for the 2016 Conference on GLA and Gorham-Stout disease. BoneKEy, 13, 2016

Ludwig, K.F., Slone, T., Cederberg, K.B., Silva, A.T., Dellinger, M.T., A new case and review of chylothorax in generalized lymphatic anomaly and Gorham-Stout disease. Lymphology, 49: 73-84, 2016

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