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Tumors are diverse eco-systems comprised of many different cell types that function together to drive progression and therapy resistance. The Maddipati laboratory is broadly interested in understanding how this cellular and molecular heterogeneity develops and impacts on tumor formation, metastatic progression, and therapy.  Our laboratory combines fundamental developmental biology tools, such as lineage tracing in genetically engineered mouse models, with bioinformatic approaches, CRISPR screening tools, bioengineered systems, and clinical specimens to study the functional consequences of tumor heterogeneity in pancreatic cancer.