Veterinary Clinical Trials
Clinical trials at VROC help evaluate new cancer treatments for pets by assessing their safety, effectiveness, and potential side effects. Participation is entirely voluntary, and the decision to enroll your pet is yours. However, enrollment in a clinical trial is required for a patient to be seen in our clinic.
Our studies build upon the current standard of care using the same advanced technologies available in leading specialty pet cancer hospitals. While specific outcomes cannot be guaranteed, our team is committed to providing the highest standard of veterinary oncology care throughout each trial.
For questions or to learn more about available studies, please contact Paige Neumann, Research Study Coordinator, at 214-645-6221 or by VROC@UTSouthwestern.edu.
Current Trials
Brain cancer clinical trials for dogs and cats
Safety and Therapeutic Efficacy of CAR-Neutrophils Combined with Radiation in Dogs with Glioma: This trial will evaluate the combination of CAR-neutrophils with radiation in dogs with glioma to induce tumor shrinkage and improve overall survival. View trial
Safety and Efficacy of Ferumoxytol in Combination with Radiation Therapy in Dogs with Glioma: This trial will evaluate the combination of ferumoxytol with radiation in glioma-bearing canines for reprogramming the tumor microenvironment, inducing tumor cell destruction, and improving radiation therapy. View trial
Other cancer clinical trials for dogs and cats
Veterinary Clinical Trials in Canine Patients Using Combination Novel Therapeutics, Devices, and Data Collection Techniques: This trial will utilize focused ultrasound (FUS), radiotherapy, novel drug combinations, immunotherapy and other therapeutic techniques to treat canines and felines with spontaneous tumors. View trial
Evaluation of Weekly Intratumoral Cow Pea Mosaic Virus (CPMV) in Dogs with Solid Tumors: This trial will assess the safety, feasibility, and immunotherapeutic effects of intratumoral administration of CPMV in dogs with naturally occurring solid tumors. View trial
Radiation and Histotripsy in Dogs and Cats with Solid Tumors: This trial will assess the safety and tumor response of combined radiation therapy (RT) and high-intensity focused ultrasound (HIFU) histotripsy in dogs with naturally occurring soft tissue sarcoma. View trial
Evaluation of Calreticulin-Nanoparticles (CRT-NP) and HIFU Immunotherapy with or without Anti-PD-L1 in Canine Melanoma: This trial will evaluate the anti-tumor immunity of CRT-NP-based immunotherapy combined with HIFU, with or without anti-PD-L1 therapy, in dogs with advanced, naturally occurring melanoma. View trial
Intratumoral vs. Intravenous Carboplatin +/- HIFU in Canine Melanoma: This trial will assess the safety, tumor response, and delivery of carboplatin administered intratumorally (nanoparticle/microparticle formulation) vs. intravenously with or without HIFU enhancement.
View trial
Prospective Non-Randomized Single-Arm Compassionate-Use Protocol for Advanced Non-Resectable Tumors in Dogs and Cats: This trial will evaluate tolerability, quality of life, and tumor immunomodulation in dogs and cats treated with investigational therapy, chemotherapy, immunotherapy, and combination approaches. View trial
