Publications"/> Publications">



Gao, B., Huang, C., Kernstine, K., Pelekanou, V., Kluger, Y., Jiang, T., Peters-Hall, J.R., Coquelin, M., Girard, L., Zhang, W., Huffman, K., Oliver, D., Kinose, F., Haura, E., Teer, J.K., Rix, U., Le, A.T., Aisner, D.L., Varella-Garcia, M., Doebele, R.C., Covington, K.R., Hampton, O.A., Doddapaneni, H.V., Jayaseelan, J.C., Hu, J., Wheeler, D.A., Shay, J.W., Rimm, D.L., Gazdar, A., Minna, J.D., Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions. Oncotarget, 2016

Pena-Llopis, S., Wan, Y., Martinez, E.D., Unique epigenetic gene profiles define human breast cancers with poor prognosis. Oncotarget, 7: 85819-85831, 2016

Posner, B.A., Peyton, M., Girard, L., Hwang, T., Wheeler, D.A., Minna, J.D., White, M.A., Gazdar, A.F., Roth, M.G., Zhang, Y.A., Zhou, Y., Luo, X., Song, K., Ma, X., Sathe, A., Girard, L., Xiao, G., Gazdar, A.F., SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II-III Diffuse Gliomas. Nat Commun, 13: 80-89, 2016

Wojtukiewicz, M.Z., Sierko, E., Skalij, P., Kaminska, M., Zimnoch, L., Brekken, R.A., Thorpe, P.E., Granulocyte-Colony Stimulating Factor Receptor, Tissue Factor, and VEGF-R Bound VEGF in Human Breast Cancer In Loco. Adv Clin Exp Med, 25: 505-11, 2016

Yan, Y., Liu, L., Xiong, H., Miller, J.B., Zhou, K., Kos, P., Huffman, K.E., Elkassih, S., Norman, J.W., Carstens, R., Kim, J., Minna, J.D., Siegwart, D.J., Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells. Proc Natl Acad Sci U S A, 113: E5702-10, 2016

Frankel, A.E., Liu, X., Minna, J.D., Developing EZH2-Targeted Therapy for Lung Cancer. Cancer Discov, 6: 949-52, 2016

Topalovski, M., Hagopian, M., Wang, M., Brekken, R.A., Hypoxia and Transforming Growth Factor beta Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer. J Biol Chem, 291: 22244-22252, 2016

Larsen, J.E., Nathan, V., Osborne, J.K., Farrow, R.K., Deb, D., Sullivan, J.P., Dospoy, P.D., Augustyn, A., Hight, S.K., Sato, M., Girard, L., Behrens, C., Wistuba, II, Gazdar, A.F., Hayward, N.K., Minna, J.D., ZEB1 drives epithelial-to-mesenchymal transition in lung cancer. J Clin Invest, 126: 3219-35, 2016

Borromeo, M.D., Savage, T.K., Kollipara, R.K., He, M., Augustyn, A., Osborne, J.K., Girard, L., Minna, J.D., Gazdar, A.F., Cobb, M.H., Johnson, J.E., ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs. Cell Rep, 16: 1259-72, 2016

Minna, J.D., Johnson, J.E., Opening a Chromatin Gate to Metastasis. Cell, 166: 275-6, 2016

Girard, L., Rodriguez-Canales, J., Behrens, C., Thompson, D.M., Botros, I.W., Tang, H., Xie, Y., Rekhtman, N., Travis, W.D., Wistuba, II, Minna, J.D., Gazdar, A.F., An Expression Signature as an Aid to the Histologic Classification of Non-Small Cell Lung Cancer. Clin Cancer Res, 22: 4880-4889, 2016

Lammoglia, G.M., Van Zandt, C.E., Galvan, D.X., Orozco, J.L., Dellinger, M.T., Rutkowski, J.M., Hyperplasia, de novo lymphangiogenesis, and lymphatic regression in mice with tissue-specific, inducible overexpression of murine VEGF-D. Am J Physiol Heart Circ Physiol, 311: H384-94, 2016

Thu, K.L., Papari-Zareei, M., Stastny, V., Song, K., Peyton, M., Martinez, V.D., Zhang, Y.A., Castro, I.B., Varella-Garcia, M., Liang, H., Xing, C., Kittler, R., Milchgrub, S., Castrillon, D.H., Davidson, H.L., Reynolds, C.P., Lam, W.L., Lea, J., Gazdar, A.F., A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas. Oncotarget, 2016

