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Publications

2022

Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X. Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain. Nat Commun. 2022 Jul 25;13(1):4273. doi: 10.1038/s41467-022-32025-5. PMID: 35879350; PMCID: PMC9314443.

Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E. Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun. 2022 Sep 23;13(1):5594. doi: 10.1038/s41467-022-33274-0. PMID: 36151101; PMCID: PMC9508239.

Nguyen PT, Deisl C, Fine M, Tippetts TS, Uchikawa E, Bai XC, Levine B. Structural basis for gating mechanism of the human sodium-potassium pump. Nat Commun. 2022 Sep 8;13(1):5293. doi: 10.1038/s41467-022-32990-x. PMID: 36075933; PMCID: PMC9458724.

Park GJ, Osinski A, Hernandez G, Eitson JL, Majumdar A, Tonelli M, Henzler-Wildman K, Pawłowski K, Chen Z, Li Y, Schoggins JW, Tagliabracci VS. The mechanism of RNA capping by SARS-CoV-2. Res Sq [Preprint]. 2022 Feb 15:rs.3.rs-1336910. doi: 10.21203/rs.3.rs-1336910/v1. Update in: Nature. 2022 Aug 9;: PMID: 35194601; PMCID: PMC8863163.

Basta T, Teng J, Lee M, Worrell BT, Stowell MHB, Hibbs RE. Structural mechanism of muscle nicotinic receptor desensitization and block by curare. Nat Struct Mol Biol. 2022 April 29(4):386-394. doi: 10.1038/s41594-022-00737-3. Epub 2022 Mar 17. PMID: 35301478.

Noviello CM, Kreye J, Pruss H, Hibbs RE. Structural mechanisms of GABAA receptor autoimmune encephalitis. Cell. 2022 Jul 7;185(14):2469-2477.e13. doi: 10.1016/j.cell.2022.06.025. PMID: 35803245; PMCID: PMC9394431.

Hongwen Chen, Kevin Chen, Weijiao Huang, Louis M. Staudt, Jason G. Cyster and Xiaochun Li. Structure of S1PR2-heterotrimeric G13 signaling complex. Sci Adv. 2022, 8(13):eabn0067. doi:10.1126/sciadv.abn0067.

Rong Wang, Yu Qin and Xiaochun Li , Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1. Cell Research. 2022, 32(2):214-217.

Yingyuan Sun and Xiaochun Li. Cholesterol Efflux Mechanism Revealed by Distinct States of ABCA1. Nat Cardiovasc. 2022, Res 1, 238–245.

Hongwen Chen, Weijiao Huang, and Xiaochun Li. Structures of Oxysterol Sensor EBI2/GPR183, a Key Regulator of the Immune Response. Structure. 2022, 30 (7):1-9.

Rong Wang, Yu Qin, Xiao-Song Xie and Xiaochun Li. Molecular Basis of mEAK-7-Mediated Human V-ATPase Regulation. Nature Communications. 2022, 13:3272.

Yang Liu, Xiaofeng Qi, Linda Donnelly, Nadia Elghobashi-Meinhardt, Tao Long, Rich W. Zhou, Yingyuan Sun, Boyuan Wang and Xiaochun Li. Mechanisms and Inhibition of Porcupine-Mediated Wnt Acylation. Nature. 2022, 10.1038/s41586-022-04952-2 (in press).

D. Lu, G. Shang, J. Li, Y. Lu, X. C. Bai and X. Zhang. Activation of STING by targeting a pocket in the transmembrane domain. Nature . 2022 Vol. 604 Issue 7906 Pages 557-562, Accession Number: 35388221 DOI: 10.1038/s41586-022-04559-7.

Gao H, Faxiang L, Ji Z, Shi Z, Li Y, Yu H. Cryo-EM structures of human p97 double hexameter capture potentiated ATPase-competent state. Cell Discov. 2022, 8:19. DOI: 10.1038/s41421-022-00379-1. PMID: 35190543.

Tagliabracci T, Park G, Osinski A, Hernandez G, Eitson J, Majumdar A, Tonelli M, Henzler-Wildman K, Pawłowski K, Chen Z, Li Y, Schoggins J. Res Sq rs.3.rs. 2022, -1336910. DOI: 10.21203/rs.3.rs-1336910/v1. PMID: 35194601.

