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Article Luminal electrophysiologi cal neuroprofiling system for gastrointestinal neuromuscular diseases Graphical abstract Highlights d The LENS is a luminal electrophysiological neuroprofiling system d The LENS electrophysiologically characterizes the GI tract for disease diagnosis d Analytical metrics are generated to differentiate neuromuscular diseases d High-resolution spatial profiles identify ganglionic- aganglionic transition zones Authors Shriya S. Srinivasan, Sabrina Liu, Ryo

Optical Printing of Conductive Silver on Ultrasmooth Nanocellulose Paper for Flexible Electronics Yueyue Pan, Zhen Qin, Sina Kheiri, Binbin Ying, Peng Pan, Ran Peng, and Xinyu Liu* 1. Introduction Flexible electronics has been thriving for applications such as wearable devices, flexible displays, and bendable sensors because of its unique merits such as highly mechanical flexibility and stable electronic functionality under deformation, which cannot be achieved by traditional electronics.[1,2

ll Review Macroencapsulated bacteria for in vivo sensing and therapeutics Yidan Lyu,1,10 Hao Huang,2,10 Yuyan Su,1,10 Binbin Ying,3,4 Wen-Che Liu,1 Kairu Dong,5 Ningjie Du,2 Robert S. Langer,6,7,* Zhen Gu,1,8,9,* and Kewang Nan1,8,9,* PROGRESS AND POTENTIAL Engineered bacterial therapeutics, with promising preclinical outcomes, are advancing in commercialization endeavors. However, their translation into widely accepted clinical products still poses significant challenges, demanding

ll OPEN ACCESS iScience Review Skin-like hydrogel devices for wearable sensing, soft robotics and beyond Binbin Ying1,2,4 and Xinyu Liu1,3,* 1Department of Mechanical and Industrial Engineering, University of Toronto, 5 King’s College Road, Toronto, ON M5S 3G8, Canada 2Department of Mechanical Engineering, McGill University, 817 Sherbrooke Street West, Montreal, QC H3A 0C3, Canada 3Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada

Develop Proposal offers information on how to prepare a proposal for a funding opportunity.

APPL I ED SC I ENCES AND ENG INEER ING Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes Xian Wang1,2, Zheyuan Gong3, Tiancong Wang3, Junhui Law3, Xin Chen1,2,4, Siyi Wanggou1,2,5,6, Jintian Wang3, Binbin Ying3, Michelle Francisco1,2, Weifan Dong1,2,7, Yi Xiong1,2,5,6, Jerry J. Fan1,2,7, Graham MacLeod8, Stephane Angers8,9,10, Xuejun Li5,6, Peter B. Dirks1,2,7, Xinyu Liu3, Xi Huang1,2,7*, Yu Sun3,11,12,13* Glioblastoma (GBM) is the most common

ll Review Theranostic gastrointestinal residence systems Binbin Ying,1,4 Hao Huang,2,3,4 Yuyan Su,2 Julia G. Howarth,1 Zhen Gu,2,* and Kewang Nan2,* 1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 2College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China 3College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China 4These authors contributed equally *Correspondence: guzhen@zju.edu.cn

Substrate pKa's. Numbers are approximations for outside the range -2 - 16, but useful to know. For an extensive list, see http://www.chem.wisc.edu/areas/reich/pkatable/ Inorganics H2O DMSO CF3SO3H -14 HCl -8 H3O+ -2 H2O 16 NH4Cl 9 Organic X-H AcOH 5 12 O+ CH3Ph H -6 Me2OH+ -4 CH3SO3H -3 2 NH+ 5 3 N H O H 15 26 MeOH 16 28 17 29 NH3 36 38 41 EWG-CH NO2-CH3 10 17 O O 9 13 O EtO O 11 14 O EtO OEt O 13 16 O 20 27 O t-BuO 25 30 O Me2N 35 O S 3533PhOH 10 18

Ready; Catalysis Nonlinear Effects Outline Definitions Origins of nonlinear effects in enantioselective reactions ML2 model Reservoir model Transition-state model Kinetic aspects of nonlinear effects Asymmetric amplification Cool tricks Origin of biotic asymmetry? Key reviews Kagan, ACIEE, 1998, 2922 (a pretty complete review, source of many of my figures) Kagan, Advanced Syn. Cat., 2001, 227 (an overview) Blackmond, Accts, 2000, 402 (kinetic aspects) Soai

Winners of the 2015-2016 CRSM Trainee Fellowships.