Biochemistry Core Facilities
Core Facilities at UT Southwestern provide researchers with access to advanced technologies, specialized expertise, and collaborative support that accelerate discovery across basic and translational science. From molecular characterization to drug development, these shared resources enable investigators to pursue complex questions with precision and efficiency. By integrating state-of-the-art instrumentation with expert consultation, the cores serve as a critical foundation for innovative research, fostering collaboration and supporting breakthroughs that impact human health.
Biochemistry Nuclear Magnetic Resonance Metabolomics Core
The Biochemistry Nuclear Magnetic Resonance Metabolomics Core offers high-resolution structural analysis of small molecules using state-of-the-art NMR instrumentation, and enables researchers to determine molecular structure, confirm compound identity, and study chemical interactions.
High-Throughput Screening Core
The High-Throughput Screening Core enables large-scale screening of chemical and genetic libraries to identify novel biological targets and therapeutic candidates. The core combines automation, assay development, and data analysis for efficient discovery workflows.
Medicinal Chemistry Core Facility
The Medicinal Chemistry Core Facility supports the design, synthesis, and optimization of small molecules for research and drug development. The core can assist researchers in launching medicinal-chemistry campaigns, synthesizing select compounds on large scale for testing, and preparing tools for chemical biology.
The Metabolomics Core Facility provides comprehensive analysis of small molecules and metabolic pathways using advanced mass spectrometry platforms, and supports both targeted and untargeted metabolomics to uncover biochemical changes in health and disease.
Preclinical Pharmacology Core Lab
The Preclinical Pharmacology Core Lab evaluates drug metabolism, pharmacokinetics, and toxicity to advance compounds toward clinical applications, and offers in vitro and in vivo studies to assess efficacy, bioavailability, and safety.
The Proteomics Core delivers protein identification, quantification, and characterization through cutting-edge mass spectrometry, and supports studies of protein expression, modifications, and interactions across diverse biological systems.
Transgenic Technology Center Core
The Transgenic Technology Center Core generates and maintains genetically engineered animal models to support studies of gene function and disease mechanisms, and provides expertise in genome editing technologies, including CRISPR-based approaches.