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A UT Southwestern Medical Center quality improvement team led a large-scale, multispecialty project in partnership with the Parkland Center of Innovation and Value to help patients with implantable cardioverter defibrillators (ICDs) better understand their devices and make choices about their care.

Repeated sessions of electrical stimulation to brain networks associated with memory improved verbal learning in some Alzheimer’s disease patients for up to eight weeks in a preliminary trial led by UT Southwestern Medical Center researchers. The findings, published in The Journal of Prevention of Alzheimer’s Disease, indicate that while future trials are needed, neurostimulation shows early promise as a treatment for Alzheimer’s and other neurodegenerative disorders, such as Lewy body dementia.

A computer model of the cellular environment inside the knee developed by UT Southwestern Medical Center researchers sheds light on why women tend to have worse outcomes after knee injuries than men. Their findings, published in Scientific Reports, could facilitate research into new therapies for knee inflammatory disorders and personalized treatments for patients with these conditions.

An experimental treatment for depression that triggers seizures with magnets significantly improved mental health in patients without some cognitive effects associated with electroconvulsive therapy (ECT), a clinical trial led by UT Southwestern Medical Center researchers showed.

Poor diets have been linked to seven of the 10 leading causes of death in the United States, from heart disease to diabetes and certain types of cancer. Yet many physicians are not equipped to counsel patients about healthy food choices, and most medical students and trainees do not receive adequate training in this discipline.

Genetic testing, which has expanded in recent years with advances in technology and the development of consumer products, is on a path to widespread acceptance in the U.S., researchers at UT Southwestern Medical Center found.

Using gene editing in a preclinical model, researchers at UT Southwestern Medical Center blocked the symptoms of a rare smooth muscle disease before they developed. Their findings, published in Circulation, could eventually lead to gene therapies for this and other genetic diseases affecting smooth muscle cells.

Italian medical geneticist Andrea Ballabio, M.D., an internationally recognized scientist who has devoted his career to elucidating the mechanisms underlying genetic diseases, has been named the recipient of the 2025 Beth Levine, M.D. Prize in Autophagy Research from UT Southwestern Medical Center.

A protein called angiopoietin-2 (ANGPT2) can both inhibit and encourage blood vessel changes critical for sepsis, a leading cause of hospital deaths worldwide, a new study led by UT Southwestern Medical Center researchers shows.

Obese mice whose fat cells were genetically altered to produce an increased amount of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lost more than a third of their body weight through a mechanism that burns energy, UT Southwestern Medical Center researchers report in a new study.