Gazdar, A.F., Minna, J.D., Developing New, Rational Therapies for Recalcitrant Small Cell Lung Cancer. J Natl Cancer Inst, 108, 2016

Wang, Y.W., Ma, X., Zhang, Y.A., Wang, M.J., Yatabe, Y., Lam, S., Girard, L., Chen, J.Y., Gazdar, A.F., ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers. J Thorac Oncol, 11: 1469-81, 2016

Zhang, Z., Wodzak, M., Belzile, O., Zhou, H., Sishc, B., Yan, H., Stojadinovic, S., Mason, R.P., Brekken, R.A., Chopra, R., Story, M.D., Timmerman, R., Saha, D., Effective Rat Lung Tumor Model for Stereotactic Body Radiation Therapy. Radiat Res, 185: 616-22, 2016

Frink, R.E., Peyton, M., Schiller, J.H., Gazdar, A.F., Shay, J.W., Minna, J.D., Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner. Oncotarget, 7: 31639-51, 2016

Freimark, B.D., Gong, J., Ye, D., Gray, M.J., Nguyen, V., Yin, S., Hatch, M.M., Hughes, C.C., Schroit, A.J., Hutchins, J.T., Brekken, R.A., Huang, X., Antibody-Mediated Phosphatidylserine Blockade Enhances the Antitumor Responses to CTLA-4 and PD-1 Antibodies in Melanoma. Cancer Immunol Res, 4: 531-40, 2016

Regan, E., Sibley, R.C., Cenik, B.K., Silva, A., Girard, L., Minna, J.D., Dellinger, M.T., Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines. PLoS One, 11: e0150963, 2016

Martinez, E.D., Gazdar, A.F., Inhibiting the Jumonji family: a potential new clinical approach to targeting aberrant epigenetic mechanisms. Epigenomics, 8: 313-6, 2016

Cheng, X., Li, L., Thorpe, P.E., Yopp, A.C., Brekken, R.A., Huang, X., Antibody-Mediated Blockade of Phosphatidylserine Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinomas Xenografts. Ann Surg Oncol, 23: 583-591, 2016

Chen, B., Trang, V., Lee, A., Williams, N.S., Wilson, A.N., Epstein, E.H., Jr., Tang, J.Y., Kim, J., Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma. Mol Cancer Ther, 15: 866-76, 2016

Young, J.H., Peyton, M., Kim, H.S., McMillan, E., Minna, J.D., White, M.A., Marcotte, E.M., Computational Discovery of Pathway-Level Genetic Vulnerabilities in Non-Small-Cell Lung Cancer. Bioinformatics, 2016

Topalovski, M., Brekken, R.A., Matrix control of pancreatic cancer: New insights into fibronectin signaling. Cancer Lett, 381: 252-8, 2016

Hu, R., Huffman, K.E., Chu, M., Zhang, Y., Minna, J.D., Yu, Y., Quantitative Secretomic Analysis Identifies Extracellular Protein Factors that Modulate the Metastatic Phenotype of Non-Small Cell Lung Cancer. J Proteome Res, 2016

Zhang, Y.A., Ma, X., Sathe, A., Fujimoto, J., Wistuba, II, Lam, S., Yatabe, Y., Wang, Y.W., Stastny, V., Gao, B., Larsen, J.E., Girard, L., Liu, X., Song, K., Behrens, C., Kalhor, N., Xie, Y., Zhang, M.Q., Minna, J.D., Gazdar, A.F., Validation of SCT Methylation as a Hallmark Biomarker for Lung Cancers. J Thorac Oncol, 11: 346-60, 2016

Gazdar, A.F., Hirsch, F.R., Minna, J.D., From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers. J Thorac Oncol, 11: 287-99, 2016

Lam, D.C., Luo, S.Y., Fu, K.H., Lui, M.M., Chan, K.H., Wistuba, II, Gao, B., Tsao, S.W., Ip, M.S., Minna, J.D., Nicotinic acetylcholine receptor expression in human airway correlates with lung function. Am J Physiol Lung Cell Mol Physiol, 310: L232-9, 2016

Trost, N., Pena-Llopis, S., Koirala, S., Stojan, J., Potts, P.R., Fon Tacer, K., Martinez, E.D., gammaKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers. Oncotarget, 7: 2611-28, 2016

Lou, T.F., Sethuraman, D., Dospoy, P., Srivastva, P., Kim, H.S., Kim, J., Ma, X., Chen, P.H., Huffman, K.E., Frink, R.E., Larsen, J.E., Lewis, C., Um, S.W., Kim, D.H., Ahn, J.M., DeBerardinis, R.J., White, M.A., Minna, J.D., Yoo, H., Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker. Cancer Prev Res (Phila), 9: 43-52, 2016

