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Original Article Creating a Comprehensive Research Platform for Surgical Technique and Operative Outcome in Primary Brain Tumor Neurosurgery Alexander Winkler-Schwartz1, Recai Yilmaz1, Dan Huy Tran1, Houssem-Eddine Gueziri3, Binbin Ying2, Marius Tuznik4, Vladimir Fonov3, Louis Collins3, David A. Rudko4-6, Jianyu Li2, Patricia Debergue7, Valerie Pazos7, Rolando Del Maestro1 -BACKGROUND: The operative environment poses many challenges to studying the relationship between surgical acts and patient

Unveiling the Mechanisms of Cell-Cell Fusion Elizabeth H. Chen1* and Eric N. Olson2* Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, but little is known of its mechanistic underpinnings. Recent studies have revealed that many proteins involved in cell-cell fusion are also required for seemingly unrelated cellular processes such as phagocytosis, cell migration, axon growth, and synaptogenesis. We review advances in understanding cell-cell fusion by

Harold C. Simmons Comprehensive Cancer Center Bioinformatics Data Science Shared Resource Data Science Collaboration Agreement SCCC-DSSR This agreement is between the DSSR user named below and the Director of SCCC-DSSR, Professor Jeon Lee. By signing this document, user acknowledges and agrees to the conditions listed below. DSSR collaborator (Full Name

CELL SCIENCE AT A GLANCE The fusogenic synapse at a glance Ji Hoon Kim1 and Elizabeth H. Chen2,3,* ABSTRACT Cell–cell fusion is a fundamental process underlying fertilization, development, regeneration and physiology of metazoans. It is a multi-step process involving cell recognition and adhesion, actin cytoskeletal rearrangements, fusogen engagement, lipid mixing and fusion pore formation, ultimately resulting in the integration of two fusion partners. Here, we focus on the asymmetric actin

ll Matter of Opinion Young martlets: Exploring the world of academia and beyond Zhen Yin,1,2,* Bihe Chen,1,* Xiangkun Elvis Cao,1,3 Binbin Ying,1,4,5 Haocheng Quan,1,6 Chonghe Wang,1,7 Yinyin Ye,1,8 Xiaocheng Mi,1,4 Chian Yan,1,9 Yudi Ding,1,10 Shiming Zhang,1,11 Aram Bahmani,1,4 Ahmed Dalaq,1,12,13 Xiaotong Li,1,14 Xiao Shang,1,4,5 Kewang Nan,1,15 and Yiran Yang1,16 The Martlets Society (www.martlets-society.com) is an independent non-profit organization found and run by young scholars. It

Requirement of the fusogenic micropeptide myomixer for muscle formation in zebrafish Jun Shia,b,1, Pengpeng Bia,b,c,1, Jimin Peid, Hui Lia,b,c, Nick V. Grishind,e, Rhonda Bassel-Dubya,b,c, Elizabeth H. Chena,b,2, and Eric N. Olsona,b,c,2 aDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390; bHamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; cSenator Paul D. Wellstone Muscular

Developmental Cell Article A Critical Function for the Actin Cytoskeleton in Targeted Exocytosis of Prefusion Vesicles during Myoblast Fusion Sangjoon Kim,1,2 Khurts Shilagardi,1,2 Shiliang Zhang,1,2 Sabrina N. Hong,1 Kristin L. Sens,1 Jinyan Bo,1 Guillermo A. Gonzalez,1 and Elizabeth H. Chen1,* 1 Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 2 These authors contributed equally to this work. *Correspondence: echen@jhmi.edu

1 Sendai virus reprogrammed iPSC Lines Line Clone# Sex GAA repeat number in fibroblasts GAA repeat number in iPSCs Earliest passage Karyotype data Karyotype passage 1 CTRL 3348 6 M Control size Control size P5 Yes, normal P11 2 CTRL 7522 5 F Control size Control size P9 Yes, normal P15 3 CTRL 6718 1 M Control size Control size P2 Yes, normal P4 4 CTRL 6718 6 M Control size Control size P2 Yes, normal P4 5 CTRL 6719 1 F Control size Control size

Eugene McDermott Center for Human Growth and Development Southwestern Medical School 5323 Harry Hines Blvd. / Dallas, Texas 75390-8591 (214) 648-1695 Fax (214) 648-1666 Email: chao.xing@utsouthwestern.edu Computational Biologist I The laboratories of Dr. Ralph DeBerardinis at Children’s Research Institute (https://cri.utsw.edu/scientists/ralph-deberardinis-laboratory/) and Dr. Chao Xing at McDermott Center for Human Growth and Development (https://labs.utsouthwestern.edu

1 Napierala Lab protocol for human skin fibroblast culture (May 2022) Necessary Reagents Reagent Company Catalog Number DMEM, high glucose Gibco/Life Technologies 11965-092 Fetal bovine serum Hyclone SH30910.03 MEM Non-essential amino acids (NEAA) Gibco/Life Technologies 11140-050 0.25% Trypsin-EDTA, phenol red Gibco/Life Technologies 25200-056 DPBS (1X) Gibco/Life Technologies 14190-144 Fibroblast Medium recipe: DMEM, high glucose 15% fetal bovine serum (FBS