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In Memoriam: David J. Mangelsdorf, Ph.D., pioneer in orphan nuclear receptor research and Chair of Pharmacology Published on: August 09, 2025 • By: Newsroom Share Share on Facebook Share on Twitter Share on LinkedIn Email this page Print this page DALLAS – Aug. 9, 2025 – David J. Mangelsdorf, Ph.D., Chair and Professor of Pharmacology at UT Southwestern Medical Center, a visionary scientist who pioneered the once-obscure realm of orphan nuclear receptors (a class of proteins involved in gene

Researchers at UT Southwestern Medical Center have discovered how a hormone interacts with a receptor on the surface of immune cells to shield cancer cells from the body’s natural defenses. The findings, published in Nature Immunology, could lead to new immunotherapy approaches for treating cancer

Millions of Americans have chronic shoulder pain, which can have a significant impact on quality of life. Although some get relief from medications, physical therapy, or joint injections, those with persistent pain often pursue more aggressive treatments such as surgeries and permanent

The National Institutes of Health (NIH) and the National Institute on Aging recently approved funding for a 2022 study by the Institute for Exercise and Environmental Medicine (IEEM).

Mandatory participation in high school science fairs is counterproductive, emphasizes winning over learning, and sometimes leads to cheating and other research misconduct.

As more DFW businesses and schools have reopened, and as cases have begun to surge again, researchers are expanding participation for the DFW COVID-19 Prevalence Study – uniquely designed to reveal how widely COVID-19 has spread and why some communities are harder hit.

A protein produced by the human immune system can potently inhibit several coronaviruses, including the one behind the current COVID-19 outbreak, an international team of investigators reports today.

Children who undergo expansive genetic sequencing may not be getting the thorough DNA analysis their parents were expecting, say experts at UT Southwestern Medical Center.

The University of Texas Southwestern Medical Center and Parkland Health are consulting the people of the Dallas area on participating in a trauma research study to investigate using one dose of fresh frozen plasma (FFP), the colorless fluid part of blood, to treat patients who suffered a traumatic

In an animal model of multiple sclerosis (MS), decreasing the amount of a protein made in the liver significantly protected against development of the disease’s characteristic symptoms and promoted recovery in symptomatic animals, UTSW scientists report.