Xue J, Han, Y, Zeng W & Jiang Y. Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron 2022, 110, 86-95. e5. doi: 10.1016/j.neuron.2021.10.006. Epub 2021 Oct 25.

Gan N, Han, Y, Zeng W, Wang Y, Xue J & Jiang Y. Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P2 and rapamycin. Proc Natl Acad Sci U S A 2022 Feb 7;119(7): e 2120404119. doi: 10.1073/pnas. 2120404119. Online ahead of print.

2021

Rong Wang, Yu Qin and Xiaochun Li Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1. Cell Research. 2021 doi: 10.1038/s41422-021-00585-8.

Fu G, Scarbrough C, Song K, Phan N, Wirschell M, Nicastro D. Structural organization of the intermediate and light chain complex of Chlamydomonas ciliary I1 dynein. FASEB J. 2021 Jun;35(6):e21646. doi: 10.1096/fj.202001857R. PMID: 33993568.

Cai K, Zhao Y, Zhao L, Phan N, Hou Y, Cheng X, Witman GB, Nicastro D. Structural organization of the C1b projection within the ciliary central apparatus. J Cell Sci 2021 Oct 15:jcs.254227. doi: 10.1242/jcs.254227. Epub ahead of print. PMID: 34651179.

Osinski A, Black MH, Pawłowski K, Chen Z, Li Y, Tagliabracci VS. Structural and mechanistic basis for protein glutamylation by the kinase fold. Mol Cell. 2021 Aug 12:S1097-2765(21)00647-X. doi: 10.1016/j.molcel.2021.08.007. Epub ahead of print. PMID: 34407442.

Kober DL, Radhakrishnan A, Goldstein JL, Brown MS, Clark LD, Bai XC, Rosenbaum DM. Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing. Cell. 2021 Jul 8;184(14):3689-3701.e22. doi: 10.1016/j.cell.2021.05.019. Epub 2021 Jun 16. PMID: 34139175; PMCID: PMC8277531.

Fabritius AS, Bayless BA, Li S, Stoddard D, Heydeck W, Ebmeier CC, Anderson L, Gunnels T, Nachiappan C, Whittall JB, Old W, Agard DA, Nicastro D, Winey M. Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs. Mol Biol Cell. 2021 Aug 18:mbcE20120786. doi: 10.1091/mbc.E20-12-0786. Epub ahead of print. PMID: 34406789.

Yu H, Bai XC, Wang W. Characterization of the subunit composition and structure of adult human glycine receptors. Neuron. 2021 Sep 1;109(17):2707-2716.e6. doi: 10.1016/j.neuron.2021.08.019. PMID: 34473954.

Xue J, Han Y, Zeng W, Wang Y, Jiang Y. Structural mechanisms of gating and selectivity of human rod CNGA1 channel. Neuron. 2021 Apr 21;109(8):1302-1313.e4. doi: 10.1016/j.neuron.2021.02.007. Epub 2021 Mar 1. PMID: 33651975; PMCID: PMC8068614.

Xue J, Han Y, Baniasadi H, Zeng W, Pei J, Grishin NV, Wang J, Tu BP, Jiang Y. TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase. Elife. 2021 Aug 10;10:e71220. doi: 10.7554/eLife.71220. PMID: 34374645; PMCID: PMC8376247.

Wang R, Wang J, Hassan A, Lee CH, Xie XS, Li X. Molecular basis of V-ATPase inhibition by bafilomycin A1. Nat Commun. 2021 Mar 19;12(1):1782. doi: 10.1038/s41467-021-22111-5. PMID: 33741963; PMCID: PMC7979754.

Schmiege P, Fine M, Li X. Atomic insights into ML-SI3 mediated human TRPML1 inhibition. Structure. 2021 Jun 19:S0969-2126(21)00207-0. doi: 10.1016/j.str.2021.06.003. Epub ahead of print. PMID: 34171299.

Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X. Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc Natl Acad Sci U S A. 2021 Aug 24;118(34):e2110483118. doi: 10.1073/pnas.2110483118. PMID: 34404721; PMCID: PMC8403869.

Long T, Liu Y, Qin Y, DeBose-Boyd RA, Li X. Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. Sci Adv. 2021 Aug 18;7(34):eabh3997. doi: 10.1126/sciadv.abh3997. PMID: 34407950; PMCID: PMC8373123.

