Publications Archive for John M. Shelton, B.Sc.

Wiseman D, Hanzlik JA, Richardson JA, Shelton JM, Evers BM, Diamond MP, Brown R, Mazzucco DC. Development of a Chronic Canine Ovariohysterectomy Model to Evaluate Vaginal Cuff Healing Using Two Closure Systems. Surg Innov. 2022 APril 18;29(2):183-194.

Xie M, Cho GW, Kong Y, Li DL, Altamirano F, Luo X, Morales CR, Jiang N, Schiattarella GG, May HI, Medina J, Shelton JM, Ferdous A, Gillette TG, Hill JA.Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury. Circ Res. 2021 Jul 23;129(3): 435-450.

Fan W, Mar KB, Sari L, Gaszek IK, Cheng Q, Evers BM, Shelton JM, Wight-Carter M, Siegwart DL, Lin MM, Schoggins JW. TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity. Cell. 2021 Jun 24;184(13):3410-3425.

Anderson DM, Anderson KM, Nelson BR, McAnally JR, Bezprozvannaya S, Shelton JM, Bassel-Duby R, Olson EN. A myocardin-adjacent lncRNA balances SRF-dependent gene transcription in the heart. Genes Dev. 2021 Jun;35(11-12):835-840.

Ramirez-Martinez A, Zhang Y, Chen K, Kim J, Cenik BK, McAnally JR, Cai C, Shelton JM, Huang J, Brennan, Evers, BM, Mammen PPA, Xu L, Bassel-Duby R, Olson EN. The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization. Nat Commun. 2021 Jan 29;12(1): 690.

Min YL, Chemello F, Li H, Rodriguez-Caycedo C, Sanchez-Ortiz E, Mireault AA, McAnally JR, Shelton JM, Zhang Y, Bassel-Duby R, Olson EN. Correction of Three Prominent Mutations in Mouse and Human Models of Duchenne Muscular Dystrophy by Single-Cut Genome Editing. Mol Ther. 2020 Sep 2;28(9): 2044-2055.

Somatilaka BN, Hwang SH, Palicharla VR, White KA, Bangandi H, Shelton JM, Mukhopadhyay S. Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenyl Cyclase SIgnaling. Dev Cell. 2020 Sep 28;54(6): 710-726.

Zhang Y, Li H, MinYL, Sanchez-Ortiz E- Huang J, Mireault AA, Shelton JM, Kim J, Mammen PPA, Bassel-Duby R, Olson EN. Enhanced CRISPR-Cas9 correction of Duchenne muscular dystrophy in mice by a self-complimentary AAV delivery system. Sci Adv. 2020 Feb 19;6(8): eaay6812.

Amoasii L, Li H, Zhang Y, Min YL, Sanchez-Ortiz E, Shelton JM, Long C, Mireault AA, Bhattacharyya S,  McAnally JR, Bassel-Duby R, Olson EN. In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse. Nat Commun. 2019 Oct 4;10(1): 4537.

Wang Z, Cui M, Shah AM, Ye W, Tan W, Min YL, Botten GA, Shelton JM, Liu N, Bassel-Duby R, Olson EN. Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling. Proc Natl Acad Sci USA. 2019 Sep 10;116(37): 18455-18465.

Shimada, I.S., Hwang, S.H., Somatilaka, B.N., Wang, X., Skowron, P., Kim, J., Kim, M., Shelton, J.M., Rajaram, V., Xuan, Z., Taylor, M.D., Mukhopadhyay, S. Basal suppression of the Sonic Hedgehog pathway by the G-protein-coupled receptor Gpr161 restricts medulloblastoma pathogenesis. Cell Rep. 2018 Jan 30; 22(5): 1169-1184.

Hwang, S.H., White, K.A., Somatilaka, B.N., Shelton, J.M., Richardson, J.A., Mukhopadhyay, S. The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in primary cilium-dependent manner. Development. 2018 Jan 8;145(1).

Amoasii, L., Long, C., Li, H, Mireault, A.A., Shelton, J.M., Sanchez-Ortiz, E., McAnally, J.T., Bhattacharyya, S., Schmidt, F., Grimm, D., Hauschka, S.D., Bassel-Duby, R., Olson, E.N. SIngle-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy. Sci Transl Med. 2017 Nov 29;9(418).

Kyrchenko, V., Kyrchenko, S., Tiburcy, M., Shelton, J.M., Long, C., Schneider, J.W., Zimmermann, W.H., Bassel-Duby, R., Olson, E.N. Functional correction of dystrophin actin binding domain mutations by genome editing. JCI Insight. 2017 Sept 21;2(18).

Benrick, A., Chanclon, B., Micallel, P., Wu, Y., Hadi, L., Shelton, J.M., Stever-Victorin, E., Wernsted Asterholm, I. Adiponectin protects against development of metabolic disturbances in a PCOS mouse model. Proc Natl Acad Sci USA. 2017 Aug 22;114(34)E7187-E7196.