Iacobas, I., Klepper, L., Kelly, J., Ferry, T., Dellinger, M.T., Meeting Report for the 2016 Conference on GLA and Gorham-Stout disease. BoneKEy, 13, 2016

Ludwig, K.F., Slone, T., Cederberg, K.B., Silva, A.T., Dellinger, M.T., A new case and review of chylothorax in generalized lymphatic anomaly and Gorham-Stout disease. Lymphology, 49: 73-84, 2016

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Hagopian, M.M., Brekken, R.A., Stromal TGFbetaR2 signaling: a gateway to progression for pancreatic cancer. Mol Cell Oncol, 2: e975606, 2015

Topalovski, M., Brekken, R.A., Matrix control of pancreatic cancer: New insights into fibronectin signaling. Cancer Lett, 2015

Gazdar, A.F., Hirsch, F.R., Minna, J.D., From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers. J Thorac Oncol, 2015

Wang, L., Kofler, M., Brosch, G., Melesina, J., Sippl, W., Martinez, E.D., Easmon, J., 2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity. PLoS One, 10: e0134556, 2015

Mastri, M., Rosario, S., Tracz, A., Frink, R.E., Brekken, R.A., Ebos, J.M., The challenges of modeling drug resistance to antiangiogenic therapy. Curr Drug Targets, 2015

Dearborn, J.T., Ramachandran, S., Shyng, C., Lu, J.Y., Thornton, J., Hofmann, S.L., Sands, M.S., Histochemical localization of palmitoyl protein thioesterase-1 activity. Mol Genet Metab, 2015

Wang, M., Topalovski, M., Toombs, J.E., Wright, C.M., Moore, Z.R., Boothman, D.A., Yanagisawa, H., Wang, H., Witkiewicz, A., Castrillon, D.H., Brekken, R.A., Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer. Cancer Res, 75: 5058-69, 2015

Trost, N., Pena-Llopis, S., Koirala, S., Stojan, J., Potts, P.R., Tacer, K.F., Martinez, E.D., gammaKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers. Oncotarget, 2015

Gerber, D.E., Hao, G., Watkins, L., Stafford, J.H., Anderson, J., Holbein, B., Oz, O.K., Mathews, D., Thorpe, P.E., Hassan, G., Kumar, A., Brekken, R.A., Sun, X., Tumor-specific targeting by Bavituximab, a phosphatidylserine-targeting monoclonal antibody with vascular targeting and immune modulating properties, in lung cancer xenografts. Am J Nucl Med Mol Imaging, 5: 493-503, 2015

Li, T., Aredo, B., Zhang, K., Zhong, X., Pulido, J.S., Wang, S., He, Y.G., Huang, X., Brekken, R.A., Ufret-Vincenty, R.L., Phosphatidylserine (PS) Is Exposed in Choroidal Neovascular Endothelium: PS-Targeting Antibodies Inhibit Choroidal Angiogenesis In Vivo and Ex Vivo. Invest Ophthalmol Vis Sci, 56: 7137-45, 2015

Bayo, J., Dalvi, M.P., Martinez, E.D., Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential. Future Med Chem, 7: 2243-61, 2015

Matharage, J.M., Minna, J.D., Brekken, R.A., Udugamasooriya, D.G., Unbiased Selection of Peptide-Peptoid Hybrids Specific for Lung Cancer Compared to Normal Lung Epithelial Cells. ACS Chem Biol, 10: 2891-9, 2015

Schneider, P., Bayo-Fina, J.M., Singh, R., Dhanyamraju, P.K., Holz, P., Baier, A., Fendrich, V., Ramaswamy, A., Baumeister, S., Martinez, E.D., Lauth, M., Corrigendum: Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1. Nat Commun, 6: 8741, 2015

Ocal, O., Pashkov, V., Kollipara, R.K., Zolghadri, Y., Cruz, V.H., Hale, M.A., Heath, B.R., Artyukhin, A.B., Christie, A.L., Tsoulfas, P., Lorens, J.B., Swift, G.H., Brekken, R.A., Wilkie, T.M., A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics. Dis Model Mech, 8: 1201-11, 2015

Pena, C.G., Nakada, Y., Saatcioglu, H.D., Aloisio, G.M., Cuevas, I., Zhang, S., Miller, D.S., Lea, J.S., Wong, K.K., DeBerardinis, R.J., Amelio, A.L., Brekken, R.A., Castrillon, D.H., LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment. J Clin Invest, 125: 4063-76, 2015