Long T, Liu Y, Li X. Molecular structures of human ACAT2 disclose mechanism for selective inhibition. Structure. 2021 Sep 11:S0969-2126(21)00259-8. doi: 10.1016/j.str.2021.07.009. Epub ahead of print. PMID: 34520735.

Lu, D., Shang, G., He, X., Bai, X.-C., & Zhang, X. (2021). Architecture of the sema3a/plexina4/neuropilin tripartite complex. Nature Communications , 12(1), 3172. PMID 34039996.

Uchikawa, E., Chen, Z., Xiao, G.-Y., Zhang, X., & Bai, X.-C. (2021). Structural basis of the activation of c-MET receptor. Nature Communications,  12(1), 4074. PMID 34210960.

Noviello, Colleen M., Anant Gharpure, Nuriya Mukhtasimova, Rico Cabuco, Leah Baxter, Dominika Borek, Steven M. Sine, and Ryan E. Hibbs. “Structure and Gating Mechanism of the Α7 Nicotinic Acetylcholine Receptor.”  Cell  184, no. 8 (April 15, 2021): 2121-2134.e13. PMID 33735609.

Jeong, Byung-Cheon, Sung Jun Bae, Lisheng Ni, Xuewu Zhang, Xiao-Chen Bai, and Xuelian Luo. “Cryo-EM Structure of the Hippo Signaling Integrator Human STRIPAK.” Nature Structural & Molecular Biology  28, no. 3 (March 2021): 290–299. PMID 33633399.

Dong, X., Yang, Y., Zou, Z. et al. Sorting nexin 5 mediates virus-induced autophagy and immunity. Nature  589, 456–461 (2021). PMID 33328639.

2020

Qi, Xiaofeng, Lucas Friedberg, Ryan De Bose-Boyd, Tao Long, and Xiaochun Li. “Sterols in an Intramolecular Channel of Smoothened Mediate Hedgehog Signaling.” Nature Chemical Biology 16, no. 12 (December 2020): 1368–1375. PMID 32929279.

Kim JJ, Gharpure A, Teng J, et al. (2020) Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature 2020; 585(7824):303-308. PMID 32879488.

Yin J, Chen KM, Clark MJ, et al. (2020) Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane. Nature 2020;584(7819):125-129. PMID 32528175.

Li F, Li Y, Ye X, et al. (2020) Cryo-EM structure of VASH1-SVBP bound to microtubules. Elife 2020;9 PMID 32773040.

Long T, Qi X, Hassan A, Liang Q, De brabander JK, Li X. (2020) Structural basis for itraconazole-mediated NPC1 inhibition. Nat Commun 2020;11(1):152. PMID 31919352.

Kuo YC, Chen H, Shang G, et al. (2020) Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation. Nat Commun 2020;11(1):1953. PMID 32327662.

Wang R, Long T, Hassan A, et al. (2020) Cryo-EM structures of intact V-ATPase from bovine brain. Nat Commun 2020;11(1):3921. PMID 32764564.

Zhang X, Bai XC, Chen ZJ. (2020) Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway. Immunity 2020;53(1):43-53. PMID 32668227.

Shi Z, Gao H, Bai XC, Yu H. (2020) Cryo-EM structure of the human cohesin-NIPBL-DNA complex. Science 2020;368(6498):1454-1459. PMID 32409525.

Peng W, Casey AK, Fernandez J, et al. (2020) A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM. Nat Struct Mol Biol 2020;27(6):589-597. PMID 32424347.

Long T, Sun Y, Hassan A, Qi X, Li X. (2020) Structure of nevanimibe-bound tetrameric human ACAT1. Nature 2020;581(7808):339-343. PMDI 32433613.

Partin AC, Zhang K, Jeong BC, et al. (2020) Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA. Mol Cell 2020;78(3):411-422.e4. PMID 32220646.

Bromberg R, Guo Y, Borek D, Otwinowski Z. (2020) High-resolution cryo-EM reconstructions in the presence of substantial aberrations. IUCrJ. 2020;7(Pt 3):445-452. PMID 32431828.

