Publications

2017 Publications

  1. Tso SC, Lou M, Wu CY, Gui WJ, Chuang JL, Morlock LK, Williams NS, Wynn RM, Qi X, Chuang DT. Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors. J Med Chem. 2017 Feb 9;60(3):1142-1150. PMCID: PMC5996997
  2. Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y, Williams NS, Nijhawan D.Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.  2017 Mar 16. pii: eaal3755. doi: 10.1126/science.aal3755. [Epub ahead of print] PubMed PMID: 28302793.
  3. McCarthy JS, Lotharius J, Rückle T, Chalon S, Phillips MA, Elliott S, Sekuloski S, Griffin P, Ng CL, Fidock DA, Marquart L, Williams NS, Gobeau N, Bebrevska L, Rosario M, Marsh K, Möhrle JJ. Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study.Lancet Infect Dis. 2017 Mar 28. pii: S1473-3099(17)30171-8. doi: 10.1016/S1473-3099(17)30171-8. [Epub ahead of print] PubMed PMID: 28363636.
  4. Luthra P, Aguirre S, Yen BC, Pietzsch CA, Sanchez-Aparicio MT, Tigabu B, Morlock LK, García-Sastre A, Leung DW, Williams NS, Fernandez-Sesma A, Bukreyev A, Basler CF. Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion. 2017 Apr 4;8(2). pii: e00368-17. doi: 10.1128/mBio.00368-17. PubMed PMID: 28377530; PubMed Central PMCID: PMC5380843.
  5. Eskiocak B, McMillan E, Mendiratta S, Kollipara R, Zhang H, Humphries C, Wang C, Garcia-Rodriguez J, Ding M, Zaman A, Rosales T, Eskiocak U, Smith MP, Sudderth J, Komurov K, DeBerardinis RJ, Wellbrock C, Davies MA, Wargo JA, Yu Y, De Brabander JK, Williams NS, Chin L, Rizos H, Long GV, Kittler R, White M. Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma.Cancer Discov. 2017 Apr 28. pii: CD-16-0955. doi: 10.1158/2159-8290.CD-16-0955. [Epub ahead of print] PubMed PMID: 28455392.
  6. Antczak MI, Zhang Y, Wang C, Doran J, Naidoo J, Voruganti S, Williams NS, Markowitz SD, Ready JM. Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair.J Med Chem. 2017 May 11;60(9):3979-4001. doi: 10.1021/acs.jmedchem.7b00271. Epub 2017 Apr 25. PubMed PMID: 28398755.
  7. Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L. Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654. doi: 10.1073/pnas.1621346114. Epub 2017 Jan 31. PubMed PMID: 28143939; PubMed Central PMCID: PMC5320972.
  8. Voorhees JR, Remy MT, Cintrón-Pérez CJ, El Rassi E, Khan MZ, Dutca LM, Yin TC, McDaniel LN, Williams NS, Brat DJ, Pieper AA. (-)-P7C3-S243 Protects a Rat Model of Alzheimer's Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia.Biol Psychiatry. 2017 Nov 6. pii: S0006- PMID: 29246437.