2025 Article Archive
Protein linked to immunotherapy resistance in kidney cancer
A protein identified by researchers at UT Southwestern Medical Center may drive resistance to immune checkpoint inhibitors, a widely used form of immunotherapy to treat cancer.
UT Southwestern and Children’s Health receive record-setting gift from Moody Foundation
UT Southwestern Medical Center and Children’s Health℠ today announced a historic nine-figure grant from the Moody Foundation to support the new $5 billion pediatric campus in Dallas, which broke ground in October 2024. The new hospital will help meet the increasing demand for pediatric health care, research and training. The Moody Foundation’s transformational grant is the largest gift to date for this landmark project.
Growing number of U.S. adolescents receive weight-loss surgery
Weight-loss surgeries for adolescents increased 15% in the U.S. between 2021 and 2023, even as the Food and Drug Administration (FDA) approved effective new weight-loss medications for this age group, a study led by UT Southwestern Medical Center researchers shows. Their findings, published in The Journal of Pediatrics, shed light on how severe obesity is being treated in teenagers, the fastest growing age group with this condition.
Obesity in childhood raises risk of experiencing weight stigma
Adults who developed severe obesity before the age of 18 were nearly three times more likely than those who developed the condition later to be subjected to severe experienced weight stigma (EWS), a study led by UT Southwestern Medical Center researchers shows.
FDA-designated orphan drug could increase radiation efficacy in lung cancer
– An FDA-designated orphan drug that can target a key vulnerability in lung cancer shows promise in improving the efficacy of radiation treatments in preclinical models, according to a study by UT Southwestern Medical Center researchers.
Differences in survival persist despite access to cancer clinical trials
Black and Hispanic children with high-risk neuroblastoma experience worse survival outcomes than their white peers, even when treated in frontline clinical trials, according to a study led by a UT Southwestern Medical Center researcher.
Artificial intelligence predicts kidney cancer therapy response
An artificial intelligence (AI)-based model developed by UT Southwestern Medical Center researchers can accurately predict which kidney cancer patients will benefit from anti-angiogenic therapy, a class of treatments that’s only effective in some cases.
Lifelong physical activity may slow cognitive decline
High levels of physical activity may mitigate brain loss in adults and help maintain long-term cognitive health, researchers at UT Southwestern Medical Center report in a study published in the Journal of Applied Physiology.
Immune protein STING key for repairing, generating lysosomes
– The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a quality control sensor for organelles that serve as cellular waste disposal systems, UT Southwestern Medical Center researchers found. Their study, published in Molecular Cell, helps explain critical features of diseases called lysosomal storage disorders and could eventually lead to new treatments for these and other neurodegenerative diseases.
Researchers create ‘wiring diagram’ for key songbird brain region
Much like human beings, songbirds learn how to vocalize from their parents. Males imitate songs from their fathers and then sing to attract mates. Although the circuits that generate human speech are more complicated to decipher, the brains of songbirds offer a viable model for better understanding how humans learn to speak and what goes wrong in communication disorders such as autism.