Publications
2023
Xiaofeng Qi, Qinli Hu, Nadia Elghobashi-Meinhardt, Tao Long, Hongwen Chen, and Xiaochun Li (2023). Molecular basis of Wnt biogenesis, secretion, and Wnt7 specific signaling. Cell. 2023 October 17; 186: 5028-5040. https://doi.org/10.1016/j.cell.2023.09.021. RP170644
Boesch DJ, Singla A, Han Y, Kramer DA, Qi Liu, Suzuki K, Juneja P, Zhao X, Long X, Medlyn MJ, Billadeau DD, Chen Z, Chen B, Burstein E. Structural organization of the Retriever-CCC endosomal recycling complex. Nature Structural & Molecular Biology. 2023 Dec 7. doi: 10.1038/s41594-023-01184-4. PMID: 38062209. RP170644
Hongwen Chen, Yu Qin, Marissa Chou, Jason Cyster and Xiaochun Li. Transmembrane protein CD69 acts as an S1PR1 agonist. eLife 2023 Apr 11:12:e88204. doi: 10.7554/eLife.88204 PMID: 37039481 PMCID: PMC10154026 . RP170644
Tian Xie, Guangjun Xu, Yun Liu, Bradley Quade, Weichun Lin Weichun, and Xiao-chen Bai. Structural insights into the assembly of the agrin/LRP4/MuSK signaling complex. PNAS May 30, 2023 120 (23) e2300453120 https://doi.org/10.1073/pnas.2300453120. RP170644
Liu X, Wang W. Asymmetric gating of a human hetero-pentameric glycine receptor. Nat Commun. 2023 Oct 11;14(1):6377. doi: 10.1038/s41467-023-42051-6. PMID: 37821459; PMCID: PMC10567788. RP170644
Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM. Molecular mechanism of fatty acid activation of FFAR1. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2219569120. doi: 10.1073/pnas.2219569120. Epub 2023 May 22. PMID: 37216523; PMCID: PMC10235965. RP170644
Cruz VE, Weirich CS, Peddada N, Erzberger JP. The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis. bioRxiv [Preprint]. 2023 Nov 2:2023.11.01.565222. doi: 10.1101/2023.11.01.565222. PMID: 37961218; PMCID: PMC10635065. RP170644
Kang G, Allard CAH, Valencia-Montoya WA, van Giesen L, Kim JJ, Kilian PB, Bai X, Bellono NW, Hibbs RE. Sensory specializations drive octopus and squid behaviour. Nature. 2023 Apr;616(7956):378-383. doi: 10.1038/s41586-023-05808-z. Epub 2023 Apr 12. PMID: 37045917; PMCID: PMC10262778. RP170644
Guo Y, Karimullina E, Emde T, Otwinowski Z, Borek D, Savchenko A. Monomer and dimer structures of cytochrome bo3 ubiquinol oxidase from Escherichia coli. Protein Sci. 2023 Apr;32(4):e4616. doi: 10.1002/pro.4616. PMID: 36880269; PMCID: PMC10037687. RP170644 and RP220582
Long T, Zhang Y, Donnelly L, Li H, Pien YC, Liu N, Olson EN, Li X. Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion. Nat Struct Mol Biol. 2023 Nov;30(11):1746-1754. doi: 10.1038/s41594-023-01110-8. Epub 2023 Sep 28. PMID: 37770716. RP170644
<p">Zhang H, Shi Z, Banigan EJ, Kim Y, Yu H, Bai XC, Finkelstein IJ. CTCF and R-loops are boundaries of cohesin-mediated DNA looping. Mol Cell. 2023 Aug 17;83(16):2856-2871.e8. doi: 10.1016/j.molcel.2023.07.006. Epub 2023 Aug 2. PMID: 37536339. RP170644
Li L, Nguyen BA, Mullapudi V, Li Y, Saelices L, Joachimiak LA. Disease-associated patterns of acetylation stabilize tau fibril formation. Structure. 2023 Sep 7;31(9):1025-1037.e4. doi: 10.1016/j.str.2023.05.020. Epub 2023 Jun 21. PMID: 37348495; PMCID: PMC10527703. RP170644
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH. Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. Cell. 2023 Jun 8;186(12):2644-2655.e16. doi: 10.1016/j. Cell. 2023.04.028. Epub 2023 May 23. PMID: 37224812; PMCID: PMC10330195. RP170644
Jiou J, Shaffer JM, Bernades NE, Fung HYJ, Kikumoto Dias J, D'Arcy S, Chook YM. Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2301199120. doi: 10.1073/pnas.2301199120. Epub 2023 Jul 14. PMID: 37450495. RP170644