Duan, L., Rai, G., Roggero, C., Zhang, Q.J., Wei, Q., Ma, S.H., Zhou, Y., Santoyo, J., Martinez, E.D., Xiao, G., Raj, G.V., Jadhav, A., Simeonov, A., Maloney, D.J., Rizo, J., Hsieh, J.T., Liu, Z.P., KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes. Chem Biol, 22: 1185-96, 2015

Thinnes, C.C., Tumber, A., Yapp, C., Scozzafava, G., Yeh, T., Chan, M.C., Tran, T.A., Hsu, K., Tarhonskaya, H., Walport, L.J., Wilkins, S.E., Martinez, E.D., Muller, S., Pugh, C.W., Ratcliffe, P.J., Brennan, P.E., Kawamura, A., Schofield, C.J., Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases. Chem Commun (Camb), 51: 15458-61, 2015

Schneider, P., Bayo-Fina, J.M., Singh, R., Kumar Dhanyamraju, P., Holz, P., Baier, A., Fendrich, V., Ramaswamy, A., Baumeister, S., Martinez, E.D., Lauth, M., Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1. Nat Commun, 6: 8023, 2015

Huffman, K.E., Carstens, R., Martinez, E.D., A Subset of Nuclear Receptors are Uniquely Expressed in Uveal Melanoma Cells. Front Endocrinol (Lausanne), 6: 93, 2015

Kirane, A., Ludwig, K.F., Sorrelle, N., Haaland, G., Sandal, T., Ranaweera, R., Toombs, J.E., Wang, M., Dineen, S.P., Micklem, D., Dellinger, M.T., Lorens, J.B., Brekken, R.A., Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis. Cancer Res, 75: 3699-705, 2015

Lu, J.Y., Nelvagal, H.R., Wang, L., Birnbaum, S.G., Cooper, J.D., Hofmann, S.L., Intrathecal enzyme replacement therapy improves motor function and survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis. Mol Genet Metab, 116: 98-105, 2015

Neverman, N.J., Best, H.L., Hofmann, S.L., Hughes, S.M., Experimental therapies in the neuronal ceroid lipofuscinoses. Biochim Biophys Acta, 1852: 2292-300, 2015

Potts, M.B., McMillan, E.A., Rosales, T.I., Kim, H.S., Ou, Y.H., Toombs, J.E., Brekken, R.A., Minden, M.D., MacMillan, J.B., White, M.A., Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B. Nat Chem Biol, 11: 401-8, 2015

Gazdar, A.F., Savage, T.K., Johnson, J.E., Berns, A., Sage, J., Linnoila, R.I., MacPherson, D., McFadden, D.G., Farago, A., Jacks, T., Travis, W.D., Brambilla, E., The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. J Thorac Oncol, 10: 553-64, 2015

Chen, Y., Terajima, M., Yang, Y., Sun, L., Ahn, Y.H., Pankova, D., Puperi, D.S., Watanabe, T., Kim, M.P., Blackmon, S.H., Rodriguez, J., Liu, H., Behrens, C., Wistuba, II, Minelli, R., Scott, K.L., Sanchez-Adams, J., Guilak, F., Pati, D., Thilaganathan, N., Burns, A.R., Creighton, C.J., Martinez, E.D., Zal, T., Grande-Allen, K.J., Yamauchi, M., Kurie, J.M., Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest, 125: 1147-62, 2015

Wei, Z.W., Xia, G.K., Wu, Y., Chen, W., Xiang, Z., Schwarz, R.E., Brekken, R.A., Awasthi, N., He, Y.L., Zhang, C.H., CXCL1 promotes tumor growth through VEGF pathway activation and is associated with inferior survival in gastric cancer. Cancer Lett, 359: 335-43, 2015

Moore, Z., Chakrabarti, G., Luo, X., Ali, A., Hu, Z., Fattah, F.J., Vemireddy, R., DeBerardinis, R.J., Brekken, R.A., Boothman, D.A., NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by beta-lapachone. Cell Death Dis, 6: e1599, 2015

Tian, H., Lu, J.Y., Shao, C., Huffman, K.E., Carstens, R.M., Larsen, J.E., Girard, L., Liu, H., Rodriguez-Canales, J., Frenkel, E.P., Wistuba, II, Minna, J.D., Hofmann, S.L., Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5. Mol Cancer Res, 13: 784-94, 2015

Awasthi, N., Hinz, S., Brekken, R.A., Schwarz, M.A., Schwarz, R.E., Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer. Cancer Lett, 358: 59-66, 2015

