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About the Core Director

Image of Dr. Posner seated at desk in lab

Bruce Posner, Ph.D.

Professor in Biochemistry

Prior to joining the faculty at UTSW, Bruce Posner, Ph.D., was a senior scientist and a principal investigator in the High Throughput Screening Center of Emphasis at Pfizer, Inc. In that capacity, he led more than 60 HTS campaigns and identified more than 20 hit-to-lead starts for early drug discovery programs. Two of these chemical series were submitted to first-in-human clinical trials. He also has expertise in informatics (data storage, management, retrieval, and visualization) and chemoinformatics, which has proven invaluable to pre-clinical drug and target discovery efforts. He has served as Director of the HTS Core at UT Southwestern since 2009. His activities include directing projects in the Core; mentoring staff scientists, postdoctoral fellows, and graduate students; co-writing grants for screening and lead discovery projects as well as shared instrumentation; managing fiscal operations and long range planning; and co-authoring peer-reviewed papers.

HTS Principal Investigators

Organic and Natural Products Chemistry in the Biochemistry Department

Pre-clinical Pharmacology

Core Director: Noelle Williams, Ph.D.

HTS Core Scientists

HTS core members
HTS Core Members: Back row (L to R): Hanspeter Niederstrasser, Ph.D. (Screening Scientist), Rafael Gonzalez (Administrative support), and Anwu Zhou, Ph.D. (Data Analyst), Middle row (L to R): Bruce Posner, Ph.D. (Director), Prema Latha Mallipeddi, Ph.D. (Cheminformatics), Hong Chen, Ph.D. (Screening Scientist and Data Analyst), and Shuguang Wei, Ph.D. (Screening Scientist). Front row (L to R): Maheshika Wanigasekara, Ph.D. (Screening Scientist) and Melissa, McCoy, Ph.D. (Screening Scientist)

HTS Oversight Committee

Role of the Committee

Access for Large Screening Projects