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The number of mutations in the DNA of cancerous tumors may not be an indicator of how well patients will respond to immune checkpoint inhibitors (ICIs), a commonly prescribed type of immunotherapy, a team led by UT Southwestern Medical Center reported in a retrospective study.

Delivering genetic material tagged with a cellular “ZIP code” prompted cells to secrete proteins or drugs into the bloodstream that successfully treated psoriasis and cancer in mouse models, UT Southwestern Medical Center scientists report in a new study.

Researchers have long known that outcomes for alcohol-associated liver disease (ALD) aren’t equal among all races and ethnicities in the U.S., but differences among these groups have been less clear.

For decades, researchers have assumed that women taking oral contraceptives have stable levels of sex hormones over each monthly cycle. However, a new study in the American Journal of Physiology-Endocrinology and Metabolism led by Yasin Dhaher, Ph.D., Professor of Physical Medicine & Rehabilitation and Orthopaedic Surgery at UT Southwestern Medical Center, shows that the opposite is true.

The traditional lipid panel may not give the full picture of cholesterol-related heart disease risk for many Americans, according to a study led by UT Southwestern Medical Center researchers and published in JAMA Cardiology.

Two genes working in tandem play a critical role in shaping the identity and behavior of prostate cancer cells and their response to treatment, UT Southwestern Medical Center researchers report.

A new initiative funded by The University of Texas System and the state of Texas seeks to improve care for trauma patients.

– Strong family relationships have long been associated with a better sense of well-being and connection. Now a research team led by UT Southwestern Medical Center has linked the quality of those relationships with how successfully people – particularly aging African Americans – manage pain.

– Two studies led by a researcher at UT Southwestern Medical Center show the effects of different SARS-CoV-2 variants on lung tissue, revealing what may cause some COVID-19 infections to be more severe than others.

A protein called torsinA plays a key role in the early development of neurons, determining where nuclear pores are placed in the membrane that encloses the nucleus of nerve cells, a study led by UT Southwestern Medical Center researchers shows.