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Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X. Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain. Nat Commun. 2022 Jul 25;13(1):4273. doi: 10.1038/s41467-022-32025-5. PMID: 35879350; PMCID: PMC9314443.

Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E. Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun. 2022 Sep 23;13(1):5594. doi: 10.1038/s41467-022-33274-0. PMID: 36151101; PMCID: PMC9508239.

Nguyen PT, Deisl C, Fine M, Tippetts TS, Uchikawa E, Bai XC, Levine B. Structural basis for gating mechanism of the human sodium-potassium pump. Nat Commun. 2022 Sep 8;13(1):5293. doi: 10.1038/s41467-022-32990-x. PMID: 36075933; PMCID: PMC9458724.

Park GJ, Osinski A, Hernandez G, Eitson JL, Majumdar A, Tonelli M, Henzler-Wildman K, Pawłowski K, Chen Z, Li Y, Schoggins JW, Tagliabracci VS. The mechanism of RNA capping by SARS-CoV-2. Res Sq [Preprint]. 2022 Feb doi: 10.21203/ Update in: Nature. 2022 Aug 9;: PMID: 35194601; PMCID: PMC8863163.

Basta T, Teng J, Lee M, Worrell BT, Stowell MHB, Hibbs RE. Structural mechanism of muscle nicotinic receptor desensitization and block by curare. Nat Struct Mol Biol. 2022 April 29(4):386-394. doi: 10.1038/s41594-022-00737-3. Epub 2022 Mar 17. PMID: 35301478.

Noviello CM, Kreye J, Pruss H, Hibbs RE. Structural mechanisms of GABAA receptor autoimmune encephalitis. Cell. 2022 Jul 7;185(14):2469-2477.e13. doi: 10.1016/j.cell.2022.06.025. PMID: 35803245; PMCID: PMC9394431.

Hongwen Chen, Kevin Chen, Weijiao Huang, Louis M. Staudt, Jason G. Cyster and Xiaochun Li. Structure of S1PR2-heterotrimeric G13 signaling complex. Sci Adv. 2022, 8(13):eabn0067. doi:10.1126/sciadv.abn0067.

Rong Wang, Yu Qin and Xiaochun Li , Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1. Cell Research. 2022, 32(2):214-217.

Yingyuan Sun and Xiaochun Li. Cholesterol Efflux Mechanism Revealed by Distinct States of ABCA1. Nat Cardiovasc. 2022, Res 1, 238–245.

Hongwen Chen, Weijiao Huang, and Xiaochun Li. Structures of Oxysterol Sensor EBI2/GPR183, a Key Regulator of the Immune Response. Structure. 2022, 30 (7):1-9.

Rong Wang, Yu Qin, Xiao-Song Xie and Xiaochun Li. Molecular Basis of mEAK-7-Mediated Human V-ATPase Regulation. Nature Communications. 2022, 13:3272.

Yang Liu, Xiaofeng Qi, Linda Donnelly, Nadia Elghobashi-Meinhardt, Tao Long, Rich W. Zhou, Yingyuan Sun, Boyuan Wang and Xiaochun Li. Mechanisms and Inhibition of Porcupine-Mediated Wnt Acylation. Nature. 2022, 10.1038/s41586-022-04952-2 (in press).

D. Lu, G. Shang, J. Li, Y. Lu, X. C. Bai and X. Zhang. Activation of STING by targeting a pocket in the transmembrane domain. Nature . 2022 Vol. 604 Issue 7906 Pages 557-562, Accession Number: 35388221 DOI: 10.1038/s41586-022-04559-7.

Gao H, Faxiang L, Ji Z, Shi Z, Li Y, Yu H. Cryo-EM structures of human p97 double hexameter capture potentiated ATPase-competent state. Cell Discov. 2022, 8:19. DOI: 10.1038/s41421-022-00379-1. PMID: 35190543.

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Xue J, Han, Y, Zeng W & Jiang Y. Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron 2022, 110, 86-95. e5. doi: 10.1016/j.neuron.2021.10.006. Epub 2021 Oct 25.

Gan N, Han, Y, Zeng W, Wang Y, Xue J & Jiang Y. Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P2 and rapamycin. Proc Natl Acad Sci U S A 2022 Feb 7;119(7): e 2120404119. doi: 10.1073/pnas. 2120404119. Online ahead of print.


Rong Wang, Yu Qin and Xiaochun Li Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1. Cell Research. 2021 doi: 10.1038/s41422-021-00585-8.

Fu G, Scarbrough C, Song K, Phan N, Wirschell M, Nicastro D. Structural organization of the intermediate and light chain complex of Chlamydomonas ciliary I1 dynein. FASEB J. 2021 Jun;35(6):e21646. doi: 10.1096/fj.202001857R. PMID: 33993568.

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Osinski A, Black MH, Pawłowski K, Chen Z, Li Y, Tagliabracci VS. Structural and mechanistic basis for protein glutamylation by the kinase fold. Mol Cell. 2021 Aug 12:S1097-2765(21)00647-X. doi: 10.1016/j.molcel.2021.08.007. Epub ahead of print. PMID: 34407442.

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Yu H, Bai XC, Wang W. Characterization of the subunit composition and structure of adult human glycine receptors. Neuron. 2021 Sep 1;109(17):2707-2716.e6. doi: 10.1016/j.neuron.2021.08.019. PMID: 34473954.

Xue J, Han Y, Zeng W, Wang Y, Jiang Y. Structural mechanisms of gating and selectivity of human rod CNGA1 channel. Neuron. 2021 Apr 21;109(8):1302-1313.e4. doi: 10.1016/j.neuron.2021.02.007. Epub 2021 Mar 1. PMID: 33651975; PMCID: PMC8068614.

Xue J, Han Y, Baniasadi H, Zeng W, Pei J, Grishin NV, Wang J, Tu BP, Jiang Y. TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase. Elife. 2021 Aug 10;10:e71220. doi: 10.7554/eLife.71220. PMID: 34374645; PMCID: PMC8376247.

Wang R, Wang J, Hassan A, Lee CH, Xie XS, Li X. Molecular basis of V-ATPase inhibition by bafilomycin A1. Nat Commun. 2021 Mar 19;12(1):1782. doi: 10.1038/s41467-021-22111-5. PMID: 33741963; PMCID: PMC7979754.

Schmiege P, Fine M, Li X. Atomic insights into ML-SI3 mediated human TRPML1 inhibition. Structure. 2021 Jun 19:S0969-2126(21)00207-0. doi: 10.1016/j.str.2021.06.003. Epub ahead of print. PMID: 34171299.

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Long T, Liu Y, Qin Y, DeBose-Boyd RA, Li X. Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. Sci Adv. 2021 Aug 18;7(34):eabh3997. doi: 10.1126/sciadv.abh3997. PMID: 34407950; PMCID: PMC8373123.

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Jeong, Byung-Cheon, Sung Jun Bae, Lisheng Ni, Xuewu Zhang, Xiao-Chen Bai, and Xuelian Luo. “Cryo-EM Structure of the Hippo Signaling Integrator Human STRIPAK.” Nature Structural & Molecular Biology  28, no. 3 (March 2021): 290–299. PMID 33633399.

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Qi, Xiaofeng, Lucas Friedberg, Ryan De Bose-Boyd, Tao Long, and Xiaochun Li. “Sterols in an Intramolecular Channel of Smoothened Mediate Hedgehog Signaling.” Nature Chemical Biology 16, no. 12 (December 2020): 1368–1375. PMID 32929279.

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