Udden, S.M.N., Peng, L., Gan, J.L., Shelton, J.M., Malter, J.S., Hooper, L.V., Zaki, M.H. NOD2 suppresses colorectal tumorogenesis via downregulation of the TLR pathways. Cell Rep. 2017 June 27;19(13)2756-2770.

Zhang, Y., Long, C., Li, H., McAnally, J.R., Baskin, K.K., Shelton, J.M., Bassel-Duby, R., Olson, E.N. CRISPR-Cpf1 correction of muscular dystrophy mutations in humancardiomyocytes and mice. Sci Adv. 2017 Apr 12;3(4).

Zhou, H., Zhang, Z., Denney, R., Williams, J.S., Gerberich, J., Stojadinovic, S., Saha, D., Shelton, J.M., Mason, R.P. Tumor physiological changes during hypofractionated stereotactic body radiation therapy assessed using multi-parametric magnetic resonance imaging. Oncotarget. 2017 June 6;8(23)37464-37477.

Bi, P., Ramirez-Martinez, A., Li, H., Cannavino, J., McAnally, J.R., Shelton, J.M., Sanchez-Ortiz, E., Bassel-Duby, R., Olson, E.N. Control of muscle formation by the fusogenic micropeptide myomixer. Science. 2017 Apr 21;356(6335):323-327.

Liu, N., Garry, G.A., Li, S., Bezprozvannaya, S., Sanchez-Ortiz, E., Chen, B., Shelton, J.M., Jaichander, P., Bassel-Duby, R., Olson, E.N. A Twist2-dependent progenitor cell contributes to adult skeletal muscle. Nat Cell Biol. 2017 Mar;19(3):202-213.

Ripperda, C.M., Maldonado, P.A., Acevedo, J.F., Keller, P.W., Akgul, Y., Shelton, J.M., Word, R.A. Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall. Menopause. 2017 Feb 6.

Anderson, D.M., Makarewich, C.A., Anderson, K.M., Shelton, J.M., Bezprozvannaya, S., Bassel-Duby, R., Olson, E.N. Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides. Sci Signal. 2016 Dec 6;9(457):ra119.

Anderson, K.M., Anderson, D.M., McAnally, J.R., Shelton, J.M., Bassel-Duby, R., Olson, E.N. Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development. Nature. 2016 Nov 17;539(7629):433-436.

Brant, S., Holmes, C., Cobert, M., Powell, L., Shelton, J., Jessen, M., Peltz, M. Successful transplantation in canines after long-term coronary sinus machine perfusion preservation of donor hearts. J Heart Lung Transplant. 2016 Aug;35(8):1031-6.

Satapati, S., Kucejova, B., Duarte, J.A., Fletcher, J.A., Reynolds, L., Sunny, N.E., He, T., Nair, L.A., Livingston, K.A., Fu, X., Merritt, M.E., Sherry, A.D., Malloy, C.R., Shelton, J.M., Lambert, J., Parks, E.J., Corbin, I., Magnuson, M.A., Browning, J.D., Burgess, S.C. Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. J Clin Invest. 2016 Apr 1;126(4):1605.

Long, C., Amoasii, L., Mireault, A.A., McAnally, J.R., Li, H., Sanchez-Ortiz, E., Bhattacharyya, S., Shelton, J.M., Bassel-Duby, R., Olson, E.N. Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy. Science. 2016 Jan 22;351(6271):400-3.

Kimura, W., Xiao, F., Canseco, D.C., Muralidhar, S., Thet, S., Zhang, H.M., Abderrahman, Y., Chen, R., Garcia, J.A., Shelton, J.M., Richardson, J.A., Ashour, A.M., Asaithamby, A., Liang, H., Xing, C., Lu, Z., Zhang, C.C., Sadek, H.A. Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart. Nature. 2015 Jul 9;523(7559):226-30.

Moreira, T.G., Zhang, L., Shaulov, L., Harel, A., Kuss, S.K., Williams, J., Shelton, J., Somatilaka, B., Seemann, J., Yang, J., Sakthivel, R., Nussenzveig, D.R., Faria, A.M., Fontoura, B.M. Sec13 Regulates Expression of Specific Immune Factors Involved in Inflammation In Vivo. Sci Rep. 2015 Dec 3;5:17655.

Satapati, S., Kucejova, B., Duarte, J.A., Fletcher, J.A., Reynolds, L., Sunny, N.E., He, T., Nair, L.A., Livingston, K.A., Fu, X., Merritt, M.E., Sherry, A.D., Malloy, C.R., Shelton, J.M., Lambert, J., Parks, E.J., Corbin, I., Magnuson, M.A., Browning, J.D., Burgess, S.C. Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. J Clin Invest. 2015 Dec;125(12):4447-62.

Cenik, B.K., Garg, A., McAnally, J.R., Shelton, J.M., Richardson, J.A., Bassel-Duby, R., Olson, E.N, Liu N. Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3. J Clin Invest. 2015 Apr;125(4):1569-78.