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Dbouk, H.A., Weil, L.M., Perera, G.K., Dellinger, M.T., Pearson, G., Brekken, R.A., Cobb, M.H., Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK. Proc Natl Acad Sci U S A, 111: 15999-6004, 2014

Dunleavey, J.M., Xiao, L., Thompson, J., Kim, M.M., Shields, J.M., Shelton, S.E., Irvin, D.M., Brings, V.E., Ollila, D.W., Brekken, R.A., Dayton, P.A., Melero-Martin, J.M., Dudley, A.C., Vascular channels formed by subpopulations of PECAM1+ melanoma cells. Nat Commun, 5: 5200, 2014

Mateo, F., Meca-Cortes, O., Celia-Terrassa, T., Fernandez, Y., Abasolo, I., Sanchez-Cid, L., Bermudo, R., Sagasta, A., Rodriguez-Carunchio, L., Pons, M., Canovas, V., Marin-Aguilera, M., Mengual, L., Alcaraz, A., Schwartz, S., Jr., Mellado, B., Aguilera, K.Y., Brekken, R., Fernandez, P.L., Paciucci, R., Thomson, T.M., SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations. Mol Cancer, 13: 237, 2014

Augustyn, A., Borromeo, M., Wang, T., Fujimoto, J., Shao, C., Dospoy, P.D., Lee, V., Tan, C., Sullivan, J.P., Larsen, J.E., Girard, L., Behrens, C., Wistuba, II, Xie, Y., Cobb, M.H., Gazdar, A.F., Johnson, J.E., Minna, J.D., ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers. Proc Natl Acad Sci U S A, 111: 14788-93, 2014

Barone, A., Sengupta, R., Warrington, N.M., Smith, E., Wen, P.Y., Brekken, R.A., Romagnoli, B., Douglas, G., Chevalier, E., Bauer, M.P., Dembowsky, K., Piwnica-Worms, D., Rubin, J.B., Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma. Oncotarget, 5: 9811-22, 2014

Tran, T.A., Wichterman-Kouznetsova, J., Varghese, D., Huang, R., Huang, W., Becker, M., Austin, C.P., Inglese, J., Johnson, R.L., Martinez, E.D., Identification of small molecule modulators of gene transcription with anticancer activity. ACS Chem Biol, 9: 2603-11, 2014

Kim, J., Hsia, E.Y., Kim, J., Sever, N., Beachy, P.A., Zheng, X., Simultaneous measurement of smoothened entry into and exit from the primary cilium. PLoS One, 9: e104070, 2014

Ostapoff, K.T., Cenik, B.K., Wang, M., Ye, R., Xu, X., Nugent, D., Hagopian, M.M., Topalovski, M., Rivera, L.B., Carroll, K.D., Brekken, R.A., Neutralizing murine TGFbetaR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis. Cancer Res, 74: 4996-5007, 2014

Taguchi, A., Taylor, A.D., Rodriguez, J., Celiktas, M., Liu, H., Ma, X., Zhang, Q., Wong, C.H., Chin, A., Girard, L., Behrens, C., Lam, W.L., Lam, S., Minna, J.D., Wistuba, II, Gazdar, A.F., Hanash, S.M., A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets. Cancer Res, 74: 4694-705, 2014

Mathur, A., Ware, C., Davis, L., Gazdar, A., Pan, B.S., Lutterbach, B., FGFR2 is amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival. PLoS One, 9: e98515, 2014

Shao, C., Sullivan, J.P., Girard, L., Augustyn, A., Yenerall, P., Rodriguez-Canales, J., Liu, H., Behrens, C., Shay, J.W., Wistuba, II, Minna, J.D., Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway. Clin Cancer Res, 20: 4154-66, 2014

Gazdar, A., Robinson, L., Oliver, D., Xing, C., Travis, W.D., Soh, J., Toyooka, S., Watumull, L., Xie, Y., Kernstine, K., Schiller, J.H., Hereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutations. J Thorac Oncol, 9: 456-63, 2014

Leroy, B., Girard, L., Hollestelle, A., Minna, J.D., Gazdar, A.F., Soussi, T., Analysis of TP53 mutation status in human cancer cell lines: a reassessment. Hum Mutat, 35: 756-65, 2014

Hubers, A.J., van der Drift, M.A., Prinsen, C.F., Witte, B.I., Wang, Y., Shivapurkar, N., Stastny, V., Bolijn, A.S., Hol, B.E., Feng, Z., Dekhuijzen, P.N., Gazdar, A.F., Thunnissen, E., Methylation analysis in spontaneous sputum for lung cancer diagnosis. Lung Cancer, 84: 127-33, 2014

