Publications Archive for James A. Richardson D.V.M., Ph.D., Diplomate (ACVP)

Wiseman D, Hanzlik JA, Richardson JA, Shelton JM, Evers BM, Diamond MP, Brown R, Mazzucco DC. "Development of a Chronic Canine Ovariohysterectomy Model to Evaluate Vaginal Cuff Healing Using Two Closure Systems." Surg Innov. 2022 April 18;29(2):183-194.

Luitel, K., Kim, S.B., Barron, S., Richardson, J.A., Shay, J.W. "Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention." Life Sci Space Res (Amst). 2020 Feb; 24:108-115.

Zhou, H., Belxile, O., Zhang, Z., Wagner, J., Ahn, C., Richardson, J.A., Saha, D., Brekken, R.A., Mason, R.P. "The effect of flow on blood oxygen level dependent (R*2) MRI of orthotopic lung tumors". Mag Reson Med. 2019 Jun;81(6):3787-3797.

Luitel, K., Bozeman, R., Kaisani, A., Kim, S.B., Barron, S., Richardson, J.A., Shay, J.W. "Proton radiation-induced cancer progression." Life Sci Space Res (Amst). 2018 Nov;19:31-42.

Zhou, X., Padanad, M.S., Evers, B.M., Smith, B., Novaresi, N., Suresh, S., Richardson, J.A., Stein, E., Zhu, J., Hammer, R.E., O'Donnell, K.A. "Modulation of Mutant KrasG12D-Driven Lung Tumorigenesis In-Vivo by Gain or Loss of PCDH7 Function." Mol Cancer Res. 2019 Feb;17(2):594-603.

Hunter, R.W., Liu, Y., Manjunath, H., Acharya, A., Jones, B.T., Zhang, H., CHen, B., Ramalingam, H., Hammer, R.E., Xie, Y., Richardson, J.A., Rakheja, D., Carroll, T.J, Mendell, J.T. "Loss of Dis3l2 partially phenocopies Perlman sundrome in mice and results in up-regulation of Igf2 in nephron progenitor cells." Genes Dev. 2018 Jul 1;32(13-14):903-908.

Cheng, b. Chatzinoff, Y., Szczepanski, D. Bing, C., Shaikh, S., Wyman, O., Perry, C.E., Richardson J.A., Burns, D.K., Evers, B.M., Greenberg, D.E., Chopra, R. "Remote acoustic sensing as a safety mechanism during exposure of metal implants to alternating magnetic fields." PLoS One. 2018 May 10;13(5).

Hwang, S.H., White, K.A., Somatilaka, B.N., Shelton, J.M., Richardson, J.A., Mukhopadhyay, S. "The G protein-coupled receptor GPR161 rugulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner." Development. 2018 Jan 8;145(1).

Hrycushko, B.A., Chopra, R., Sayre, J.W., Richardson, J.A., Folkert, M.R., Timmerman, R.D., Medin, P.M. "Local hypothermia as a radioprotector of the rectal wall during prostate stereotactic body radiation therapy." Int J Radiat Oncol Biol Phys. 2017 May 1;98(1):75-82.

Herbert, C.E., Veeram Reddy, S., Welch, T.R., Wang, J., Richardson, J.A., Forbess, J.M., Nugent, A.W. "Bench and initial preclinical results of a novel 8 mm diameter double opposed helical biodegradable stent." Catheter Cardiovasc Interv. 2016 Nov 15;88(6):902-911.

Kim, S.B., Bozeman, R.G., Kaisani, A., Kim, W., Zhang, L., Richardson, J.A., Wright, W.E., Shay, J.W. "Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses." Oncogene. 2016 Jun 30;35(26):3365-75.

Kimura, W., Xiao, F., Canseco, D.C., Muralidhar, S., Thet, S., Zhang, H.M., Abderrahman, Y., Chen, R., Garcia, J.A., Shelton, J.M., Richardson, J.A., Ashour, A.M., Asaithamby, A., Liang, H., Xing, C., Lu, Z., Zhang, C.C., Sadek, H.A. "Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart." Nature. 2015 Jul 9;523(7559):226-30.

Cenik, B.K., Garg, A., McAnally, J.R., Shelton, J.M., Richardson, J.A., Bassel-Duby, R., Olson, E.N., Liu, N. "Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3." J Clin Invest. 2015 Apr;125(4):1569-78.

Bing, C., Ladouceur-Wodzak, M., Wanner, C.R., Shelton, J.M., Richardson, J.A., Chopra, R. "Trans-cranial opening of the blood-brain barrier in targeted regions using a stereotaxic brain atlas and focused ultrasound energy." J Ther Ultrasound. 2014 Aug 4;2:13.

Funato, N., Nakamura, M., Richardson, J.A., Srivastava, D., Yanagisawa, H. "Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia." Hum Mol Genet. 2015 Jan 15;24(2):424-35.

Zeitels, L.R., Acharya, A., Shi, G., Chivukula, D., Chivukula, R.R., Anandam, J.L., Abdelnaby, A.A., Balch, G.C., Mansour, J.C., Yopp, A.C., Richardson, J.A., Mendell, J.T. "Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis." Genes Dev. 2014 Dec 1;28(23):2585-90.

Veeram Reddy, S.R., Welch, T.R., Wang, J., Richardson, J.A., Forbess, J.M., Riegel, M., Nugent, A.W. "A novel design biodegradable stent for use in congenital heart disease: mid-term results in rabbit descending aorta." Catheter Cardiovasc Interv. 2015 Mar;85(4):629-39.

Long, C., Grueter, C.E., Song, K., Qin, S., Qi, X., Kong, Y.M., Shelton, J.M., Richardson, J.A., Zhang, C.L., Bassel-Duby, R., Olson, E.N. "Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor." Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11521-6.

Williams, S.S., Cobo-Stark, P., Hajarnis, S., Aboudehen, K., Shao, X., Richardson, J.A., Patel, V., Igarashi, P. "Tissue-specific regulation of the mouse Pkhd1 (ARPKD) gene promoter." Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F356-68.

Liu, N., Nelson, B.R., Bezprozvannaya, S., Shelton, J.M., Richardson, J.A., Bassel-Duby, R., Olson, E.N. Requirement of MEF2A, C, and D for skeletal muscle regeneration. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4109-14.

Delgado, O., Batten, K.G., Richardson, J.A., Xie, X.J., Gazdar, A.F., Kaisani, A.A., Girard, L., Behrens, C., Suraokar, M., Fasciani, G., Wright, W.E., Story, M.D., Wistuba, I.I., Minna, J.D.,Shay, J.W. "Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer." Clin Cancer Res. 2014 Mar 15;20(6):1610-22.

Pop, L.M., Barman, S., Shao, C., Poe, J.C., Venturi, G.M., Shelton, J.M., Pop, I.V., Gerber, D.E., Girard, L., Liu, X.Y., Behrens, C., Rodriguez-Canales, J., Liu, H., Wistuba, I.I., Richardson, J.A., Minna, J.D., Tedder, T.F., Vitetta, E.S. "A reevaluation of CD22 expression in human lung cancer." Cancer Res. 2014 Jan 1;74(1):263-71.

Singh, S., Canseco, D.C., Mandam, S.M., Shelton, J.M., Chirumamilla, R.R., Goetsch, S.C., Ye, Q., Gerard, R.D., Schneider, J.W., Richardson, J.A., Rothermel, B.A., Mammen, P.P. "Cytoglobin modulates myogenic progenitor cell viability and muscle regeneration." Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E129-38.

Pozo, K., Castro-Rivera, E., Tan, C., Plattner, F., Schwach, G., Siegl, V., Meyer, D., Guo, A., Gundara, J., Mettlach, G., Richer, E., Guevara, J.A., Ning, L., Gupta, A., Hao, G., Tsai, L.H., Sun, X., Antich, P., Sidhu, S., Robinson, B.G., Chen, H., Nwariaku, F.E., Pfragner, R., Richardson, J.A., Bibb, J.A. "The role of Cdk5 in neuroendocrine thyroid cancer." Cancer Cell. 2013 Oct 14;24(4):499-511.

Chapman, K.M., Powell, H.M., Chaudhary, J., Shelton, J.M., Richardson, J.A., Richardson, T.E., Hamra, F.K. "Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success." Mol Cell Proteomics. 2013 Nov;12(11):3221-36.

Winterberg, P.D., Wang, Y., Lin, K.M., Hartono, J.R., Nagami, G.T., Zhou, X.J., Shelton, J.M., Richardson, J.A., Lu, C.Y. "Reactive-oxygen species (ROS) and IRF1 stimulate IFNŒ± production by proximal tubules during ischemic AKI." Am J Physiol Renal Physiol. 2013 July 15;305(2):F164-72.

Veeram Reddy, S.R., Welch, T.R., Wang, J., Bernstein, F., Richardson, J.A., Forbess, J.M., Nugent, A.W. "A Novel Biodegradable Stent Applicable for Use in Congenital Heart Disease: Bench Testing and Feasibility Results in a Rabbit Model." Catheter Cardiovasc Interv. 2013 Feb 15;83(3):448-56.

Ma, S., Richardson, J.A., Bitmansour, A., Solberg, T.D., Pidikiti, R., Song, K., Stojadinovic, S., Vitetta, E.S., Meyer, J.J. "Partial depletion of regulatory T cells does not influence the inflammation caused by high dose hemi-body irradiation." PLoS One. 2013;8(2):e56607.

Liu, N., Williams, A.H., Maxeiner, J.M., Bezprozvannaya, S., Shelton, J.M., Richardson, J.A.,  Bassel-Duby, R., Olson, E.N. "microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice." J Clin Invest. 2012 Jun 1;122(6):2054-65.

Akhtar, M.W., Kim, M.S., Adachi, M., Morris, M.J., Qi, X., Richardson, J.A., Bassel-Duby, R., Olson, E.N., Kavalali, E.T, Monteggia LM. "In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival." PLoS One. 2012;7(4):e34863.

Taurog, J.D., Rival, C., van Duivenvoorde, L.M., Satumtira, N., Dorris, M.L., Sun, M., Shelton, J.M., Richardson, J.A., Hamra, F.K., Hammer, R.E., Tung, K.S. "Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats." Arthritis Rheum. 2012 Aug;64(8):2518-28.