Anderson, D.M., Anderson, K.M., Chang, C.L., Makarewich, C.A., Nelson, B.R., McAnally, J.R., Kasaragod, P., Shelton, J.M., Liou, J., Bassel-Duby, R., Olson, E.N. A micropeptide encoded  by a putative long noncoding RNA regulates muscle performance. Cell. 2015 Feb 12;160(4):595-606.

Brant, S.M., Cobert, M.L., West, L.M., Shelton, J.M., Jessen, M.E., Peltz, M. Characterizing cardiac donation after circulatory death: implications for perfusion preservation. Ann Thorac Surg. 2014 Dec;98(6):2107-13; discussion 2113-4.

Hu, M.C., Shi, M., Cho, H.J., Adams-Huet, B., Paek, J., Hill, K., Shelton, J., Amaral, A.P., Faul, C., Taniguchi, M., Wolf, M., Brand, M., Takahashi, M., Kuro-O, M., Hill, J.A., Moe, O.W. Klotho and phosphate are modulators of pathologic uremic cardiac remodeling. J Am Soc Nephrol. 2015 Jun;26(6):1290-302.

Bing, C., Ladouceur-Wodzak, M., Wanner, C.R., Shelton, J.M., Richardson, J.A., Chopra, R. Trans-cranial opening of the blood-brain barrier in targeted regions using a stereotaxic brain atlas and focused ultrasound energy. J Ther Ultrasound. 2014 Aug 4;2:13.

Long, C., McAnally, J.R., Shelton, J.M., Mireault, A.A., Bassel-Duby, R., Olson, E.N. Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA. Science. 2014 Sep 5;345(6201):1184-8.

Long, C., Grueter, C.E., Song, K., Qin, S., Qi, X., Kong, Y.M., Shelton, J.M., Richardson, J.A., Zhang, C.L., Bassel-Duby, R., Olson, E.N. Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11521-6.

Chen, Z., Holland, W., Shelton, J.M., Ali, A., Zhan, X., Won, S., Tomisato, W., Liu, C., Li, X., Moresco, E.M., Beutler, B. Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7367-72.

Abedin, M.J., Nguyen, A., Jiang, N., Perry, C.E., Shelton, J.M., Watson, D.K., Ferdous, A. Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation. Circ Res. 2014 May 23;114(11):1690-9.

Luo, Y., Kumar, P., Chen, C.C., Latham, J., Wang, L., Tudela, C., Alexander, J.M., Shelton, J.M., McKown, L., Mendelson, C.R. Estrogen-related receptor γ serves a role in blood pressure homeostasis during pregnancy. Mol Endocrinol. 2014 Jun;28(6):965-75.

Liu, N., Nelson, B.R., Bezprozvannaya, S., Shelton, J.M., Richardson, J.A., Bassel-Duby, R., Olson, E.N. Requirement of MEF2A, C, and D for skeletal muscle regeneration. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4109-14.

Pop, L.M., Barman, S., Shao, C., Poe, J.C., Venturi, G.M., Shelton, J.M., Pop, I.V., Gerber, D.E., Girard, L., Liu, X.Y., Behrens, C., Rodriguez-Canales, J., Liu, H., Wistuba, I.I., Richardson, J.A., Minna, J.D., Tedder, T.F., Vitetta, E.S. A reevaluation of CD22 expression in human lung cancer. Cancer Res. 2014 Jan 1;74(1):263-71.

Singh, S., Canseco, D.C., Manda, S.M., Shelton, J.M., Chirumamilla, R.R., Goetsch, S.C., Ye, Q., Gerard, R.D., Schneider, J.W., Richardson, J.A., Rothermel, B.A., Mammen, P.P. Cytoglobin modulates myogenic progenitor cell viability and muscle regeneration. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E129-38.

Davis, C.G., Eisner, E., McGlynn, M., Shelton, J.M., Richardson, J., Borrelli, J. Jr, Chen, C.C. Posttraumatic Chondrocyte Apoptosis in the Murine Xiphoid. Cartilage. 2013 Oct;4(4):345-53.

Chapman, K.M., Powell, H.M., Chaudhary, J., Shelton, J.M., Richardson, J.A., Richardson, T.E., Hamra, F.K. Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success. Mol Cell Proteomics. 2013 Nov;12(11):3221-36. 

Xin, M., Kim, Y., Sutherland, L.B., Murakami, M., Qi, X., McAnally, J., Porrello, E.R., Mahmoud, A.I., Tan, W., Shelton, J.M., Richardson, J.A., Sadek, H.A., Bassel-Duby, R., Olson, E.N. Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13839-44.

Millay, D.P., O'Rourke, J.R., Sutherland, L.B., Bezprozvannaya S., Shelton, J.M., Bassel-Duby, R., Olson, E.N. Myomaker is a membrane activator of myoblast fusion and muscle formation. Nature. 2013 Jul 18;499(7458):301-5.

Winterberg, P.D., Wang, Y., Lin, K.M., Hartono, J.R., Nagami, G.T., Zhou, X.J., Shelton, J.M., Richardson, J.A., Lu, C.Y. Reactive-oxygen species (ROS) and IRF1 stimulate IFNα production by proximal tubules during ischemic AKI. Am J Physiol Renal Physiol. 2013 Jul 15;305(2):F164-72.