Dellinger, M.T., Garg, N., Olsen, B.R., Viewpoints on vessels and vanishing bones in Gorham-Stout disease. Bone, 63: 47-52, 2014

Yang, L., Kwon, J., Popov, Y., Gajdos, G.B., Ordog, T., Brekken, R.A., Mukhopadhyay, D., Schuppan, D., Bi, Y., Simonetto, D., Shah, V.H., Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology, 146: 1339-50 e1, 2014

Kim, D.J., Kim, J., Spaunhurst, K., Montoya, J., Khodosh, R., Chandra, K., Fu, T., Gilliam, A., Molgo, M., Beachy, P.A., Tang, J.Y., Open-Label, Exploratory Phase II Trial of Oral Itraconazole for the Treatment of Basal Cell Carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014

Delgado, O., Batten, K.G., Richardson, J.A., Xie, X.J., Gazdar, A.F., Kaisani, A.A., Girard, L., Behrens, C., Suraokar, M., Fasciani, G., Wright, W.E., Story, M.D., Wistuba, II, Minna, J.D., Shay, J.W., Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer. Clin Cancer Res, 20: 1610-22, 2014

D'Amico, G., Korhonen, E.A., Anisimov, A., Zarkada, G., Holopainen, T., Hagerling, R., Kiefer, F., Eklund, L., Sormunen, R., Elamaa, H., Brekken, R.A., Adams, R.H., Koh, G.Y., Saharinen, P., Alitalo, K., Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest, 124: 824-34, 2014

Gazdar, A.F., EGFR mutations in lung cancer: different frequencies for different folks. J Thorac Oncol, 9: 139-40, 2014

Brekken, R.A., Faulty ECM signaling facilitates autoimmune lymphomagenesis. Cancer Discov, 4: 25-6, 2014

Song, S.Y., Das, A.K., Minna, J.D., Comparison between concurrent and sequential chemoradiation for non-small cell lung cancer. Oncol Lett, 7: 307-310, 2014

Aguilera, K.Y., Rivera, L.B., Hur, H., Carbon, J.G., Toombs, J.E., Goldstein, C.D., Dellinger, M.T., Castrillon, D.H., Brekken, R.A., Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma. Cancer Res, 74: 1032-44, 2014

Zaganjor, E., Osborne, J.K., Weil, L.M., Diaz-Martinez, L.A., Gonzales, J.X., Singel, S.M., Larsen, J.E., Girard, L., Minna, J.D., Cobb, M.H., Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene, 33: 5457-66, 2014

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Wu, Q., Ishikawa, T., Sirianni, R., Tang, H., McDonald, J.G., Yuhanna, I.S., Thompson, B., Girard, L., Mineo, C., Brekken, R.A., Umetani, M., Euhus, D.M., Xie, Y., Shaul, P.W., 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. Cell Rep, 5: 637-45, 2013

Pikor, L.A., Lockwood, W.W., Thu, K.L., Vucic, E.A., Chari, R., Gazdar, A.F., Lam, S., Lam, W.L., YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway. Cancer Res, 73: 7301-12, 2013

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Meng, J., Majidi, M., Fang, B., Ji, L., Bekele, B.N., Minna, J.D., Roth, J.A., The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner. PLoS One, 8: e77067, 2013

Bu, D., Lewis, C.M., Sarode, V., Chen, M., Ma, X., Lazorwitz, A.M., Rao, R., Leitch, M., Moldrem, A., Andrews, V., Gazdar, A., Euhus, D., Identification of breast cancer DNA methylation markers optimized for fine-needle aspiration samples. Cancer Epidemiol Biomarkers Prev, 22: 2212-21, 2013

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Dellinger, M.T., Meadows, S.M., Wynne, K., Cleaver, O., Brekken, R.A., Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. PLoS One, 8: e74686, 2013

Coe, B.P., Thu, K.L., Aviel-Ronen, S., Vucic, E.A., Gazdar, A.F., Lam, S., Tsao, M.S., Lam, W.L., Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer. PLoS One, 8: e71670, 2013

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Myers, B.R., Sever, N., Chong, Y.C., Kim, J., Belani, J.D., Rychnovsky, S., Bazan, J.F., Beachy, P.A., Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Developmental Cell, 26: 346-57, 2013

