Publications

Publications for Preclinical Pharmacology Core

RECENT PUBLICATION (core staff in bold)

  1. McMillan EA, Ryu MJ, Diep CH, Mendiratta S, Clemenceau JR, Vaden RM, Kim JH, Motoyaji T, Covington KR, Peyton M, Huffman K, Wu X, Girard L, Sung Y, Chen PH, Mallipeddi PL, Lee JY, Hanson J, Voruganti S, Yu Y, Park S, Sudderth J, DeSevo C, Muzny DM, Doddapaneni H, Gazdar A, Gibbs RA, Hwang TH, Heymach JV, Wistuba I, Coombes KR, Williams NS, Wheeler DA, MacMillan JB, Deberardinis RJ, Roth MG, Posner BA, Minna JD, Kim HS, White MA. Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell. 2018 May 3;173(4):864-878.e29. doi: 10.1016/j.Cell.2018.03.028. Epub 2018 Apr 19. PubMed PMID: 29681454; PubMed Central PMCID: PMC5935540.
  2. Qi C, Wang X, Shen Z, Chen S, Yu H, Williams N, Wang G. Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells.Cell Res. 2018 Mar 1. doi: 10.1038/s41422-018-0018-6. [Epub ahead of print] PubMed PMID: 29497138.
  3. Nanayakkara AK, Follit CA, Chen G, Williams NS, Vogel PD, Wise JG. Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells.Sci Rep. 2018 Jan 17;8(1):967. doi: 10.1038/s41598-018-19325-x. PubMed PMID: 29343829; PubMed Central PMCID: PMC5772368.
  4. Voorhees JR, Remy MT, Cintrón-Pérez CJ, El Rassi E, Khan MZ, Dutca LM, Yin TC, McDaniel LN, Williams NS, Brat DJ, Pieper AA. (-)-P7C3-S243 Protects a Rat Model of Alzheimer's Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia.Biol Psychiatry. 2017 Nov 6. pii: S0006-3223(17)32145-5. doi: 10.1016/j.biopsych.2017.10.023. [Epub ahead of print] PubMed PMID: 29246437.
  5. Eskiocak B, McMillan EA, Mendiratta S, Kollipara RK, Zhang H, Humphries CG, Wang C, Garcia-Rodriguez J, Ding M, Zaman A, Rosales TI, Eskiocak U, Smith MP, Sudderth J, Komurov K, Deberardinis RJ, Wellbrock C, Davies MA, Wargo JA, Yu Y, De Brabander JK, Williams NS, Chin L, Rizos H, Long GV, Kittler R, White MA. Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma.Cancer Discov. 2017 Aug;7(8):832-851. doi: 10.1158/2159-8290.CD-16-0955. Epub 2017 Apr 28. PubMed PMID: 28455392; PubMed Central PMCID: PMC5540806.
  6. McCarthy JS, Lotharius J, Rückle T, Chalon S, Phillips MA, Elliott S, Sekuloski S, Griffin P, Ng CL, Fidock DA, Marquart L, Williams NS, Gobeau N, Bebrevska L, Rosario M, Marsh K, Möhrle JJ. Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study.Lancet Infect Dis. 2017 Jun;17(6):626-635. doi: 10.1016/S1473-3099(17)30171-8. Epub 2017 Mar 28. PubMed PMID: 28363636; PubMed Central PMCID: PMC5446412.
  7. Antczak MI, Zhang Y, Wang C, Doran J, Naidoo J, Voruganti S, Williams NS, Markowitz SD, Ready JM. Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair.J Med Chem. 2017 May 11;60(9):3979-4001. doi: 10.1021/acs.jmedchem.7b00271. Epub 2017 Apr 25. PubMed PMID: 28398755; PubMed Central PMCID: PMC5580352.
  8. Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y, Williams NS, Nijhawan D. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science. 2017 Apr 28;356(6336). pii: eaal3755. doi: 10.1126/science.aal3755. Epub 2017 Mar 16. Erratum in: Science. 2017 May 26;356(6340):null. PubMed PMID: 28302793.
  9. Luthra P, Aguirre S, Yen BC, Pietzsch CA, Sanchez-Aparicio MT, Tigabu B, Morlock LK, García-Sastre A, Leung DW, Williams NS, Fernandez-Sesma A, Bukreyev A, Basler CF. Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion. MBio. 2017 Apr 4;8(2). pii: e00368-17. doi: 10.1128/mBio.00368-17. PubMed PMID: 28377530; PubMed Central PMCID: PMC5380843.
  10. Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L. Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654. doi: 10.1073/pnas.1621346114. Epub 2017 Jan 31. PubMed PMID: 28143939; PubMed Central PMCID: PMC5320972.
  11. Tso SC, Lou M, Wu CY, Gui WJ, Chuang JL, Morlock LK, Williams NS, Wynn RM, Qi X, Chuang DT. Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.J Med Chem. 2017 Feb 9;60(3):1142-1150. doi: 10.1021/acs.jmedchem.6b01540. Epub 2017 Jan 31. PubMed PMID: 28085286.
  12. You L, Zhang C, Yarravarapu N, Morlock L, Wang X, Zhang L, Williams NS, Lum L, Chen C. Development of a triazole class of highly potent Porcn inhibitors.Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895. doi: 10.1016/j.bmcl.2016.11.012. Epub 2016 Nov 11. PubMed PMID: 27876319; PubMed Central PMCID: PMC5142825.
  13. Huang X, Motea EA, Moore ZR, Yao J, Dong Y, Chakrabarti G, Kilgore JA, Silvers MA, Patidar PL, Cholka A, Fattah F, Cha Y, Anderson GG, Kusko R, Peyton M, Yan J, Xie XJ, Sarode V, Williams NS, Minna JD, Beg M, Gerber DE, Bey EA, Boothman DA. Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors.Cancer Cell. 2016 Dec 12;30(6):940-952. doi: 10.1016/j.ccell.2016.11.006. PubMed PMID: 27960087; PubMed Central PMCID: PMC5161231.
  14. Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer.Sci Transl Med. 2016 Oct 19;8(361):361ra140. PubMed PMID: 27798265.
  15. Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, William NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Schulze PC, Lynch C, Jain MK, Wang Y. Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. Circulation. 2016 May 24;133(21):2038-49. doi: 10.1161/CIRCULATIONAHA.115.020226. Epub 2016 Apr 8. PubMed PMID: 27059949; PubMed Central PMCID: PMC4879058.
  16. Chen B, Trang V, Lee A, Williams NS, Wilson AN, Epstein EH Jr, Tang JY, Kim J. Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma.Mol Cancer Ther. 2016 May;15(5):866-76. doi: 10.1158/1535-7163.MCT-15-0729-T. Epub 2016 Jan 28. PubMed PMID: 26823493; PubMed Central PMCID: PMC4873341.
  17. Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D. Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.Nat Chem Biol. 2016 Apr;12(4):218-25. doi: 10.1038/nchembio.2016. Epub 2016 Feb 1. PubMed PMID: 26829472; PubMed Central PMCID: PMC4798879.