Gonzalez A, Kim HJ, Freibaum BD, Fung HYJ, Brautigam CA, Taylor JP, Chook YM. A new Karyopherin-β2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders. Structure. 2023 Aug 3;31(8):924-934.e4. doi: 10.1016/j.str.2023.05.010. Epub 2023 Jun 5. PMID: 37279758; PMCID: PMC10524338. RP170644
Xue J, Zeng W, Han, Y, John S, Ottolia M, Jiang Y (2023). Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1.Nature Communications14, 6181 (2023). https://doi.org/10.1038/s41467-023-41885-4 RP170644
Zhang J, Zeng W, Han, Y, Lee W, Liou J, Jiang Y(2023). Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol Cell 2023 Jul 20;83(14):2524-2539.e7. doi: 10.1016/j.molcel.2023.06.004. Epub 2023 Jun 29 RP170644
Liu S, Chen H, Yin Y, Lu D, Gao G, Li J, Bai XC, Zhang X. Inhibition of FAM46/TENT5 activity by BCCIPalpha adopting a unique fold. Sci Adv. 2023;9(14):eadf5583. Epub 20230405. PMID: 37018411. RP170644
Wang L, Hall CE, Uchikawa E, Chen D, Choi E, Zhang X, Bai XC. Structural basis of insulin fibrillation. Sci Adv. 2023;9(37):eadi1057. Epub 20230915. PMID: 37713485. RP170644
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y. Activation of human STING by a molecular glue-like compound. Nat Chem Biol. 2023. Epub 20231012. PMID: 37828400 RP220582
Schrad JR, Fu G, Hable WE, Tayar AM, Oliveira K, Nicastro D (2023) Cryo-electron tomography of eel sperm flagella reveals a molecular “minimum system” for motile cilia. bioRxiv 2023.07.16.549168; doi: https://doi.org/10.1101/2023.07.16.549168 (submitted)
Fu G, Augspurger K, Sakizadeh J, Reck J, Bower R, Tritschler D, Gui L, Nicastro D, Porter ME. (2023) The ciliary MBO2 complex targets assembly of inner arm dynein b and reveals additional doublet microtubule asymmetries. bioRxiv. 2023 Aug 2:2023.07.31.551375. doi: 10.1101/2023.07.31.551375. Preprint. PMID: 37577467 (under review at MBoC)
Gui L, O'Shaughnessy WJ, Cai K, Reetz E, Reese ML, Nicastro D. Cryo-tomography reveals rigid-body motion and organization of apicomplexan invasion machinery. Nat Commun. 2023 Mar 30;14(1):1775. doi: 10.1038/s41467-023-37327-w. PMID: 36997532; PMCID: PMC10063558. RP170644
Raquel Bromberg, Yirui Guo, Dominika Borek, Zbyszek Otwinowski. CryoEM single particle reconstruction with a complex-valued particle stack. Structural Biology. 2023 June; Volume 215, Issue 2, June 2023, 107945. doi: https://doi.org/10.1016/j.jsb.2023.107945 RP170644 and RP220582
Liwei Wang, Catherine Hall, Jie Li, Eunhee Choi & Xiao-chen Bai. Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor. Nat Struct Mol Biol. 2023 April 13; volume 30, pages 661–669 (2023). doi: https://doi.org/10.1038/s41594-023-00974-0. RP170644
Kamil Sekulski, Victor Emmanuel Cruz, Christine S. Weirich & Jan P. Erzberger . rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly. Nat Commun. 2023 March 2; volume 14, Article number: 1207 (2023). doi: https://doi.org/10.1038/s41467-023-36867-5. RP170644
Victor M. Ruiz-Arroyo, Rishi Raj, Kesavan Babu, Otgonbileg Onolbaatar, Paul H. Roberts & Yunsun Nam. Structures and mechanisms of tRNA methylation by METTL1–WDR4. Nature. 2023 Jan 3;volume 613, pages 383–390 (2023). doi: https://doi.org/10.1038/s41586-022-05565-5. RP170644
2022
Bromberg R, Cai K, Guo Y, Plymire D, Emde T, Puzio M, Borek D, Otwinowski Z. The His-tag as a decoy modulating preferred orientation in cryoEM. Front Mol Biosci.. 2022 Oct 17; 9:912072. doi: 10.3389/fmolb.2022.912072. PMID: 36325274; PMCID: PMC9619061.
