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Our Impact

The Center provides a valuable resource for investigative endeavors in pulmonary and vascular biology (PVB) across the UT Southwestern campus. This is represented by active collaborations between PVB faculty and UT Southwestern faculty, including those from the O’Donnell School of Public Health and Departments such as:

  • Internal Medicine
  • Cell Biology
  • Physiology
  • Pharmacology
  • Biophysics

PVB researchers also collaborate with faculty in the Department of Biomedical Engineering at the University of Texas at Dallas and other institutions, and PVB faculty participate in numerous training grants across the campus.

2024 Impact

  • By the Numbers 2024

    By the Numbers 2024

    Faculty and Staff icon

    Faculty

    • 7 faculty
    Doctors in Training icon

    Education

    • 2 graduate students
    • 3 postdoctoral fellows
    Clinical Studies Icon

    Research

    • AWARDNUM active awards
    • $1,027,413 total funding from grants (FY25)
    • 2 active awards
    • 1 lab and data study
    • 7 publications
    • 1,218 citations
  • Honors and Awards

    Honors and Awards

    • Mohan Krishnan
      • NIH/NHLBI (2023-2027), R01 HL163043: Liver-Gut Axis in Neonatal Anemia and Its Role in RBC Transfusion Associated Gut Injury
      • NIH/NICHD (2024-2029), R01 HD116950: RBC-transfusion exacerbates brain inflammation in anemic murine neonates and causes long-term neurodevelopment impairment.
    • Danielle Callaway
      • Parker B Francis Fellowship Award, 2022
      • K08 Mentored Clinical Scientist Research Career Development Award, 2024
    • Vivian Lee
      • NIH NHLBI K99/R00 Pathway to Independence Award - 2022-2027
      • Brigham and Women's Hospital Lerner Junior Faculty Award - 2023
    • Philip Shaul/Chieko Mineo
      • NIH/NHLBI (2023-2027), R01 DK130961: Novel role of cholesterol and SR-BI in adipocyte biology
      • NIH/NHLBI (2024-2027), R01 HL168276: Novel role of endothelial breakpoint cluster region protein in vascular health and disease
      • NIH/NHLBI (2025-2029), R01 HL181134: Endothelial cell SR-BI regulation and novel protein partners in atherosclerosis
  • Top Peer-Reviewed Publications and Book Chapters

    Top Peer-Reviewed Publications and Book Chapters

    • MohanKumar K, Namachivayam K, Song T, Cha BJ, Slate A, Hendrickson JE, Pan H, Wickline SA, Oh JY, Patel RP, Torres BA, Maheshwari A. A Novel Murine Model of Necrotizing Enterocolitis Caused by Anemia and Red Blood Cell Transfusion. Nat Commun; 2019; 10(1): 3494. PMID:31375667.
    • Namachivayam K, MohanKumar K, Shores DR, Jain SK, Fundora J, Everett AD, He L, Pan H, Wickline SA, and Maheshwari A. Targeted Inhibition of thrombin attenuates murine neonatal necrotizing enterocolitis. Proc Natl Acad Sci. 2020 May 19:117(20):10958-10969. PMID:32366656.
    • Callaway DA, Penkala IJ, Zhou S, Cardenas-Diaz FL, Babu A, Lopes M, Garcia BA, Morley MP, Morrisey EE. TGFβ controls alveolar type 1 epithelial cell plasticity and alveolar matrisome gene transcription. JCI. 2024 Jan 11;134(6):e172095. PMID: 38488000. Also see journal commentary PMID: 38488005.
    • Callaway D, Jiang W, Lingappan K, Moorthy B. Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone, and differential sex-specific effects. Free Radic Biol Med. 2020 Aug; 160: 208-218. PMID: 32791187 PMCID: PMC7704914.
    • Lee VS, Halabi CM, Hoffman EP, Carmichael N, Leshchiner I, Lian CG, Bierhals AJ, Vuzman D; Brigham Genomic Medicine; Mecham RP, Frank NY, Stitziel NO. Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8759-64. doi: 10.1073/pnas.1601442113. Epub 2016 Jul 18. PMID: 27432961; PMCID: PMC4978273.
    • Yu L, Xu L, Chu H, Peng J, Sacharidou A, Hsieh H-H, Weinstock A, Khan S, Ma L, Barcia Duran JG, McDonald J, Nelson ER, Park S, McDonnell DP, Moore KJ, Huang LJ, Fisher EA, Mineo C, Huang L, and Shaul PW. Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice. Nat. Commun. 14:4101, 2023. PMID: 37491347.
    • Sacharidou A, Chambliss K, Peng J, Barrera J, Tanigaki K, Luby-Phelps K, Oezdemir I, Khan S, Sirsi S, Kim SH, Katzenellenbogen BS, Katzenellenbogen JA, Kanchwala M, Sathe AA, Lemoff A, Xing C, Hoyt K, Mineo C, Shaul PW. Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle. Nat. Commun. 14:4989, 2023. PMID: 37591837.
    • Sacharidou A, Chambliss KL, Peng J, Tanigaki K, Islam MN, Sirsi S, Lemoff A, Hoyt K, Mineo C, Shaul PW. Apolipoprotein E receptor 2 in endothelium promote glucose tolerance by mediating insulin delivery to skeletal muscle. Mol. Metab. 101:102238, 2025. PMID: 40907945.
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