Core Facilities and Labs
The Division of Cardiology maintains a number of facilities to support the research of its investigators. Each core is supported by professional and technical personnel dedicated to its specialized function. These arrangements provide a level of expertise that would be difficult to achieve within a single laboratory.
Joseph Hill Lab
Research Interests: Our laboratory focuses on molecular mechanisms of remodeling in the stressed myocardium. In particular, we strive to decipher mechanisms of structural, functional, and electrical remodeling in heart disease with an eye toward therapeutic intervention. Presently, our studies are based largely on genetic and surgical models of cardiac hypertrophy and failure in animals.
Nikhil Munshi Lab
Research Interests: The cardiac conduction system is an electrically-coupled structure within the heart responsible for initiation and propagation of each heartbeat. Our lab is interested in elucidating the transcriptional mechanisms that dictate formation of the cardiac conduction system and its impact on the establishment of normal cardiac rhythm.
Jim Richardson Lab
Research Interests: The Richardson Molecular Pathology Core facilitates morphologic and histologic assessment of experimental disease models. The lab relies on extensive expertise in gross pathology, routine histology, special stains, in-situ hybridization, immunohistochemistry, laser-capture microdissection, photomicrography, and image analysis to carry out its support of fundamental and clinical cardiovascular research as well as other research in other clinical sciences.
Beverly Rothermel Lab
Research Interests: Research in the Rothermel laboratory focuses on deciphering the molecular mechanisms that control cardiac structure and function during normal development and in response to pathological stress. The gene regulator of calcineurin 1 (RCAN1) plays a central role in our studies. Ongoing projects are focused on understanding (1) the fundamental processes through which RCAN1 regulates calcineurin signaling, (2) circadian regulation of cardiac function, (3) RCAN1's role in adipocyte differentiation an metabolism, and (4) mitophagy in cardiac disease and aging.
Hesham Sadek Lab
Research Interests: Cardiac regeneration and stem cell metabolism