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Articles https://doi.org/10.1038/s41551-020-00675-9 1Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. 2Department of Pathology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. 3Department of Otolaryngology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. 4Howard Hughes

Sieber Lab publications.

ARTICLES PUBLISHED ONLINE: 8 DECEMBER 2013 | DOI: 10.1038/NMAT3819 A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals Yiguang Wang1, Kejin Zhou1, Gang Huang1, Christopher Hensley2, Xiaonan Huang1, Xinpeng Ma1, Tian Zhao1, Baran D. Sumer3, Ralph J. DeBerardinis2 and Jinming Gao1* Stimuli-responsive nanomaterials are increasingly important in a variety of applications such as biosensing, molecular imaging, drug

Skip to main content Publications Featured Publications Bacterial Peptidoglycan Fragments Differentially Regulate Innate Immune Signaling. Bersch KL, DeMeester KE, Zagani R, Chen S, Wodzanowski KA, Liu S, Mashayekh S, Reinecker HC , Grimes CL, ACS Cent Sci 2021 Apr 7 4 688-696 GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses. Kashyap AS, Fernandez-Rodriguez L, Zhao Y, Monaco G, Trefny MP, Yoshida N, Martin K, Sharma A

ll Review Macroencapsulated bacteria for in vivo sensing and therapeutics Yidan Lyu,1,10 Hao Huang,2,10 Yuyan Su,1,10 Binbin Ying,3,4 Wen-Che Liu,1 Kairu Dong,5 Ningjie Du,2 Robert S. Langer,6,7,* Zhen Gu,1,8,9,* and Kewang Nan1,8,9,* PROGRESS AND POTENTIAL Engineered bacterial therapeutics, with promising preclinical outcomes, are advancing in commercialization endeavors. However, their translation into widely accepted clinical products still poses significant challenges, demanding

Skip to main content Microbial Transcriptional Regulators Control Mucosal Host Defenses We demonstrated that Interferon regulatory factor (IRF)1 is a component of cyclic dinucleotide recognition that allows mucosal DCs to induce host defense through TH1 7 cells and shape protective immune responses in the intestine to cope with entero-invasive pathogens such as S. typhimurium. We identified IRF1 as a pivotal transcription factor in the Sensor Stimulator of Interferon Genes (STING) nucleotide

APPL I ED SC I ENCES AND ENG INEER ING Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes Xian Wang1,2, Zheyuan Gong3, Tiancong Wang3, Junhui Law3, Xin Chen1,2,4, Siyi Wanggou1,2,5,6, Jintian Wang3, Binbin Ying3, Michelle Francisco1,2, Weifan Dong1,2,7, Yi Xiong1,2,5,6, Jerry J. Fan1,2,7, Graham MacLeod8, Stephane Angers8,9,10, Xuejun Li5,6, Peter B. Dirks1,2,7, Xinyu Liu3, Xi Huang1,2,7*, Yu Sun3,11,12,13* Glioblastoma (GBM) is the most common

Skip to main content Research A Microtubule-Based Microbial Pattern Recognition System Our work has revealed polymorphisms that show that microbial defense systems could be linked to human autoimmune diseases. Find out more Development of Mucosal Immunity We study human genetic diversity associated with inflammatory bowel diseases to understand the principal mechanisms of mucosal immunity that control the intestinal barrier function and the microbiome. Find out more GEF-H1 Regulation of Anti

Optical Printing of Conductive Silver on Ultrasmooth Nanocellulose Paper for Flexible Electronics Yueyue Pan, Zhen Qin, Sina Kheiri, Binbin Ying, Peng Pan, Ran Peng, and Xinyu Liu* 1. Introduction Flexible electronics has been thriving for applications such as wearable devices, flexible displays, and bendable sensors because of its unique merits such as highly mechanical flexibility and stable electronic functionality under deformation, which cannot be achieved by traditional electronics.[1,2

Skip to main content GEF-H1-Dependent Regulation of Anti-Tumor Immunity We discovered that intracellular activation of the GEF-H1 signaling pathway induces immune responses and dendritic cell maturation similar to microbial pattern recognition receptors. GEF-H1 directed immunity emerges as a critical mechanism that controls dendritic cell maturation upon disruption of microtubules. This immune activation pathway is induced by microtubule destabilization and controls maturation of dendritic cells