Funato, N., Nakamura, M., Richardson, J.A., Srivastava, D., Yanagisawa, H. "Tbx1 regulates oral epithelial adhesion and palatal development." Hum Mol Genet. 2012 Jun 1;21(11):2524-37.

Moresi, V., Carrer, M., Grueter, C.E., Rifki, O.F., Shelton, J.M., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice." Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1649-54.

Hoopman, T.C., Liu, W., Joslin, S.N., Pybus, C., Sedillo, J.L., Labandeira-Rey, M., Laurence, C.A., Wang, W., Richardson, J.A., Bakaletz, L.O., Hansen, E.J. "Use of the chinchilla model for nasopharyngeal colonization to study gene expression by Moraxella catarrhalis." Infect Immun. 2012 Mar;80(3):982-95.

Xin, M., Kim, Y., Sutherland, L.B., Qi, X., McAnally, J., Schwartz, R.J., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size." Sci Signal. 2011 Oct 25;4(196): 70.

Ferdous, A., Morris, J., Abedin, M.J., Collins, S., Richardson, J.A., Hill, J.A. "Forkhead factor FoxO1 is essential for placental morphogenesis in the developing embryo." Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16307-12.

Xie, X., Brown, M.S., Shelton, J.M., Richardson, J.A., Goldstein, J.L., Liang, G. "Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice." Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15330-5.

Liu, N., Bezprozvannaya, S., Shelton, J.M., Frisard, M.I., Hulver, M.W., McMillan, R.P., Wu, Y., Voelker, K.A., Grange, R.W., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "Mice lacking microRNA 133a develop dynamin 2‚ dependent centronuclear myopathy." J Clin Invest. 2011 Aug;121(8):3258-68.

Porrello, E.R., Mahmoud, A.I., Simpson, E., Hill, J.A., Richardson, J.A., Olson, E.N., Sadek, H.A. "Transient regenerative potential of the neonatal mouse heart." Science. 2011 Feb 25;331(6020):1078-80.

Donato, J. Jr., Cravo, R.M., Frazero, R., Gautron, L., Scott, M.M., Lachey, J., Castro, I.A., Margatho, L.O., Lee, S., Lee, C., Richardson, J.A., Friedman, J., Chua, S. Jr., Coppari, R., Zigman, J.M., Elmquist, J.K., Elias, C.F. "Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons." J Clin Invest. 2011 Jan;121(1):355-68.

Chen, J., John, R., Richardson, J.A., Shelton, J.M., Zhou, X.J., Wang, Y., Wu, Q.Q., Hartono, J.R., Winterberg, P.D., Lu, C.Y. "Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury." Kidney Int. 2011 Feb;79(3):288-99.

Moresi V., Williams, A.H., Meadows, E., Flynn, J.M., Potthoff, M.J., McAnally, J., Shelton, J.M., Backs, J., Klein, W.H., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases." Cell. 2010 Oct 1;143(1):35-45.

Hatley, M.E., Patrick, D.M., Garcia, M.R., Richardson, J.A., Bassel-Duby, R., van Rooij, E., Olson, E.N. "Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21." Cancer Cell. 2010 Sep 14;18(3):282-93.

Farkas, J.P., Richardson, J.A., Brown, S.A., Ticker, B., Walgama, E., Burrus, C.F., Hoopman, J.E., Barton, F.E., Kenkel, J.M. "TUNEL assay to characterize acute histopathological injury following treatment with the active and deep FX fractional short-pulse CO2 devices." Aesthet Surg J. 2010 Jul-Aug;30(4):603-13.

Zhao, T.J., Sakata, I., Li, R.L., Liang, G., Richardson, J.A., Brown, M.S., Goldstein, J.L., Zigman, J.M. "Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice." Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15868-73.

Tukel, T., Sosic, D., Al-Gazali, L.I., Erazo, M., Casasnovas, J., Franco, H.L., Richardson, J.A., Olson, E.N., Cadilla, C.L., Desnick, R.J. "Homozygous nonsense mutations in TWIST2 cause Setleis syndrome." Am J Hum Genet. 2010 Aug 13;87(2):289-96.

Farkas, J.P., Richardson, J.A., Burrus, C.F., Hoopman, J.E., Brown, S.A., Kenkel, J.M. "In vivo histopathologic comparison of the acute injury following treatment with five fractional ablative laser devices." Aesthet Surg J. 2010 May-Jun;30(3):457-64.

Small, E.M., Thatcher, J.E., Sutherland, L.B., Kinoshita, H., Gerard, R.D., Richardson, J.A., Dimaio, J.M., Sadek, H., Kuwahara, K., Olson, E.N. "Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction." Circ Res. 2010 Jul 23;107(2):294-304.

Frost, R.J., Hamra, F.K., Richardson, J.A., Qi, X., Bassel-Duby, R., Olson, E.N. "MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs." Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11847-52.

Kisanuki, Y.Y., Emoto, N., Ohuchi, T., Widyantoro, B., Yagi, K., Nakayama, K., Kedzierski, R.M., Hammer, R.E., Yanagisawa, H., Williams, S.C., Richardson, J.A., Suzuki, T., Yanagisawa, M. "Low blood pressure in endothelial cell-specific endothelin 1 knockout mice." Hypertension. 2010 Jul;56(1):121-8.

Cho, J., Kodym, R., Seliounine, S., Richardson, J.A., Solberg, T.D., Story, M.D. "High dose-per-fraction irradiation of limited lung volumes using an image-guided, highly focused irradiator: simulating stereotactic body radiotherapy regimens in a small-animal model." Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):895-902.

Hill, J.W., Elias, C.F., Fukuda, M., Williams, K.W., Berglund, E.D., Holland, W.L., Cho, Y.R., Chuang, J.C., Xu, Y., Choi, M., Lauzon, D., Lee, C.E., Coppari, R., Richardson, J.A., Zigman, J.M., Chua, S., Scherer, P.E., Lowell, B.B., Bruning, J.C., Elmquist, J.K . "Direct insulin and leptin action on pro-opiomeanocortin neurons is required for normal glucose homeostasis and fertility." Cell Metab 11(4): 286-297, 2010.

Small, E.M., O'Rourke, J.R., Moresi, V., Sutherland, L.B., McAnally, J., Gerard, R.D., Richardson, J.A., Olson, E.N. "Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486." Proc Natl Acad Sci USA 107(9): 4218-4223, 2010.

Evers, B.M., Farooqi, M.S., Shelton, J.M., Richardson, J.A., Goldstein, J.L., Brown, M.S., Liang, G. "Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin." J Invest Dermatol 130(5): 1237-1248, 2010.

van Rooij, E., Quiat, D., Johnson, B.A., Sutherland, L.B., Qi, X., Richardson, J.A., Kelm, R.J., Olson, E.N. "a family of microRNAs encoded by myosin genes governs myosin expression and muscle performance." Dev Cell 17(5): 662-673, 2009.

Xin, M., Small, E.M., Sutherland, L.B., Qi, Z., McAnally, J., Plato, C.F., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury." Genes Dev 23(18): 2166-2178, 2009.

Lin, L., Chen, J., Richardson, J.A., Parada, L.F. "Mice lacking neurofibromin develop gastric hyperplasia." Am J Physol; Gastrointest Liver Physiol. In-Press, 2009.

Munshi, N.V., McAnally, J., Bezprozvannaya, S., Berry, J.M., Richardson, J.A., Hill, J.A., Olson, E.N. "Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay." Development 136(15): 2665-2674, 2009.

Farkas, J.P., Richardson, J.A., Hoopman, J., Brown, S.A., Kenkel, J.M. "Micro-island damage with nonablative 1540nm Er:Glass fractional laser device in human skin." J Cosmet Dermatol 8(2): 119-126, 2009.

Chamberland, D.L., Taurog, J.D., Richardson, J.A., Wang, X. "Photoacoustic tomography: a new imaging technology for inflammatory arthritis - as applied to tail spondylitis ion rats." Clin Exp Rheumatol 27(2): 387-388, 2009.

Wang, Y., John, R., Chen, J., Richardson, J.A., Shelton, J.M., Bennett, M., Zhou, X.J., Nagami, G.T., Zhang, Y., Wu, Q.C., Lu, C.Y. "IRF-1 promotes inflammation early after ischemic acute kidney injury." J Am Soc Nephrol 20(7): 1544-1555, 2009.

Montgomery, R.L., Hsieh, J., Barbosa, A.C., Richardson, J.A., Olson, E.N. "Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development." Proc Natl Acad Sci (USA) 106(19): 7876-7881, 2009.

Shivnani, S.B., Shelton, J.M., Richardson, J.A., Maalouf, N.M. "Hypoercalcemia of malignancy with simultaneous elevation in serum parathyroid hormone-related peptide and 1,25-dihydroxyvitamin D in a patient with metastatic renal cell carcinoma." Endocr Pract 15(3): 234-239, 2009.

Liu, N., Barboas, A.C., Chapman, S.L., Bezprozvannaya, S., Qi, X., Richardson, J.A., Yanagisawa, H., Olson, E.N. "DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis." Development 136(6): 933-942, 2009.

Backs, J., Backs, T., Neef, S., Kresser, M.M., Lehmann, L.H., Patrick, D.M., Grueter, C.E., Qi, X., Richardson, J.A., Hill, J.A., Katus, H.A., Bassel-Duby, R., Maier, L.S., Olson, E, N. "The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload." Proc Natl Acad Sci (USA) 107(7): 2342-2347, 2009.

Funato, N., Chapman, S.L., McKee, M.D., Funato, H., Morris, J.A., Shelton, J.M., Richardson, J.A., Yanagisawa, H. "Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2." Development 134(4): 615-625, 2009.

Ferdous, A., Caprioli, A., Iacovino, M., Martin, C.M., Morris, J., Richardson, J.A., Latif, S., Hammer, R.E., Harvey, R.P., Olson, E.N., Kyba, M., Garry, D.J. "Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo." Proc Natl Acad Sci (USA) 106(3): 814-819, 2009.

Maitra, M., Schluterman, M.K., Nichols, H.A., Richardson, J.A., Lo, C.W., Srivastava, D., Garg, V. "Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development." Dev Biol 326(2): 368-377, 2008.

Farkas, J.P., Richardson, J.A., Bown, S.A., Hoopman, J.E., Kenkel, J.M. "Effects of common laser treatments on hyaluronic acid fillers in a porcine model." Aesthet Surg J 28(5): 503-511, 2008.