Cao, D.J., Jiang, N., Blagg, A., Johnstone, J.L., Gondalia, R., Oh, M., Luo, X., Yang, K.C., Shelton, J.M., Rothermel, B.A., Gillette, T.G., Dorn, G.W., Hill, J.A. Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy. J Am Heart Assoc. 2013 Apr 8;2(2):e000016.

Quintens, R., Singh, S., Lemaire, K., De Bock, K., Granvik, M., Schraenen, A., Vroegrijk, I.O., Costa, V., Van Noten, P., Lambrechts, D., Lehnert, S., Van Lommel, L., Thorrez, L., De Faudeur, G., Romijn, J.A., Shelton, J.M., Scorrano, L., Lijnen, H.R., Voshol, P.J., Carmeliet, P., Mammen, P.P., Schuit, F. Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance. PLoS One. 2013;8(2):e56719.

Peterson, J.R., Watts, C.R., Morris, J.A., Shelton, J.M., Cooper, B.G. Laryngeal aging and acoustic changes in male rat ultrasonic vocalizations. Dev Psychobiol. 2012 Dec; 55(8):818-828.

Liu, N., Williams, A.H., Maxeiner, J.M., Bezprozvannaya, S., Shelton, J.M., Richardson, J.A., Bassel-Duby, R., Olson, E.N. microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice. J Clin Invest. 2012 Jun 1;122(6):2054-65.

Satapati, S., Sunny, N.E., Kucejova, B., Fu, X., He, T.T., Mendez-Lucas, A., Shelton, J.M., Perales, J.C., Browning, J.D., Burgess, S.C. Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver. J Lipid Res. 2012 Jun;53(6):1080-92.

Taurog, J.D., Rival, C., van Duivenvoorde, L.M., Satumtira, N., Dorris, M.L., Sun, M., Shelton, J.M., Richardson, J.A., Hamra, F.K., Hammer, R.E., Tung, K.S. Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats. Arthritis Rheum. 2012 Aug;64(8):2518-28.

Battiprolu, P.K., Hojayev, B., Jiang, N., Wang, Z.V., Luo, X., Iglewski, M., Shelton, J.M., Gerard, R.D., Rothermel, B.A., Gillette, T.G., Lavandero, S., Hill, J.A. Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. J Clin Invest. 2012 Mar 1;122(3):1109-18.

Moresi, V., Carrer, M., Grueter, C.E., Rifki, O.F., Shelton, J.M., Richardson, J.A., Bassel-Duby, R., Olson, E.N. Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1649-54.

Xie, X., Brown, M.S., Shelton, J.M., Richardson, J.A., Goldstein, J.L., Liang, G. Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15330-5.

Liu, N., Bezprozvannaya, S., Shelton, J.M., Frisard, M.I., Hulver, M.W., McMillan, R.P, Wu, Y., Voelker, K.A., Grange, R.W., Richardson, J.A., Bassel-Duby, R., Olson, E.N. Mice lacking microRNA 133a develop dynamin 2-dependent centronuclear myopathy. J Clin Invest. 121(8): 3258-3268, 2011.

Sachan, N., Dey, A., Rotter, D., Grinsfelder, D.B., Battiprolu, P.K., Sikder, D., Copeland, V., Oh, M. Bush, E., Shelton, J.M., Bibb, J.A., Hill, J.A., Rothermel, B.A. Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart. Circ Res 108(4): 437-445, 2011.

Chen, J., John, R., Richardson, J.A., Shelton, J.M., Zhou, X.J., Wang, Y., Wu, Q.Q., Hartono, J.R., Winterberg, P.D., Lu. C.Y. Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury. Kidney Int 79(3): 289-299, 2010.

Moresi, V., Williams, A.H., Meadows, E., Flynn, J.M., Potthoff, M.J., McAnally, J., Shelton, J.M., Backs, J., Klein, W.H., Richardson, J.A. Bassel-Duby, R., Olson, E.N. Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases. Cell 143(1): 35-45, 2010.

Massare, J, Berry, JM, Luo, X, Rob, F, Johnstone, JL, Shelton, J.M., Bassel-Duby, R, Hill, JA, Naseem, RH. Diminished cardiac fibrosis in heart failure is associated with altered ventricular arrhythmia phenotype. J Cardiovasc Electrophysiol 21(9): 1031-1037, 2010.

Evers, BM, Farooqi, MS, Shelton, J.M., Richardson, JA, Goldstein, JL, Brown, MS, Liang, G. Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin. J Invest Dermatol 130(5): 1237-1248, 2010.

van Rooij, E, Fielitz, J, Sutherland, LB, Thijsse, VL, Crijns, HJ, Dimaio, MJ, Shelton, J.M., De Windt, LJ, Hill, JA, Olson, EN. Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor. Circ Res 106(1): 155-165, 2009.

