Pediatric Pulmonary & Vascular Biology Research

The need for aggressive research in pulmonary and vascular biology is clear.

Cardiovascular disease is responsible for 18 million deaths each year worldwide, and across the globe, the lives of over 460 million are threatened by Type 2 diabetes. Endothelial cells make up the single cell lining of larger blood vessels and are the sole cell type found in capillaries, dictating vascular function and macromolecule exchange between the blood and the tissues.

Research Labs

Krishnan Lab

Using the first preclinical model of anemia-transfusion in the newborn, the Krishnan Lab addresses longstanding controversies about the contributions of anemia versus its treatment, transfusion, to necrotizing enterocolitis (NEC), systemic inflammatory response syndrome (SIRS), and neuroinflammation.

Callaway Lab

Using a neonatal mouse mechanical ventilation technique, unique transgenic mouse models, and cutting-edge imaging and informatics, the Callaway Lab is working to discover how type 1 pulmonary epithelial cells (AT1) and the lung as a whole respond to mechanical force-related injury, leading to abnormal development and human neonatal lung disease.

Lee Lab

The Lee Lab leverages human genetic data to identify and validate novel genetic factors influencing cardiovascular health and disease through studies in human cell culture and mouse models.

Shaul-Mineo Lab

The Shaul-Mineo Lab seeks to fill key gaps in our understanding of how mechanisms in endothelial cells contribute to cardiovascular and metabolic health and disease.