Qi X, Friedberg L, De bose-boyd R, Long T, Li X. (2020) Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat Chem Biol. 2020; PMID 32929279.

Wang R, Qi X, Schmiege P, Coutavas E, Li X. (2020) Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments. Sci Adv. 2020;6(7):eaaz1466. PMID 32095534.

2019

Gui L, Song K, Tritschler D, et al. (2019) Scaffold subunits support associated subunit assembly in the ciliary nexin-dynein regulatory complex. Proc Natl Acad Sci USA 2019;116(46):23152-23162. PMID 31659045.

Li J, Shang G, Chen YJ, et al. (2019) Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands. Elife 2019;8 PMID 31535977

Uchikawa E, Choi E, Shang G, Yu H, Bai XC. (2019) Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife 2019;8 PMID 31436533.

Prinslow EA, Stepien KP, Pan YZ, Xu J, Rizo J (2019) Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and αSNAP. eLife 8. pii: e38880. doi: 10.7554/eLife.38880.

Zhang C, Shang G, Gui X, Zhang X*, Bai X*, Chen ZJ* (2019) Structural basis of STING binding with and phosphorylation by TBK1. Nature 567:394-398. doi: 10.1038/s41586-019-1000-2.

Shang G, Zhang C, Chen ZJ*, Bai X*, Zhang X* (2019) Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP. Nature 567:389-393. doi: 10.1038/s41586-019-0998-5.

Quade B, Camacho M, Zhao X, Orlando M, Trimbuch T, Xu J, Li W, Nicastro D, Rosenmund C, Rizo J (2019) Membrane bridging by Munc13-1 is crucial for neurotransmitter release. eLife 8:e42806. [PMCID: PMC6407922].

She J, Zeng W, Guo J, Chen Q, Bai X*, Jiang Y* (2019) Structural mechanisms of phospholipid activation of the human TPC2 channel. eLife 8. pii: e45222. doi: 10.7554/eLife.45222.

Hariri H, Speer N, Bowerman J, Rogers S, Fu G, Reetz E, Datta S, Feathers JR, Ugrankar R, Nicastro D, Henne WM (2019) Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating lipid droplet biogenesis. J Cell Biol. jcb.201808119. [PMCID: PMC6446837].

Spietz RL, Lundeen RA, Zhao X, Nicastro D, Ingalls AE, Morris RM (2019) Heterotrophic carbon metabolism and energy acquisition in Candidatus Thioglobus singularis strain PS1, a member of the SUP05 clade of marine Gammaproteobacteria. Environ Microbiol DOI: https://doi.org/10.1111/1462-2920.14623 [PMID 30951247].

Chen Q, Zeng W, She J, Bai XC, Jiang Y (2019) Structural and functional characterization of an otopetrin family proton channel. eLife 8. pii: e46710. doi: 10.7554/eLife.46710.

Shah V*, Zhao X*, Lundeen RA, Ingalls AE, Nicastro D, Morris RM (2019) Morphological plasticity in a sulfur-oxidizing bacterium from the SUP05 clade enhances dark carbon fixation. mBio DOI: 10.1128/mBio.00216-19. [PMCID: PMC6509183].

Wang Y, Nguyen NX, She J, Zeng W, Yang Y, Bai X*, Jiang Y* (2019) Structural mechanism of EMRE-dependent gating of the human mitochondrial calcium uniporter. Cell 177(5):1252-1261.e13. doi: 10.1016/j.cell.2019.03.050.

Peng W, de Souza Santos M, Li Y, Tomchick DR, Orth K (2019) High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers. PLoS One 14:e0213423. doi: 10.1371/journal.pone.0213423.

Qi X, Liu H, Thompson B, McDonald J, Zhang C, Li X (2019) Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi. Nature 571:279-283. doi: 10.1038/s41586-019-1286-0.

Peng W, de Souza Santos M, Li Y, Tomchick DR, Orth K (2019) High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers. PLoS One 14:e0213423. doi: 10.1371/journal.pone.0213423.

Dymek EE, Lin J*, Fu G*, Porter ME, Nicastro D, Smith EF (2019) PACRG and FAP20 form the inner junction of axonemal doublet microtubules and regulate ciliary motility. Mol Biol Cell 30:1805-1816. [PMCID: PMC6727744].