Victor Emmanuel Cruz, Kamil Sekulski, Nagesh Peddada, Carolin Sailer, Sahana Balasubramanian, Christine S. Weirich, Florian Stengel & Jan P. Erzberger. Sequence-specific remodeling of a topologically complex RNP substrate by Spb4. Nat Struct Mol Biol. 2022 December 08; volume 29, pages 1228–1238 (2022). doi: https://doi.org/10.1038/s41594-022-00874-9.
Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X. Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain. Nat Commun. 2022 Jul 25;13(1):4273. doi: 10.1038/s41467-022-32025-5. PMID: 35879350; PMCID: PMC9314443.
Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E. Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun. 2022 Sep 23;13(1):5594. doi: 10.1038/s41467-022-33274-0. PMID: 36151101; PMCID: PMC9508239.
Nguyen PT, Deisl C, Fine M, Tippetts TS, Uchikawa E, Bai XC, Levine B. Structural basis for gating mechanism of the human sodium-potassium pump. Nat Commun. 2022 Sep 8;13(1):5293. doi: 10.1038/s41467-022-32990-x. PMID: 36075933; PMCID: PMC9458724.
Park GJ, Osinski A, Hernandez G, Eitson JL, Majumdar A, Tonelli M, Henzler-Wildman K, Pawłowski K, Chen Z, Li Y, Schoggins JW, Tagliabracci VS. The mechanism of RNA capping by SARS-CoV-2. Res Sq [Preprint]. 2022 Feb 15:rs.3.rs-1336910. doi: 10.21203/rs.3.rs-1336910/v1. Update in: Nature. 2022 Aug 9;: PMID: 35194601; PMCID: PMC8863163.
Basta T, Teng J, Lee M, Worrell BT, Stowell MHB, Hibbs RE. Structural mechanism of muscle nicotinic receptor desensitization and block by curare. Nat Struct Mol Biol. 2022 April 29(4):386-394. doi: 10.1038/s41594-022-00737-3. Epub 2022 Mar 17. PMID: 35301478.
Noviello CM, Kreye J, Pruss H, Hibbs RE. Structural mechanisms of GABAA receptor autoimmune encephalitis. Cell. 2022 Jul 7;185(14):2469-2477.e13. doi: 10.1016/j.cell.2022.06.025. PMID: 35803245; PMCID: PMC9394431.
Hongwen Chen, Kevin Chen, Weijiao Huang, Louis M. Staudt, Jason G. Cyster and Xiaochun Li. Structure of S1PR2-heterotrimeric G13 signaling complex. Sci Adv. 2022, 8(13):eabn0067. doi:10.1126/sciadv.abn0067.
Rong Wang, Yu Qin and Xiaochun Li , Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1. Cell Research. 2022, 32(2):214-217.
Yingyuan Sun and Xiaochun Li. Cholesterol Efflux Mechanism Revealed by Distinct States of ABCA1. Nat Cardiovasc. 2022, Res 1, 238–245.
Hongwen Chen, Weijiao Huang, and Xiaochun Li. Structures of Oxysterol Sensor EBI2/GPR183, a Key Regulator of the Immune Response. Structure. 2022, 30 (7):1-9.
Rong Wang, Yu Qin, Xiao-Song Xie and Xiaochun Li. Molecular Basis of mEAK-7-Mediated Human V-ATPase Regulation. Nature Communications. 2022, 13:3272.
Yang Liu, Xiaofeng Qi, Linda Donnelly, Nadia Elghobashi-Meinhardt, Tao Long, Rich W. Zhou, Yingyuan Sun, Boyuan Wang and Xiaochun Li. Mechanisms and Inhibition of Porcupine-Mediated Wnt Acylation. Nature. 2022, 10.1038/s41586-022-04952-2 (in press).
D. Lu, G. Shang, J. Li, Y. Lu, X. C. Bai and X. Zhang. Activation of STING by targeting a pocket in the transmembrane domain. Nature . 2022 Vol. 604 Issue 7906 Pages 557-562, Accession Number: 35388221 DOI: 10.1038/s41586-022-04559-7.