Farkas, J.P, Richardson, J.A., Hoopman, J.E., Brown, S.A., Kenkel, J.M. "TUNEL assay for histopathologic evaluation of irreversible chromosomal damage following nonablative fractional photothermolysis." Plast Reconstr Surg 122(6): 1660-1668, 2008.

Liu, N., Bezprozvannaya, S., Williams, A.H., Qi, X., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart." Genes Dev 22(23): 3242-3254, 2008.

Le Saux, O., Teeters, K., Miyasato, S., Choi, J., Nakamatsu, G., Richardson, J.A., Starcher, B., Davis, E.C., Tam, E.K., Jourdan-Le Saux, C. "The role of caveolin-1 in pulmonary matrix remodeling and mechanical properties." Am J Physiol Lung Cell Mol Physiol 295(6): L1007-L1017, 2008.

Montgomery, R.L., Potthoff, M.J., Haberland, M., Qi, X., Matsuzaki, S., Humphries, K.M., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice." J Clin Invest, 118(11): 3588-3597, 2008.

Wang, S., Aurora, A.B., Johnson, B.A., Qi, X, McAnally, J., Hill, J.A., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis." Dev Cell 15(2): 261-271, 2008.

Barbosa, A.C., Kim, M.S., Ertunc, M., Adachi, M., Nelson, E.D., McAnally, J., Richardson, J.A., Kavalali, E.T., Monteggia, L.M., Bassel-Duby, R., Olson, E.N. "MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function." Proc Nat Acad Sci (USA) 105(27): 9391-9396, 2008.

Huang, J., Shelton, J.M., Richardson, J.A., Kamm, K.E., Stull, J.T. "Myosin regulatory light chain kinase phosphorylation attenuates cardiac hypertrophy." J Biol Chem 283(28): 19748-19756, 2008.

Kim, M.S., Fielitz, J., McAnally, J., Shelton, J.M., Lemon, D.D., McKinsey, T.A., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "Protein kinase D1 stimulates MEF2 activity in skeletal muscle and enhances muscle performance." Mol Cell Biol 28(11): 3600-3609, 2008.

Fielitz, J., Kim, M.S., Shelton, J.M., Qi, X. Hill, J.A., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "Requirement of protein kinase D1 for pathological cardiac remodeling." Proc Natl Acad Sci USA 105(8): 3059-3063, 2008.

Lavery, G.G., Walker, E.A., Turan, N., Rogoff, D., Ryder, J.W., Shelton, J.M., Richardson, J.A., Falciani, F., White, P.C., Stewart, P.M., Parker, K.L., McMillan, D.R. "Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal muscle myopathy." J Biol Chem 283(13): 8453-8461, 2008.

Zhao, G., Jeoung, N.H., Burgess, S.C., Rosaaen-Stowe, K.A., Inagaki, T., Latif, S., Shelton, J.M., McAnally, J., Bassel-Duby, R., Harris, R.A., Richardson, J.A., Kliewer, S.A. Am J Physiol Heart Circ Physiol 294(2): H936-H943, 2008.

Kim, Y., Phan, D., van Rooij, E., Wang, D.Z., McAnally, J., Qi, X., Richardson, J.A., Hill, J.A., Bassel-Duby, R.< Olson, E.N. "The MEF2D transcription factor mediates stress-dependent cardiac remodeling i mice." J Clin Invest 118(1): 124-132, 2008.

Hoeffer, C.A., Dey, A., Sachan, N., Wong, H., Patterson, R.J., Shelton, J.M., Richardson, J.A., Klann, E., Rothermel, B.A. "The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphate signalling." J Neurosci 27(48): 13161-13172, 2007.

Liu, N., Williams, A.H., Kim, Y., McAnally, J., Bezprozvannaya, S., Sutherland, L.B., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133." Proc Natl Acad Sci USA 104(52): 20844-20849, 2007.

Rybkin, I.I., Kim, M.S., Bezprozvannaya, S., Qi, X., Richardson, J.A., Plato, C.F., Hill, J.A., Bassel-Duby, R., Olson, E.N. "Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein." J Cel Biol 179(3): 527-537, 2007.

Potthoff, M.J., Arnold, M.A., McAnally, J., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c." Mol Cel Biol 27(23): 8143-8151, 2007.

Smallshaw, J.E., Richardson, J.A., Vitetta, E.S. "RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol." Vaccine 25(42): 7459-7469, 2007.

Fielitz, J., Kim, M.S., Shelton, J.M., Latif, S., Spencer, J.A., Glass, D.J., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3." J Clin Invest 117(9): 2486-2495, 2007.

Potthoff, M.J., Wu, H. Arnold, M.A., Shelton, J.M., Backs, J., McAnally, J., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers." J Clin Invest 117(9): 2459-2467, 2007.

Barbosa, A.C., Funato, N., Chapman, S., McKee, M.D., Richardson, J.A., Olson, E.N., Yanagisawa H. "Hand transcription factors cooperatively regulate development of the distal midline mesenchyme." Dev Biol 310(1): 154-168, 2007.

Montgomery, R.L., Davis, C.A., Potthoff, M.J., Haberland, M., Fielitz, J., Qi, X., Hill, J.A., Richardson, J.A., Olson, E.N. "Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility." Genes Dev 21(14): 1790-1802, 2007.

Zhu, H., Tannous, P., Johnstone, J.L., Kong, Y., Shelton, J.M., Richardson, J.A., Le, V., Levine, B., Rothermel, B.A., Hill, J.A. "Cardiac autophagy is a maladaptive response to hemodynamic stress." J Clin Invest 117(7): 1782-1793, 2007.

Aghaloo, T.L., Amantea, C.M., Cowan, C.M., Richardson, J.A., Wu, B.M., Parhami, F., Tetradis, S. "Oxysterols enhance osteoblast differentiation i vitro and bone healing in-vivo." J Orthop Res 25(11): 1488-1497, 2007.

Liu, B., Xie, C., Richardson, J.A., Turley, S.D., Dietschy, J.M. "Receptor-mediated and bulk-phase lipoprotein endocytosis along with macrophage infiltration contribute to cholesterol accumulation in Niemann-Pick type C disease." J Lipid Res 48(8): 1710-1723, 2007.

Xin, M., Small, E.M., van Rooij, E., Qi, X., Richardson, J.A., Srivastava, D., Nakagawa, O., Olson, E.N. "Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function." Proc Nat Acad Sci USA 104(19): 7975-7980, 2007.

Kuwahara, K., Pipes, G.C., McAnally, J., Richardson, J.A., Hill, J.A., Bassel-Duby, R., Olson, E.N. "Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity." J Clin Invest 117(5): 1324-1334, 2007

van Rooij, E., Sutherland, L.B., Qi, X., Richardson, J.A., Hill, J.A., Olson, E.N. "Control of stress-dependent cardiac growth and gene expression by a microRNA." Science 316 (5824): 575-579., 2007.

Fielitz, J., van Rooij, E., Spencer, J.A., Shelton, J.M., Latif, S., van der Nagel, R., Bezprozvannaya, S., de Windt, L., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction." Proc Nat Acad Sci USA 104(11): 4377-4382, 2007.

Arnold, M.A., Kim, Y., Czubryt, M.P., Phan, D., McAnally, J., Qi, X., Shelton, J.M., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "MEF2C transcription factor controls chondrocyte hypertrophy and bone development." Dev Cell 12(3) 377-389, 2007.

Barientos, T., Frank, D., Kuwahara, K., Bezprozvannaya, S., Bassel-Duby, R., Richardson, J.A., Katus, H.A., Olson, E.N., Frey, N. "Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin." J Biol Chem 282(11): 8393-8403, 2007.

Minguela, A., Pastor, S., Mi, W., Richardson, J.A., Ward, E.S. "Feedback regulation of muring autoimmunity via dormant anti-inflammatory effects of interferon {gamma}." J Immunol 178(1) 134-144, 2007.

Zheng, Q., Davis, E.C., Richardson, J.A., Starcher, B.C., Li, T., Gerard, R.D., Yanagisawa, H. "Molecular analysis of fibulin-5 function during de novo synthesis of elastic fibers." Mol Cell Biol In-Press, 2007.

van Rooij, E., Sutherland, L.B., Liu, N., Williams, A.H., McAnally, J., Gerard, R.D., Richardson, J.A., Olson, E.N. "A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure." Proc Nat Acad Sci USA 103(48): 18255-18260, 2006.

Kuwahara, K., Wang, Y., McAnally, J., Richardson, J.A., Bassel-Duby, R., Hill, J.H., Olson, E.N. "TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling." J Clin Invest 116(12): 3114-3126, 2006. COVER MANUSCRIPT

Choi, M., Moschetta, A., Bookout, A.L., Peng, L., Unetani, M, Holstrom, S.R., Suino-Powell, K., Xu, H.E., Richardson, J.A., Gerard, R.D., Mangelsdorf, D.J., Kliewer, S.A. "Identification of a hormonal basis for gall bladder filling." Nat Med 12(11): 1253-1255, 2006.

Creemers, E.E., Sutherland, L.B., McAnally, J., Richardson, J.A., Olson, E.N. "Myocardin is a direct transcriptional target of MEF2, Tead and Foxo proteins during cardiovascular development." Development 133(21): 4245-4256, 2006.

Engelking, L., Evers, B.M., Richardson, J.A., Goldstein, J.L., Brown, M.S., Liang, G. "Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin." J Clin Invest 116(9): 2356-2365, 2006. COVER MANUSCRIPT

Zheng, Q., Choi, J., Rouleau, L., Leask, R.L., Richardson, J.A., Davis, E.C., Yanagisawa, H. "Normal wound healing in mice deficient for Fibulin-5, an elastin binding protein essential for dermal elastic fiber assembly." J Invest Dermatol 126(12): 2707-2714, 2006.

Mammen, P.P., Shelton, J.M., Ye, Q., Kanatous, S.B., McGrath, A.J., Richardson, J.A., Garry, D.J. "Cytoglobin is a stress-responsive hemoprotein that is expressed in the developing and adult brain." J Histochem Cytochem 54(12): 1349-1361, 2006.

Mieda, M., Williams, S.C., Richardson, J.A., Tanaka, K., Yanagisawa, M. "The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker." Proc Nat Acad Sci USA 103(32): 12150-12155, 2006.

