Focuses on understanding the regulation of the inflammatory response at a molecular level, and elucidating how these events may participate in human disease.
We are particularly interested in pathways that regulate inflammation in the gastrointestinal mucosa and their potential role in the pathogenesis of inflammatory bowel disease.
We are specifically interested in understanding the regulation of NF-κB, a transcription factor essential for the inflammatory response. We are particularly focused on elucidating pathways that terminate NF-κB activity. This has led us to uncover a critical role for the factor COMMD1 in the termination of NF-κB through ubiquitin-mediated degradation.
Elucidating the range of activities of COMMD proteins and their underlying mechanism of action through a combination of genetic, biochemical and molecular approaches.
Our work has identified specific pathways for the termination of NF-κB mediated transcription that involve the ubiquitination and proteasomal degradation of this transcription factor.