Gao H, Faxiang L, Ji Z, Shi Z, Li Y, Yu H. Cryo-EM structures of human p97 double hexameter capture potentiated ATPase-competent state. Cell Discov. 2022, 8:19. DOI: 10.1038/s41421-022-00379-1. PMID: 35190543.
Tagliabracci T, Park G, Osinski A, Hernandez G, Eitson J, Majumdar A, Tonelli M, Henzler-Wildman K, Pawłowski K, Chen Z, Li Y, Schoggins J. Res Sq rs.3.rs. 2022, -1336910. DOI: 10.21203/rs.3.rs-1336910/v1. PMID: 35194601.
Xue J, Han, Y, Zeng W & Jiang Y. Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron 2022, 110, 86-95. e5. doi: 10.1016/j.neuron.2021.10.006. Epub 2021 Oct 25.
Gan N, Han, Y, Zeng W, Wang Y, Xue J & Jiang Y. Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P2 and rapamycin. Proc Natl Acad Sci U S A 2022 Feb 7;119(7): e 2120404119. doi: 10.1073/pnas. 2120404119. Online ahead of print.
2021
Rong Wang, Yu Qin and Xiaochun Li Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1. Cell Research. 2021 doi: 10.1038/s41422-021-00585-8.
Fu G, Scarbrough C, Song K, Phan N, Wirschell M, Nicastro D. Structural organization of the intermediate and light chain complex of Chlamydomonas ciliary I1 dynein. FASEB J. 2021 Jun;35(6):e21646. doi: 10.1096/fj.202001857R. PMID: 33993568.
Cai K, Zhao Y, Zhao L, Phan N, Hou Y, Cheng X, Witman GB, Nicastro D. Structural organization of the C1b projection within the ciliary central apparatus. J Cell Sci 2021 Oct 15:jcs.254227. doi: 10.1242/jcs.254227. Epub ahead of print. PMID: 34651179.
Osinski A, Black MH, Pawłowski K, Chen Z, Li Y, Tagliabracci VS. Structural and mechanistic basis for protein glutamylation by the kinase fold. Mol Cell. 2021 Aug 12:S1097-2765(21)00647-X. doi: 10.1016/j.molcel.2021.08.007. Epub ahead of print. PMID: 34407442.
Kober DL, Radhakrishnan A, Goldstein JL, Brown MS, Clark LD, Bai XC, Rosenbaum DM. Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing. Cell. 2021 Jul 8;184(14):3689-3701.e22. doi: 10.1016/j.cell.2021.05.019. Epub 2021 Jun 16. PMID: 34139175; PMCID: PMC8277531.
Fabritius AS, Bayless BA, Li S, Stoddard D, Heydeck W, Ebmeier CC, Anderson L, Gunnels T, Nachiappan C, Whittall JB, Old W, Agard DA, Nicastro D, Winey M. Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs. Mol Biol Cell. 2021 Aug 18:mbcE20120786. doi: 10.1091/mbc.E20-12-0786. Epub ahead of print. PMID: 34406789.
Yu H, Bai XC, Wang W. Characterization of the subunit composition and structure of adult human glycine receptors. Neuron. 2021 Sep 1;109(17):2707-2716.e6. doi: 10.1016/j.neuron.2021.08.019. PMID: 34473954.
Xue J, Han Y, Zeng W, Wang Y, Jiang Y. Structural mechanisms of gating and selectivity of human rod CNGA1 channel. Neuron. 2021 Apr 21;109(8):1302-1313.e4. doi: 10.1016/j.neuron.2021.02.007. Epub 2021 Mar 1. PMID: 33651975; PMCID: PMC8068614.
Xue J, Han Y, Baniasadi H, Zeng W, Pei J, Grishin NV, Wang J, Tu BP, Jiang Y. TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase. Elife. 2021 Aug 10;10:e71220. doi: 10.7554/eLife.71220. PMID: 34374645; PMCID: PMC8376247.
Wang R, Wang J, Hassan A, Lee CH, Xie XS, Li X. Molecular basis of V-ATPase inhibition by bafilomycin A1. Nat Commun. 2021 Mar 19;12(1):1782. doi: 10.1038/s41467-021-22111-5. PMID: 33741963; PMCID: PMC7979754.
Schmiege P, Fine M, Li X. Atomic insights into ML-SI3 mediated human TRPML1 inhibition. Structure. 2021 Jun 19:S0969-2126(21)00207-0. doi: 10.1016/j.str.2021.06.003. Epub ahead of print. PMID: 34171299.
