Basic science research in the Division of Digestive and Liver Diseases focuses on inflammation and injury, metabolism, and cancer biology. See faculty profiles for further detail.
Ezra Burstein, M.D., Ph.D.
Research Interests: COMMD proteins: We study the regulation of endosomal protein sorting and immune function by members of this protein family. Genetics of inflammatory disorders: Our lab investigates the genetic basis of disorders of immune function, particularly affecting the GI tract Mucosal immunity and immune-tumor interactions in the GI tract.
Burstein Research Lab
Jeffrey D. Browning, M.D.
Research Interests:Pathogenesis of Non-Alcoholic Fatty Liver Disease
Jay Horton, M.D.
Research Interests: Hepatic steatosis, Lipid metabolism
Josephine Ni, M.D.
Research Interests: Our goal is to predictably engineer the microbiota to treat intestinal diseases using a pipeline based on next-generation sequencing of patient-derived samples coupled with bacterial genetics.
Ni Research Lab
Suraj Patel, M.D., Ph.D.
Research Interests: The Patel laboratory asks fundamental questions about how the liver works, and by doing so we hope to gain new insights into the metabolic causes and consequences of liver disease with the ultimate goal of developing new clinical therapies. Our laboratory has a particular interest in hepatic metabolism and its regulation by the immune system. We utilize genetic, epigenetic and proteomic approaches, combined with detailed physiological studies, to understand the complex mechanisms that causally link inflammation to metabolic dysfunction in obesity and fatty liver disease.
Patel Research Lab
Hans-Christian Reinecker, M.D.
Research Interests: Control of adaptive host-defenses by Schlafen family proteins. Controlling innate and adaptive immune responses by Sensor Stimulator of Interferon Genes (STING). Developing strategies to induce anti-tumor immunity for cancer immunotherapy. Targeting intracellular microtubule based microbial pattern recognition to control disease mechanisms of Inflammatory Bowel Diseases.
Reinecker Research Lab