News

News

Announcing the 2022 graduate course Multiscale Microscopy for Biomedical Research

(CMB_5306W_01_1275_3221)

Dates: January 10 - May 6, 2022

Days and Time: M F 1:30 to 3 pm

Place: NL3.120 (MASKS REQUIRED, maximum of 10 students)


Graduate students may register for 3 credits

Hands-on labs and demos are limited to registered graduate students. Auditors will be accommodated if space allows. Click here to sign up for the waiting list kate.phelps@utsouthwestern.edu.

Click here for syllabus: https://ppms.us/utsw/getfile/?pf=2&id=827-43C653B4
Click here to download ics file: https://ppms.us/utsw/getfile/?pf=2&id=828-1C0D36A4

Recent Publications

Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles. Li X, Vemireddy V, Cai Q, Xiong H, Kang P, Li X, Giannotta M, Hayenga HN, Pan E, Sirsi SR, Mateo C, Kleinfeld D, Greene C, Campbell M, Dejana E, Bachoo R, Qin Z.Nano Lett. 2021 Nov 24;21(22):9805-9815. doi: 10.1021/acs.nanolett.1c02996. Epub 2021 Sep 13.PMID: 34516144

Gallardo-Montejano VI, Yang C, Hahner L, McAfee JL, Johnson JA, Holland WL, Fernandez-Valdivia R, Bickel PE. Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance. Nat Commun. 2021;12(1):3320-. doi: 10.1038/s41467-021-23601-2. PubMed PMID: 34083525.

Developmental regulation of oocyte lipid intake through 'patent' follicular epithelium in Drosophila melanogaster. Row S, Huang YC, Deng WM.iScience. 2021 Mar 6;24(4):102275. doi: 10.1016/j.isci.2021.102275. eCollection 2021 Apr 23.PMID: 33817579

Transiently structured head domains control intermediate filament assembly. Zhou X, Lin Y, Kato M, Mori E, Liszczak G, Sutherland L, Sysoev VO, Murray DT, Tycko R, McKnight SL.Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2022121118. doi: 10.1073/pnas.2022121118.PMID: 33593918 

Cryo-EM structure of the Hippo signaling integrator human STRIPAK. Jeong BC, Bae SJ, Ni L, Zhang X, Bai XC, Luo X.Nat Struct Mol Biol. 2021 Mar;28(3):290-299. doi: 10.1038/s41594-021-00564-y. Epub 2021 Feb 25.PMID: 33633399

 The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization. Ramirez-Martinez A, Zhang Y, Chen K, Kim J, Cenik BK, McAnally JR, Cai C, Shelton JM, Huang J, Brennan A, Evers BM, Mammen PPA, Xu L, Bassel-Duby R, Liu N, Olson EN.Nat Commun. 2021 Jan 29;12(1):690. doi: 10.1038/s41467-021-20987-x.PMID: 33514739

Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease. Datta S, Bowerman J, Hariri H, Ugrankar R, Eckert KM, Corley C, Vale G, McDonald JG, Henne WM.Proc Natl Acad Sci U S A. 2020 Dec 11;117(52):33282-94. doi: 10.1073/pnas.2011124117. Online ahead of print.PMID: 33310904

 A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding. Wendt G, Zhao L, Chen R, Liu C, O'Donoghue AJ, Caffrey CR, Reese ML, Collins JJ 3rd.Science. 2020 Sep 25;369(6511):1644-1649. doi: 10.1126/science.abb7709.PMID: 32973030

Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure. Zhang Y, Seemann J.J Cell Biol. 2021 Jan 4;220(1):e202007052. doi: 10.1083/jcb.202007052.PMID: 33301566 

Mechanism of Eccentric Cardiomyocyte Hypertrophy Secondary to Severe Mitral Regurgitation. Li S, Nguyen NUN, Xiao F, Menendez-Montes I, Nakada Y, Tan WLW, Anene-Nzelu CG, Foo RS, Thet S, Cardoso AC, Wang P, Elhelaly WM, Lam NT, Pereira AHM, Hill JA, Sadek HA.Circulation. 2020 Jun 2;141(22):1787-1799. doi: 10.1161/CIRCULATIONAHA.119.043939. Epub 2020 Apr 10.PMID: 32272846

Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein. Zhang R, Lee DM, Jimah JR, Gerassimov N, Yang C, Kim S, Luvsanjav D, Winkelman J, Mettlen M, Abrams ME, Kalia R, Keene P, Pandey P, Ravaux B, Kim JH, Ditlev JA, Zhang G, Rosen MK, Frost A, Alto NM, Gardel M, Schmid SL, Svitkina TM, Hinshaw JE, Chen EH.Nat Cell Biol. 2020 Jun;22(6):674-688. doi: 10.1038/s41556-020-0519-7. Epub 2020 May 25.PMID: 32451441 