Wang, Y, John, R, Chen, J, Richardson, JA, Shelton, J.M., Bennett, M, Zhou, XJ, Nagami, GT, Zhang, Y, Wu, QC, Lu, CY. IRF-1 promotes inflammation early after ischemic acute kidney injury. J Am Soc Nephrol 20(7): 1544-1555, 2009. 

Shivnani, SB, Shelton, J.M., Richardson, JA, Maalouf, NM. Hypercalcemia of malignancy with simultaneous elevation in serum parathyroid hormone-related peptide and 1,25-dihydroxyvitamnin D in a patient with metastatic renal cell carcinoma. Endocr Pract 15(3): 234-239, 2009. 

Bock-Marquette, I, Shrivastava, S, Pipes, GC, Thatcher, JE, Blystone, A, Shelton, J.M., Galindo, CL, Melegh, B, Srivastava, D, Olson, EN, DiMaio, JM. Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo. J Mol Cell Cardiol 46(5):728-728, 2009.

Funato, N, Chapman, SL, McKee, MD, Funato, H, Morris, JA, Shelton, J.M., Richardson, JA, Yanagisawa, H. Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DBA binding of Runx2. Development136(4): 615-625, 2009.

Tannous, P, Zhu, H, Johnstone, JL, Shelton, J.M., Rajasekaran, NS, Benjamin, IJ, Nguyen, L, Gerard, RD, Levine, B, Rothermel, BA, Hill, JA. Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Nat Acad Sci USA 105(28): 9745-9750, 2008.

Tannous, P, Zhu, H, Nemchenko, A, Berry, JM, Johnstone, JL, Shelton, J.M., Miller, FJ, Rothermel, BA, Hill, JH. Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation 117(24): 3070-3078, 2008.

Huang, J, Shelton, J.M., Richardson, JA, Kamm, KE, Stull, JT. Myosin regulatory light chain phosphorylation attenuates cardiac hypertrophy. J Biol Chem 283(28): 19748-19756, 2008.

Kim, MS, Fielitz, J, McAnally, J, Shelton, J.M., Lemon, DD, McKinsey, TA, Richardson, JA, Bassel-Duby, R, Olson, EN. Protein kinase D1 stimulates MEF2 activity in skeletal muscle and enhances muscle performance. Mol Cell Biol 28(11): 3600-3609, 2008.

Fielitz, J, Kim, MS, Shelton, J.M., Qi, X, Hill, JA, Richardson, JA, Bassel-Duby, R, Olson, EN. Requirement of protein kinase D1 for pathological cardiac remodeling. Proc Nat Acad Sci USA 105(8): 3059-3063, 2008.

Lavery, GG, Walker, EA, Turan, N, Rogoff, D, Ryder, JW, Shelton, J.M., Richardson, JA, Falciani, F, White, PC, Stewart, PM, Parker, KL, McMillan, DR. Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy. J Biol Chem 283(13): 8453-8461, 2008.

Zhao, G, Jeoung, NH, Burgess, SC, Rosaaen-Stowe, KA, Inagaki, T, Latif, S, Shelton, J.M., McAnally, J, Bassel-Duby, R, Harris, RA, Richardson, JA, Kliewer, SA. Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol 294(2): H963-H943, 2008.

Hoeffer, CA, Dey, A, Sachan, N, Wong, H, Patterson, RJ, Shelton, J.M., Richardson, JA, Klann, E, Rothermel, BA. The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling. J Neurosci 27(48): 13161-13172, 2007.

Fielitz, J, Kim, MS, Shelton, J.M., Latif, S, Spencer, JA, Glass, DJ, Richardson, JA, Bassel-Duby, R, Olson, EN. Myosin accumulation and striated muscle myopathy result from the loss of muscle RING. finger 1 and 3. J Clin Invest 117(9): 2486-2495, 2007.

Potthoff, MJ, Wu, H, Arnold, MA, Shelton, J.M., Backs, J, McAnally, J, Richardson, JA, Bassel-Duby, R, Olson, EN. Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest 117(9) 2459-2467, 2007.

Zhu, H, Tannous, P, Johnstone, JL, Kong, Y, Shelton, J.M., Richardson, JA, Le, V, Levine, B, Rothermel, BA, Hill, JA. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest 117(7): 1782-1793, 2007.

Fielitz, J, van Rooij, E, Spencer, JA, Shelton, J.M., Latif, S, van der Nagel, R, Bezprozvannaya, S, de Windt, L, Richardson JA, Bassel-Duby, R, Olson, EN. Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction. Proc Nat Acad Sci USA 104(11): 4377-4382, 2007.

Arnold, MA, Kim, Y, Czubryt, MP, Phan D, McAnally, J, Qi, X, Shelton J.M., Richardson, JA, Bassel-Duby, R, Olson, EN. MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell 12(3): 377-389, 2007.

Zhao, W, Swanson, SA, Ye, J, Li, X, Shelton, J.M., Zhang, W, Thomas, GD. Reactive oxygen species impair sympathetic vasoregulation in skeletal muscle in angiotensin II-dependent hypertension. Hypertension 48(4): 637-643, 2006.