Chang, S., Young, B.D., Li, S., Qi, X., Richardson, J.A., Olson, E.N. "Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10." Cell126(2): 321-334, 2006.

Li, S., Chang, S., Qi, X., Richardson, J.A., Olson, E.N. "Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells." Mol Cell Biol 26(15): 5797-5808, 2006.

Xin, M., Davis, C.A., Molkentin, J.D., Lien, C.L., Duncan, S.A., Richardson, J.A., Olson, E.N. "A threshold of GATA4 and GATA6 expression is required for cardiovascular development." Proc Natl Acad Sci USA103(30): 11189-11194, 2006.

Song, K., Backs, J., McAnally, J., Qi, X., Gerard, R.D., Richardson, J.A., Hill, J.A., Bassel-Duby, R., Olson, E.N. "The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases." Cell 125(3): 453-466, 2006.

Harrison, B.C., Kim, M.S., van Rooij, E., Plato, C.F., Papst, P.J., Vega, R.B., McAnally, J.A., Richardson, J.A., Bassel-Duby, R., Olson, E.N., McKinsey, T.A. "Regulation of cardiac stress signaling by protein kinase d1." Mol Cell Biol 26(10): 3875-3888, 2006.

Lee, Y., Naseem, R.H., Park, B.H., Garry, D.J., Richardson, J.A., Schaffer, J.E., Unger, R.H. "Alpha-Lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice." Biochem Biophys Res Commun, 344(1): 446-452, 2006.

Tran, T.M., Dorris, M.L., Satumtira, N., Richardson, J.A., Hammer, R.E., Shang, J., Taurog, J.D. "Additional human beta(2)-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27 transgenic rats." Arthritis Rheum 54(4): 1317-1327, 2006.

Davis, C.A., Haberland, M., Arnold, M.A., Sutherland, L.B., McDonald, O.G., Richardson, J.A., Childs, G., Harris, S., Owens, G.K., Olson, E.N. "PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells." Mol Cell Biol 26(7): 2626-2636, 2006.

Inagaki, T., Moschett, A., Lee, Y.K., Peng, L., Zhao, G., Downes, M., Yu, R.T., Shelton, J.M., Richardson, J.A., Repa, J.J., Mangelsdorf, D.J., Kliewer, S.A. "Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor." Proc Nat Acad Sci (USA) 103(10): 3920-3925, 2006.

Xie, C., Richardson, J.A., Turley, S.D., Dietschy, J.M. "Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein." J Lipid Res In-Press, 2006. COVER MANUSCRIPT

Guenette, S., Chang, Y., Hiesberger, T, Richardson, J.A., Eckman, C.B., Eckman, E.A., Hammer, R.E, Herz, J. "Essential roles of FE65 amyloid precursor protein-interacting proteins in brain development." EMBO J 25(2): 420-431, 2006.

Durham, J.T., Brand, O.M., Arnold, M., Reynolds, J.G., Muthukumar, L., Weiler, H., Richardson, J.A., Naya, F.J. "Myospryn is a direct transcriptional target of MEF2A that encodes a striated muscle, alpha-actinin interacting , costamere localized protein." J Biol Chem 281(10): 6841-6849, 2006.

Pipes, G.C., Sinha, S., Qi, X., Zhu, C.H., Gallardo, T.D., Shelton, J.M., Creemers, E.E., Sutherland, L., Richardson, J.A., Garry, D.J., Wright, W.E., Owens, G.K., Olson, E.N. "Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression." Dev Biol 288(2): 502-513, 2005. COVER MANUSCRIPT

Oh, J., Richardson, J.A., Olson, E.N. "Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation." Proc Nat Acad Sci (USA) 102(42): 15122-15127, 2005.

Kielar, M.L., John, R., Bennett, M., Richardson, J.A., Shelton, J.M., Chen, L., Jeyarajah, D.R., Zhou, X.J., Zhou, H., Chiquett, B., Nagami, G.T., Lu, C.Y. "Maladaptive role of IL-6 in ischemic acute renal failure." J Am Soc Nephrol 16(11): 3315-3325, 2005.

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C.L., McDonald, J.G., Luo, G., Jones, S.A., Goodwin, B., Richardson, J.A., Gerard, R.D., Repa, J.J., Mangelsdorf, D.J., Kliewer, S.A. "Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis." Cell Metab 2(4): 217-225, 2005.

Castillero-Trejo, Y., Eliazer, S., Xiang, L., Richardson, J.A., Ilaria, R.L. Jr. "Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells results in EWS/FLI-1 dependent, Ewing sarcoma-like tumors." Cancer Res 65(19): 8698-8705, 2005.

Pieper, A.A., Wu, X., Han, T.W., Estill, S.J., Dang, Q., Wu, L.C., Reece-Fincanon, S., Dudley, C.A., Richardson, J.A., Brat, D.J., McKnight, S.L. "The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice." Proc Natl Acad Sci (USA) 102(39): 14052-14057, 2005.

Beltroy, E.P., Ricahrdson, J.A., Horton, J.D., Turley, S.D., Dietschy, J.M. "Cholesterol accumulation and liver cell death in mice with Niemann-Pick type C disease." Hepatology 42(4): 886-893, 2005.

Chugh, P., Matta, H., Schamus, S., Zachariah, S., Kumar, A., Richardson, J.A., Smaith, A.L., Chaudhary, P.M. "Constitutive NF-{kappa} B activation, normal Fas-induced apoptosis and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice." Proc Natl Acad Sci (USA) 102(36): 12885-12890, 2005.

Nakagawa, O., Arnold, M., Nakagawa, M., Hamada, H., Shelton, J.M., Kusano, J., Harris, T.M., Childs, G., Campbell, K.P., Richardson, J.A., Nishino, I., Olson, E.N."Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2." Gen and Dev 19(17): 2066-2077, 2005. COVER MANUSCRIPT

Oh, M., Rybkin, I.I., Copeland, V., Czubryt M.P., Shelton, J.M., van Rooij, E., Richardson, J.A., Hill, J.A., De Windt, L.J., Bassel-Duby, R., Olson, E.N., Rothermel, B.A. "Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers." Mol Cell Biol 25(15): 6629-6638, 2005.

Kelly, M.A., Beuckmann, C.T., Williams, S.C., Sinton, C.M., Motoike, T., Richardson, J.A., Hammer, R.E., Garry, M.G., Yanagisawa, M. "Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain." Proc Natl Acad Sci USA 102(28): 9942-9947, 2005.

Mendelson, C.R., Jiang, B., Shelton, J.M., Richardson, J.A., Hinshelwood, M.M. "Transcriptional regulation of aromatase in placenta and ovary." J Steroid Biochem Mol Biol 95(1-5): 25-33, 2005.

Hinshelwood, M.M., Shelton, J.M., Richardson, J.A., Mendelson, C.R. "Temporal and spatial expression of liver receptor homologue-1 (LRH-1) during embryogenesis suggests a potential role in gonadal development." Dev Dyn 234(1): 159-168, 2005.

Smallshaw, J.E., Richardson, J.A., Pincus, S., Schindler, J., Vitetta, E.S. "Preclinical toxicity and efficacy testing of RiVax, a recombinant protein vaccine against ricin." Vaccine 23(39): 4775-4784, 2005.

Ferguson, D.A., Chiang, J.T., Richardson, J.A., Graff, J. "eXPRESSION: An in silico tool to predict patterns of gene expression." Gene Expr Patterns 5(5): 619-628, 2005.

Phan, D., Rasmussen, T.L., Nakagawa, O., McAnally, J., Gottlieb, P.D., Tucker, P.W., Richardson, J.A., Bassel-Duby, R., Olson, E.N. "BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart." Development 132(11): 2669-2678, 2005.

Kasus-Jacobi, A., Ou, J., Birch, D.G., Locke, K.G., Shelton, J.M., Richardson, J.A., Murphy,A.J., Valenzuela, D.M., Yancopoulos, G.D., Edwards, A.O. "Functional characterization of mRDH11 as a retinol dehydrogenase involved in dark adaptation in vivo." J Biol Chem 280(21): 20413-20420, 2005.

Kamat, A., Smith, M.E., Shelton, J.M., Richardson, J.A., Mendelson, C.R. "Genomic regions that mediate placental cell-specific and developmental regulation of human CYP19 (aromatase) gene expression in transgenic mice." Endocrinology 146(5): 2481-2488, 2005.

Scortegagna, M., Ding, K., Zhang, O., Oktay, Y., Bennett, M.J., Bennett, M., Shelton, J.M., Richardson, J.A., Moe, O., Garcia, J.A. "HIF-2{alpha} regulates murine hematopoietic development in an erythropoietin-dependent manner." Blood 105(8): 3133-3140, 2005.

Spencer, J.A., Hacker, S.L., Davis, E.C., Mecham, R.P., Knutsen, R.H., Li, D.Y., Gerard, R.D., Richardson, J.A., Olson, E.N., Yanagisawa, H. "Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration." Proc Natl Acad Sci USA 102(8): 2946-2951, 2005.

Herron, B.J., Rao, C., Liu, S., Laprade, L., Richardson, J.A., Olivieri, E., Semsarian, C., Millar, S.E., Stubbs, L., Beier, D.R. "A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice." Hum Mol Genet 14(5): 667-677, 2005.

Li, S., Czubryt, M.P., McAnally, J., Bassel-Duby, R., Richardson, J.A., Wiebel, F.F, Nordheim, A., Olson, E.N. "Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice." Proc Natl Acad Sci USA 102(4): 1082-1087, 2005.

Cao, D., Wang, Z., Zhang, C.L., Oh, J., Xing, W., Li, S., Richardson, J.A., Wang, D.Z., Olson, E.N. "Modulation of smooth muscle gene expression by the association of histone acetyltransferase and deacetylases with myocardin." Mol Cell Biol 25(1): 364-376, 2005.

McFadden, D.G., Barbosa, A.C., Richardson, J.A., Schneider, M.D., Srivastava, D., Olson, E.N. "The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner." Development 132(1): 189-201, 2005.

Straach, K.J., Shelton, J.M., Richardson, J.A., Hascall, V.C., Mahendroo, M.S. "Regulation of hyaluronan expression during cervical ripening." Glycobiology 15(1): 55-65, 2005.