Villalta, S.A., Lang, J., Kubeck, S., Kabre, B., Szot, G.L., Calderon, B., Wasserfall, C., Atkinson, M.A., Brekken, R.A., Pullen, N., Arch, R.H., Bluestone, J.A., Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function. Diabetes, 62: 2870-8, 2013

Dai, B., Yoo, S.Y., Bartholomeusz, G., Graham, R.A., Majidi, M., Yan, S., Meng, J., Ji, L., Coombes, K., Minna, J.D., Fang, B., Roth, J.A., KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer. Cancer Res, 73: 5532-43, 2013

Wang, L., Chang, J., Varghese, D., Dellinger, M., Kumar, S., Best, A.M., Ruiz, J., Bruick, R., Pena-Llopis, S., Xu, J., Babinski, D.J., Frantz, D.E., Brekken, R.A., Quinn, A.M., Simeonov, A., Easmon, J., Martinez, E.D., A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun, 4: 2035, 2013

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Ma, X., Wang, Y.W., Zhang, M.Q., Gazdar, A.F., DNA methylation data analysis and its application to cancer research. Epigenomics, 5: 301-16, 2013

Bennett, K.M., Afanador, M.D., Lal, C.V., Xu, H., Persad, E., Legan, S.K., Chenaux, G., Dellinger, M., Savani, R.C., Dravis, C., Henkemeyer, M., Schwarz, M.A., Ephrin-B2 reverse signaling increases alpha5beta1 integrin-mediated fibronectin deposition and reduces distal lung compliance. Am J Respir Cell Mol Biol, 49: 680-7, 2013

Kutluk Cenik, B., Ostapoff, K.T., Gerber, D.E., Brekken, R.A., BIBF 1120 (nintedanib), a triple angiokinase inhibitor, induces hypoxia but not EMT and blocks progression of preclinical models of lung and pancreatic cancer. Mol Cancer Ther, 12: 992-1001, 2013

Ding, L.H., Park, S., Peyton, M., Girard, L., Xie, Y., Minna, J.D., Story, M.D., Distinct transcriptome profiles identified in normal human bronchial epithelial cells after exposure to gamma-rays and different elemental particles of high Z and energy. BMC Genomics, 14: 372, 2013

Hooda, J., Cadinu, D., Alam, M.M., Shah, A., Cao, T.M., Sullivan, L.A., Brekken, R., Zhang, L., Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells. PLoS One, 8: e63402, 2013

Ostapoff, K.T., Awasthi, N., Cenik, B.K., Hinz, S., Dredge, K., Schwarz, R.E., Brekken, R.A., PG545, an angiogenesis and heparanase inhibitor, reduces primary tumor growth and metastasis in experimental pancreatic cancer. Mol Cancer Ther, 12: 1190-201, 2013

Osborne, J.K., Larsen, J.E., Shields, M.D., Gonzales, J.X., Shames, D.S., Sato, M., Kulkarni, A., Wistuba, II, Girard, L., Minna, J.D., Cobb, M.H., NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM. Proc Natl Acad Sci U S A, 110: 6524-9, 2013

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Currier, M.A., Eshun, F.K., Sholl, A., Chernoguz, A., Crawford, K., Divanovic, S., Boon, L., Goins, W.F., Frischer, J.S., Collins, M.H., Leddon, J.L., Baird, W.H., Haseley, A., Streby, K.A., Wang, P.Y., Hendrickson, B.W., Brekken, R.A., Kaur, B., Hildeman, D., Cripe, T.P., VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells. Mol Ther, 21: 1014-23, 2013

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Kim, H.S., Minna, J.D., White, M.A., GWAS meets TCGA to illuminate mechanisms of cancer predisposition. Cell, 152: 387-9, 2013

Konstantinidou, G., Ramadori, G., Torti, F., Kangasniemi, K., Ramirez, R.E., Cai, Y., Behrens, C., Dellinger, M.T., Brekken, R.A., Wistuba, II, Heguy, A., Teruya-Feldstein, J., Scaglioni, P.P., RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas. Cancer Discov, 3: 444-57, 2013

Tang, H., Xiao, G., Behrens, C., Schiller, J., Allen, J., Chow, C.W., Suraokar, M., Corvalan, A., Mao, J., White, M.A., Wistuba, II, Minna, J.D., Xie, Y., A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients. Clin Cancer Res, 19: 1577-86, 2013

Said, N., Frierson, H.F., Sanchez-Carbayo, M., Brekken, R.A., Theodorescu, D., Loss of SPARC in bladder cancer enhances carcinogenesis and progression. J Clin Invest, 123: 751-66, 2013

