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Harold C. Simmons Comprehensive Cancer Center Bioinformatics Data Science Shared Resource Data Science Collaboration Agreement SCCC-DSSR This agreement is between the DSSR user named below and the Director of SCCC-DSSR, Professor Jeon Lee. By signing this document, user acknowledges and agrees to the conditions listed below. DSSR collaborator (Full Name

Harold C. Simmons Comprehensive Cancer Center Bioinformatics Data Science Shared Resource Data Science On-Demand User Agreement SCCC-DSSR This agreement is between the DSSR client named below and the Director of SCCC-DSSR, Professor Jeon Lee. By signing this document, user acknowledges and agrees to the conditions listed below. DSSR client (Full Name

1 R Co(CO)3(OC)3Co O O Δ (OC)3Co O R H O R H2 R H O (OC)4Co R (OC)4Co Co(CO)4 H H (CO)4CoH H2 CO R O H R CO (OC)3Co R (OC)3Co H R H2 R (OC)3Co R The Oxo process -developed in 1938 by Otto Roelen -Principle method for hydroformylation of terminal alkenes industrially -more that 4 million tons aldehyde annually -linear aldehydes more desirable Co2(CO)8 H2/CO (200-300 atm) 120-170 oC linear (normal) branched (iso) + chemical feed stocks linear alcohols

Ready; Catalysis Conjugate Addition Topics covered 1. 1,4 addition involving copper a. stoichiometric reactions b. catalytic reactions c. allylic substitution 2. Conjugate addition without copper a. Ni-based systems b. Rh-based systems 3. Catalytic addition of heteroatoms Topics not covered: enolate conjugate additions, Friedel-Crafts-type conjugate additions Ready; Catalysis Conjugate Addition: origin 1,4 addition reactions involving

Oxidation of Unsaturated Systems 2 general reactivity patterns: X H X Yn+2 X+ Yn ++ OH simple example O A- Me2SCl+ S+ O + S + Cl- 2 electron oxidation 1 electron oxidation Xor -1 e- or X we will focus on oxidation of aromatic rings and enol/enolate systems Couple Eo Fe(III) + e- Fe(II) 0.77 V(V) + e- V(IV) 1.00 Tl(III) + 2 e- Th(I) 1.25 Pb(IV) + 2 e- Pb(II) 1.6-1.7 Mn(III) + e- 1.56Mn(II) Ce(IV) + e- Ce(III) 1.6 Reduction potentials of oxidants we will look at (bigger number

Reductions General Resource: Trost, Comp. Org. Syn. 1991, vol 8 March,1992, chap 19 Carey and Sundberg, vol B, Chap 5 Smith, Organic Synthesis, Chap 4 Material organized (roughly) by transformation From March, 1992, p1208 H H Two general classes: Transition metal hydrogenation and dissolving metal reduction Hydrogenation: Covered in much more detail in Advanced Synthesis and Catalysis. H HM H2 General trends: more substituted = slower relationship of pressure:rate often not simple

Oxidations at Carbon General references March, Advanced Org Chem, 1992, 1158-1238 Trost, Comp. Org. Syn. 1991, vol 7 Carey and Sundberg, Advanced Org Chem, part B, 615-664 Smith, Org Syn, Chap 3 H CH3 C(-IV) R CH3 C(-III) R CH2 OH C(-1) R CH OH RR H2 C R C(-II) R C O R C(0) R CH O C(+I) H CH2 OH C(-II) H CH O C(0) C(II) R COR O C(+III) H COH O C(+II) O C O C(+IV) RO COR O C(+IV) alkane RCH2M RCH2SiR3 RCH2X X=halide RCH2NR2 RCH2SR RCH2PR2 Acetal: RCH(OR)2

Surface hydrolysis of poly(glycolic acid) meshes increases the seeding density of vascular smooth muscle cells Jinming Gao,1,2 Laura Niklason,1,2 Robert Langer1 1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 2Department of Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 02114 Received 22 January 1998; accepted 7 May 1998 Abstract: A procedure for surface hydrolysis of poly(gly- colic acid) (PGA) meshes was

JOURNAL OF RAMAN SPECTROSCOPY, VOL. 27, 549-554 (1996) Structure Characterization of W03/Zr02 Catalysts by Raman Spectroscopy Biying Zhao,* Xianping Xu, Jinming Gao, Qiang Fu and Youqi Tang Institute of Physical Chemistry, Peking University, Beijing 100871, China WO,/ZrO, catalysts prepared by different methods are distinct in their catalytic behaviour. In this work, WO,/ZrO, catalysts prepared by impregnating Zr(OH), and crystallized ZrO, and then calcining at selected temperatures

Subscriber access provided by UNIV TEXAS SW MEDICAL CENTER Journal of the American Chemical Society is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Using Electrospray Ionization FTICR Mass Spectrometry To Study Competitive Binding of Inhibitors to Carbonic Anhydrase Xueheng Cheng, Ruidan Chen, James E. Bruce, Brenda L. Schwartz, Gordon A. Anderson, Steven A. Hofstadler, David C. Gale, Richard D. Smith, Jinming Gao, George B. Sigal, Mathai Mammen