Wang, Z., Zhai, W., Richardson, J.A., Olson, E.N., Meneses, J.J., Firpo, M.T., Kang, C., Skarnes, W.C., Tijan, R. "Polybromo protein BAF180 functions in mammalian cardiac chamber maturation." Genes Dev 18(24): 3106-3116, 2004.

Frey, N. Barrientos, T., Shelton, J.M., Frank, D., Rutten, H., Gehring, D. Kuhn, C. Lutz, M., Rothermel, B, Bassel-Duby, R., Richardson, J.A., Katus, H.A., Hill, J.A., Olson, E.N. "Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress." Nat Med 10(12): 1336-1343, 2004.

Tamura, N., Doolittle, L.K., Hammer, R.E., Shelton, J.M., Richardson, J.A., Garbers, D.L. "Critical roles of guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs." Proc Natl Acad Sci USA 101(49): 17300-17305, 2004.

Mieda, M., Williams, S.C., Sinton, C.M., Richardson, J.A., Sakurai, T., Yanagisawa, M. "Orexin neurons function in a efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness." J Neurosci 24(46): 10493-10501, 2004.

Vega, R.B., Matsuda, K., Oh, J., Barbosa, A.C., Yang, X., Meadow, E., McAnally, J., Pomajzl, C., Shelton, J.M., Richardson, J.A., Karsenty, G., Olson, E.N. "Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis." Cell 119(4): 555-566, 2004. COVER MANUSCRIPT

Chang, S., McKinsey, T.A., Zhang, C.L., Richardson, J.A., Hill, J.A., Olson, E.N. "Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development." Mol Cell Biol 24(19): 8467-8476, 2004. COVER MANUSCRIPT

Lee, Y., Naseem, R.H., Duplomb, L., Park, B.H., Garry, D.J., Richardson, J.A., Schaffer, J.E., Unger, R.H. "Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice." Proc Natl Acad Sci USA 101(37): 13624-13629, 2004.

Ivanov, S.V., Ward, J.M., Tessarollo, L., McAreavey, D., Sachdev, V., Fananapazir, L., Banks, M.K., Morris, N., Djurickovic, D., Devor-Henneman, D.E., Wei, M.H., Alvord, G.W., Gao, B., Richardson, J.A., Minna, J.D., Rogawski, M.A., Lerman, M.I. "Cerebellar ataxia, seizures, premature death, and cardia abnormalities in mice with targeted disruption o Cacna2d2 gene." Am J Pathol 165(3): 1007-1018, 2004.

Blevins, J.S., Revel, A.T., Caimano, M.J., Yang, X.F., Richardson, J.A., Hagman, K.F., Norgard, M.V. "The luxS gene is not required for Borrelia burgdorei tick colonization." Infect Immun 72(8): 4864-4867, 2004.

Mahendroo, M., Wilson, J.D., Richardson, J.A., Auchus, R.J. "Steroid 5alpha-reductase 1 promotes 5alpha-androstane-3alpha, 17beta-diol synthesis in immature mouse testes by two pathways." Mol Cell Endocrinol 222(1-2): 113-120, 2004.

Feulner, J.A., Lu, M., Shelton, J.M., Zhang, M., Richardson, J.A., Munford, R.S. "Identification of acyloxyacyl hydrolase, a lipopolysaccharide-detoxifying enzyme, in the murine urinary tract." Infect Immun 72(6: 3171-3178, 2004.

Zhang, Y., Woodward, V.K., Shelton, J.M., Richardson, J.A., Zhou, X.J., Link, D., Kielar, M.L., Jeyarajah, D.R., Lu, C.Y. "Ischemia-reperfusion induces G-CSF gene expression by renal mudullary thick ascending limb cells in vivo and in vitro." Am J Physiol Renal Physiol 286(6): F1193-F1201, 2004.

Beuckmann, C.T., Sinton, C.M., Williams, S.C., Richardson, J.A., Hammer, R.E., Sakurai, T., Yanagisawa, M. "Expression of poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat." J Neurosc 24(18): 4469-4477, 2004.

Marschang, P., Brich, J., Weeber, E.J., Sweatt, J.D., Shelton, J.M., Richardson, J.A., Hammer, R.E., Herz, J. "Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggests functional compensation by LRP1." Mol Cell Biol 24(9): 3782-3793, 2004.

Lopez-Rodriguez, C., Antos, C.L., Shelton, J.M., Richardson, J.A., Lin, F., Novobrantseva, T.I., Bronson, R.T., Igarashi, P., Rao, A., Olson, E.N. "Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression." Proc Natl Acad Sci USA 101(8): 2392-2397, 2004.

Cui, Y., Huang, L., Elefteriou, F., Yang, G., Shelton, J.M., Giles, J.E., Oz, O.K., Pourbahrami, T., Lu, C.Y., Richardson, J.A., Karsenty, G., Li, C. "Essential role of STAT3 in body weight and glucose homeostasis." Mol Cell Biol 24(1): 258-269, 2004.

Martin, C.M., Meeson, A.P., Robertson, S.M., Hawke, T.J., Richardson, J.A., Bates, S., Goetsch, S.C., Gallardo, T.D., Garry, D.J. "Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart." Dev Biol 265(1): 262-275, 2004.

Scortegagna, M., Ding, K., Oktay, Y., Gaur, A., Thurmond, F., Yan, L.J., Marck, B.T., Matsumoto, A.M., Shelton, J.M., Richardson, J.A., Bennett, M.J., Garcia, J.A. "Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice." Nat Genet 35(4): 331-340, 2003.

Kedzierski, R.M., Grayburn, P.A., Kisanuki, Y.Y, Williams, S.C., Hammer, R.E., Richardson, J.A., Schneider, M.D., Yanagisawa, M. "Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol." Mole Cell Biol 23(22): 8226-8232, 2003.

Gupta, P., Soyombo, A.A., Shelton, J.M., Wilkofsky, I.G., Wisniewski, K.E., Richardson, J.A., Hofmann, S.L. "Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features." Proc Natl Acad Sci USA 100(21): 12325-12330, 2003.

Hinshelwood, M.M., Repa, J.J., Shelton, J.M., Richardson, J.A., Mangelsdorf, D.J., Mendelson, C.R. "Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function." Mol Cell Endocrinol 207(1-2): 39-45, 2003.

Clouthier, D.E., Williams, S.C., Hammer, R.E., Richardson, J.A., Yanagisawa, M. "Cell-autonomous and nonautonomous actions of endothelin-A receptor signaling in craniofacial and cardiovascular development." Dev Biol 261(2): 506-519, 2003.

Kasus-Jacobi, A., Ou, J., Bashmakov, Y.K., Shelton, J.M., Richardson, J.A., Goldstein, J.L., Brown, M.S. "Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins." J Biol Chem 278(34): 32380-32389, 2003.

Goetsch, S.C., Hawke, T.J., Gallardo, T.D., Richardson, J.A., Garry, D.J. "Transcriptional profiling and regulation of the extracellular matrix during muscle regeneration." Physiol Genomics 14(3): 261-271, 2003.

Li, S., Wang, D.Z., Wang, Z., Richardson, J.A., Olson, E.N. "The serum response factor coactivator myocardin is required for vascular smooth muscle development." Proc Natl Acad Sci USA 100(16): 9366-9370, 2003.

Cha, J.H., Chang, M.Y, Richardson, J.A., Eidels, L." Transgenic mice expressing diphtheria toxin receptor are sensitive to the toxin." Mol Microbiology 49(1):235-240, 2003.

Wolff, N/C., Richardson, J.A., Egorin, M., Ilaria, R.L. Jr. "The CNS is a sanctuary for leukemic cells in mice receiving imatinib meylate for Bcr/Abl-induced leukemia." Blood 101(12): 5010-5013, 2003.

Willie, J.T., Chemelli, R.M., Sinton, C.M., Tokita, S., Williams, S.C., Kisanuki, Y.Y., Marcus, J.N., KLee, C., Elmquist, J.K., Kohlmeier, K.A., Leonard, C.S., Richardson, J.A., Hammer, R.E., Yanagisawa, M. "Distinct narcolepsy sundromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes." Neuron 38(5): 715-730, 2003.

Tanaka, H., Yoshida, T., Miyamoto, N., Motoike, T., Kurosu, H., Shibata, K., Yamanaka, A., Williams, S.C., Richardson, J.A., Tsujino, N., Garry, M.G., Lerner, M.R., King, D.S., O'Dowd, B.F., Sakurai, T., Yanagisawa, M. "Characterization of a family of endogenous neuropeptide ligands for G protein-coupled receptors GPR7 and GPR8." Proc Natl Acad Sci USA 100(10): 6251-6256, 2003.

Yanagisawa, H., Clouthier, D.E., Richardson, J.A., Charite, J., Olson, E.N. "Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development." Development 130(6): 1069-1078, 2003.

Sosic, D., Richardson, J.A., Yu, K., Ornitz, D.M., Olson, E.N. "Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity." Cell 112)2): 169-180, 2003.

Gotthardt, M., Hammer, R.E., Hubner, N., Monti, J., Witt, C.C., McNabb, M., Richardson, J.A., Granzier H., Labeit, S., Herz, J. J Biol Chem 278(8): 6059-6065, 2003.

Velasco-Miguel, S., Richardson, J.A., Gerlach, V.L., Lai, W.C., Gao, T., Russell, L.D., Hladik C.L., White, C.L., Friedberg, E.C. "Constitutive and regulated expression of the mouse DinB (Polkappa) gene encoding DNA polymerase kappa." DNA Repair (Amst) 2(1): 91-106, 2003.

Lu, J.R., Bassel-Duby, R., Hawkins, A., Chang, P., Valdez, R. Wu, H., Gan, L., Shelton, J.M., Richardson, J.A., Olson, E.N. "Control of facial muscle development by MyoR and capsulin." Science 298(5602): 2378-2381, 2002.

Mammen, P.P, Shelton, J.M., Goetsch, S.C., Williams, S.C., Richardson, J.A., Garry, M.G., Garry, D.J. "Neuroglobin, a novel member of the globin family, is expressed in focal regions of the brain." J Histochem Cytochem 50(12): 1591-1598, 2002.

Barlow, G.M., Lyons, G.E., Richardson, J.A., Sarnat, H.B., Korenberg, J.R. "DSCAM: an endogenous promoter drives expression in the developing CNS and neural crest." Biochem Biophys Res Commun 299(1): 1-6, 2002.