Kim, J., Aftab, B.T., Tang, J.Y., Kim, D., Lee, A.H., Rezaee, M., Kim, J., Chen, B., King, E.M., Borodovsky, A., Riggins, G.J., Epstein, E.H., Jr., Beachy, P.A., Rudin, C.M., Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell, 23: 23-34, 2013

Li, X., Zhou, Q., Hanus, J., Anderson, C., Zhang, H., Dellinger, M., Brekken, R., Wang, S., Inhibition of multiple pathogenic pathways by histone deacetylase inhibitor SAHA in a corneal alkali-burn injury model. Mol Pharm, 10: 307-18, 2013

Yoshida, K., Sato, M., Hase, T., Elshazley, M., Yamashita, R., Usami, N., Taniguchi, T., Yokoi, K., Nakamura, S., Kondo, M., Girard, L., Minna, J.D., Hasegawa, Y., TIMELESS is overexpressed in lung cancer and its expression correlates with poor patient survival. Cancer Sci, 104: 171-7, 2013

Byers, L.A., Diao, L., Wang, J., Saintigny, P., Girard, L., Peyton, M., Shen, L., Fan, Y., Giri, U., Tumula, P.K., Nilsson, M.B., Gudikote, J., Tran, H., Cardnell, R.J., Bearss, D.J., Warner, S.L., Foulks, J.M., Kanner, S.B., Gandhi, V., Krett, N., Rosen, S.T., Kim, E.S., Herbst, R.S., Blumenschein, G.R., Lee, J.J., Lippman, S.M., Ang, K.K., Mills, G.B., Hong, W.K., Weinstein, J.N., Wistuba, II, Coombes, K.R., Minna, J.D., Heymach, J.V., An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin Cancer Res, 19: 279-90, 2013

Travis, W.D., Brambilla, E., Noguchi, M., Nicholson, A.G., Geisinger, K., Yatabe, Y., Ishikawa, Y., Wistuba, I., Flieder, D.B., Franklin, W., Gazdar, A., Hasleton, P.S., Henderson, D.W., Kerr, K.M., Petersen, I., Roggli, V., Thunnissen, E., Tsao, M., Diagnosis of lung cancer in small biopsies and cytology: implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. Arch Pathol Lab Med, 137: 668-84, 2013

Dasgupta, S., Jang, J.S., Shao, C., Mukhopadhyay, N.D., Sokhi, U.K., Das, S.K., Brait, M., Talbot, C., Yung, R.C., Begum, S., Westra, W.H., Hoque, M.O., Yang, P., Yi, J.E., Lam, S., Gazdar, A.F., Fisher, P.B., Jen, J., Sidransky, D., SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling. J Mol Med (Berl), 91: 381-93, 2013

Sunaga, N., Kaira, K., Imai, H., Shimizu, K., Nakano, T., Shames, D.S., Girard, L., Soh, J., Sato, M., Iwasaki, Y., Ishizuka, T., Gazdar, A.F., Minna, J.D., Mori, M., Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer. Oncogene, 32: 4034-42, 2013

Travis, W.D., Brambilla, E., Noguchi, M., Nicholson, A.G., Geisinger, K., Yatabe, Y., Ishikawa, Y., Wistuba, I., Flieder, D.B., Franklin, W., Gazdar, A., Hasleton, P.S., Henderson, D.W., Kerr, K.M., Nakatani, Y., Petersen, I., Roggli, V., Thunnissen, E., Tsao, M., Diagnosis of lung adenocarcinoma in resected specimens: implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. Arch Pathol Lab Med, 137: 685-705, 2013

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Kirane, A., Toombs, J.E., Ostapoff, K., Carbon, J.G., Zaknoen, S., Braunfeld, J., Schwarz, R.E., Burrows, F.J., Brekken, R.A., Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer. Clin Cancer Res, 18: 5031-42, 2012

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Hezel, A.F., Deshpande, V., Zimmerman, S.M., Contino, G., Alagesan, B., O'Dell, M.R., Rivera, L.B., Harper, J., Lonning, S., Brekken, R.A., Bardeesy, N., TGF-beta and alphavbeta6 integrin act in a common pathway to suppress pancreatic cancer progression. Cancer Res, 72: 4840-5, 2012

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Yao, Y., Fan, Y., Wu, J., Wan, H., Wang, J., Lam, S., Lam, W.L., Girard, L., Gazdar, A.F., Wu, Z., Zhou, Q., Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis. Biochem Biophys Res Commun, 423: 613-9, 2012

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