Software

Software

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GUSSI

GUSSI is a program that can illustrate the output of SEDFIT and SEDPHAT. In some cases, it can perform some simple calculations with the data. It is designed to work with sedimentation velocity, sedimentation equilibrium, ITC, DLS, and isotherm data.

Click below to view some examples of GUSSI's output:

GUSSI Gallery

If you would like to download GUSSI, please click the link below, then click the 'Download' button at the top of the page:

Download GUSSI

Read the README.txt file for terms and installation instructions.

NITPIC

NITPIC is a program for the integration of ITC data based on ideas developed mainly by Peter Schuck at NIH. It uses unique algorithms to calculate the baselines of such data and integrates them, putting them in a format for subsequent analysis in SEDPHAT.

If you would like to read more about NITPIC, follow this link for the PubMed citation.

If you would like to download NITPIC, please click the link below, then click the 'Download' button at the top of the page:

Download NITPIC

Read NITPIC's README.txt file for terms and installation instructions.

REDATE

REDATE corrects data-acquisition time errors in analytical ultracentrifugation data.

Check out these links for more information on this issue: Paper 1; Paper 2.

Read REDATE's README.txt file for terms and installation instructions.

If you would like to download REDATE, please click the link below, then click the 'Download' button at the top of the page:

Download REDATE

PALMIST

PALMIST is a program for the analysis of MST data and the simulation of binding experiments for multiple data types. PALMIST's error-estimation routines are advanced compared to other software for MST data analysis, and it features a competition binding model.

If you have trouble reading data with the program, please contact Chad Brautigam; his email is in the README.txt file.

Links for the papers describing the algorithms in PALMIST are here and here.

Read PALMIST's README.txt file for terms and installation instructions.

If you would like to download PALMIST, please click the link below, then click the 'Download' button at the top of the page:

Download PALMIST

D/STAIN

D/STAIN is a program that analyzes calorimetric demicellization data. It takes input from NITPIC (see above) and analyzes the integrated peaks to estimate CMC, enthalpy of micellization, and other thermodynamic parameters.

Read the paper associated with D/STAIN's algorithms here.

Read D/STAIN's README.txt file for terms and installation instructions.

If you would like to download D/STAIN, please click the link below, then click the 'Download' button at the top of the page: 

Download D/STAIN

DiSECT

DiSECT is software that evaluates data from a difference sedimentation velocity (DSV) experiment.  Such experiments are carried out with Rayleigh interference optics and are useful to detect the conformational change in a macromolecule upon addition of a ligand.

The paper describing the algorithms in DiSECT can be found here.

Read DiSECT's README.txt file for terms, conditions, and installation instructions.

If you would like to download DiSECT, please click the link below, then click the 'Download' button at the top of the page:

Download DiSECT

 

Page maintained by Chad A. Brautigam

Last updated July 15, 2020