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X. Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc Natl Acad Sci U S A. 2021 Aug 24;118(34):e2110483118. doi: 10.1073/pnas.2110483118. PMID: 34404721; PMCID: PMC8403869.
Long T, Liu Y, Qin Y, DeBose-Boyd RA, Li X. Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. Sci Adv. 2021 Aug 18;7(34):eabh3997. doi: 10.1126/sciadv.abh3997. PMID: 34407950; PMCID: PMC8373123.
Long T, Liu Y, Li X. Molecular structures of human ACAT2 disclose mechanism for selective inhibition. Structure. 2021 Sep 11:S0969-2126(21)00259-8. doi: 10.1016/j.str.2021.07.009. Epub ahead of print. PMID: 34520735.
Lu, D., Shang, G., He, X., Bai, X.-C., & Zhang, X. (2021). Architecture of the sema3a/plexina4/neuropilin tripartite complex. Nature Communications , 12(1), 3172. PMID 34039996.
Uchikawa, E., Chen, Z., Xiao, G.-Y., Zhang, X., & Bai, X.-C. (2021). Structural basis of the activation of c-MET receptor. Nature Communications, 12(1), 4074. PMID 34210960.
Noviello, Colleen M., Anant Gharpure, Nuriya Mukhtasimova, Rico Cabuco, Leah Baxter, Dominika Borek, Steven M. Sine, and Ryan E. Hibbs. “Structure and Gating Mechanism of the Α7 Nicotinic Acetylcholine Receptor.” Cell 184, no. 8 (April 15, 2021): 2121-2134.e13. PMID 33735609.
Jeong, Byung-Cheon, Sung Jun Bae, Lisheng Ni, Xuewu Zhang, Xiao-Chen Bai, and Xuelian Luo. “Cryo-EM Structure of the Hippo Signaling Integrator Human STRIPAK.” Nature Structural & Molecular Biology 28, no. 3 (March 2021): 290–299. PMID 33633399.
Dong, X., Yang, Y., Zou, Z. et al. Sorting nexin 5 mediates virus-induced autophagy and immunity. Nature 589, 456–461 (2021). PMID 33328639.
2020
Qi, Xiaofeng, Lucas Friedberg, Ryan De Bose-Boyd, Tao Long, and Xiaochun Li. “Sterols in an Intramolecular Channel of Smoothened Mediate Hedgehog Signaling.” Nature Chemical Biology 16, no. 12 (December 2020): 1368–1375. PMID 32929279.
Kim JJ, Gharpure A, Teng J, et al. (2020) Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature 2020; 585(7824):303-308. PMID 32879488.
Yin J, Chen KM, Clark MJ, et al. (2020) Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane. Nature 2020;584(7819):125-129. PMID 32528175.
Li F, Li Y, Ye X, et al. (2020) Cryo-EM structure of VASH1-SVBP bound to microtubules. Elife 2020;9 PMID 32773040.
Long T, Qi X, Hassan A, Liang Q, De brabander JK, Li X. (2020) Structural basis for itraconazole-mediated NPC1 inhibition. Nat Commun 2020;11(1):152. PMID 31919352.
Kuo YC, Chen H, Shang G, et al. (2020) Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation. Nat Commun 2020;11(1):1953. PMID 32327662.
Wang R, Long T, Hassan A, et al. (2020) Cryo-EM structures of intact V-ATPase from bovine brain. Nat Commun 2020;11(1):3921. PMID 32764564.
Zhang X, Bai XC, Chen ZJ. (2020) Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway. Immunity 2020;53(1):43-53. PMID 32668227.
Shi Z, Gao H, Bai XC, Yu H. (2020) Cryo-EM structure of the human cohesin-NIPBL-DNA complex. Science 2020;368(6498):1454-1459. PMID 32409525.
Peng W, Casey AK, Fernandez J, et al. (2020) A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM. Nat Struct Mol Biol 2020;27(6):589-597. PMID 32424347.
Long T, Sun Y, Hassan A, Qi X, Li X. (2020) Structure of nevanimibe-bound tetrameric human ACAT1. Nature 2020;581(7808):339-343. PMDI 32433613.
Partin AC, Zhang K, Jeong BC, et al. (2020) Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA. Mol Cell 2020;78(3):411-422.e4. PMID 32220646.