Wang, D.Z., Li, S., Hockemeyer, D., Sutherland, L., Wang, Z., Schratt, G., Richardson, J.A., Nordheim, A., Olson, E.N."Potentiation of serum response factor activity by a family of myocardin-related transcription factors." Proc Natl Acad Sci USA 99(23): 14855-14860, 2002.

McMillan, D.R., Christians, E., Forster, M., Xiao, X., Connell, P., Plumier, J.C., Zuo, X., Richardson, J.A., Morgan, S., Benjamin, I.J. "Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice." Mol Cell Biol 22(22): 8005-8014, 2002.

Naya, F.J., Black, B.L., Wu, H, Bassel-Duby, R., Richardson, J.A., Hill, J.A., Olson, E.N. "Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor." Nat Med 8(11): 1303-1309, 2002.

Shin, C.H., Liu, Z.P., Passier, R., Zhang, C.L., Wang, D.Z., Harris, T.M., Yamagishi, H., Richardson, J.A., Childs, G., Olson, E.N. "Modulation of cardiac growth and development by HOP, an unusual homeodomain protein." Cell 110(6): 725-735, 2002. COVER MANUSCRIPT

Shi, X., Xie, C, Kreska, D., Richardson, J.A., Mohan, C. "Genetic dissection of SLE: SLE1 and FAS impact alternate pathways leading to lymphoproliferative autoimmunity." J Exp Med 196(3): 281-289, 2002

Shao, X., Johnson, J.E., Richardson, J.A., Hiesberger, T., Igarashi, P. "A minimal Ksp-cadherin promoter linked to a green fluorescent protein reporter gene exhibits tissue-specific expression in the developing kidney and genitourinary tract." J Am Soc Nephrol 13(7):1824-1836, 2002.

McFadden, D.G., McAnally, J., Richardson, J.A., Charite, J., Olson, E.N. "Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding." Development 129(13): 3077-3088, 2002.

Richardson J.A., Burns, D.K. "Mouse models of Alzheimer's disease: a quest for plaques and tangles." ILAR J 43(2): 89-99, 2002.

Repa, J.J., Berge, K.E., Pomajzl, C., Richardson, J.A., Hobbs, H, Mangelsdorf, D.J. "Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by liver x receptors alpha and beta." J Biol Chem 277(21): 18793-18800, 2002.

Lien, C.L., McAnally, J., Richardson J.A., Olson E.N. "Cardiac-specificity activity of an Nkx2-5 enhancer requires an evolutionary conserved Smad binding site." Dev Biol 244(2): 257-266, 2002.

Antos, C.L., McKinsey, T.A., Frey, N., Kutschke, W., McAnally, J., Shelton, J.M., Richardson, J.A., Olson, E.N. "Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo." Proc Natl Acad Sci USA 99(2): 907-1012, 2002.

Yanagisawa, H., Davis, E.C., Starcher, B.C., Ouchi, T., Yanagisawa, M., Richardson, J.A., Olson, E.N. "Fibulin-5 is an elastin-binding protein essential for elastic fiber development in vivo." Nature 415(6868): 168-171, 2002.

Henderson, J.R., Brown, D., Richardson, J.A., Olson, E.N., Beckerle, M.C. "Expression of the gene encoding the LIM protein CRP2: a developmental profile." J Histochem Cytochem 50(1): 107-111, 2002.

van der Horst, G.T., Meira, L., Gorgels, T.G., de Wit, J., Velasco-Miguel, S., Richardson, J.A., Kamp, Y., Vreeswijk, M.P., Smit, B., Bootsma, D., Hoeijmakers, J.H., Friedberg, E.C. DNA Repair (Amst) 1(2): 143-157, 2002.

McMillan, D.R., Kayes-Wandover, K.M., Richardson, J.A., White, P.C. "Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in developing central nervous system. "J Biol Chem 277(1): 785-792, 2002.

Gupta, P., Soyombo, A.A., Atashband, A., Wisniewski, K.E., Shelton, J.M., Richardson, J.A., Hammer, R.E., Hofmann, S.L. Proc Natl Acad Sci USA 98(24): 13566-13571, 2001.

Antos, C.L., Frey, N., Marx, S.O., Reiken, S., Gaburjakova, M., Richardson, J.A., Marks, A.R., Olson, E.N. "Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a." Circ Res 89(11): 997-1004, 2001.

Wang, D.Z., Vadez, M.R., McAnally, J., Richardson, J.A., Olson, E.N. "The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development." Development 128(22): 4623-4633, 2001.

Charite, J. McFadden, D.G., Merlo, G., Levi, G., Clouthier, D.E>, Yanagisawa, M., Richardson, J.A., Olson, E.N. "Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer." Genes Dev 15(22): 3039-3049, 2001."

Honarpour, N., Tabuchi, K., Stark, J.M., Hammer, R.E., Sudhof, T.C., Parada, L.F., Wang, X., Richardson, J.A., Herz, J. "Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of APAF-1." Neuroscience 106(2):263-274, 2001.

Kong, Y., Shelton, J.M., Rothermel, B., Li, X., Richardson, J.A., Bassel-Duby, R., Williams, R.S. "Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to b-adrenergic stimulation." Circulation 103: 2731-2738, 2001. COVER MANUSCRIPT

Nicol, R.L., Frey, N., Pearson, G., Cobb, M., Richardson, J.A., Olson, E.N. "Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy." EMBO 20(11): 2757-2767, 2001.

Xiong, U., Tanaka, H.,Richardson, J.A., Williams, S.C., Slaughter, C.A., Nakamura, M., Chen, J.L., Yanagisawa, M. "Endothelin-1 stimulates leptin production in adipocytes." J Biol Chem 276: 28471-28477, 2001.

Kisanuki Y.Y., Hammer R.E., Miyazaki J., Williams S.C., Richardson J.A., Yanagisawa M. "Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo." Dev Biol 230(2): 230-242, 2001.

Wang, D-Z., Chang,, P.S., Wang,, Z., Sutherland, L., Richardson, J.A., Small, E., Krieg,, P.A., Olson, E.N. "Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor." Cell 105: 851-862, 2001.

Liu, Z-P., Nakagawa, O., Nakagawa, M., Yanagisawa, H., Passier, R., Richardson, J.A., Srivastava, D., Olson., E.N. "CHAMP, A novel cardiac-specific helicase regulated by MEF2C." Dev Bio 234(2) 497-509, 2001.

Passier, R., Richardson, J.A., Olson, E.N. "Oracle, a novel PDZ-LIM domain protein expressed in heart and skeletal muscle." Mech of Dev 92:277-84, 2000.

Frey N., Richardson, J.A., Olson, E.N. "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins." Proc Natl Acad Sci USA 97(26): 14632-14637, 2000.

McFadden, D.G., Charite, J., Richardson, J.A., Srivastava, D., Firulli, A.B., Olson, E.N. "A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart." Development 127 5331-5341, 2000.

Gerlach, V.L., Feaver, W.J., Fischhaber, P L., Richardson, J.A., Aravind, L., Koonin, E.V., Bebenek, K., Kunkel, T. A., Friedberg, E.C. "Human DNA polymerase K: a novel DNA polymerase of unknown biological function encoded by the DINBI gene." Cold Spring Harbor Symposia on Quantitative Biology 65: 41-49, 2000.

Lu, J, Chang, P., Richardson, J.A., Gan, L, Weiler, H., Olson, E.N. "The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis." Proc Natl Acad Sci USA 97: 9525-9530, 2000.

Spencer, J.A., Eliazer, S., Ilaria, R.L., Richardson, J.A., Olson, E.N. "Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein." J. Cell Biol 150: 771-784, 2000.

Zhang, W., Li, J-L., Hosaka, M., Janz, R., Shelton, J.M., Albright, G. M., Richardson, J.A., Sudhof, T.C. and Victor, R.G. "Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings." Proc Natl Acad Sci USA 97: 9765-9770, 2000.

Molekentin, J.D., Tymitz, M., Richardson, J.A., and Olson, E.N. "Abnormalities of the genitourinary tract in female mice lacking GATA5." Mol Cell Biol20: 5256-5260, 2000.

Gotthardt, M., Trommsdorff, M., Shelton, J.M., Richardson, J.A., and Herz, J. "Interactions of the Low Density Lipoprotein (LDL) Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction." J Bio Chem 275: 25616-25624, 2000.

Passier, R., Zeng, H., Grey, N., Naya, F.J., Nicol, R.L., McKinsey, T.A., Oberbeek, P., Richardson, J.A., Grant, S.R., and Olson, E.N. "CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo." J Clin Inv 105:1395-1406, 2000.

Yanagisawa, H., Hammer, R.E., Richardson, J.A., Emoto, N., Williams, S.C., Takeda, S., Clouthier, D.E., and Yanagisawa, M. "Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting-enzyme-2 in murine cardiac development." J Clin Inv 105:1373-1382, 2000. COVER MANUSCRIPT

Gariepy, C.E., Ohuchi, T., Williams, S.C., Richardson, J.A., and Yanagisawa, M. "Salt-sensitive hypertension in endothelin-B receptor-deficient rats." J Clin Inv 105: 1092-1101, 2000.

Li, K., Li, Y., Shelton, J.M., Richardson, J.A., Spencer, E., Chen, Z.J., Wang, X., and Williams, R.S. "Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis." Cell 101: 389-399, 2000.

Shelton, J.M., Lee, M.H., Richardson, J.A., and Patel, S.B. "Microsomal triglyceride transfer protein expression during mouse development." J Lip Res 41(4): 532-537, 2000. COVER MANUSCRIPT

Valdez, M.R., Richardson, J.A., Klein, W.H., and Olson, E.N. "Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4." Dev Biol 219(2): 287-298, 2000.

Naya, F.J., Mercer, B., Shelton, J.M., Richardson, J.A., Williams, R.S., and Olson, E.N. "Stimulation of Slow Skeletal Muscle Fiber Gene Expression by Calcineurin in Vivo." J Bio Chem 275(7): 4545-4548, 2000.

Honarpour, N., Du, C., Richardson, J.A., Hammer, R.E., Wang, X., and Herz, J. "Adult Apaf-1-deficient mice exhibit male infertility." Dev Biol 218(2): 248-258, 2000.

