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Loss of a gene known as SYNCRIP in prostate cancer tumors unleashes cellular machinery that creates random mutations throughout the genome that drive resistance to targeted treatments, a team led by UT Southwestern Medical Center researchers discovered.

A majority of Americans suffering from heart failure face substantial socioeconomic challenges, researchers at UT Southwestern Medical Center found.A majority of Americans suffering from heart failure face substantial socioeconomic challenges, researchers at UT Southwestern Medical Center found. The study revealed that 8 in 10 ambulatory heart failure patients are adversely affected by two or more social determinants of health (SDOH).

A novel combination of drugs successfully killed breast cells carrying double mutations in the HER2 gene that had rendered them resistant to a commonly used cancer therapy, a study led by UT Southwestern Medical Center researchers showed.

Two postdoctoral researchers at UT Southwestern Medical Center are among 25 early-career scientists nationwide selected as Howard Hughes Medical Institute (HHMI) Hanna H. Gray Fellows for 2023.

Zhijian “James” Chen, Ph.D., Professor of Molecular Biology at UT Southwestern Medical Center, has been awarded the 2023 Louisa Gross Horwitz Prize in recognition of his groundbreaking work on innate immunity.

Todd Aguilera, M.D., Ph.D., Assistant Professor of Radiation Oncology and member of the Experimental Therapeutics Program in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center, has been named one of 11 inaugural Cancer Moonshot Scholars. The national program recognizes a cohort of early-career investigators from underrepresented groups who have been identified as emerging leaders in cancer research and innovation.

Mitochondria that power cellular activity fragment and change shape in breast cancer cells that migrate to the brain, an adaptation that appears necessary for the cells to survive, UT Southwestern Medical Center researchers report in a new study. The findings, published in Nature Cancer, could lead to new ways to prevent brain metastases, or the spread of cells from primary tumors to the brain.

The painful experience of having a kidney stone has become more common in recent years, including in Texas, part of the “Stone Belt” where hot weather can cause dehydration. But small dietary changes as well as drinking lots of water can help avert the discomfort, says a board-certified physician assistant in the Department of Urology at UT Southwestern Medical Center.

Whether it’s after a natural disaster, a fatal shooting, or a tragedy closer to home, parents may find themselves trying to navigate difficult conversations with their children. What to say is just as important as what not to say, according to experts at UT Southwestern Medical Center. Children are naturally curious and may have questions, or they may be worried about their own safety.

The resilience and coping abilities of post-liver transplantation patients vary and change over time and are often linked to sociodemographic factors including income, race, and education, a study led by UT Southwestern Medical Center researchers shows.