Faculty and Research Interests
J. David Farrar, Ph.D., Associate Professor
The Farrar Lab is generally interested in understanding how external signals regulate T cell function and development. We study both the regulatory components that impact allergic diseases and external signals that control inflammation and immune homeostasis.
Dustin Hancks, Ph.D., Assistant Professor
The genome sequence of an organism can be thought of as a type of “encyclopedia.” Filled with vast amounts of information including the blueprint of an organism, genomes also contain a historical record of past battles with pathogens. Using these molecular scars of battle along with evolutionary analysis, genomics, and molecular biology, the Hancks Lab aims to better understand host defenses against pathogens including the identification of new battlefronts critical in determining the outcome of infection. Furthermore, another major goal is to increase our understanding of cell biology by exploiting insights from the adaptive mechanisms used by viruses.
Lora Hooper, Ph.D., Professor and Chair
The Hooper lab studies how the resident intestinal microbiota interacts with the immune system of humans and other mammalian hosts. Group members use a broad mix of experimental approaches, ranging from studies in animal models to the use of structural methods to understand protein function.
Robert Orchard, Ph.D., Assistant Professor
The goal of the Orchard lab is to have a more comprehensive understanding of host-pathogen interactions by leveraging functional genomic CRISPR/Cas9 screens. We hope to identify novel vulnerabilities in a virus or bacterial life cycle which could represent a therapeutic target. Additionally, the Orchard lab uses viruses as tools to better understand mammalian physiology and immune responses. We currently are investigating norovirus, influenza virus, and enterovirus biology.
Tiffany Reese, Ph.D., Assistant Professor
The Reese lab studies how chronic viruses and other pathogens change the immune system and how the immune system controls these pathogens. Our goal is to use mouse pathogens to model how chronic infections change responses to coinfections and vaccinations.
Nicolai van Oers, Ph.D., Associate Professor
We are interested in understanding the molecular mechanisms that regulate the development and regeneration of the thymus under normal and disease states. The studies incorporate our recent discoveries of the coding and noncoding RNAs responsible for primary immunodeficiency diseases in humans, specifically with those connected with a hypoplasia of the thymus. We are using mouse models of selected human disorders along with thymic tissues from patients with the goal of regenerating normal thymic tissue functions. Our findings are revealing novel contributions of both noncoding RNAs, such as long intergenic noncoding RNAs (lncRNAs), microRNAs (miRNAs), and small noncoding RNAs (sncRNAs) in normal health and disease, including tuberculosis.
Ellen Vitetta, Ph.D., Professor
The Vitetta lab has developed and patented a highly stable, safe, and effective recombinant ricin vaccine that protects mice and primates against aerosolized ricin; it is safe and immunogenic in humans. Prior to carrying out the pivotal clinical trial, we are profiling epitope-specific antibodies from archived sera to develop an assay that predicts protection. This assay will be used in the final dose-finding clinical trial. We are also exploring a novel vaccine platform based on synthetic "peptoid" (B cell) epitopes that are protease-resistant and highly immunogenic when attached to carrier proteins. The lab will screen large, diverse libraries of peptoids with broadly protective monoclonal antibodies against pathogens, toxins, and prions and use our "hits" to generate protective vaccines.
Edward K. Wakeland, Ph.D., Professor
The Wakeland Lab utilizes state-of-the-art genomic strategies to investigate the diversity of the human and mouse immune systems. Our primary focus in human genetics is to delineate the genetic basis for autoimmune diseases such as Lupus and to identify the molecular pathways that contribute to disease pathology. We are also investigating the genetic diversity of innate immune responses in the human myeloid cell lineage.
Nan Yan, Ph.D., Associate Professor
The Yan lab is primarily interested in the molecular mechanisms of innate immunity and how they impact infectious and autoimmune diseases. We all know that innate immune signaling pathways are essential for detecting pathogens, and mutations in key molecules of these pathways can also cause autoimmune diseases. We study both ends of the spectrum, with a strong focus on monogenic immune diseases that affect genes that also play important roles in infection.
Zhenyu Zhong, Ph.D., Assistant Professor
The goal of the Zhong lab is to investigate the fundamental mechanisms by which mitochondria sense perturbation of tissue homeostasis, initiate inflammation and orchestrate tissue repair and regeneration. The Zhong Lab is also interested in understanding how dysregulation of such processes leads to disease development.