Clouthier, D.E., Williams, S.C., Yanagisawa, H., Wieduwilt, M., Richardson, J.A., and Yanagisawa, M. "Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice." Dev Biol 217(1): 10-24, 2000. COVER MANUSCRIPT

Nakagawa, O., Nakagawa, M., Richardson, J.A., Olson, E.N., and Srivastava, D.E. "HRT1, HRT2, and HRT3: A New Subclass of bHLH Transcription Factors Marking Specific Cardiac, Somitic, and Pharyngeal Arch Segments." Dev Biol 216: 72-84, 1999.

Xiao, X.Z., Zuo, X.X., Davis, A.A., McMillan, D.R., Curry, B.B., Richardson, J.A., and Benjamin, I.J. "HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice." EMBO 18(21): 5943-5952, 1999.

Horton, S., Meredith, A., Richardson, J.A., and Johnson J.E. "Correct coordination of neuronal differentiation events in ventral forebrain requires the bHLH factor MASH1." Mol Cell Neuro 14(4-5):355-369, 1999.

Piedrahita, J.A., Octama, B., Bennett, G.D., van Waes, J., Kamen, B.A., Richardson, J.A., Lacey, S.W., Anderson, R.G.W., and Finnell, R.H. "Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development." Nat Gen 23: 228-232, 1999.

Taurog, J.D., Maika, S.D., Satumtira, N., Dorris, M.L., McLean, I.L., Yanagisawa, H., Sayad, A., Stagg, A.J., Fox, G.M., Le O'Brien, A., Rehman, M., Zhou, M., Weiner, A.L., Splawski, J.B., Richardson, J.A., and Hammer, R.E. "Inflammatory disease in HLA-B27 transgenic rats." [Review] Immun Reviews 169: 209-223, 1999.

Cao, G., Zhao, L., Stangl, H., Hasegawa, T., Richardson, J.A., Parker, K.L., and Hobbs, H.H. "Developmental and hormonal regulation of murine scavenger receptor, class B, type 1." Mol Endocrinol 13(9): 1460-1473, 1999.

Chemelli, R.M., Willie, J.T., Sintonm C.M., Elmquist, J.K., Scammell, T., Lee, C., Richardson, J.A., Williams, S.C., Xiong, Y., Kisanuki, Y., Fitch, T.E., Nakazato, M., Hammer, R.E., Saper, C.B., and Yanagisawa, M. "Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation." Cell 98(4): 437-451, 1999.

Cianga, P., Medesan, C., Richardson, J.A., Ghetie, V., and Ward, E.S. "Identification and function of neonatal Fc receptor in mammary gland of lactating mice." Eur J Immunol 29: 2525-2523, 1999.

Trommsdorff M., Gotthardt M., Hiesberger T., Shelton J.M., Stockinger W., Nimpf J., Hammer R.E., Richardson J.A., Herz J. "Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2." Cell 97: 689-701, 1999. COVER MANUSCRIPT

Naya, F.J., Wu, C.Z., Richardson, J.A., Overbeek, P., and Olson, E.N. "Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene." Development 126: 2045-2-52, 1999.

Kowal R.C., Richardson J.A., Miano J.M., and Olson E.N. "EVEC, a Novel Epidermal Growth Factor-Like Repeat-Containing Protein Upregulated in Embryonic and Diseased Adult Vasculature." Circ Res 84: 1166-1176, 1999. COVER MANUSCRIPT

Henderson, J.R., Macalma, T., Brown, D., Richardson, J.A., and Olson, E.N., and Beckerle, M.C. "The LIM protein, CRP1, is a smooth muscle marker." Dev Dyn 214(3): 229-238, 1999.

Lu, J.R., McKinsey, T.A., Xu, H., Wang, D.Z., Richardson, J.A., and Olson, E.N. "FOG-2, a heart- and brain-enriched cofactor for GATA transcription factors."  Mol Cell Biol 19(6):4495-4502, 1999.

Kamat, A., Graves, K.H., Smith, M.E., Richardson, J.A., and Mendelson, C.R. "A 500-bp region, ~40kb upstream of the human CYP19 (aromatase) gene, mediates placenta-specific expression in transgenic mice." Proc Nat Acad Sci 96: 4575-4580, 1999.

Lu, J., Webb, R.C., Richardson, J.A., and Olson, E.N. "Myo-R: A muscle-restricted basic helix-loop-helix transcription factor that antagonizes the actions of MyoD." Proc Nat Acad Sci 96: 552-557, 1999.

Lien, C.L., Wu, C., Mercer, B., Webb, R.C., Richardson, J.A. and Olson, E.N. "Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer." Development 126(1): 75-84, 1999.

Brown, D., Wagner, D., Li, X.Q., Richardson, J.A., and Olson, E.N. "Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis." Development 126:4317-4329, 1999.

Onderdonk, A.B., Richardson, J.A., Hammer, R.E., and Taurog, J.D. "Correlation of cecal microflora of HLA-B27 transgenic rats with inflammatory bowel disease." Infect Immun 66(12): 6022-6023, 1998.

Borvak, J., Richardson, J.A., Medesan, C., Antohe, F., Radu, C., Simionescu, M., Ghetie, V. and Ward, E.S. "Functional expression of the MHC class I related receptor, FcRn, in endothelial cells of mice." Int J Immunol 10(9): 1289-1298, 1998.

Lin, Q., Lu, J., Yanagisawa, H., Webb, R.C., Lyons, G.E., Richardson, J.A., and Olson, E.N. "Requirement of the MADS-box transcription factor MEF2C for vascular development." Development 125(22): 4565-4574, 1998.

Shimomura, I., Hammer, R.E., Richardson, J.A., Ikemoto, S., Bashmakov, Y., Goldstein, J.L., and Brown, M.S. "Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy." Gene & Dev 12(20): 3182-3194, 1998.

Zhu, Y., Richardson, J.A., Parada, L.F., and Graff, J.M. "Smad3 Mutant Mice Develop Metastatic Colorectal Cancer." Cell 94:703-714, 1998.

Gariepy, C.E., Williams, S.C., Richardson, J.A., Hammer, R.E., and Yanagisawa, M. "Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease." J Clin Invest 102(6):1092-1101, 1998.

Chin, E., Olson, E.N., Richardson, J.A., Yang, Q., Humphries, C., Shelton, J.M., Wu, H., Zhu, W., Bassel-Duby, R., Williams, R.S. "A Calcineurin-Dependent Transcriptional Pathway Controls Skeletal Muscle Fiber Type." Gen and Dev 12: 16; 2499-2509, 1998. COVER MANUSCRIPT

Zhou, M. Sayad, A. Simmons, W.A., Jones, R.C., Maika, S.D., Satumtira, N., Dorris, M.D., Gaskell, S.J., Bordoli, R.S., Sartor, R. B., Slaughter, C.A., Richardson, J.A., Hammer, R.. E., Taurog, J.D. "The specificity of peptides bound to HLA-B27 influences the prevalence of joint swelling in HAL-B27 transgenic rats." J. Exp Med 188: 877-886, 1998.

Rawls, A., Valdez, M.R., Zhang, W., Richardson, J.A.,Klein, W.H., Olson, E.N. "Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice." Development 125: 2349-2358, 1998.

Yanagisawa, H., Hammer, R.E., Richardson, J.A., Williams, S.C., Clouthier, D.E., Yanagisawa, M. "Role of endothelin-1/endothelin-A receptor-mediated signaling in the aortic arch patterning in mice." J. Clin Invest 102: 22-33, 1998. COVER MANUSCRIPT

Lu, J., Richardson, J.A., Olson, E.N. "Capsulin: A Novel bHLH Transcription Factor Expressed in Epicardial Progenitors and Mesenchyme of Visceral Organs." Mech of Dev 73: 23-32, 1998. COVER MANUSCRIPT

Yanagisawa, H., Yanagisawa, M., Kapur, R.P., Richardson, J.A., Williams, S.C., Clouthier, D.E., de Wit, D., Emoto, N., Hammer, R.E. "Dual genetic pathways of endothelin-mediated signaling defined by targeted disruption of endothelin converting enzyme-1 gene." Development, 125: 825-836, 1998.

Molkentin, J.D., Lu, J, Antos, C.L., Richardson, J.A., Robbins, J., Wu, C., Grant, S. Olson, E.N. "A calcineurin-dependent transcriptional pathway for cardiac hypertrophy." Cell, 93, 215-228, 1998. COVER MANUSCRIPT

Clouthier, D.E., Hosoda, K. Richardson, J.A., Williams, S.C., Yanagisawa, H. Kuwaki, T., Kumada, M., Hammer, R.E., Yanagisawa, M. "Endothelin A. receptor-mediated signaling in cephalic neural crest development." Development, 125: 813-824, 1998. COVER MANUSCRIPT

Bryant, D., Becker, L., Richardson, J., Shelton, J., Franco, F., Peshock, R., Giroir, B. "Cardiac Failure in Transgenic Mice with Myocardial Expression of Tumor Necrosis Factor-a (TNF)." Circulation 97: 14; 1375-1381, 1998.

Sakuari, T., Amemiya, A., Ishii, M. Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richardson, J.A., Kozlowski, G.P. Wilson, S., Arch, J.R.S., Buckingham, R.E., Haynes, A.C., Carr, S.A., Annan, R.S., McNulty, D.E., Liu, W-S., Terrett, J.A. Elshourbagy, N.A., Bergsma, D.J. Yanagisawa, M. "Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior." Cell, 92: 573-585, 1998. COVER MANUSCRIPT

Benjamin, I.J., Shelton, J.M., Garry, D.J., and Richardson, J.A.. "Temporospatial Expression of the Small HSP/aB-Crystallin in Cardiac and Skeletal Muscle During Mouse Development." Dev Dyn 208: 75-84, 1997. COVER MANUSCRIPT

Zhou, Y., Barnard, M., Tian, H., Li, X., Ring, H.Z., Francke, U., Shelton, J.M., Richardson, J.A., Russell, D.W., McKnight, S.L. "Molecular Characterization of Two Mammalian bHLH-PAS Domain Proteins Selectively Expressed in the Central Nervous System." Proc Natl Acad Sci USA 94: 2; 713-718, 1997.

Garry, D.J., Bassel-Duby, R.S., Richardson, J.A., Grayson, J.M., Neufer, P.D., Williams, R.S. "Postnatal development and plasticity of specialized muscle fiber characteristics in the hindlimb." Dev Gene 19:146-156, 1996.