Loss of a conserved MAPK causes catastrophic failure in assembly of a specialized cilium-like structure in Toxoplasma gondii. O'Shaughnessy WJ, Hu X, Beraki T, McDougal M, Reese ML.Mol Biol Cell. 2020 Apr 15;31(9):881-888. doi: 10.1091/mbc.E19-11-0607. Epub 2020 Feb 19.PMID: 32073987

Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice. Chen B, Aredo B, Ding Y, Zhong X, Zhu Y, Zhao CX, Kumar A, Xing C, Gautron L, Lyon S, Russell J, Li X, Tang M, Anderton P, Ludwig S, Moresco EMY, Beutler B, Ufret-Vincenty RL. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12931-12942. doi: 10.1073/pnas.1921224117. Epub 2020 May 26. PMID: 32457148; PMCID: PMC7293615.

Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemiaFernández ÁF, Liu Y, Ginet V, Shi M, Nah J, Zou Z, Zhou A, Posner BA, Xiao G, Tanguy M, Paradis V, Sadoshima J, Rautou P-E, Puyal J, Hu MC, Levine B. JCI Insight. 2020;5(1). doi: 10.1172/jci.insight.133282.

Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles. Gao X, Zhang Z, Mashimo T, Shen B, Nyagilo J, Wang H, Wang Y, Liu Z, Mulgaonkar A, Hu XL, Piccirillo SGM, Eskiocak U, Davé DP, Qin S, Yang Y, Sun X, Fu YX, Zong H, Sun W, Bachoo RM, Ge WP.  Cell Rep. 2020 Feb 25;30(8):2489-2500.e5. doi: 10.1016/j.celrep.2020.01.089. PMID: 32101730.

Mechanism of Eccentric Cardiomyocyte Hypertrophy Secondary to Severe Mitral Regurgitation. Li S, Nguyen NUN, Xiao F, Menendez-Montes I, Nakada Y, Tan WLW, Anene-Nzelu CG, Foo RS, Thet S, Cardoso AC, Wang P, Elhelaly WM, Lam NT, Pereira AHM, Hill JA, Sadek HA. Circulation. 2020 Jun 2;141(22):1787-1799. doi: 10.1161/CIRCULATIONAHA.119.043939. Epub 2020 Apr 10. PMID: 32272846.

The tripartite interaction of phosphate, autophagy, and αKlotho in health maintenance. Shi M, Maique J, Shaffer J, Davidson T, Sebti S, Fernández ÁF, Zou Z, Yan S, Levine B, Moe OW, Hu MC. The FASEB Journal. 2020;34(2):3129-50. doi: 10.1096/fj.201902127R.

Dynamic structural order of a low-complexity domain facilitates assembly of intermediate filaments. Sysoev VO, Kato M, Sutherland L, Hu R, McKnight SL, Murray DT. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23510-23518. doi: 10.1073/pnas.2010000117. Epub 2020 Sep 9. PMID: 32907935; PMCID: PMC7519307.

Insulin receptor preserves mitochondrial function by binding VDAC1 in insulin insensitive mucosal epithelial cellsTitone R, Robertson DM. The FASEB Journal. 2020;34(1):754-75. doi: 10.1096/fj.201901316RR.

Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation. Tyra LK, Nandi N, Tracy C, Kramer H. Dev Cell. 2020;52(5):605-16 e7. Epub 2020/02/08. doi: 10.1016/j.devcel.2020.01.011

Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes. Ugrankar R, Bowerman J, Hariri H, Chandra M, Chen K, Bossanyi MF, Datta S, Rogers S, Eckert KM, Vale G, Victoria A, Fresquez J, McDonald JG, Jean S, Collins BM, Henne WM.  Dev Cell. 2019 Sep 9;50(5):557-572.e5. doi: 10.1016/j.devcel.2019.07.021. Epub 2019 Aug 15. PMID: 31422916; PMCID: PMC7446143.

A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feedingWendt G, Zhao L, Chen R, Liu C, O'Donoghue AJ, Caffrey CR, Reese ML, Collins JJ 3rd. Science. 2020 Sep 25;369(6511):1644-1649. doi: 10.1126/science.abb7709. PMID: 32973030.

Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein. Zhang R, Lee DM, Jimah JR, Gerassimov N, Yang C, Kim S, Luvsanjav D, Winkelman J, Mettlen M, Abrams ME, Kalia R, Keene P, Pandey P, Ravaux B, Kim JH, Ditlev JA, Zhang G, Rosen MK, Frost A, Alto NM, Gardel M, Schmid SL, Svitkina TM, Hinshaw JE, Chen EH.  Nat Cell Biol. 2020 Jun;22(6):674-688. doi: 10.1038/s41556-020-0519-7. Epub 2020 May 25. PMID: 32451441.

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