Bromberg R, Guo Y, Borek D, Otwinowski Z. (2020) High-resolution cryo-EM reconstructions in the presence of substantial aberrations. IUCrJ. 2020;7(Pt 3):445-452. PMID 32431828.
Qi X, Friedberg L, De bose-boyd R, Long T, Li X. (2020) Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat Chem Biol. 2020; PMID 32929279.
Wang R, Qi X, Schmiege P, Coutavas E, Li X. (2020) Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments. Sci Adv. 2020;6(7):eaaz1466. PMID 32095534.
2019
Gui L, Song K, Tritschler D, et al. (2019) Scaffold subunits support associated subunit assembly in the ciliary nexin-dynein regulatory complex. Proc Natl Acad Sci USA 2019;116(46):23152-23162. PMID 31659045.
Li J, Shang G, Chen YJ, et al. (2019) Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands. Elife 2019;8 PMID 31535977
Uchikawa E, Choi E, Shang G, Yu H, Bai XC. (2019) Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife 2019;8 PMID 31436533.
Prinslow EA, Stepien KP, Pan YZ, Xu J, Rizo J (2019) Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and αSNAP. eLife 8. pii: e38880. doi: 10.7554/eLife.38880.
Zhang C, Shang G, Gui X, Zhang X*, Bai X*, Chen ZJ* (2019) Structural basis of STING binding with and phosphorylation by TBK1. Nature 567:394-398. doi: 10.1038/s41586-019-1000-2.
Shang G, Zhang C, Chen ZJ*, Bai X*, Zhang X* (2019) Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP. Nature 567:389-393. doi: 10.1038/s41586-019-0998-5.
Quade B, Camacho M, Zhao X, Orlando M, Trimbuch T, Xu J, Li W, Nicastro D, Rosenmund C, Rizo J (2019) Membrane bridging by Munc13-1 is crucial for neurotransmitter release. eLife 8:e42806. [PMCID: PMC6407922].
She J, Zeng W, Guo J, Chen Q, Bai X*, Jiang Y* (2019) Structural mechanisms of phospholipid activation of the human TPC2 channel. eLife 8. pii: e45222. doi: 10.7554/eLife.45222.
Hariri H, Speer N, Bowerman J, Rogers S, Fu G, Reetz E, Datta S, Feathers JR, Ugrankar R, Nicastro D, Henne WM (2019) Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating lipid droplet biogenesis. J Cell Biol. jcb.201808119. [PMCID: PMC6446837].
Spietz RL, Lundeen RA, Zhao X, Nicastro D, Ingalls AE, Morris RM (2019) Heterotrophic carbon metabolism and energy acquisition in Candidatus Thioglobus singularis strain PS1, a member of the SUP05 clade of marine Gammaproteobacteria. Environ Microbiol DOI: https://doi.org/10.1111/1462-2920.14623 [PMID 30951247].
Chen Q, Zeng W, She J, Bai XC, Jiang Y (2019) Structural and functional characterization of an otopetrin family proton channel. eLife 8. pii: e46710. doi: 10.7554/eLife.46710.
Shah V*, Zhao X*, Lundeen RA, Ingalls AE, Nicastro D, Morris RM (2019) Morphological plasticity in a sulfur-oxidizing bacterium from the SUP05 clade enhances dark carbon fixation. mBio DOI: 10.1128/mBio.00216-19. [PMCID: PMC6509183].
Wang Y, Nguyen NX, She J, Zeng W, Yang Y, Bai X*, Jiang Y* (2019) Structural mechanism of EMRE-dependent gating of the human mitochondrial calcium uniporter. Cell 177(5):1252-1261.e13. doi: 10.1016/j.cell.2019.03.050.
Peng W, de Souza Santos M, Li Y, Tomchick DR, Orth K (2019) High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers. PLoS One 14:e0213423. doi: 10.1371/journal.pone.0213423.
Qi X, Liu H, Thompson B, McDonald J, Zhang C, Li X (2019) Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi. Nature 571:279-283. doi: 10.1038/s41586-019-1286-0.
Peng W, de Souza Santos M, Li Y, Tomchick DR, Orth K (2019) High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers. PLoS One 14:e0213423. doi: 10.1371/journal.pone.0213423.
Dymek EE, Lin J*, Fu G*, Porter ME, Nicastro D, Smith EF (2019) PACRG and FAP20 form the inner junction of axonemal doublet microtubules and regulate ciliary motility. Mol Biol Cell 30:1805-1816. [PMCID: PMC6727744].