Mammen, PP, Shelton, J.M., Ye, Q, Kanatous, SB, McGrath, AJ, Richardson, JA, Garry, DJ. Cytoglobin is a stress-responsive hemoprotein that is expressed in developing and adult brain. J Histochem Cytochem 54(12): 1349-1361, 2006.

Inagaki, T, Moschetta, A, Lee, YK, Peng, L, Zhao, G, Downes, M, Yu, RT, Shelton, J.M., Richardson, JA, Repa, JJ, Mangelsdorf, DJ, Kliewer, SA. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Nat Acad Sci USA 103(10): 3920-3925, 2006.

Pipes, GC, Sinha, S, Qi, X, Zhu, CH, Gallardo, TD, Shelton, J.M., Creemers, EE, Sutherland, L, Richardson, JA, Garry, DJ, Wright, WE, Owens, GK, Olson, EN. Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression. Dev Biol 288(2): 502-513, 2005. COVER MANUSCRIPT

Kielar, ML, John, R, Bennett, M, Richardson, JA, Shelton, J.M., Chen, L, Jeyarajah, DR, Zhou, H, Chiquett, B, Nagami, GT, Lu, CY. Maladaptive role of IL-6 in ischemic acute renal failure. J Am Soc Nephrol 16(11): 3315-3325, 2005.

Nakagawa, O, Arnold, M, Nakagawa, M, Hamada, H, Shelton, J.M., Kusano, J, Harris, TM, Childs, G, Campbell, KP, Richardson, JA, Nishino, I, Olson, EN. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Gen and Dev 19(17): 2066-2077, 2005. COVER MANUSCRIPT

Hinshelwood, MM, Shelton, J.M., Richardson, JA, Mendelson, CR. Temporal and spatial expression of liver receptor homologue-1 (LRH-1) during embryogenesis suggests a potential role in gonadal development. Dev Dyn 234: 159-168, 2005.

Mendelson, CR, Jiang, B, Shelton, J.M., Richardson, JA, Hinshelwood, MM. Transcriptional regulation of aromatase in placenta and ovary. J Steroid -Biochem Mol Biol 95(1-5): 25-33, 2005.

Oh, M, Rybkin, II, Copeland, V, Czubryt MP, Shelton, J.M., van Rooij, E, Richardson, JA, Hill, JA, De Windt, LJ, Bassel-Duby, R, Olson, EN, Rothermel, BA. Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers. Mol Cell Biol 25(15): 6629-6638, 2005.

Kasus-Jacobi, A, Ou, J, Birch, DG, Locke, KG, Shelton, J.M., Richardson, JA, Murphy, AJ, Valenzuela, DM, Yancopoulos, GD, Edwards, AO. Functional characterization of mRDH11 as a retinol dehydrogenase involved in dark adaptation in vivo. J Biol Chem 280(21): 20413-20420, 2005.

Kamat, A, Smith, ME, Shelton, J.M., Richardson, JA, Mendelson, CR. Genomic regions that mediate placental cell-specific and developmental regulation of human CYP19 (aromatase) gene expression in transgenic mice. Endocrinology 146(5): 2481-2488, 2005.

Scortegagna M, Ding K, Zhang Q, Oktay Y, Bennett MJ, Bennett M, Shelton J.M., Richardson JA, Moe O, Garcia JA. HIF-2{alpha} regulates murine hemapoietic development in an erythropoietin-dependent manner. Blood105(8): 3133-3140, 2005.

Arany, Z, He, H, Lin, J, Hoyer, K, Handschin, C, Toka, O, Ahmad, F, Matsui, T, Chin, S, Wu, P, Rybkin, II, Shelton, J.M., Manieri, M, Cinti, S, Schoen, FJ, Bassel-Duby, R, Rosenzweig, A, Ingwall, JS, Spiegelman, BM. Transcriptional coactivator PGC-1alpha controls the energy state and contractile function of cardiac muscle. Cell Metab 1(4): 259-271, 2005. COVER MANUSCRIPT.

Arai, S, Shelton, J.M., Chen, M, Bradley, MN, Castrillo, A, Bookout, AL, Mak, PA, Edwards, PA, Mangelsdorf, DJ, Tontonoz, P, Miyazaki, T. A role for the apoptosis inhibitory factor AIM/Sp-alpha/Api6 in atherosclerosis development. Cell Metab 1(3): 201-213, 2005.

Tamura N, Doolittle LK, Hammer RE, Shelton J.M., Richardson JA, Garbers DL. Critical roles of guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs. Proc Natl Acad Sci USA 101(49): 17300-17305, 2004.

Frey N, Barrientos T, Shelton J.M., Frank D, Rutten H, Gehring D, Kuhn C, Lutz M, Rothermel B, Bassel-Duby R, Richardson JA, Katus HA, Hill JA, Olson EN. Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress. Nat Med 10(12): 1336-1343, 2004.

Vega RB, Matsuda K, Oh J, Barbosa AC, Yang X, Meadows E, McAnally J, Pomajzl C, Shelton J.M., Richardson JA, Karsenty G, Olson EN. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 119(4) 555-566, 2004. COVER MANUSCRIPT.

