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Our Laboratory

Focuses on understanding the regulation of the inflammatory response at a molecular level, and elucidating how these events may participate in human disease.

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Intestinal inflammation

We are particularly interested in pathways that regulate inflammation in the gastrointestinal mucosa and their potential role in the pathogenesis of inflammatory bowel disease.

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NF-κB

We are specifically interested in understanding the regulation of NF-κB, a transcription factor essential for the inflammatory response. We are particularly focused on elucidating pathways that terminate NF-κB activity. This has led us to uncover a critical role for the factor COMMD1 in the termination of NF-κB through ubiquitin-mediated degradation.

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COMMD proteins

Elucidating the range of activities of COMMD proteins and their underlying mechanism of action through a combination of genetic, biochemical and molecular approaches.

Research

Our work has identified specific pathways for the termination of NF-κB mediated transcription that involve the ubiquitination and proteasomal degradation of this transcription factor.

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