Gharpure A, Noviello C, Teng J, Zaveri N, Hibbs R (2019) Agonist selectivity and ion permeation in the α3β4 ganglionic nicotinic receptor. Neuron 104:501-511.e6. doi: 10.1016/j.neuron.2019.07.030.
Uchikawa E*, Choi E*, Shang G, Yu H*, Bai X* (2019) Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. eLife 8. pii: e48630. doi: 10.7554/eLife.48630.
Li J*, Shang G*, Chen YJ, Brautigam CA, Liou J, Zhang X*, Bai X* (2019) Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands. eLife 8. pii: e47650. doi: 10.7554/eLife.47650.
Lin J*, Le TV*, Augsperger K, Tritschler D, Bower R, Fu G, Perrone C, O’Toole ET, VanderWaal Mills K, Dymek EE, Smith EF, Nicastro D*, Porter ME* (2019) FAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia. Mol Biol Cell 30:2659-2680, doi: 10.1091/mbc.E19-07-0367 [PMCID: PMC6761771].
Li J, Choi E, Yu H, Bai XC (2019) Structural basis of the activation of type 1 insulin-like growth factor receptor. Nat Commun 10:4567. doi: 10.1038/s41467-019-12564-0.
Fu G*, Zhao L*, Dymek E, Hou Y, Song K, Phan N, Shang Z, Smith EF, Witman GB, Nicastro D (2019) Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus. J Cell Biol. pii: jcb.201906006. doi: 10.1083/jcb.201906006. [Epub ahead of print].
Gui L, Song K, Tristchler D, Bower R, Si Y, Dai A, Augsperger K, Sakizadeh J, Grzemska M, Ni T, Porter ME, Nicastro D (2019) Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex. PNAS pii: 201910960. doi: 10.1073/pnas.1910960116. [Epub ahead of print].
Trötschel C, Hamzeh H, Alvarez L, Pascal R, Lavryk F, Bönigk W, Körschen HG, Müller A, Poetsch A, Rennhack A, Gui L, Nicastro D, Strünker T, Seifert R, Kaupp UB (2019) Absolute proteomic quantification reveals design principles of flagellar chemosensation. EMBO J (accepted).
2018
She J, Guo J, Chen Q, Zeng W, Jiang Y* & Bai X* (2018). Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel. Nature 556, 130-134. doi:10.1038/nature26139.
Fu G, Wang Q, Phan N, Urbanska P, Joachimiak E, Wloga D, Nicastro D (2018) The I1 dynein-associated tether and tether head complex is a conserved regulator of ciliary motility. Mol Biol Cell 29:1048-1059. [PMCID: PMC5921572].
Nguyen NX, Armache JP, Lee C, Yang Y, Zeng W, Mootha VK, Cheng Y, Bai X* & Jiang Y* (2018). Cryo-EM structure of a fungal mitochondrial calcium uniporter. Nature 559, 570-574. doi: 10.1038/s41586-018-0333-6.
Walsh RM Jr., Roh SH, Gharpure A, Morales-Perez CL, Teng J, Hibbs RE (2018). Structural principles of distinct assemblies of the human α4β2 nicotinic receptor. Nature 557(7704):261-265. [PMCID PMC6132059].
Zhu S, Noviello CM, Teng J, Walsh RM Jr., Kim JJ, Hibbs RE (2018). Structure of a human synaptic GABAA receptor. Nature 559 (7712):67-72.
Qi X, Schmiege P, Coutavas E, Wang J, Li X (2018). Structures of human Patched and its complex with native palmitoylated Sonic Hedgehog. Nature 560: 128–132.
Fine M, Schmiege P, Li X (2018). Structural basis for PtdInsP2mediated human TRPML1 regulation. Nature Comm 9:4192.
Qi X, Schmiege P, Coutavas E, Xiaochun Li (2018). Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex. Science 362: 52. pii: eaas8843.
2017
Guo J, She J, Zeng W, Chen Q, Bai X* & Jiang Y* (2017). Structures of the Calcium-activated Non-Selective Cation Channel TRPM4. Nature 552, 205–209. doi:10.1038/nature24997.
Chen Q, She J, Zeng W, Guo J, Xu H, Bai X* & Jiang Y* (2017). Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature 550, 415-418. doi:10.1038/nature24035.