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Publications from 2020 to Present

2022

Adduri RSR, Vasireddy R, Mroz MM, Bhakta A, Li Y, Chen Z, Miller JW, Velasco-Alzate KY, Gopalakrishnan V, Maier LA, Li L, Konduru NV. "Realistic biomarkers from plasma extracellular vesicles for detection of beryllium exposure." Int Arch Occup Environ Health. 2022 Oct;95(8):1785-1796. doi: 10.1007/s00420-022-01871-7. Epub 2022 May 12. PMID: 35551477; PMCID: PMC9489591.

Bernardes NE, Fung HYJ, Li Y, Chen Z, Chook YM. "Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex." Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2207177119. doi: 10.1073/pnas.2207177119. Epub 2022 Sep 14. PMID: 36103578; PMCID: PMC9499513.

Park GJ, Osinski A, Hernandez G, Eitson JL, Majumdar A, Tonelli M, Henzler-Wildman K, Pawłowski K, Chen Z, Li Y, Schoggins JW, Tagliabracci VS. "The mechanism of RNA capping by SARS-CoV-2." Nature. 2022 Sep;609(7928):793-800. doi: 10.1038/s41586-022-05185-z. Epub 2022 Aug 9. PMID: 35944563; PMCID: PMC9492545.

Dewangan PS, Beraki TG, Paiz EA, Appiah Mensah D, Chen Z, Reese ML. "Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain." Biochem J. 2022 Sep 16;479(17):1877-1889. doi: 10.1042/BCJ20220076. PMID: 35938919.

Gao H, Li F, Ji Z, Shi Z, Li Y, Yu H. "Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state." Cell Discov. 2022 Feb 22;8(1):19. doi: 10.1038/s41421-022-00379-1. PMID: 35190543; PMCID: PMC8861141.

2021

Strand A, Shen ST, Tomchick DR, Wang J, Wang CR, Deisenhofer J. "Structure and dynamics of major histocompatibility class Ib molecule H2-M3 complexed with mitochondrial-derived peptides." J Biomol Struct Dyn. 2021 Jun 28:1-13. doi: 10.1080/07391102.2021.1942214. Epub ahead of print. PMID: 34176438; PMCID: PMC8722451

Osinski A, Black MH, Pawłowski K, Chen Z, Li Y, Tagliabracci VS. "Structural and mechanistic basis for protein glutamylation by the kinase fold." Mol Cell. 2021 Nov 4;81(21):4527-4539.e8. doi: 10.1016/j.molcel.2021.08.007. Epub 2021 Aug 17. PMID: 34407442; PMCID: PMC8571041

Hsieh TS, Lopez VA, Black MH, Osinski A, Pawłowski K, Tomchick DR, Liou J, Tagliabracci VS. "Dynamic remodeling of host membranes by self-organizing bacterial effectors." Science 2021 May 28; 372(6545):935-941. doi: 10.1126/science.aay8118. Epub 2021 Apr 29. PMID: 33927055; PMCID: PMC8543759

Palmer MJ, Deng X, Watts S, Krilov G, Gerasyuto A, Kokkonda S, El Mazouni F, White J, White KL, Striepen J, Bath J, Schindler KA, Yeo T, Shackleford DM, Mok S, Deni I, Lawong A, Huang A, Chen G, Wang W, Jayaseelan J, Katneni K, Patil R, Saunders J, Shahi SP, Chittimalla R, Angulo-Barturen I, Jiménez-Díaz MB, Wittlin S, Tumwebaze PK, Rosenthal PJ, Cooper RA, Aguiar ACC, Guido RVC, Pereira DB, Mittal N, Winzeler EA, Tomchick DR, Laleu B, Burrows JN, Rathod PK, Fidock DA, Charman SA, Phillips MA. "Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series." J Med Chem. 2021 May 13;64(9):6085-6136. doi: 10.1021/acs.jmedchem.1c00173. Epub 2021 Apr 20. PMID: 33876936; PMCID: PMC8171248

Li B, Deng X, Kim SH, Buhrow L, Tomchick DR, Phillips MA, Michael AJ. "Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin." J Biol Chem. 2021 Jan-Jun;296:100146. doi: 10.1074/jbc.RA120.016738. Epub 2020 Dec 10. PMID: 33277357; PMCID: PMC7857480

2020

Peng W, Casey AK, Fernandez J, Carpinone EM, Servage KA, Chen Z, Li Y, Tomchick DR, Starai VJ, Orth K "A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM." Nat Struct Mol Biol. 2020 Jun;27(6):589-597. doi: 10.1038/s41594-020-0429-1. Epub 2020 May 18. PMID: 32424347

Jiao L, Shubbar M, Yang X, Zhang Q, Chen S, Wu Q, Chen Z, Rizo J, Liu X. "A partially disordered region connects gene repression and activation functions of EZH2." Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):16992-17002. doi: 10.1073/pnas.1914866117. Epub 2020 Jul 6. PMID: 32631994; PMCID: PMC7382310

Kokkonda S, Deng X, White KL, El Mazouni F, White J, Shackleford DM, Katneni K, Chiu FCK, Barker H, McLaren J, Crighton E, Chen G, Angulo-Barturen I, Jimenez-Diaz MB, Ferrer S, Huertas-Valentin L, Martinez-Martinez MS, Lafuente-Monasterio MJ, Chittimalla R, Shahi SP, Wittlin S, Waterson D, Burrows JN, Matthews D, Tomchick D, Rathod PK, Palmer MJ, Charman SA, Phillips MA. "Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.J Med Chem. 2020 May 14;63(9):4929-4956. doi: 10.1021/acs.jmedchem.0c00311. Epub 2020 Apr 16. PMID: 32248693; PMCID: PMC7394244

Sreelatha A, Nolan C, Park BC, Pawłowski K, Tomchick DR, Tagliabracci VS. "Legionella effector kinase is activated by host inositol hexakisphosphate." J Biol Chem. 2020 May 1;295(18):6214-6224. doi: 10.1074/jbc.RA120.013067. Epub 2020 Mar 30. PMID: 32229585; PMCID: PMC7196655

Zhong X, Su L, Yang Y, Nair-Gill E, Tang M, Anderton P, Li X, Wang J, Zhan X, Tomchick DR, Brautigam CA, Moresco EMY, Choi JH, Beutler B. "Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function." Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8563-8572. doi: 10.1073/pnas.2000703117. Epub 2020 Mar 27. PMID: 32220963; PMCID: PMC7165429