Tumor heterogeneity

We are interested in understanding the mechanisms that give rise to phenotypic heterogeneity of pancreatic tumors and their responses to therapy.


Tumor metastasis

Metastasis is a critical barrier to therapy and survival in most cancers. We have developed novel model systems and approaches to understand the key factors that drive metastatic spread in pancreas cancer and design therapies to halt tumor spread.


Clonal evolution

We are particularly interested in identifying and characterizing the properties of cell populations that drive normal pancreas growth, tumor formation, and metastasis.


Our work combines novel genetic models, bioinformatics approaches, and human biospecimens to understand the mechanisms driving tumor heterogeneity and metastasis in cancer