Neufer, P.D., Ordway, G.A., Hand, G.A., Shelton, J.M., Richardson, J.A., Benjamin, I.J., and Williams, R.S. "Continuous Contractile Activity Induces Fiber Type Specific Expression of HSP70 in Skeletal Muscle." Am J Physiol 271 (Heart Circ Physiol 40): C1828-C1837, 1996.

W.J. Parsons, R.S. Williams, J.M. Shelton, Y. Luo, D.J. Kessler, and J.A. Richardson. "Developmental Regulation of Cytochrome Oxidase Subunit VIa Isoforms in Cardiac and Skeletal Muscle." Am J Physiol 270 (Heart Circ Physiol 39): H567-H574, 1996.

Breban, M., Fernandez-Sueiro, J.L., Richardson, J.A., Hadavand, R., Maika, S.D., Hammer, R.E., and Taurog, J.D. "T cells but not thymic exposure to B27 are required for inflammatory disease of HLA-B27 transgenic rats." J Immunol 156:794-803, 1996.

Yanagisawa, H., Richardson, J.A., Taurog, J.D., and Hammer, R.E. "Characterization of psoriasiform and alopecic skin lesions in HLA-B27 transgenic rats." Am J Pathol 147(4): 955-964, 1995.

Hammer, R.E., Richardson, J.A., Simmons, W.A., White, A.L., Breban, M., and Taurog JD. "High prevalence of colorectal cancer in HLA-B27 transgenic F344 rats with chronic inflammatory bowel disease." J Inv Med 43(3): 262-268, 1995.

Norgard, M.V., Riley, B.S., Richardson, J.A., and Radolf, J.D. "Dermal inflammation elicited by synthetic analogs of Treponema pallidum and Borrelia burgdorferi lipoproteins." Infect Immun 63(4): 1507-1515, 1995.

Huang, Y.W., Richardson, J.A., and Vitetta, E.S. "Anti-CD54 (ICAM-1) has antitumor activity in SCID mice with human myeloma cells." Cancer Res 55(3): 610-616, 1995.

Hosada, K., Hammer, R.E., Richardson, J. A., Baynash, A.G>, Cheung, J.C., Giaid, A., and Yanagisawa, M. "Targeted and Natural (Piebald-Lethal) Mutations of Endothelin-B Receptor Gene Produce Megacolon Associated with Spotted Coat Color in Mice." Cell 79:1267-1276, 1994. COVER MANUSCRIPT

Baynash, A.G., Hosada, K., Giaid, A., Richardson, J.A., Emoto, N., Hammer, R.E., and Yanagisawa, M. "Interaction of Endothelin-3 with Endothelin-B Receptor Is Essential for Development of Epidermal Melanocytes and Enteric Neurons." Cell 79:1277-1285, 1994.

Taurog, J.D., Richardson, J.A., Croft, J.T., Simmons, W.A., Zhou, M., Fernandez-Sueiro, J.L., Balish, E., and Hammer, R.E. "The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats." J Exp Med 180(6): 2359-2364, 1994.

Ghetie, M.A., Tucker, K., Richardson, J.A., Uhr, J.W., and Vitetta, E.S. "Eradication of minimal disease in severe combined immunodeficient mice with disseminated Daudi lymphoma using chemotherapy and an immunotoxin cocktail." Blood 84(3): 702-707, 1994.

Michel, J.B., Ordway, G.A, Richardson, J.A., and Williams, R.S. "Biphasic Induction of Immediate Early Gene Expression Accompanies Activity-dependent Angiogenesis and Myofiber Remodeling of Rabbit Skeletal Muscle." J Clin Inves 94: 277-285, 1994

Linton, C.G., Gordon, B.E., and Richardson, J.A. "Diagnostic exercise: thickened auricular pinnae in a Sprague Dawley rat." Lab An Sci 44(1): 69-70, 1994.

Ghetie, M.A., Picker, L.J., Richardson, J.A., Tucker, K., Uhr, J.W., and Vitetta, E.S. "Anti-CD19 inhibits the growth of human B-cell tumor lines in vitro and of Daudi cells in SCID mice by inducing cell cycle arrest." Blood 83(5): 1329-1336, 1994.

Li, K., Smagula, C.S., Parsons, W.J., Richardson, J.A., Gonzalez, M., Hagler, H.K., and Williams, R.S. "Subcellular Partitioning of MRP RNA Assessed by Ultrastructural and Biochemical Analysis." J Cell Bio 124(6): 871-882, 1994.

Hansen, E.J., Lumbley, S.R., Richardson, J.A., Purcell, B.K., Stevens, M.K., Cope, L.D., Datte, J., and Radolf, J.D. "Induction of protective immunity to Haemophilus ducreyi in the temperature-dependent rabbit model of experimental chancroid." J Immun 152(1):184-192, 1994.

Nordin, A.J., Richardson, J.A., and Smith, S.C. "Primary invasive adenocarcinoma of the fallopian tube diagnosed by histological examination of a surgical sterilization specimen. Case report." Eur J Gyn Onc 14(6); 466-468, 1993.

Breban, M., Hammer, R.E., Richardson, J.A., and Taurog, J.D. "Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment." J Exp Med 178(5): 1607-1616, 1993.

Amlot, P.L., Stone, M.J., Cunningham, D., Fay, J., Newman, J., Collins, R., May, R., McCarthy, M., Richardson, J.A., and Ghetie, V. "A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy." Blood 82(9): 2624-2633, 1993.

Bassel-Duby, R., Grohe, C.M., Jesse, M.E., Parsons, W.J., Richardson, J.A., Chao, R., Grayson, J., Ring, W.S., and Williams, R.S. "Sequence Elements Required for Transcriptional Activity of the Human Myoglobin Promoter in Intact Myocardium." Circ Res 73(2): 360-366, 1993.

Huang, Y.W., Richardson, J.A., Tong, A.W., Zhang, B.Q., Stone, M.J., and Vitetta, E.S. "Disseminated growth of a human multiple myeloma cell line in mice with severe combined immunodeficiency disease." Cancer Res 53(6): 1392-1396, 1993.

Parsons, W.J., Richardson, J.A., Graves, K.H., Williams, R.S., and Moreadith, R.W. "Gradients of transgene expression directed by the human myoglobin promoter in the developing heart." Proc Nat Acad Sci 90: 1726-1730, 1993.

Ghetie, M.A., Tucker, K., Richardson, J.A., Uhr, J.W., and Vitetta, E.S. "The antitumor activity of an anti-CD22 immunotoxin in SCID mice with disseminated Daudi lymphoma is enhanced by either an anti-CD19 antibody or an anti-CD19 immunotoxin." Blood 80(9): 2315-2320, 1992.

Soler-Rodriguez, A.M., Uhr, J.W., Richardson, J.A. and Vitetta, E.S. "The toxicity of chemically deglycosylated ricin A-chain in mice." Int J Immunopharm 14(2):281-291, 1992.

Gordon, B.E., Durfee, W.J., Feldman, S.H., and Richardson, J.A. "Diagnostic exercise: pneumonia in a congenic immunodeficient mouse." Lan An Sci 42(1): 76-77, 1992.

Beyers, T.M., Richardson, J.A., and Prince, M.D. "Axonal degeneration and self-mutilation as a complication of the intramuscular use of ketamine and xylazine in rabbits." Lab An Sci 41(5): 519-520, 1991.

Richardson, J.A., Tang, K., and Burns, D.K. "Myeloencephalopathy with Rosenthal fiber formation in a miniature poodle." Vet Path 28(6): 536-538, 1991.

Ghetie, M.A., Richardson, J.A., Tucker, T., Jones, D., Uhr, J.W., and Vitetta, E.S. "Antitumor activity of Fab' and IgG-anti-CD22 immunotoxins in disseminated human B lymphoma grown in mice with severe combined immunodeficiency disease: effect on tumor cells in extranodal sites." Cancer Res 51(21): 5876-5880, 1991.

Purcell, B.K., Richardson, J.A., Radolf, J.D., and Hansen, E.J. "A temperature-dependent rabbit model for production of dermal lesions by Haemophilus ducreyi." J Infect Dis 164(2):359-367, 1991.

Ghetie, V., Till, M.A., Ghetie, M.A., Tucker, T., Porter, J., Patzer, E.J., Richardson, J.A., Uhr, J.W., and Vitetta, E.S. "Preparation and characterization of conjugates of recombinant CD4 and deglycosylated ricin A chain using different cross-linkers." Bioconjug Chem 1(1): 24-31, 1990.

Hammer, R.E., Maika, S.D., Richardson, J.A., Tang, J.P., and Taurog J,D. "Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders." Cell 63(5): 1099-1112, 1990. COVER MANUSCRIPT

Feldman, S.H., and Richardson, J.A. "Diagnostic exercise: wasting syndrome in a flock of Japanese quail." Lab An Sci 40(4): 409-410, 1990.

Ghetie, M.A., Richardson, J.A., Tucker, T., Jones, D., Uhr, J.W., and Vitetta, E.S. "Disseminated or localized growth of a human B-cell tumor (Daudi) in SCID mice." Int J Cancer 45(3): 481-485, 1990.

Feldman, S.H., Richardson, J.A., and Clubb Jr, F.J. "Necrotizing Viral Bronchopneumonia in Guinea Pigs." Lab An Sci 40(1), 1990.

Schick, M.P., Schick, R.O., and Richardson, J.A. "Calcinosis cutis secondary to percutaneous penetration of calcium chloride in dogs." J Am Vet Med Assoc 191: 207-211, 1987.

Richardson, J.A., Morter, R.L., Rebar, A.H., and Olander, H.J. "The lesions of porcine necrotic ear syndrome." Vet Path 21: 152-157, 1984.

Richardson, J.A., Burgener, j., Winterfield, R.W., and Dhillon, A.S. "Deep pectoral myopathy in seven-week-old broiler chickens." Avian Dis 24: 1054-1059, 1980.

Dhillon, A.S., Winterfield, R.W., Thacker, H.L., and Richardson, J.A. "Erysipelas in white Peking ducks." Avian Dis 24: 784-787, 1980.

Richardson, J.A., Kazacos, K.R., Thacker, H.L., Dhillon, A.S., and Winterfield, R.W. "Verminous encephalitis in commercial chickens." Avian Dis 24: 498-503, 1980.

Julian, R.J., Harrison, K.B., and Richardson, J.A. "Nervous signs in bovine coccidiosis." Mod Vet Pract 57: 711-718, 1976.

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