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In Vitro Metabolic Stability: Preclinical Pharmacology Core - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/preclinical-pharmacology/pricing-and-services/in-vitro-metabolic-stability.html
In Vitro Metabolic Stability Unless a compound is a pro-drug, good metabolic stability is important for achieving therapeutic concentrations for the sufficient amount of time in vivo. The liver is the most important site of drug metabolism in vivo , although other organs (gastrointestinal tract and l…
Older Publications: Preclinical Pharmacology core Lab - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/preclinical-pharmacology/publications/older-publications.html
Older Publications for the Preclinical Pharmacology Core at UT Southwestern
Plasma Protein Binding: Preclinical Pharmacology Lab - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/preclinical-pharmacology/pricing-and-services/plasma-protein-binding.html
Plasma Protein Binding Plasma protein binding (PPB) plays an important role in the pharmacokinetics (PK) and pharmacodynamics (PD) of a drug. Free drug levels are closely related to the pharmacological effects of a compound as the principal determinant of tissue distribution, cell entry, receptor int…
Whole Transcriptome - Next Generation Sequencing Core - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/next-generation-sequencing/ngs-applications/whole-transcriptome.html
Whole Transcriptome Samples are run on the Agilent Tapestation 4200 to determine level of degradation thus ensuring only high quality RNA is used (RIN Score 8 or higher). The Qubit fluorometer is used to determine the concentration prior to staring library prep. One microgram of total DNAse treated R…
General Usage: Electron Microscopy Core Facility - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/emcf/policies/general-usage.html
The Electron Microscopy Core Facility (EMCF) offers TEM of cells & tissues, negative staining, whole-mount SEM, correlative LM and EM, and Immunogold labeling.
Sample Submission: Electron Microscopy Core Facility - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/emcf/policies/sample-submission.html
The Electron Microscopy Core Facility (EMCF) offers TEM of cells & tissues, negative staining, whole-mount SEM, correlative LM and EM, and Immunogold labeling.
Nikon CSU-W1 SoRa: Quantitative Light Microscopy Core Facility - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/quantitative-light-microscopy/equipment-fees-and-services/nikon-csu-w1-sora.html
Nikon CSU-W1 SoRa (NL5.120R) Spinning disk confocal microscope for fixed or live samples Build for speed, allowing visualization of rapid dynamics in live cells and tissues SoRa module for resolution down to 120 nm. Piezo z-drive for fast z-stack acquisition. Fast xy-stage for multi-point acquisition…
OMX SR: Quantitative Light Microscopy Core Facility - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/quantitative-light-microscopy/equipment-fees-and-services/omx-sr.html
OMX SR (NL5.120R) 3D structured illumination microscopy (SIM) TIRF SIM 2D PALM/STORM Ring TIRF FRAP, photoactivation Deconvolution Nanopositioning motorized xyz stage Live cell incubation Sign Up Back-to top
Data Management: Quantitative Light Microscopy Core Facility - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/quantitative-light-microscopy/policies/data-management.html
Data Management Our computers are not intended for storage, only for data acquisition, and we are not responsible for your data! Data must be backed up at the end of each session to a storage location managed by the user! To provide enough storage for new data, we reserve the right to delete older da…
Critical Anatomy - Services - Histo Pathology Core - EDU - UT Southwestern, Dallas, Texas
https://www.utsouthwestern.edu/research/core-facilities/histo-pathology/services/critical-anatomy.html
Critical Anatomy/IHC The Histo Pathology Core is based upon the premise that research-oriented histology is about meeting the client investigators' need for critical anatomy. The lab is well versed in: Performing dark-field assisted cut-and-look microtomy to meet comparative anatomy between specimens…