News
Children’s Research Institute at UT Southwestern identifies metabolic inflexibility that keeps damage at bay during liver regeneration
Liver cells have a vital metabolic inflexibility during regeneration to starve dysfunctional cells and keep damage from spreading, according to new research from Children’s Medical Center Research Institute at UT Southwestern (CRI) published in Science.
Socioeconomic status affects survival of children with cancer
Socioeconomic factors can influence the diagnosis and treatment of children in Texas with malignant solid tumors, increasing the risk of the cancer’s spread and lowering the five-year survival rate, according to researchers at UT Southwestern Medical Center.
Children’s Research Institute at UT Southwestern discovers tumor growth fueled by nucleotide salvage
Cancer cells salvage purine nucleotides to fuel tumor growth, including purines in foods we eat, an important discovery with implications for cancer therapies from research by Children’s Medical Center Research Institute at UT Southwestern published in Cell.
UTSW study identifies RNA molecule that regulates cellular aging
A team led by UT Southwestern Medical Center researchers has discovered a new way that cells regulate senescence, an irreversible end to cell division. The findings, published in Cell, could one day lead to new interventions for a variety of conditions associated with aging, including neurodegenerative and cardiovascular diseases, diabetes, and cancer, as well as new therapies for a collection of diseases known as ribosomopathies.
Research could lead to treatments for obesity, extreme weight loss
Mysterious cells that secrete hormones in the large intestine play a key role in regulating body weight through their relationship with intestinal bacteria, a study led by UT Southwestern Medical Center researchers suggests. Their findings, published in Nature Metabolism, could lead to new treatments for obesity and extreme weight loss.
UT System initiative funds trauma research to improve care
A new initiative funded by The University of Texas System and the state of Texas seeks to improve care for trauma patients.
Tumor mutations may not predict response to immunotherapy
The number of mutations in the DNA of cancerous tumors may not be an indicator of how well patients will respond to immune checkpoint inhibitors (ICIs), a commonly prescribed type of immunotherapy, a team led by UT Southwestern Medical Center reported in a retrospective study.
Fibromyalgia, IBS patients linked to multiple-drug intolerance
Patients with fibromyalgia and irritable bowel syndrome (IBS) who take multiple medications are more likely to develop severe drug intolerance than healthy patients, UT Southwestern Medical Center researchers reported.
Children’s Health and UT Southwestern receive $100 million donation from the Pogue family for new $5 billion Dallas pediatric campus
Children's HealthSM and UT Southwestern Medical Center on Wednesday announced a historic gift of $100 million from the Jean and Mack Pogue family in support of the $5 billion transformative new Dallas pediatric campus, unveiled earlier this year. The gift from the Pogue Foundation is one of only four $100 million philanthropic gifts ever publicly announced in North Texas, and it is the largest donation yet to the new pediatric campus project, which will replace the existing Children’s Medical Center Dallas.
Mutations protected mice from B-cell cancers
By completely or even partially depleting a protein called midnolin in B cells, UT Southwestern Medical Center researchers suppressed leukemia and lymphoma in a mouse model genetically prone to these cancers.