Straach KJ, Shelton J.M., Richardson JA, Hascall VC, Mahendroo MS. Regulation of hyaluronan expression during cervical ripening. Glycobiology15(1): 55-65, 2004.

Rosenberg P, Hawkins A, Stiber J, Shelton J.M., Hutcheson K, Bassel-Duby R, Shin DM, Yan Z, Williams RS. TRPC3 channels confer cellular memory of recent neuromuscular activity. Proc Natl Acad Sci USA 101(25): 9387-9392, 2004.

Feulner JA, Lu M, Shelton J.M., Zhang M, Richardson JA, Munford RS. Identification of acyloxyacyl hydrolase, a lipopolysaccharide-detoxifying enzyme, in the murine urinary tract. Infect Immun 72(6): 3171-3178, 2004.

Marschang P, Brich J, Weeber EJ, Sweatt JD, Shelton J.M., Richardson JA, Hammer RE, Herz J. Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol Cell Biol 24(9): 3782-3793, 2004.

Lopez-Rodriguez C, Antos CL, Shelton J.M., Richardson JA, Lin F. Novobrantseva TI, Bronson RT, Igarashi P, Rao A, Olson EN. Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci USA 101(8): 2392-2397, 2004.

I Zhang Y, Woodward VK, Shelton J.M., Richardson JA, Zhou XJ, Link D, Kielar ML, Jeyarajah, Lu CY. Ischemia-reperfusion induces G-CSF gene expression by renal medullary thick ascending limb cells in vivo and in vitro. Am J Physiol Renal Physiol 286(6): F1193-F1201, 2004.

Cui Y, Huang L, Elefteriou F, Yang G, Shelton J.M., Giles JE, Oz OK, Pourbahrami T,Lu CY, Richardson JA, Karsenty G, Li C. Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol 24(1): 258-269, 2004.

Scortegagna M, Ding K, Oktay Y, Gaur A, Thurmond, F, Yan LJ, Marck BT, Matsumoto AM, Shelton J.M., Richardson JA, Bennett MJ, Garcia JA. Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1 -/- mice. Nat Genet 35(4): 331-340, 2003.

Gupta P, Soyombo AA, Shelton J.M., Wilkofsky IG, Wisniewski KE, Richardson JA, Hofmann, SL. Disruption of PPT2 in Mice Causes an Unusual Lysosomal Storage Disorder with Neurovisceral Features. Proc Nat Acad Sci USA 100: 12325-12330, 2003.

Hinselwood MM, Repa JJ, Shelton J.M., Richardson JA, Mangelsdorf DJ, Mendelson CR. Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function. Mol Cell Endocrinol 207(1-2): 39-45, 2003.

Kasus-Jacobi A, Ou J, Bashmakov YK, Shelton J.M., Richardson JA, Goldstein JL, Brown MS. Characterization of mouse short-chain aldehyde dehydrogenase (SCALD), an enzyme regulated by SREBPs. J Biol Chem 278(34): 32380-32389, 2003.

Chin ER, Grange RW, Viau F, Simard AR, Humphries C, Shelton J, Bassel-Duby R, Williams RS, Michel RN. Alterations in slow-twitch muscle phenotype in transgenic mice overexpressing the Ca2+ buffering protein parvalbumin. J Physiol 547(Pt 2): 649-663, 2003.

Lu JR, Bassel-Duby R, Hawkins A, Chang P, Valdez R, Wu H, Gan L, Shelton J.M., Richardson JA, Olson EN. Control of facial muscle development by MyoR and capsulin. Science 298(5602): 2378-2381, 2002.

Mammen, PPA, Shelton J.M.,, Goetsch, SC, Williams, SC, Richardson JA, Garry, MG, and Garry, DJ. Neuroglobin, a Novel Member of the Globin Family, is Expressed in Focal Regions of the Brain. J Hist Cyt 50(12): 1591-1598, 2002.

Antos CL, McKinsey TA, Frey N, Kutschke W, McAnally J, Shelton J.M., Richardson JA, Hill JA, and Olson EN. Activated Glycogen Synthase-3 Beta Suppresses Cardiac Hypertrophy In Vivo. Proc Nat Acad Sci USA 99(2) 907-912, 2002.

Wu H, Rothermel B, Kanatous S, Rosenberg P, Naya FJ, Shelton J.M., Hutcheson KA, DiMaio JM, Olson EN, Bassel-Duby R, and Williams RS. Activation of MEF2 by Muscle Activity is Mediated Through a Calcineurin-Dependent Pathway. EMBO 20(22): 6414-6423, 2001.

Gupta, P, Soyombo, AA, Atashband, A, Wisinewski, KE, Shelton, J.M., Richardson, JA, Hammer, RH, and Hoffman, SL. Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice. Proc Nat Acad Sci USA 98(24) 13566-13571, 2001.

Grange, RW, Meeson, A, Chin, E, Lau, KS, Stull, JT, Shelton, J.M., Williams, RS, and Garry, DJ. Functional and Molecular Adaptations in Skeletal Muscle of Myoglobin-Mutant Mice. Am J Physiol Cell Physiol 281: C1487-C1494, 2001.