Gharpure A, Noviello C, Teng J, Zaveri N, Hibbs R (2019) Agonist selectivity and ion permeation in the α3β4 ganglionic nicotinic receptor. Neuron 104:501-511.e6. doi: 10.1016/j.neuron.2019.07.030.

Uchikawa E*, Choi E*, Shang G, Yu H*, Bai X* (2019) Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. eLife 8. pii: e48630. doi: 10.7554/eLife.48630.

Li J*, Shang G*, Chen YJ, Brautigam CA, Liou J, Zhang X*, Bai X* (2019) Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands. eLife 8. pii: e47650. doi: 10.7554/eLife.47650.

Lin J*, Le TV*, Augsperger K, Tritschler D, Bower R, Fu G, Perrone C, O’Toole ET, VanderWaal Mills K, Dymek EE, Smith EF, Nicastro D*, Porter ME* (2019) FAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia. Mol Biol Cell 30:2659-2680, doi: 10.1091/mbc.E19-07-0367 [PMCID: PMC6761771].

Li J, Choi E, Yu H, Bai XC (2019) Structural basis of the activation of type 1 insulin-like growth factor receptor. Nat Commun 10:4567. doi: 10.1038/s41467-019-12564-0.

Fu G*, Zhao L*, Dymek E, Hou Y, Song K, Phan N, Shang Z, Smith EF, Witman GB, Nicastro D (2019) Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus. J Cell Biol. pii: jcb.201906006. doi: 10.1083/jcb.201906006. [Epub ahead of print].

Gui L, Song K, Tristchler D, Bower R, Si Y, Dai A, Augsperger K, Sakizadeh J, Grzemska M, Ni T, Porter ME, Nicastro D (2019) Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex. PNAS pii: 201910960. doi: 10.1073/pnas.1910960116. [Epub ahead of print].

Trötschel C, Hamzeh H, Alvarez L, Pascal R, Lavryk F, Bönigk W, Körschen HG, Müller A, Poetsch A, Rennhack A, Gui L, Nicastro D, Strünker T, Seifert R, Kaupp UB (2019) Absolute proteomic quantification reveals design principles of flagellar chemosensation. EMBO J (accepted).

2018

She J, Guo J, Chen Q, Zeng W, Jiang Y* & Bai X* (2018). Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel. Nature 556, 130-134. doi:10.1038/nature26139.

Fu G, Wang Q, Phan N, Urbanska P, Joachimiak E, Wloga D, Nicastro D (2018) The I1 dynein-associated tether and tether head complex is a conserved regulator of ciliary motility. Mol Biol Cell 29:1048-1059. [PMCID: PMC5921572].

Nguyen NX, Armache JP, Lee C, Yang Y, Zeng W, Mootha VK, Cheng Y, Bai X* & Jiang Y* (2018). Cryo-EM structure of a fungal mitochondrial calcium uniporter. Nature 559, 570-574. doi: 10.1038/s41586-018-0333-6.

Walsh RM Jr., Roh SH, Gharpure A, Morales-Perez CL, Teng J, Hibbs RE (2018). Structural principles of distinct assemblies of the human α4β2 nicotinic receptor. Nature 557(7704):261-265. [PMCID PMC6132059].

Zhu S, Noviello CM, Teng J, Walsh RM Jr., Kim JJ, Hibbs RE (2018). Structure of a human synaptic GABAA receptor. Nature 559 (7712):67-72.

Qi X, Schmiege P, Coutavas E, Wang J, Li X (2018). Structures of human Patched and its complex with native palmitoylated Sonic Hedgehog. Nature 560: 128–132.

Fine M, Schmiege P, Li X (2018). Structural basis for PtdInsP2mediated human TRPML1 regulation. Nature Comm 9:4192.

Qi X, Schmiege P, Coutavas E, Xiaochun Li (2018). Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex. Science 362: 52. pii: eaas8843.

2017

Guo J, She J, Zeng W, Chen Q, Bai X* & Jiang Y* (2017). Structures of the Calcium-activated Non-Selective Cation Channel TRPM4. Nature 552, 205–209. doi:10.1038/nature24997.

Chen Q, She J, Zeng W, Guo J, Xu H, Bai X* & Jiang Y* (2017). Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature 550, 415-418. doi:10.1038/nature24035.

 

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