Available Postdoctoral Positions

Ocular Genetics, Genomics, & Therapeutics

A postdoctoral training opportunity in ocular genetics and genomics is now available in the laboratory of V. Vinod Mootha, M.D. in the Department of Ophthalmology and the McDermott Center for Human Growth and Development at UT Southwestern Medical Center:

The Mootha Lab studies the molecular genetic basis of a common age-related eye disease called Fuchs’ endothelial corneal dystrophy. Fuchs’ dystrophy is the most common DNA trinucleotide repeat expansion disorder in humans and the leading indication for corneal transplantation in the United States. Dr. Mootha has elucidated that CUG repeat RNA is the “root cause” of Fuchs’ Dystrophy in a majority of cases. He has collaborated with David Corey, Ph.D. in the Departments of Pharmacology and Biochemistry at UT Southwestern Medical Center to pioneer the development of antisense oligonucleotide and duplex RNA therapeutics for this debilitating degenerative corneal disease: https://www.utsouthwestern.edu/labs/mootha/

The candidate will work on a project aimed to understand the cell type specificity of repeat expansion disorders and the molecular events linking CUG repeat RNA accumulation to end-stage Fuchs’ dystrophy. The candidate will also participate in pre-clinical development of oligonucleotide therapeutics for eye disease. The candidate will have access to patient derived cell-, patient derived tissue-, and mouse- model systems to study repeat RNA mediated corneal and neurodegenerative disease. This is an exciting opportunity for a candidate to gain expertise in human genetics, genomics molecular genetics, transcriptomic methods, imaging of the mouse eye, and pre-clinical development of oligonucleotide and gene therapies.

The ideal candidate will hold a Ph.D. and/or M.D. degree and have strong cell and molecular biology skills. Information on our postdoctoral training program, benefits, and a virtual tour can be found at Postdoctoral Scholars page.

Interested applicants should email a CV, a brief statement of research interests and goals, and a list of three references to:


V. Vinod Mootha, MD
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390-9057
vinod.mootha@utsouthwestern.edu
Venkateswara Mootha, M.D. - Faculty Profile - UT Southwestern
https://www.utsouthwestern.edu/labs/mootha/

 

Statistical Genomics & Genetics

A postdoctoral training opportunity is now available in the Bioinformatics Lab in the McDermott Center for Human Growth and Development at UT Southwestern Medical Center at Dallas. We are currently accepting applications for a postdoctoral fellowship in statistical genomics, genetics, and computational biology. https://labs.utsouthwestern.edu/bioinformatics-lab

We seek highly motivated individuals with strong problem-solving skills to develop, implement and apply innovative approaches for analyzing high throughput genetic and genomic data. Multiple project directions are available in statistical genetics (such as genetic epidemiology study in diverse, multi-ancestry datasets using genome-wide sequencing data, gene-environment interaction, meta-analysis) and genomics (such as single-cell omics analysis, multi-omics data integration, network analysis).

The training activities of this position will include data management, analysis, development and/or implementation of novel analytical approaches and bioinformatics tools for data analysis, implementation of pipelines, interpretation and presentation of analysis results, and writing manuscripts.

https://labs.utsouthwestern.edu/xing-lab
https://profiles.utsouthwestern.edu/profile/92824/chao-xing.html

Requirements:
Candidates with Ph.D. in statistics, biostatistics, epidemiology, computational biology, bioinformatics, or biology with advanced sequencing data analysis skills are encouraged to apply.

Information on our postdoctoral training program, benefits, and a virtual tour can be found at http://www.utsouthwestern.edu/postdocs.

Interested individuals should send a CV, cover letter briefly describing previous research experience, summary of current research interests, and list of three references to:

Chao Xing, PhD
chao.xing@UTSouthwestern.edu

Genetics of Autism Spectrum Disorder 

A postdoctoral training opportunity is now available in the laboratory of Dr. Maria Chahrour in the Eugene McDermott Center for Human Growth and Development and the Department of Neuroscience at UT Southwestern Medical Center.

https://profiles.utsouthwestern.edu/profile/159554/maria-chahrour.html 

Our laboratory has several exciting projects investigating the genetics of autism spectrum disorder and the underlying molecular mechanisms.  We seek highly motivated, creative, and independent individuals with a background in Molecular Neuroscience, Mouse Genetics, and Biochemistry. Strong communication and writing skills, and a willingness to work in a collaborative, interdisciplinary environment are also required. For more information about the lab, please visit: http://chahrourlab.org/index.html 

Requirements:

  1. Candidates must have a recent Ph.D. in Neuroscience, Genetics, or a related field, with less than two years of prior postdoctoral experience, and a demonstrated track record with at least one first author publication
  2. Strong background and expertise in neuroscience, molecular biology, biochemistry, microscopy, and mouse genetics

Information on our postdoctoral training program and benefits can be found in our Postdoc Handbook or at http://www.utsouthwestern.edu/postdocs.  

Interested individuals should send a CV, cover letter briefly describing previous research experience, summary of current research interests, and list of three references to: 

Maria Chahrour, PhD
UT Southwestern Medical Center
5323 Harry Hines Blvd
Dallas, Texas 75390-9057
Maria.Chahrour@UTSouthwestern.edu

Genetics of Fatty Liver Disease

A postdoctoral position is available immediately in the laboratory of Drs. Helen H. Hobbs and Jonathan C. Cohen at the University of Texas Southwestern Medical Center (UT Southwestern) in Dallas. The candidate will study the molecular and metabolic mechanisms underlying fatty liver disease. The overall goal of the project is to determine how genetic variants and environmental stressors trigger inflammatory and fibrotic responses that lead to liver cirrhosis and hepatocellular carcinoma. The candidate will have the opportunity to integrate human genetics with basic cell and molecular biology approaches using animal models and human tissues.

A Ph.D., M.D. and/or equivalent doctoral degree with experience in cellular and molecular biology is essential. The candidate will also be provided with significant training in various technologies (CRISPR/Cas9-mediated genetic manipulation, lipid mass spectrometry, single-cell sequencing), as well as significant mentoring to facilitate their transition to an independent research career.

Interested individuals are encouraged to forward a curriculum vitae, a list of three references, and a statement of research interests and career goals to:

Jonathan Cohen, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, Texas 75390-8591
Jonathan.Cohen@utsouthwestern.edu
Hobbs-Cohen Lab

(posted 2018-07)

UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. In accordance with federal and state law, the University prohibits unlawful discrimination, including harassment, on the basis of: race; color; religion; national origin; sex, including sexual harassment; age; disability; genetic information; citizenship status; and protected veteran status. In addition, it is UT Southwestern policy to prohibit discrimination on the basis of sexual orientation, gender identity, or gender expression.