Rothermel, BA, McKinsey, TA, Vega, R, Nicol, RL, Mammen, PPA, Yang, J, Antos, CL, Shelton, J.M., Bassel-Duby, R, Olson, EN, and Williams, RS. Myocyte-Enriched Calcineurin-Interacting Protein, MCIP1, Inhibits Cardiac Hypertrophy In-Vivo. Proc Natl Acad Sci USA 98: 3328-3333, 2001.

Meeson, A, Radford, N, Shelton, J.M., Mammen, PPA, DiMaio, JM, Hutcheson, KA, Kong, Y, Elterman, J, Williams, RS, and Garry, DJ. Adaptive Mechanisms That Preserve Cardiac Function in Mice Without Myoglobin. Cir Res 88(7): 713-720, 2001.

Kong, Y, Shelton, J.M., Rothermel, B, Li, X, Richardson, JA, Bassel-Duby, R, Williams, RS. Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to b-adrenergic stimulation. Circulation 103: 2731-2738, 2001. COVER MANUSCRIPT.

Zhang, W, Li, JL, Hosaka, M, Janz, R, Shelton, J.M., Albright, GM, Richardson, JA, Sudhof, TC, Victor, RG. Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings. Proc Natl Acad Sci USA 97: 9765-9770, 2000.

Gotthardt, M, Trommsdorff, M, Shelton, J.M., Richardson, JA, Herz, J. Interactions of the Low Density Lipoprotein (LDL) Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction. J Bio Chem 275: 25616-25624, 2000. 

Wu, H, Naya, FJ, McKinsey, T, Mercer, B, Shelton, J.M., Chin, ER, Bassel-Duby, R, Olson, EN, Williams, RS. MEF2 Responds to Multiple Calcium-Regulated Signals in the Control of Skeletal Muscle Fiber Type. EMBO 19(9): 1963-1973, 2000.

Li, K, Li, Y, Shelton, J.M.,Richardson, JA, Wang, X, Williams, RS. Cytochrome C Deficiency Causes Embryonic Lethality and Attenuates Stress Induced Apoptosis. Cell 101: 389-399, 2000.

Shelton J.M., Lee MH, Richardson JA, and Patel SB. Microsomal Triglyceride Transfer Protein Expression during Mouse Development. J Lip Res 41(4): 532-537, 2000. COVER MANUSCRIPT

Naya FJ, Mercer B, Shelton J.M., Richardson JA, Williams, RS, Olson EN. Stimulation of Slow Skeletal Muscle Fiber Gene Expression by Calcineurin. J Bio Chem 275(7): 4545-4548, 2000.

Trommsdorff M., Gotthardt M., Hiesberger T., Shelton J.M., Stockinger W., Nimpf J., Hammer R.E., Richardson J.A., and Herz J. Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2. Cell 97: 689-701, 1999. COVER MANUSCRIPT.

Chin, E., Olson, E.N., Richardson, J.A., Yang, Q., Humphries, C., Shelton, J.M., Wu, H., Zhu, W., Bassel-Duby, R., and Williams, R.S. A Calcineurin-Dependent Transcriptional Pathway Controls Skeletal Muscle Fiber Type. Gen and Dev 12: 16; 2499-2509, 1998. COVER MANUSCRIPT.

Bryant, D., Becker, L., Richardson, J.A., Shelton, J.M., Franco, F., Peshock, R., and Giroir, B. Cardiac Failure in Transgenic Mice with Myocardial Expression of Tumor Necrosis Factor-a (TNF). Circulation 97: 14; 1375-1381, 1998.

Zhou, Y.D., Barnard, M., Tian, H., Li, X., Ring, H.Z., Francke,U., Shelton, J.M., Richardson, J.A.. Russell,D.W., and McKnight, S.L. Molecular Characterization of Two Mammalian bHLH-PAS Domain Proteins Selectively Expressed in the Central Nervous System. Proc Natl Acad Sci USA 94: 2; 713-718, 1997.

Benjamin, I.J., Shelton, J.M., Garry, D.J., and Richardson, J.A. Temporospatial Expression of the Small HSP/aB-Crystallin in Cardiac and Skeletal Muscle During Mouse Development. Dev Dyn 208: 75-84, 1997. COVER MANUSCRIPT.

Neufer, P.D., Ordway, G.A., Hand, G.A., Shelton, J.M., Richardson, J.A., Benjamin,I.J., and Williams, R.S. Continuous Contractile Activity Induces Fiber Type Specific Expression of HSP70 in Skeletal Muscle. Am J Physiol 271 (Heart Circ Physiol 40): C1828-C1837 1996.

W.J. Parsons, R.S. Williams, Shelton, J.M., Y. Luo, D.J. Kessler, and J.A. Richardson. Developmental Regulation of Cytochrome Oxidase Subunit Via Isoforms in Cardiac and Skeletal Muscle. Am J Physiol 270 (Heart Circ Physiol 39): H567-H574, 1996.

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